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https://www.readbyqxmd.com/read/29684923/percutaneous-endoscopic-interlaminar-unilateral-ventral-dural-approach-for-symptomatic-bilateral-l5-s1-herniated-nucleus-pulposus-technical-note
#1
Sung Ho Choi, Nitin Maruti Adsul, Hyeun Sung Kim, Ki Joon Kim, Jeong Hoon Kim, Sung Kyun Chung, Jeong Hoon Choi, Jee Soo Jang, Il Tae Jang, Seong Hoon Oh
BACKGROUND:  Percutaneous endoscopic lumbar diskectomy is a good treatment modality for lumbar disk herniation. However, when a patient complains of bilateral lower limb radicular pain with severe disk protrusion at the L5-S1 level, the transforaminal approach is often unable to resolve both lesions owing to anatomical limitations. It is also very difficult to resolve both lesions in an ipsilateral direction using the percutaneous interlaminar approach. We report our surgical technique and clinical results using a ventral dural approach of percutaneous endoscopic interlaminar lumbar diskectomy for L5-S1 herniated nucleus pulposus (HNP) in patients with bilateral radiculopathy due to a severe disk protrusion...
April 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29684921/clinical-efficacy-of-bone-reconstruction-surgery-with-frozen-cortical-bone-allografts-for-nonunion-of-radial-and-ulnar-fractures-in-toy-breed-dogs
#2
Shuntaro Munakata, Yukari Nagahiro, Daichi Katori, Norihiro Muroi, Hiroyuki Akagi, Nobuo Kanno, Yasuji Harada, Shinya Yamaguchi, Kei Hayashi, Yasushi Hara
OBJECTIVE:  To evaluate the effectiveness of frozen cortical bone allografts (FCBA) in the treatment of severe radial and ulnar atrophic nonunion fractures. ANIMALS:  Toy breed dogs with nonunion of radial and ulnar fractures ( n  = 15). METHODS:  Severe atrophic nonunion fractures were treated with FCBA (eight infected and seven non-infected fractures). Radiographs obtained immediately after surgery, and 1, 2, 3, 6 and 12 months later were evaluated and scored for the periosteal reaction at the bone regeneration sites, the healing process in the bone connection areas at both the proximal and distal sites, and the bone remodelling process within the allografts...
April 23, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29684826/ongoing-child-welfare-services-understanding-the-relationship-of-worker-and-organizational-characteristics-to-service-provision
#3
Kristen Lwin, John Fluke, Nico Trocmé, Barbara Fallon, Faye Mishna
Ongoing child welfare services are put in place after completion of the initial maltreatment investigation when there is a perceived need to mitigate the risk of future harm. The knowledge of how clinical, worker, and organizational characteristics interact with this decision to provide ongoing child welfare services is not well integrated in the research literature. Using secondary data from the Canadian Incidence Study of Reported Child Abuse and Neglect-2008, this study's primary objective is to understand the relationship of clinical, worker, and organizational characteristics to the decision to transfer a case to ongoing child welfare services and their relative contribution to the transfer decision in Canada...
April 20, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29684805/detecting-a-rare-composite-small-bowel-lymphoma-by-magnetic-resonance-imaging-coincidentally-a-case-report-with-radiological-surgical-and-histopathological-features
#4
M Pezzella, B Brogna, A Romano, F Torelli, G Esposito, M Petrillo, F M Romano, N Di Martino, A Reginelli, R Grassi
INTRODUCTION: Diagnosing lymphoma continues to prove challenging in the clinical practice. Composite lymphoma (CL) is defined by the coexistence of different lymphoma subtypes in the same anatomical location. This condition has seldom been witnessed in the gastrointestinal (GI) tract. We weren't able to find previous cases in the literature about small bowel CL with follicular lymphoma (FL) and classical Hodgkin lymphoma (CHL). Surgery is the treatment of choice to obtain accurate histology, to manage and prevent acute complications...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29684638/medication-related-osteonecrosis-of-the-jaw-a-survey-of-knowledge-attitudes-and-practices-among-dentists-in-the-principality-of-asturias-spain
#5
M Escobedo, L García-Consuegra, S Junquera, S Olay, G Ascani, L Junquera
INTRODUCTION: The objective of this study was to investigate the knowledge and capabilities of dentists and dental students in their last year of study in regard to risk factors of medication-related osteonecrosis of the jaw (MRONJ) in Spain. MATERIAL AND METHOD: We conducted a cross-sectional study consisting of a questionnaire survey in Asturias, Spain. The study was divided into three groups: dentists who worked for the public dental health care system (n=32), dentists who worked exclusively as private health care practitioners (n= 136), and dental students in their last year (year five) of study (n= 38)...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29684637/reconstruction-of-condyles-by-transport-distraction-osteogenesis-3-case-report-with-complication-management
#6
Dogan Dolanmaz, Kayhan Ozturk, Mehmet Bahadir Llik, Murat Celik
OBJECTIVE: The aim of this case report is to evaluate the clinical outcomes that including minor postoperative complications of the transport distraction osteogenesis (TDO) for reconstruction of the ramus-condyle unit. STUDY DESIGN: We present 3 cases of the ramus condyle unit reconstruction after the resection of bone tumors. All three bone tumors were excised intraoperatively and the histologic assessment confirmed the clinical diagnosis of osteochondroma, condylar hyperplasia and osteoma...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29684634/interactive-electronic-decision-trees-for-the-integrated-primary-care-management-of-febrile-children-in-low-resource-settings-review-of-existing-tools
#7
REVIEW
Kristina Keitel, Valérie D'Acremont
BACKGROUND: The lack of effective, integrated diagnostic tools pose a major challenge to the primary care management of febrile childhood illnesses. These limitations are especially evident in low-resource settings and are often inappropriately compensated by antimicrobial over-prescription. Interactive electronic decision trees (IEDTs) have the potential to close these gaps: guiding antibiotic use and better identifying serious disease. AIMS: This narrative review summarizes existing IEDTs, to provide an overview of their degree of validation, as well as to identify gaps in current knowledge and prospects for future innovation...
April 20, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29684586/targeted-biochemical-profiling-of-brain-from-huntington-s-disease-patients-reveals-novel-metabolic-pathways-of-interest
#8
Stewart F Graham, Xiaobei Pan, Ali Yilmaz, Shirin Macias, Andrew Robinson, David Mann, Brian D Green
Huntington's disease (HD) is a devastating, progressive neurodegenerative disease with a distinct phenotype characterized by chorea and dystonia, incoordination, cognitive decline and behavioral difficulties. The precise mechanisms of HD progression are poorly understood; however, it is known that there is an expansion of the trinucleotide cytosine-guanosine-guanine (CAG) repeat in the Huntingtin gene. Herein DI/LC-MS/MS was used to accurately identify and quantify 185 metabolites in post mortem frontal lobe and striatum from HD patients and healthy control cases...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684577/predictors-of-switching-from-non-steroidal-anti-inflammatory-drugs-to-corticosteroids-in-patients-with-acute-pericarditis-and-impact-on-clinical-outcome
#9
George Lazaros, Alexios S Antonopoulos, Charalambos Vlachopoulos, Evangelos Oikonomou, Apostolos Karavidas, Christina Chrysohoou, Emilia Lazarou, Dimitrios Vassilopoulos, Massimo Imazio, Dimitris Tousoulis
BACKGROUND: Aspirin and non-steroidal anti-inflammatory drugs (A/NSAIDs) are the mainstay treatments for of acute pericarditis. We sought to identify factors predicting A/NSAIDs failure and switch to corticosteroid treatment (STCT) as well as the impact of STCT on pericarditis recurrence. METHODS: We enrolled 148 patients with acute pericarditis receiving A/NSAID (n=110) or corticosteroids (n=38) as first line treatment according to clinical indications. In case of poor response to A/NSAIDs (n=37), STCT was performed and factors contributing to such failure were explored...
April 20, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29684539/fewer-complications-after-uka-than-tka-in-patients-over-85-years-of-age-a-case-control-study
#10
Quentin Ode, Romain Gaillard, Cécile Batailler, Yannick Herry, Philippe Neyret, Elvire Servien, Sébastien Lustig
INTRODUCTION: Implanting a knee prosthesis in patients aged over 85 years is not without risk. Unicompartmental knee arthroplasty (UKA) is reputed to show lower morbidity and mortality than total knee arthroplasty (TKA). Elderly patients with isolated unicompartmental osteoarthritis without specific contraindications are thus good candidates for this procedure. The present retrospective case-control study compared complications rates in elderly patients receiving UKA versus TKA. The study hypothesis was that UKA incurs fewer complications, with equivalent functional results...
April 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29684522/microcalcifications-in-breast-cancer-from-pathophysiology-to-diagnosis-and-prognosis
#11
REVIEW
S O'Grady, M P Morgan
The implementation of mammographic screening programmes in many countries has been linked to a marked increase in early detection and improved prognosis for breast cancer patients. Breast tumours can be detected by assessing several features in mammographic images but one of the most common are the presence of small deposits of calcium known as microcalcifications, which in many cases may be the only detectable sign of a breast tumour. In addition to their efficacy in the detection of breast cancer, the presence of microcalcifications within a breast tumour may also convey useful prognostic information...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684517/nickel-related-adverse-reactions-in-the-treatment-of-cerebral-aneurysms-a-literature-review
#12
REVIEW
Anderson Chun On Tsang, Patrick Nicholson, Vitor Mendes Pereira
BACKGROUND: Nickel is the most common metal allergen and predominantly affects women. It is also the ubiquitous component in the alloys used to manufacture intracranial devices for aneurysm treatments, including aneurysm clips, self-expanding stents, flow-diverting stents and endosaccular occlusion devices. Adverse events related to nickel-allergy after deployment of such devices are uncommon but can be severe, resulting in dilemmas in the choice of treatment strategies and devices in managing nickel-sensitive patients with intracranial aneurysms...
April 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29684500/the-clinicopathological-comparison-among-nodal-cases-of-idiopathic-multicentric-castleman-disease-with-and-without-tafro-syndrome
#13
Nozomu Kurose, Chizuru Futatsuya, Ken-Ichi Mizutani, Motona Kumagai, Akihiro Shioya, Xin Guo, Akane Aikawa, Satoko Nakada, Shino Fujimoto, Hiroshi Kawabata, Yasufumi Masaki, Kazue Takai, Sadao Aoki, Masaru Kojima, Shigeo Nakamura, Sohsuke Yamada
Multicentric Castleman disease (MCD) is a systemic inflammatory disease potentially caused by an increase in the serum interleukin-6 (IL-6) level. Idiopathic MCD (iMCD) is histopathologically classified into three types: plasmacytic (PC), mixed, and hypervascular (hyperV) types. Recently, a unique clinical phenotype with a poor prognosis overlap with iMCD, thrombocytopenia, anasarca, fever, renal failure or reticulin fibrosis, and organomegaly (TAFRO syndrome), has been reported from Japan, but its detailed clinicopathological features remain unclear...
April 20, 2018: Human Pathology
https://www.readbyqxmd.com/read/29684464/tracking-single-membrane-targets-of-human-autoantibodies-using-single-nanoparticle-imaging
#14
Julie Jézéquel, Julien P Dupuis, François Maingret, Laurent Groc
BACKGROUND: Over the past decade, an increasing number of neurological and neuropsychiatric diseases have been associated with the expression of autoantibodies directed against neuronal targets, including neurotransmitter receptors. Although cell-based assays are routinely used in clinics to detect the presence of immunoglobulins, such tests often provide heterogeneous outcomes due to their limited sensitivity, especially at low titers. Thus, there is an urging need for new methods allowing the detection of autoantibodies in seropositive patients that cannot always be clinically distinguished from seronegative ones...
April 20, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29684412/no-association-of-il2-il4-il6-tnf-and-ifng-gene-polymorphisms-was-found-with-taenia-solium-human-infection-or-neurocysticercosis-severity-in-a-family-based-study
#15
A Fleury, C Alaez, A Dessein, M Rosetti, B Saenz, M Hernández, R J Bobes, R Aquino, E Sciutto, C Gorodezky, G Fragoso
Neurocysticercosis (NC) is caused by the establishment of the metacestode stage of Taenia solium in the human central nervous system. A great heterogeneity in the susceptibility to the infection and to the disease has been reported. While the factors involved in this heterogeneity are not completely understood, clearly different immune-inflammatory profiles have been associated to each condition. This study evaluated the association of cytokine single nucleotide polymorphisms (SNPs) with susceptibility to infection and disease severity in NC patients...
April 20, 2018: Human Immunology
https://www.readbyqxmd.com/read/29684381/serum-chloride-as-a-novel-marker-for-adding-prognostic-information-of-mortality-in-chronic-heart-failure
#16
Yang Zhang, Rui Peng, Xinqiang Li, Jinxing Yu, Xi Chen, Zhou Zhou
BACKGROUND: Serum chloride concentrations have clinical significance in the prognosis of heart failure (HF). Little is known regarding the prognostic value of serum chloride in patients with chronic heart failure (CHF). This study sought to investigate the prognostic ability of admission serum chloride for long-term mortality in CHF patients. METHODS: We recruited 1021 patients diagnosed with CHF. Participants were followed up for all-cause mortality at 21 ± 9 months to establish the survival models and analyze the association between admission serum chloride concentrations and death risk...
April 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29684274/preclinical-development-of-novel-psma-targeting-radioligands-modulation-of-albumin-binding-properties-to-improve-prostate-cancer-therapy
#17
Christoph A Umbricht, Martina Benesova, Roger Schibli, Cristina Müller
The treatment of metastatic castration-resistant prostate cancer (mCRPC) remains challenging with current treatment options. The development of more effective therapies is, therefore, urgently needed. Targeted radionuclide therapy with prostate-specific membrane antigen (PSMA)-targeting ligands has revealed promising clinical results. In an effort to optimize this concept, it was the aim of this study to design and investigate PSMA ligands comprising different types of albumin binders. PSMA-ALB-53 and PSMA-ALB-56 were designed by combining the glutamate-urea PSMA-binding entity, a DOTA chelator and an albumin binder based on the 4-(p-iodophenyl)-moiety or p-(tolyl)-moiety...
April 23, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29684225/primary-intraocular-malignant-rhabdoid-tumor-without-extrascleral-compromise
#18
Eva Ayala Barroso, Alejandra Tapia Bahamondes, Juan Carlos Sánchez España, Llúcia Alós, Ramón Medel Jiménez
Primary intraocular malignant rhabdoid tumor is classified as a malignant extrarenal rhabdoid tumor. It is extremely rare, highly aggressive, and, so far, only one case (in a newborn) has been described in the medical literature. The authors report a second case of primary intraocular malignant rhabdoid tumor, this time without extrascleral involvement and in a teenager, and describe its histological, immunohistochemical, and radiological characteristics along with clinical correlations. [J Pediatr Ophthalmol...
April 23, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29684120/atrial-fibrillation-in-patients-with-inherited-cardiomyopathies
#19
Cynthia Yeung, Andres Enriquez, Laiden Suarez-Fuster, Adrian Baranchuk
Atrial fibrillation (AF) often complicates the course of inherited cardiomyopathies and, in some cases, may be the presenting feature. Each inherited cardiomyopathy has its own peculiar pathogenetic characteristics that can contribute to the development and maintenance of AF. Atrial fibrillation may occur as a consequence of disease-specific defects, non-specific cardiac chamber changes secondary to the primary illness, or a combination thereof. The presence of AF can denote a turning point in the progression of the disease, promoting clinical deterioration and increasing morbidity and mortality...
April 19, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29684106/urine-antigen-detection-as-an-aid-to-diagnose-invasive-aspergillosis
#20
Kieren A Marr, Kausik Datta, Seema Mehta, Darin B Ostrander, Michelle Rock, Jesse Francis, Marta Feldmesser
Background: Establishing rapid diagnoses of invasive aspergillosis (IA) is priority, given poor outcomes of late therapy. Non-culture based tests that detect galactomannan and β-D glucan are available, but are technically cumbersome and rely on invasive sampling (blood or bronchoalveolar lavage). Methods: We optimized a lateral flow dipstick assay using the galactofuranose -specific monoclonal antibody (mAb476), which was previously shown to recognize urine antigens after Aspergillus fumigatus pulmonary infection in an`imals...
April 19, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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