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https://www.readbyqxmd.com/read/28211592/a-methodology-for-assessing-deployment-trauma-and-its-consequences-in-oef-oif-ond-veterans-the-tracts-longitudinal-prospective-cohort-study
#1
Regina E McGlinchey, William P Milberg, Jennifer R Fonda, Catherine Brawn Fortier
Many US veterans of Afghanistan and Iraq have multiple physical and psychiatric problems. A major focus of research has been on determining the effects of mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in the absence of co-occurring conditions such as blast exposure, post-traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological and physical conditions produce complex patterns of cognitive, psychological, and physical symptoms that impede civilian reintegration and complicate efficient and effective treatment planning...
February 17, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28210980/molecular-mechanisms-of-ire1%C3%AE-ask1-pathway-reactions-to-unfolded-protein-response-in-drn-neurons-of-post-traumatic-stress-disorder-rats
#2
Fanzhen Kong, Fang Han, Yanhao Xu, Yuxiu Shi
The goal of this study was to further elucidate the molecular mechanisms of post-traumatic stress disorder (PTSD) pathogenesis and to provide experimental evidence for new drug targets for effective PTSD treatment. Expression changes of IRE1α, ASK1, and other downstream molecules of the IRE1α-ASK1 endoplasmic reticulum stress (ERS) signaling pathway were investigated. JNK, P38, CHOP, Bcl-2, and Bax were analyzed at both protein and mRNA levels of dorsal raphe nucleus (DRN) neurons of PTSD rats. The rat PTSD model was established via the single-prolonged stress (SPS) method...
February 16, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28210542/dynamic-association-between-perfusion-and-white-matter-integrity-across-time-since-injury-in-veterans-with-history-of-tbi
#3
Alexandra L Clark, Katherine J Bangen, Scott F Sorg, Dawn M Schiehser, Nicole D Evangelista, Benjamin McKenna, Thomas T Liu, Lisa Delano-Wood
OBJECTIVE: Cerebral blood flow (CBF) plays a critical role in the maintenance of neuronal integrity, and CBF alterations have been linked to deleterious white matter changes. Although both CBF and white matter microstructural alterations have been observed within the context of traumatic brain injury (TBI), the degree to which these pathological changes relate to one another and whether this association is altered by time since injury have not been examined. The current study therefore sought to clarify associations between resting CBF and white matter microstructure post-TBI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28210229/longitudinal-associations-between-posttraumatic-stress-disorder-severity-and-personality-disorder-features-among-female-rape-survivors
#4
Michelle J Bovin, Erika J Wolf, Patricia A Resick
This study evaluated how change in posttraumatic stress disorder (PTSD) symptoms was associated with residualized change in comorbid personality disorder (PD) features and vice versa over the course of 5-10 years. The sample was comprised of 79 female rape survivors who met criteria for PTSD and who were a part of a larger study examining the effects of trauma-focused therapy. PTSD was assessed with the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) version of the Clinician-Administered PTSD Scale [CAPS-IV (1)] and PD features were assessed with the DSM-IV dimensional PD scales on the Schedule for Non-adaptive and Adaptive Personality [SNAP (2)]...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28209155/intranasal-oxytocin-reduces-provoked-symptoms-in-female-patients-with-posttraumatic-stress-disorder-despite-exerting-sympathomimetic-and-positive-chronotropic-effects-in-a-randomized-controlled-trial
#5
M Sack, D Spieler, L Wizelman, G Epple, J Stich, M Zaba, U Schmidt
BACKGROUND: Posttraumatic stress disorder (PTSD) is a severe psychiatric disease accompanied by neuroendocrine changes such as adrenergic overdrive and hence an elevated cardiovascular morbidity. Current pharmacotherapeutic options for PTSD are less than suboptimal, necessitating the development of PTSD-specific drugs. Although the neuropeptide oxytocin has been repeatedly suggested to be effective in PTSD treatment, there are, to our knowledge, only three studies that have assessed its efficacy on the intensity of PTSD symptoms in PTSD patients - among them one symptom provocation study in male veterans...
February 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28208816/posttraumatic-stress-disorder-in-the-dsm-5-controversy-change-and-conceptual-considerations
#6
REVIEW
Anushka Pai, Alina M Suris, Carol S North
The criteria for posttraumatic stress disorder PTSD have changed considerably with the newest edition of the American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Changes to the diagnostic criteria from the DSM-IV to DSM-5 include: the relocation of PTSD from the anxiety disorders category to a new diagnostic category named "Trauma and Stressor-related Disorders", the elimination of the subjective component to the definition of trauma, the explication and tightening of the definitions of trauma and exposure to it, the increase and rearrangement of the symptoms criteria, and changes in additional criteria and specifiers...
February 13, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28207917/the-role-of-ect-in-posttraumatic-stress-disorder-a-systematic-review
#7
Nagy A Youssef, W Vaughn McCall, Chittaranjan Andrade
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with a high burden of disability and mortality and frequently is treatment resistant. There is little to offer patients who are not responding to standard interventions. Thus, the objective of this report is to systematically review human data on whether electroconvulsive therapy (ECT) is effective in PTSD. METHODS: We performed a systematic literature review from 1958 through August 2016 for clinical studies and case reports published in English examining the efficacy of ECT in improving PTSD symptoms...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28207775/the-contribution-of-gender-based-violence-and-network-trauma-to-gender-differences-in-post-traumatic-stress-disorder
#8
Derrick Silove, Jess R Baker, Mohammed Mohsin, Maree Teesson, Mark Creamer, Meaghan O'Donnell, David Forbes, Natacha Carragher, Tim Slade, Katherine Mills, Richard Bryant, Alexander McFarlane, Zachary Steel, Kim Felmingham, Susan Rees
BACKGROUND: Posttraumatic stress disorder (PTSD) occurs twice as commonly amongst women as men. Two common domains of trauma, network trauma and gender based violence (GBV), may contribute to this gender difference in PTSD rates. We examined data from a nationally representative sample of the Australian population to clarify the characteristics of these two trauma domains in their contributions to PTSD rates in men and women. METHODS: We drew on data from the 2007 Australian National Survey of Mental Health and Well-being to assess gender differences across a comprehensive range of trauma domains, including (1) prevalence of lifetime exposure; (2) identification of an index trauma or DSM-IV Criterion A event; and (3) the likelihood of developing full DSM-IV PTSD symptoms once an index trauma was identified...
2017: PloS One
https://www.readbyqxmd.com/read/28206802/exploring-the-post-deployment-reintegration-experiences-of-veterans-with-ptsd-and-their-significant-others
#9
I Magaly Freytes, Jennifer H LeLaurin, Susan L Zickmund, Rosana D Resende, Constance R Uphold
Veterans with family support have better functional recovery and reintegration outcomes. However, families' ability to support the veteran with PTSD's rehabilitation and reintegration oftentimes is hindered by interpersonal challenges. We report findings of a qualitative study that examined OEF/OIF veterans with PTSD/TBI and their significant others' (SOs') perceptions of family functioning. We conducted 24 in-depth interviews with 12 veteran/SO dyads using an adapted version of the Family Assessment Device Structured Interview...
2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28206785/relationships-among-traumatic-experiences-ptsd-and-posttraumatic-growth-for-police-officers-a-path-analysis
#10
Brian A Chopko, Patrick A Palmieri, Richard E Adams
OBJECTIVE: Law enforcement officers tend to be exposed to a high frequency of potentially traumatic incidents. A dichotomous distinction among these events involves the witnessing of threat or harm to others and the experiencing of threat or harm directly to oneself. Past research suggests that different types of trauma exposure produce varying levels of negative posttraumatic responses including posttraumatic stress disorder (PTSD) symptoms and positive outcomes such as posttraumatic growth (PTG)...
February 16, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28205604/selectively-bred-rats-provide-a-unique-model-of-vulnerability-to-ptsd-like-behavior-and-respond-differentially-to-fgf2-augmentation-early-in-life
#11
Katherine E Prater, Elyse L Aurbach, Hanna K Larcinese, Taylor N Smith, Cortney A Turner, Peter Blandino, Stanley J Watson, Stephen Maren, Huda Akil
Individuals respond differently to traumatic experiences including their propensity to develop post-traumatic stress disorder (PTSD). Understanding individual differences in PTSD vulnerability will allow the development of improved prevention and treatment options. Here, we characterized fear conditioning and extinction in rats selectively bred for differences in their locomotor response to a novel environment. Selectively bred high responder (bHR) and low responder (bLR) male rats are known to differ in their emotional reactivity on a range of measures of spontaneous anxiety- and depressive-like behaviors...
February 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28199913/new-dsm-5-ptsd-guilt-and-shame-symptoms-among-italian-earthquake-survivors-impact-on-maladaptive-behaviors
#12
Claudia Carmassi, Carlo Antonio Bertelloni, Camilla Gesi, Ciro Conversano, Paolo Stratta, Gabriele Massimetti, Alessandro Rossi, Liliana Dell'Osso
Important changes were introduced concerning posttraumatic-stress disorder (PTSD) by the DSM-5 recognizing the role of negative emotions such as guilt and shame, but little evidence is yet available on their prevalence in population assessed by means of DSM-5 criteria. In this study we explored the rates of guilt and shame DSM-5 PTSD diagnostic symptoms among Italian survivors to a massive earthquake and their possible correlation with PTSD and maladaptive behaviors. 869 residents of the town of L'Aquila exposed to the earthquake of April 6th, 2009 were investigated by the Trauma and Loss Spectrum-Self Report (TALS-SR) with particular attention to guilt and shame feelings...
November 22, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28199430/-posttraumatic-stress-disorder-conceptualization-and-psychopharmacological-treatment-update
#13
Leandro N Grendas
Posttraumatic stress disorder (PTSD) is characterized by four symptom complexes: the reexperience/intrusion of the traumatic event, a state of hyperarousal when exposed to traumatic events, emotional block and emotional/affective deregulation with negative cognitive and mood alterations. Its evolution tends to be chronic and its related with a significative morbidity, affecting the functionality of the individual in his interpresonal, social and employment areas. In 1980, the American Psychiatric Association includes PTSD in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), and thereafter several research studies are developed to evaluate the effectiveness of drugs on its treatment...
March 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28199429/-emotional-processing-theory-and-prolonged-exposure-therapy-for-posttraumatic-stress-disorder
#14
Rafael Kichic, Noelí D'Alessio
Prolonged exposure therapy is a first-line treatment for posttraumatic stress disorder. In this article we discuss the theoretical underpinnings and underlying mechanisms of PE, its efficacy and safety. We briefly describe the procedures involved in PE with special emphasis in imaginal exposure. Also, we present examples of efforts to integrate evidence-based treatments that concurrently target PTSD and borderline personality disorder. Next, we review efforts made to adapt the intervention to Hispanics. Finally, obstacles for disseminating and implementing PE are discussed...
March 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28199426/-translating-hysteria-ptsd-dissociative-subtype
#15
Elena Levy Yeyati
To address the symptoms of depersonalization and derealization a specific dissociative subtype of posttraumatic stress disorder has been included in DSM-5. Depersonalization and derealization have been defined as acute and chronic symptoms of dissociative disorders since DSM-III. Dissociative disorders with chronic features are often diagnosed in North America, Canada and other European countries, but this is not the case in Argentina. Dissociative disorders have clinical and historical features that are strongly connected with hysteria...
March 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28197680/effect-of-a-condolence-letter-on-grief-symptoms-among-relatives-of-patients-who-died-in-the-icu-a-randomized-clinical-trial
#16
Nancy Kentish-Barnes, Sylvie Chevret, Benoît Champigneulle, Marina Thirion, Virginie Souppart, Marion Gilbert, Olivier Lesieur, Anne Renault, Maïté Garrouste-Orgeas, Laurent Argaud, Marion Venot, Alexandre Demoule, Olivier Guisset, Isabelle Vinatier, Gilles Troché, Julien Massot, Samir Jaber, Caroline Bornstain, Véronique Gaday, René Robert, Jean-Philippe Rigaud, Raphaël Cinotti, Mélanie Adda, François Thomas, Laure Calvet, Marion Galon, Zoé Cohen-Solal, Alain Cariou, Elie Azoulay
PURPOSE: Family members of patients who die in the intensive care unit (ICU) may experience symptoms of stress, anxiety, depression, posttraumatic stress disorder (PTSD), and/or prolonged grief. We evaluated whether grief symptoms were alleviated if the physician and the nurse in charge at the time of death sent the closest relative a handwritten condolence letter. METHODS: Multicenter randomized trial conducted among 242 relatives of patients who died at 22 ICUs in France between December 2014 and October 2015...
February 14, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28196348/investigation-of-implicit-avoidance-of-displacement-related-stimuli-in-offspring-of-trauma-exposed-forcibly-displaced-individuals
#17
Charlotte E Wittekind, Christoph Muhtz, Steffen Moritz, Lena Jelinek
There is an ongoing debate as to whether traumatization also affects the close relatives of trauma survivors who have symptoms of PTSD. Although many studies provide evidence favoring a transgenerational transmission, other studies have not found evidence to support this idea. The present study examined whether adult offspring of individuals exposed to trauma during forced displacement with (n=22) and without PTSD (n=24) exhibit an implicit avoidance of stimuli related to the parental trauma compared to children of non-trauma exposed control participants (n=23) using an Approach-Avoidance task (AAT)...
February 3, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28196108/post-traumatic-stress-disorder-symptom-burden-and-gender-each-affect-generalization-in-a-reward-and-punishment-learning-task
#18
Milen L Radell, Kevin D Beck, Mark W Gilbertson, Catherine E Myers
Post-traumatic stress disorder (PTSD) can develop following exposure to a traumatic event. Re-experiencing, which includes intrusive memories or flashbacks of the trauma, is a core symptom cluster of PTSD. From an associative learning perspective, this cluster may be attributed to cues associated with the trauma, which have come to elicit symptoms in a variety of situations encountered in daily life due to a tendency to overgeneralize. Consistent with this, prior studies have indicated that both individuals with clinically diagnosed with PTSD, and those with self-reported symptoms who may not meet full diagnostic criteria, show changes in generalization...
2017: PloS One
https://www.readbyqxmd.com/read/28195856/pharmacoepidemiologic-analyses-of-opioid-use-among-oef-oif-ond-veterans
#19
Teresa J Hudson, Jacob T Painter, Brad Martin, Mark A Austen, James S Williams, John Fortney, Mark D Sullivan, Mark E Edlund
There is a great deal of concern about opioid use in Veterans, particularly those that served in Afghanistan (OEF) and Iraq (OIF and OND). The current study provides a detailed pharmacoepidemiologic analysis of opioid use among OEF/OIF/OND Veterans from FY09 to FY12. Data from three data repositories from the Veterans Health Administration (VHA) were used to describe demographic, clinical, and medication characteristics associated with opioid use among OEF/OIF/OND Veterans and among those with TBI. Logistic regression models were used to identify risks associated with chronic opioid use in FY12...
February 11, 2017: Pain
https://www.readbyqxmd.com/read/28195577/hippocampus-glutamate-and-n-acetyl-aspartate-markers-of-excitotoxic-neuronal-compromise-in-posttraumatic-stress-disorder
#20
Isabelle M Rosso, David J Crowley, Marisa M Silveri, Scott L Rauch, J Eric Jensen
Hippocampus atrophy is implicated in posttraumatic stress disorder (PTSD), and may partly reflect stress-induced glutamate excitotoxicity that culminates in neuron injury and manifests as re-experiencing symptoms and other memory abnormalities. This study used high-field proton magnetic resonance spectroscopy (MRS) to determine whether PTSD is associated with lower hippocampus levels of the neuron marker N-acetyl aspartate (NAA), along with higher levels of glutamate (Glu) and Glu/NAA. We also predicted that metabolite levels would correlate with re-experiencing symptoms and lifetime trauma load...
February 13, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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