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https://www.readbyqxmd.com/read/29222138/application-of-large-scale-aptamer-based-proteomic-profiling-to-planned-myocardial-infarctions
#1
Jaison Jacob, Debby Ngo, Nancy Finkel, Rebecca Pitts, Scott Gleim, Mark D Benson, Michelle J Keyes, Laurie A Farrell, Thomas Morgan, Lori L Jennings, Robert Gerszten
Background -Emerging proteomic technologies using novel affinity-based reagents allow for efficient multiplexing with high sample throughput. To identify early biomarkers of myocardial injury, we recently applied an aptamer-based proteomic profiling platform that measures 1,129 proteins to samples from patients undergoing septal alcohol ablation for hypertrophic cardiomyopathy, a human model of "planned myocardial injury" (PMI). Here we examined the scalability of this approach using a markedly expanded platform to study a far broader range of human proteins in the context of myocardial injury...
December 8, 2017: Circulation
https://www.readbyqxmd.com/read/29221700/acute-and-long-term-results-after-contemporary-subcutaneous-implantable-cardioverter-defibrillator-implantation-a-single-center-experience
#2
Miguel A Arias, Marta Pachón, Finn Akerström, Alberto Puchol, Cristina Martín-Sierra, Luis Rodríguez-Padial
INTRODUCTION AND OBJECTIVES: The subcutaneous implantable cardioverter-defibrillator (S-ICD) has emerged as an alternative to the transvenous defibrillator. The incidence of complications is similar, with inappropriate shocks (IS) being more frequent than those occurring with contemporary programming of transvenous defibrillators. Several improvements have been implemented after the S-ICD was approved for use in Europe in 2009. This study reports the results of S-ICD use in a single center, whose experience began late, at the end of 2013...
December 5, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29218105/systemic-inflammation-is-associated-with-myocardial-fibrosis-diastolic-dysfunction-and-cardiac-hypertrophy-in-patients-with-hypertrophic-cardiomyopathy
#3
Lu Fang, Andris H Ellims, Anna L Beale, Andrew J Taylor, Andrew Murphy, Anthony M Dart
BACKGROUND: Regional or diffuse fibrosis is an early feature of hypertrophic cardiomyopathy (HCM) and is related to poor prognosis. Previous studies have documented low-grade inflammation in HCM. The aim of this study was to examine the relationships between circulating inflammatory markers and myocardial fibrosis, systolic and diastolic dysfunction, and the degree of cardiac hypertrophy in HCM patients. METHODS AND RESULTS: Fifty HCM patients were recruited while 20 healthy subjects served as the control group...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217433/hypertrophic-cardiomyopathy-linked-mutation-in-troponin-t-causes-myofibrillar-disarray-and-pro-arrhythmic-action-potential-changes-in-human-ipsc-cardiomyocytes
#4
Lili Wang, Kyungsoo Kim, Shan Parikh, Adrian Gabriel Cadar, Kevin R Bersell, Huan He, Jose R Pinto, Dmytro O Kryshtal, Bjorn C Knollmann
BACKGROUND: Mutations in cardiac troponin T (TnT) are linked to increased risk of ventricular arrhythmia and sudden death despite causing little to no cardiac hypertrophy. Studies in mice suggest that the hypertrophic cardiomyopathy (HCM)-associated TnT-I79N mutation increases myofilament Ca sensitivity and is arrhythmogenic, but whether findings from mice translate to human cardiomyocyte electrophysiology is not known. OBJECTIVES: To study the effects of the TnT-I79N mutation in human cardiomyocytes...
December 4, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29211880/corrigendum-to-clinical-long-term-outcome-of-septal-myectomy-for-obstructive-hypertrophic-cardiomyopathy-in-infants-eur-j-cardiothorac-surg-2017-doi-10-1093-ejcts-ezx369
#5
Julia Schleihauf, Julie Cleuziou, Jelena Pabst von Ohain, Christian Meierhofer, Heiko Stern, Nerejda Shehu, Naira Mkrtchyan, Emanuel Kaltenecker, Andreas Kühn, Nicole Nagdyman, Alfred Hager, Heide Seidel, Rüdiger Lange, Peter Ewert, Cordula M Wolf
No abstract text is available yet for this article.
December 2, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29210613/reproductive-tract-infection-and-related-factors-among-female-migrants-working-in-industrial-zones-in-vietnam-2013-2014
#6
Anh Thi Kim Le, Hanh Thi Duc Tran, Tuan Kim Duong, Chuong Canh Nguyen, Ha Thi Thu Bui
We conducted this study to analyse factors related to reproductive tract infections (RTIs) among female migrant workers (FMWs) in four industrial zones across four regions in Vietnam. A analytical cross-sectional study was implemented with FMWs aged between 18-49 years old in four industrial zones in Hanoi, Da Nang, Ho Chi Minh city (HCM) and Binh Duong, Vietnam. Stratified sampling was used to select about 6400 married and unmarried FMWs. Cases were identified through self-reporting of female migrants concerning RTIs symtoms experienced in the 1 year prior to the study...
December 6, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/29209507/routinely-collected-health-data-to-study-inherited-heart-disease-a-systematic-review-2000-2016
#7
Bianca Blanch, Joanna Sweeting, Christopher Semsarian, Jodie Ingles
Objective: Our understanding of inherited heart disease is predominantly based on retrospective specialised clinic cohorts, which have inherent selection bias. Population-based routinely collected data can provide insight into unbiased, large-scale patterns of treatment and care but may be limited by the granularity of clinical information available. We sought to synthesise the global literature to determine whether we can identify patients with inherited heart diseases using routinely collected health data...
2017: Open Heart
https://www.readbyqxmd.com/read/29207362/alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy-indications-technical-aspects-and-clinical-outcomes
#8
REVIEW
Marco Spaziano, Fadi J Sawaya, Thierry Lefèvre
Hypertrophic cardiomyopathy is the most common genetically transmitted heart disease. Around two-thirds of patients develop symptoms caused by the dynamic left ventricular outflow tract obstruction, either at rest or during effort. For patients with hypertrophic obstructive cardiomyopathy (HOCM) that remain symptomatic despite optimal medical treatment, septal reduction is a valuable therapeutic strategy. While surgical myomectomy was considered the gold standard until the end of the 1990s, alcohol septal ablation (ASA) has gained rapid popularity and acceptance, especially in Europe...
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29203298/the-genetic-and-molecular-bases-for-hypertrophic-cardiomyopathy-the-role-for-calcium-sensitization
#9
REVIEW
Xianfeng Ren, Nadia Hensley, Mary Beth Brady, Wei Dong Gao
Hypertrophic cardiomyopathy (HCM) affects millions of people around the world as one of the most common genetic heart disorders and leads to cardiac ischemia, heart failure, dysfunction of other organ systems, and increased risk for sudden unexpected cardiac deaths. HCM can be caused by single-point mutations, insertion or deletion mutations, or truncation of cardiac myofilament proteins. The molecular mechanism that leads to disease progression and presentation is still poorly understood, despite decades of investigations...
May 19, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29203164/atrial-fibrillation-and-hypertrophic-cardiomyopathy-co-existing-conditions-with-additive-risks
#10
EDITORIAL
Kazuo Miyazawa, Gregory Y H Lip
No abstract text is available yet for this article.
December 1, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29203036/comparison-of-the-prognostic-usefulness-of-the-european-society-of-cardiology-and-american-heart-association-american-college-of-cardiology-foundation-risk-stratification-systems-for-patients-with-hypertrophic-cardiomyopathy
#11
Kevin M W Leong, Ji-Jian Chow, Fu Siong Ng, Emanuela Falaschetti, Norman Qureshi, Michael Koa-Wing, Nicholas W F Linton, Zachary I Whinnett, David C Lefroy, D Wyn Davies, Phang Boon Lim, Nicholas S Peters, Prapa Kanagaratnam, Amanda M Varnava
Implantable cardiodefibrillators (ICDs) have proven benefit in preventing sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HC), making risk stratification essential. Data on the predictive accuracy on the European Society of Cardiology (ESC) risk scoring system have been conflicting. We independently evaluated the ESC risk scoring system in our cohort of patients with HC from a large tertiary center and compared this with previous guidance by the American College of Cardiology Foundation and Heart Association (ACCF/AHA)...
November 7, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29202154/changing-student-attitudes-toward-interprofessional-learning-and-collaboration-evidence-for-the-effectiveness-of-partnering-with-healthcare-mentors-in-the-academic-setting
#12
Robert Wellmon, Mary Baumberger-Henry, Normajean Colby, Linda Knauss, Patricia Fletcher
PURPOSE: Individuals living with chronic health conditions serving as healthcare mentors (HCM) allow the creation of high impact, authentic learning experiences. The purpose of this study was to examine the effectiveness of a 6-hour curricular experience involving HCM in changing student attitudes toward interprofessional learning (IPL) and collaboration (IPC). METHODS: Thirty-eight students from clinical psychology, nursing, physical therapy, and social work programs participated in either the learning intervention (n=19) or the control group (n=19)...
2017: Journal of Allied Health
https://www.readbyqxmd.com/read/29197462/contractile-persistence-in-apical-hypertrophic-cardiomyopathy-definitely-too-much-of-a-good-thing
#13
EDITORIAL
Iacopo Olivotto
No abstract text is available yet for this article.
January 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29197461/ineffective-and-prolonged-apical-contraction-is-associated-with-chest-pain-and-ischaemia-in-apical-hypertrophic-cardiomyopathy
#14
Edward Stephenson, Pierre Monney, Francesca Pugliese, James Malcolmson, Steffen E Petersen, Charles Knight, Peter Mills, Andrew Wragg, Constantinos O'Mahony, Neha Sekhri, Saidi A Mohiddin
OBJECTIVES: To investigate the hypothesis that persistence of apical contraction into diastole is linked to reduced myocardial perfusion and chest pain. BACKGROUND: Apical hypertrophic cardiomyopathy (HCM) is defined by left ventricular (LV) hypertrophy predominantly of the apex. Hyperdynamic contractility resulting in obliteration of the apical cavity is often present. Apical HCM can lead to drug-refractory chest pain. METHODS: We retrospectively studied 126 subjects; 76 with apical HCM and 50 controls (31 with asymmetrical septal hypertrophy (ASH) and 19 with non-cardiac chest pain and culprit free angiograms and structurally normal hearts)...
January 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29197221/mirna-21-expression-in-the-serum-of-elderly-patients-with-acute-myocardial-infarction
#15
Zhong-Hua Wang, Xin-Yong Sun, Chun-Lei Li, Yan-Ming Sun, Jia Li, Lan-Feng Wang, Zhu-Qin Li
BACKGROUND The aims of this study were to examine the expression of miRNA-21 in the serum of elderly patients (>65 years) with acute myocardial infarction (AMI) and to investigate the potential role of serum miRNA-21 as a marker of early cardiac myocyte damage. MATERIAL AND METHODS Thirty-eight elderly patients with recent AMI, 27 elderly patients with unstable angina pectoris, and 25 healthy elderly individuals were included in the study. Serum miRNA-21 expression was determined following total RNA extraction and reverse-transcribed into cDNA, followed by reverse transcription-polymerase chain reaction (RT-PCR)...
December 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29193756/investigating-the-cardiac-pathology-of-sco2-mediated-hypertrophic-cardiomyopathy-using-patients-induced-pluripotent-stem-cell-derived-cardiomyocytes
#16
Tova Hallas, Binyamin Eisen, Yuval Shemer, Ronen Ben Jehuda, Lucy N Mekies, Shulamit Naor, Revital Schick, Sivan Eliyahu, Irina Reiter, Eugene Vlodavsky, Yeshayahu Shai Katz, Katrin Õunap, Avraham Lorber, Richard Rodenburg, Hanna Mandel, Mihaela Gherghiceanu, Ofer Binah
Mutations in SCO2 are among the most common causes of COX deficiency, resulting in reduced mitochondrial oxidative ATP production capacity, often leading to hypertrophic cardiomyopathy (HCM). To date, none of the recent pertaining reports provide deep understanding of the SCO2 disease pathophysiology. To investigate the cardiac pathology of the disease, we were the first to generate induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) from SCO2-mutated patients. For iPSC generation, we reprogrammed skin fibroblasts from two SCO2 patients and healthy controls...
November 28, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29193358/cardiovascular-magnetic-resonance-elastography-a-review
#17
Saad Khan, Faisal Fakhouri, Waqas Majeed, Arunark Kolipaka
Cardiovascular diseases are the leading cause of death worldwide. These cardiovascular diseases are associated with mechanical changes in the myocardium and aorta. It is known that stiffness is altered in many diseases, including the spectrum of ischemia, diastolic dysfunction, hypertension and hypertrophic cardiomyopathy. In addition, the stiffness of the aortic wall is altered in multiple diseases, including hypertension, coronary artery disease and aortic aneurysm formation. For example, in diastolic dysfunction in which the ejection fraction is preserved, stiffness can potentially be an important biomarker...
November 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29191938/an-international-external-validation-study-of-the-2014-european-society-of-cardiology-guideline-on-sudden-cardiac-death-prevention-in-hypertrophic-cardiomyopathy-evidence-from-hcm
#18
Constantinos O'Mahony, Fatima Jichi, Steve R Ommen, Imke Christiaans, Eloisa Arbustini, Pablo Garcia-Pavia, Franco Cecchi, Iacopo Olivotto, Hiroaki Kitaoka, Israel Gotsman, Gerald Carr-White, Jens Mogensen, Loizos Antoniades, Saidi Mohiddin, Mathew S Maurer, Hak Chiaw Tang, Jeffrey B Geske, Konstantinos C Siontis, Karim Mahmoud, Alexa Vermeer, Arthur Wilde, Valentina Favalli, Oliver Guttmann, Maria Gallego-Delgado, Fernando Dominguez, Ilaria Tanini, Toru Kubo, Andre Keren, Teofila Bueser, Sarah Waters, Issa F Issa, James Malcolmson, Thomas Burns, Neha Sekhri, Christopher W Hoeger, Rumana Z Omar, Perry M Elliott
Background -Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk of sudden cardiac death (SCD) and require prophylactic implantable cardioverter defibrillator (ICD) is challenging. In 2014, the European Society of Cardiology (ESC) proposed a new risk stratification method based on a risk prediction model (HCM Risk-SCD) which estimates the 5-year risk of SCD. The aim was to externally validate the 2014 ESC recommendations in a geographically diverse cohort of patients recruited from North America, Europe, The Middle East and Asia...
November 30, 2017: Circulation
https://www.readbyqxmd.com/read/29191297/verification-of-heart-disease-implications-for-a-new-heart-transplantation-allocation-system
#19
Pejman Raeisi-Giglou, E Rene Rodriguez, Eugene H Blackstone, Carmela D Tan, Eileen M Hsich
OBJECTIVES: This study sought to determine the accuracy of the pre-transplantation clinical diagnosis of heart disease in the United Network for Organ Sharing (UNOS) database. BACKGROUND: Because survival on the heart transplantation waitlist depends on underlying heart disease, a new allocation system will include the type of heart disease. Accuracy of the pre-transplantation clinical diagnosis and the effect of misclassification are unknown. METHODS: We included all adults who received transplants at our center between January 2009 to December 2015...
December 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29190684/respiratory-syncytial-and-influenza-viruses-in-children-under-2-years-old-with-severe-acute-respiratory-infection-sari-in-maputo-2015
#20
Mirela Pale, Afonso Nacoto, Almiro Tivane, Neuza Nguenha, Loira Machalele, Félix Gundane, Délcio Muteto, Josina Chilundo, Sandra Mavale, Cynthia Semá-Baltazar, Germano Pires, Orvalho Augusto, Tufária Mussá, Eduardo Gudo
INTRODUCTION: Although respiratory syncytial virus (RSV) and influenza virus (influenza) infections are one of the leading causes of Severe Acute Respiratory Infections (SARI) and death in young children worldwide, little is known about the burden of these pathogens in Mozambique. MATERIAL AND METHODS: From January 2015 to January 2016, nasopharyngeal swabs from 450 children, aged ≤2 years, who had been admitted to the Pediatric Department of the Maputo Central Hospital (HCM) in Mozambique, suffering with SARI were enrolled and tested for influenza and RSV using a real-time PCR assay...
2017: PloS One
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