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Vitamin D3 acne

Kabir Sardana, Gunjan Verma
Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (IL-17, IL-1 β, IL-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. Drugs such as Vitamin D3 and isotretinoin which target the Th17 pathway may offer an additional pathway for their therapeutic response...
July 2017: Indian Journal of Dermatology
Parviz Toossi, Zahra Azizian, Hassan Yavari, Tannaz Hoseinzade Fakhim, Seyed Hadi Sadat Amini, Ramin Enamzade
BACKGROUND: Since vitamin D is a recent known immunoregulatory factor in some diseases which are addressed in immune system disorders such as SLE, [psoriasis] and others. OBJECTIVE: To determine the serum levels of 25-hydroxy vitamin D3 [25(OH)D] in patients with acne vulgaris and its association with clinical features. METHODS: This cross-sectional study was conducted over months. This study included 39 patients with acne vulgaris and 40 healthy controls...
September 2015: Clinical Cases in Mineral and Bone Metabolism
George W Agak, Min Qin, Jennifer Nobe, Myung-Hwa Kim, Stephan R Krutzik, Grogan R Tristan, David Elashoff, Hermes J Garbán, Jenny Kim
Acne vulgaris is the most common skin disorder affecting millions of people worldwide and inflammation resulting from the immune response targeting Propionibacterium acnes has a significant role in its pathogenesis. In this study, we have demonstrated that P. acnes is a potent inducer of T helper 17 (Th17) and Th1, but not Th2 responses in human peripheral blood mononuclear cells (PBMCs). P. acnes stimulated expression of key Th17-related genes, including IL-17A, RORα, RORc, IL-17RA, and IL-17RC, and triggered IL-17 secretion from CD4(+), but not from CD8(+) T cells...
February 2014: Journal of Investigative Dermatology
Tam Nguyen, Ramiro Zuniga
New drugs are available for managing several common skin disorders. For psoriasis, topical corticosteroids remain the first-line therapy, but topical vitamin D3 analogs, such as calcipotriene, now have a role. They are as effective as medium-potency topical steroids but without steroid side effects, though they can induce hypercalcemia if the dose exceeds 100 g/week. For more severe cases, methotrexate has been widely used, but other drugs now also are prescribed. They include calcineurin inhibitors, such as cyclosporine, and more recently, biologic agents, such as tumor necrosis factor inhibitors...
April 2013: FP Essentials
Jörg Reichrath
Most vertebrates need vitamin D to develop and maintain a healthy mineralized skeleton. However, 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)], the biologically active vitamin D metabolite, exerts a multitude of important physiological effects independent from the regulation of calcium and bone metabolism. We know today that the skin has a unique role in the human body's vitamin D endocrine system. It is the only site of vitamin D photosynthesis, and has therefore a central role in obtaining a sufficient vitamin D status...
July 2007: Experimental Dermatology
N Hayashi, H Watanabe, H Yasukawa, H Uratsuji, H Kanazawa, M Ishimaru, N Kotera, M Akatsuka, M Kawashima
BACKGROUND: Retinoids and active vitamin D(3) analogues regulate the proliferation and differentiation of keratinocytes and are effective in the treatment of psoriasis. Retinoids are known to be effective against acne vulgaris through comedolysis. However, the comedolytic effect of active vitamin D(3) analogues has not been reported. OBJECTIVES: To investigate whether maxacalcitol, one of the active vitamin D(3) analogues, has a comedolytic effect by using spontaneously comedogenic rhino mice...
November 2006: British Journal of Dermatology
Giuliana Trifirò, Guido Norbiato
The prolonged use of retinoids has been reported to be associated with changes of bone biochemical markers and toxic skeletal effects. Among collagen markers, type I collagen N-telopeptide (NTx) is present in all tissues that contain type I collagen, mostly in bone and in cutaneous tissue. It is a reliable indicator of bone resorption in metabolic bone disease, but has not previously been investigated in dermatological diseases during retinoid therapy. Isotretinoin, a synthetic 13-cis-retinoic acid, is highly effective in the treatment of severe acne vulgaris...
January 2002: Journal of Pediatric Endocrinology & Metabolism: JPEM
C E Griffiths
Receptors for retinoids and vitamin D belong to the superfamily of ligand-dependent nuclear transcription factors. Development of topical and systemic retinoids and topical vitamin D3 analogues is revolutionizing dermatological therapy, particularly the management of acne, psoriasis, ichythyoses, photoageing and skin cancer.
January 1998: Hospital Medicine
K Yoshikawa
One of the synthetic retinoids Etretinate has been used in dermatology for the various inflammatory keratosis, congenital hyperkeratotic disorders and etc., and plays an important role in the treatment of these otherwise intractable skin diseases. But, it still has various side effects, the most serious among which being teratogenicity, and contraception for at least two years after cessation of the drug is recommended because of its very long half life. Acitretin, a nonesterified analogue with a much shorter half life and Isotretinoin are also used in the USA and Europe...
April 1993: Nihon Rinsho. Japanese Journal of Clinical Medicine
R Swain, B Kaplan
BACKGROUND: At one time vitamins were considered as essential nutrients needed only in very small amounts to prevent deficiency syndromes. Many vitamins and their derivatives, however, are currently being used in the mainstream of medicine as therapeutic modalities. METHODS: A MEDLINE literature search for clinical reviews and original studies on the use of vitamins in medicine was conducted along with a search of the obtained papers' bibliographies. The primary years of search were 1990-1994...
May 1995: Journal of the American Board of Family Practice
H Horiuchi, I Nagata, K Takahashi, M Tsuchimoto, K Komoriya
1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) in concentrations from 0.1 to 10 nM suppressed immunoreactive thromboxane B2 (iTXB2) release from Propionibacterium acnes (P. acnes)-elicited liver adherent cells stimulated with lipopolysaccharide (LPS, 1 microgram/ml). These suppressive effects of 1,25-(OH)2D3 were also observed in oyster glycogen-elicited peritoneal macrophages. On the contrary, it did not inhibit iTXB2 release from both resident Kupffer cells and peritoneal macrophages stimulated with the same concentration of LPS...
November 1992: Research Communications in Chemical Pathology and Pharmacology
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