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https://www.readbyqxmd.com/read/28635375/therapeutic-effect-of-increased-openness-investigating-mechanism-of-action-in-mdma-assisted-psychotherapy
#1
Mark T Wagner, Michael C Mithoefer, Ann T Mithoefer, Rebecca K MacAulay, Lisa Jerome, Berra Yazar-Klosinski, Rick Doblin
A growing body of research suggests that traumatic events lead to persisting personality change characterized by increased neuroticism. Relevantly, enduring improvements in Post-Traumatic Stress Disorder (PTSD) symptoms have been found in response to 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy. There is evidence that lasting changes in the personality feature of "openness" occur in response to hallucinogens, and that this may potentially act as a therapeutic mechanism of change. The present study investigated whether heightened Openness and decreased Neuroticism served as a mechanism of change within a randomized trial of MDMA-assisted psychotherapy for chronic, treatment-resistant PTSD...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28634644/minimal-clinically-important-differences-mcid-in-assessing-outcomes-of-post-traumatic-stress-disorder
#2
Elina A Stefanovics, Robert A Rosenheck, Karen M Jones, Grant Huang, John H Krystal
This study sought to determine the minimal clinically important difference (MCID) for two frequently used measures of symptom severity in Post-Traumatic Stress Disorder: the Clinician Administered PTSD Scale (CAPS) and the PTSD Symptom Checklist (PCL). Data from a randomized clinical trial of antipsychotic medication in military-related treatment-resistant PTSD (N= 267) included assessments 4 times over 26 weeks. Methods for estimating the MCID were based on both the anchor-based approach, using the Clinical Global Impressions (CGI) severity and improvement scales, rated by both clinicians and patients; and the distribution-based approach (based on standardized z-scores)...
June 21, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28633076/resting-state-functional-connectivity-of-anterior-and-posterior-hippocampus-in-posttraumatic-stress-disorder
#3
Amit Lazarov, Xi Zhu, Benjamin Suarez-Jimenez, Bret R Rutherford, Yuval Neria
Posttraumatic stress disorder (PTSD) has been associated with altered resting-state functional connectivity (rs-FC) of several brain regions within the salience (SN) and default-mode (DMN) networks, including the hippocampus. However, most rs-FC studies have not focused primarily on the hippocampus, nor have they appreciated its structural heterogeneity, despite clear evidence for a dissociation between posterior and anterior hippocampal connectivity. Here, we examine rs-FC of anterior and posterior hippocampus with key regions in the SN (amygdala, insula, and dorsal anterior cingulate cortex/pre-supplementary motor area) and DMN (ventromedial prefrontal cortex, posterior cingulate cortex, and precuneus) previously implicated in PTSD, using a seed-based approach...
June 13, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28632513/prevalence-and-predictors-of-posttraumatic-stress-and-depression-symptoms-among-syrian-refugees-in-a-refugee-camp
#4
Ceren Acarturk, Mustafa Cetinkaya, Ibrahim Senay, Birgul Gulen, Tamer Aker, Devon Hinton
Turkey is hosting the majority of Syrian refugees. The current study investigates the prevalence of probable posttraumatic stress disorder (PTSD) and depression among adult Syrians residing in a camp (N = 781) and potential predictors. The Impact of Event Scale-Revised was used to measure PTSD and the Beck Depression Inventory depression. Probable PTSD prevalence was 83.4%, with predictors being female sex (odds ratio [OR], 4.1), previous mental health problems (OR, 4.5), life threat (OR, 3.0), and injury of a loved one (OR, 1...
June 19, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28632462/examining-changes-in-negative-mood-regulation-expectancies-ptsd-depression-and-substance-use-following-integrated-cognitive-behavioral-therapy
#5
Emma Y Siegel, Moira Haller, Ruifeng Cui, Ryan S Trim, Susan R Tate, Sonya B Norman
BACKGROUND: The comorbidity of depression, posttraumatic stress disorder (PTSD), and substance use disorder (SUD) is common among veterans. Some research indicates that poor expectancies for negative mood regulation (NMR) may be associated with depression, trauma symptoms, and substance abuse. However, little is known about whether NMR expectancies can be changed through psychotherapy and if so, whether changes in NMR expectancies are related to changes in depression, PTSD, and SUD. METHODS: Therefore, this study examined 1) whether negative mood regulation (NMR) expectancies correlate with depression, PTSD, and SUD symptoms, 2) whether NMR expectancies improve after group integrated cognitive behavioral therapy (ICBT) and 3) whether these changes were associated with improvements in depression, PTSD, and SUD symptoms in a sample of 123 veterans (89% male, 64% non-Hispanic Caucasian) recruited from a Department of Veteran Affairs (VA) Healthcare System...
June 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28632358/increased-beta-power-in-the-bereaved-families-of-the-sewol-ferry-disaster-a-paradoxical-compensatory-phenomenon-a-two-channel-electroencephalography-study
#6
Kuk-In Jang, Miseon Shim, Sang Min Lee, Hyu Jung Huh, Seung Huh, Ji-Young Joo, Seung-Hwan Lee, Jeong-Ho Chae
AIM: The Sewol ferry capsizing accident in South Korea's southern coast had resulted in the death of 304 people, and serious bereavement problems of their families. Electroencephalography (EEG) beta frequency is associated with psychiatric symptoms such as insomnia. The aim of this study was to investigate the relationship between frontal beta power, psychological symptoms, and insomnia in the bereaved families. METHODS: Eighty-four family members of the Sewol ferry victims (32 men and 52 women) were recruited and their EEG was compared with that of 25 (13 men and 12 women) healthy controls...
June 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28632345/multiple-traumatic-experiences-post-traumatic-stress-disorder-and-offending-behaviour-in-female-prisoners
#7
Thanos Karatzias, Kevin Power, Caroline Woolston, Prathima Apurva, Amelie Begley, Carol Quinn, Sally Jowett, Ruth Howard, Allister Purdie
BACKGROUND: Although it is well established that prisoners commonly have histories of childhood trauma, little is known about mediators between exposure to trauma and criminal behaviour. HYPOTHESES: We hypothesised that the experience of trauma in adulthood, post-traumatic stress disorder (PTSD) and emotional dysregulation would mediate the relationship between childhood traumatic events and later criminal behaviour. METHODS: Eighty-nine female prisoners were interviewed using standardised scales, in a cross-sectional study design...
June 20, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/28632107/linking-attentional-control-and-ptsd-symptom-severity-the-role-of-rumination
#8
Rebecca C Cox, Bunmi O Olatunji
Although deficits in attentional control have been linked to posttraumatic stress disorder (PTSD), the mechanism that may account for this association has not been fully elucidated. The present study examined rumination as a mediator of the relationship between attentional control and PTSD symptoms. Veterans with PTSD and trauma-exposed veterans without PTSD completed measures of attentional control, rumination, and PTSD symptom severity. As predicted, the findings showed that veterans with PTSD reported significantly lower levels of attentional control than veterans without PTSD...
March 3, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28630531/rates-of-subthreshold-ptsd-among-u-s-military-veterans-and-service-members-a-literature-review
#9
Hannah E Bergman, Amy Przeworski, Norah C Feeny
No abstract text is available yet for this article.
March 2017: Military Psychology
https://www.readbyqxmd.com/read/28630453/longitudinal-analyses-of-the-dna-methylome-in-deployed-military-servicemen-identify-susceptibility-loci-for-post-traumatic-stress-disorder
#10
B P F Rutten, E Vermetten, C H Vinkers, G Ursini, N P Daskalakis, E Pishva, L de Nijs, L C Houtepen, L Eijssen, A E Jaffe, G Kenis, W Viechtbauer, D van den Hove, K G Schraut, K-P Lesch, J E Kleinman, T M Hyde, D R Weinberger, L Schalkwyk, K Lunnon, J Mill, H Cohen, R Yehuda, D G Baker, A X Maihofer, C M Nievergelt, E Geuze, M P M Boks
In order to determine the impact of the epigenetic response to traumatic stress on post-traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide blood DNA methylation profiles in relation to the development of PTSD symptoms in two prospective military cohorts (one discovery and one replication data set). In the first cohort consisting of male Dutch military servicemen (n=93), the emergence of PTSD symptoms over a deployment period to a combat zone was significantly associated with alterations in DNA methylation levels at 17 genomic positions and 12 genomic regions...
June 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28629990/employment-stability-in-veterans-and-service-members-with-traumatic-brain-injury-a-va-traumatic-brain-injury-model-systems-study
#11
Christina Dillahunt-Aspillaga, Mary Jo Pugh, Bridget A Cotner, Marc A Silva, Adam Haskin, Xinyu Tang, Marie E Saylors, Risa Nakase-Richardson
OBJECTIVE: To examine incidence and predictors of employment stability in Veterans and Military Service Members (V/SM) with traumatic brain injury (TBI) who return to work. DESIGN: Prospective observational cohort study. SETTING: Four Department of Veterans Affairs (VA) Polytrauma Rehabilitation Centers (PRCs). PARTICIPANTS: 110 V/SM with mild (26%), moderate (22%), or severe (52%) TBI enrolled in the VA PRC TBI Model Systems database within 2 years of injury who were discharged between January 2009 and June 2015...
June 16, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28629393/the-effect-of-an-elective-cesarean-section-on-maternal-request-on-peripartum-anxiety-and-depression-in-women-with-childbirth-fear-a-systematic-review
#12
Renske M Olieman, Femke Siemonsma, Margaux A Bartens, Susan Garthus-Niegel, Fedde Scheele, Adriaan Honig
BACKGROUND: Obstetricians are often reluctant to grant requests for an elective cesarean section (ECS) due to childbirth fear. To date, it is unknown if an ECS on request improves mental well-being in the mother in the peripartum period and if possible beneficial effects on anxiety and depression could outweigh the increased risk of complications associated with a surgical delivery. A systematic review was conducted to explore the effect of ECS on request on peripartum anxiety and depression...
June 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28629292/increased-blood-pressures-in-veterans-with-post-traumatic-stress-disorder
#13
Ehsan Moazen-Zadeh, Alireza Khoshdel, Farhad Avakh, Arash Rahmani
Objective Veterans of war affected by posttraumatic stress disorder (PTSD) are at increased risk for cardiovascular diseases. We aimed to compare brachial and central blood pressures between veterans with PTSD and controls. Method In this case-control study on veterans of Iran-Iraq war, 50 veterans with PTSD and 50 veterans as controls were selected from an outpatient clinic and matched for age ±3 years. Exclusion criteria were malignancies, severe anatomical defects such as amputated extremities, history of PTSD before serving in war, comorbid psychiatric disorders other than anxiety or depressive disorders...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28628792/sleep-disturbances-as-predictors-of-prolonged-exposure-therapy-effectiveness-among-veterans-with-ptsd
#14
Minden B Sexton, Kimberly M Avallone, Erin R Smith, Katherine E Porter, Lisham Ashrafioun, J Todd Arnedt, Sheila A M Rauch
Sleep disturbances (SD) are pronounced in Veterans with posttraumatic stress disorder (PTSD). In clinical trials, SD have been shown to limit the effectiveness of evidence-based treatments for non-PTSD disorders. The purpose of this study was to investigate the relationships between pretreatment SD and the effectiveness of Prolonged Exposure (PE) therapy for Veterans with PTSD. Twenty-one Veterans completed the Pittsburgh Sleep Quality Index (PSQI) and the Clinician Administered PTSD Scale upon presenting to a PTSD specialty clinic...
June 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28628764/psychiatric-disorders-moderate-the-relationship-between-insomnia-and-cognitive-problems-in-military-soldiers
#15
Janeese A Brownlow, Elizabeth A Klingaman, Elaine M Boland, Glenna S Brewster, Philip R Gehrman
BACKGROUND: There has been a great deal of research on the comorbidity of insomnia and psychiatric disorders, but much of the existing data is based on small samples and does not assess the full diagnostic criteria for each disorder. Further, the exact nature of the relationship between these conditions and their impact on cognitive problems are under-researched in military samples. METHOD: Data were collected from the All Army Study of the Army Study to Assess Risk and Resilience in Service members (unweighted N = 21, 449; weighted N = 674,335; 18-61 years; 13...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28628623/use-of-the-deka-arm-for-amputees-with-brachial-plexus-injury-a-case-series
#16
Linda Resnik, Christopher Fantini, Gail Latlief, Samuel Phillips, Nicole Sasson, Eve Sepulveda
OBJECTIVE: Patients with upper limb amputation and brachial plexus injuries have high rates of prosthesis rejection. Study purpose is to describe experiences of subjects with transhumeral amputation and brachial plexus injury, who were fit with, and trained to use, a DEKA Arm. METHODS: This was a mixed-methods study utilizing qualitative (e.g. interview, survey) and quantitative data (e.g. self-report and performance measures). Subject 1, a current prosthesis user, had a shoulder arthrodesis...
2017: PloS One
https://www.readbyqxmd.com/read/28627921/risk-factors-for-concurrent-suicidal-ideation-and-violent-impulses-in-military-veterans
#17
Eric B Elbogen, H Ryan Wagner, Nathan A Kimbrel, Mira Brancu, Jennifer Naylor, Robert Graziano, Eric Crawford
Suicide and violence are significant problems in a subset of Iraq/Afghanistan-era veterans. This study investigates how posttraumatic stress disorder (PTSD) and resilience in veterans are associated with suicidal ideation and violent impulses while controlling for known covariates of both adverse outcomes. Structured clinical interviews were conducted of N = 2,543 Iraq/Afghanistan-era U.S. veterans. Compared with veterans denying suicidal ideation or violent impulses (n = 1,927), veterans endorsing both (n = 171) were more likely to meet diagnostic criteria for PTSD, report childhood abuse, combat exposure, physical pain symptoms, and drug misuse, and less likely to endorse self-direction/life purpose...
June 19, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28627380/post-traumatic-stress-disorder-and-risk-of-dementia-among-members-of-a-health-care-delivery-system
#18
Jason D Flatt, Paola Gilsanz, Charles P Quesenberry, Kathleen B Albers, Rachel A Whitmer
INTRODUCTION: Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia in male veterans, but little is known in females and civilians. METHODS: PTSD and comorbidities were abstracted from medical records from 1/1/1996 to 12/31/2001. Dementia incidence from 1/1/2002 to 12/31/2014 in 499,844 health care members aged 60+ years over an average of 8.2 years. Cox proportional hazard models were adjusted for age, demographics, and comorbidities...
June 13, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28626847/injury-intense-dust-exposure-and-chronic-disease-among-survivors-of-the-world-trade-center-terrorist-attacks-of-september-11-2001
#19
Howard E Alper, Shengchao Yu, Steven D Stellman, Robert M Brackbill
BACKGROUND: The World Trade Center attack of September 11, 2001 in New York City (9/11) exposed thousands of people to intense concentrations of hazardous materials that have resulted in reports of increased levels of asthma, heart disease, diabetes, and other chronic diseases along with psychological illnesses such as post-traumatic stress disorder (PTSD). Few studies have discriminated between health consequences of immediate (short-term or acute) intense exposures versus chronic residential or workplace exposures...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28626208/posttraumatic-stress-disorder-eliminates-association-of-trkb-rs1187327-with-hdl-c-in-chinese-han-adolescents
#20
Ting Cao, Qiwei Guo, Mi Su, Yue Feng, Mei Fan, Yanjun Si, Nazakat H Memon, Jia Lin, Dingzhi Fang
Tropomyosin-related kinase receptor B (TrkB) has been observed to be a common player in posttraumatic stress disorder (PTSD) and the regulation of serum lipids levels. However, interplays of PTSD with TrkB on serum lipids levels have not been explored yet. This study was to investigate the interplays of PTSD and TrkB rs1187327 on serum lipid profiles. Variants of TrkB rs1187327 of 709 high school students were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses and verified by DNA sequencing...
June 18, 2017: Bioscience Trends
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