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https://www.readbyqxmd.com/read/28822349/the-icrc-am-pm-database-challenges-in-forensic-data-management-in-the-humanitarian-sphere
#1
Ute Hofmeister, Shuala S Martin, Carlos Villalobos, Juliana Padilla, Oran Finegan
Large-scale forensic investigations should include a robust data management system with software capable of performing all tasks relevant to achieving the objectives of the investigation. Data management involves the collection, archiving, analysis and reporting of data. A successful data management system requires the development of protocols, procedures and policies, such as on data protection, as well as tools, including software. Adequate training for staff is also required, along with strict quality control and assurance regimens...
July 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28822342/responses-of-trophic-structure-and-zooplankton-community-to-salinity-and-temperature-in-tibetan-lakes-implication-for-the-effect-of-climate-warming
#2
Qiuqi Lin, Lei Xu, Juzhi Hou, Zhengwen Liu, Erik Jeppesen, Bo-Ping Han
Warming has pronounced effects on lake ecosystems, either directly by increased temperatures or indirectly by a change in salinity. We investigated the current status of zooplankton communities and trophic structure in 45 Tibetan lakes along a 2300 m altitude and a 76 g/l salinity gradient. Freshwater to hyposaline lakes mainly had three trophic levels: phytoplankton, small zooplankton and fish/Gammarus, while mesosaline to hypersaline lakes only had two: phytoplankton and large zooplankton. Zooplankton species richness declined significantly with salinity, but did not relate with temperature...
August 1, 2017: Water Research
https://www.readbyqxmd.com/read/28822338/in-vitro-bioaccessibility-and-health-risk-assessment-of-heavy-metals-in-atmospheric-particulate-matters-from-three-different-functional-areas-of-shanghai-china
#3
Huang Huang, Ying Jiang, Xiaoyun Xu, Xinde Cao
The bioaccessibility and human health risks of heavy metals in PM2.5 and PM10 samples from three functional areas of Shanghai, China including a commercial area (CA), a residential area (RA), and an industrial area (IA), were investigated. Gamble's solution and physiologically based extraction test were employed to simulate human respiratory and digestive system, respectively. Both PM2.5 and PM10 concentration in the three areas exceeded the guideline of WHO, and followed the order of IA>CA≈RA. Zinc and Pb were the most abundant metals with a concentration range of 0...
August 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822326/second-malignant-neoplasms-after-childhood-non-central-nervous-system-embryonal-tumours-in-north-america-a%C3%A2-population-based-study
#4
Xuchen Zong, Jason D Pole, Paul E Grundy, Salaheddin M Mahmud, Louise Parker, Rayjean J Hung
BACKGROUND: Few studies in North America have quantified the risks of second malignant neoplasms (SMNs) among survivors of childhood non-central nervous system (non-CNS) embryonal tumours due to their rarity. We aimed to investigate these risks by combining population-based data from the United States of America and Canada. METHODS: We evaluated patients with childhood non-CNS embryonal tumours reported to the Surveillance Epidemiology and End Results program and eight Canadian cancer registries from 1969 to 2010...
August 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28822314/a-portable-smart-phone-device-for-rapid-and-sensitive-detection-of-e-coli-o157-h7-in-yoghurt-and-egg
#5
Mohamed Maarouf Ali Zeinhom, Yijia Wang, Yang Song, Mei-Jun Zhu, Yuehe Lin, Dan Du
The detection of E. coli O157:H7 in foods has held the attention of many researchers because of the seriousness attributed to this pathogen. In this study, we present a simple, sensitive, rapid and portable smartphone based fluorescence device for E. coli O157:H7 detection. This field-portable fluorescent imager on the smartphone involves a compact laser-diode-based photosource, a long-pass (LP) thin-film interference filter and a high-quality insert lenses. The design of the device provided a low noise to background imaging system...
August 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28822305/an-optimal-control-approach-to-design-entire-relaxation-dispersion-experiments
#6
Thoa T Nguyen, Steffen J Glaser
A general approach is introduced to optimize experiments for the analysis of spin systems in the presence of chemical exchange. Rather than optimizing individual pulse sequence elements, such as refocusing pulses, entire relaxation dispersion sequences are optimized in the form of a single shaped pulse. This is achieved by defining a performance index that is only based on the remaining signal after the relaxation dispersion sequence for a range of exchange, relaxation, offset, and rf inhomogeneity parameters...
July 31, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28822300/drinking-water-to-reduce-alcohol-craving-a-randomized-controlled-study-on-the-impact-of-ghrelin-in-mediating-the-effects-of-forced-water-intake-in-alcohol-addiction
#7
Anne Koopmann, Katharina Lippmann, Rilana Schuster, Iris Reinhard, Patrick Bach, Georg Weil, Marcella Rietschel, Stephanie H Witt, Klaus Wiedemann, Falk Kiefer
BACKGROUND: Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on craving reduction in alcoholism is mediated by acute changes in ghrelin secretion. METHODS: In this randomized human laboratory study, we included 23 alcohol-dependent male inpatient subjects who underwent alcohol cue exposure...
August 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28822274/emergent-properties-of-bacterial-chemotaxis-pathway
#8
REVIEW
Remy Colin, Victor Sourjik
The chemotaxis pathway of Escherichia coli is the most studied sensory system in prokaryotes. The highly conserved general architecture of this pathway consists of two modules which mediate signal transduction and adaptation. The signal transduction module detects and amplifies changes in environmental conditions and rapidly transmits these signals to control bacterial swimming behavior. The adaptation module gradually resets the activity and sensitivity of the first module after initial stimulation and thereby enables the temporal comparisons necessary for bacterial chemotaxis...
August 16, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28822273/ligand-binding-characterization-of-simulated-%C3%AE-adrenergic-like-octopamine-receptor-in-schistocerca-gregaria-via-progressive-structure-simulation
#9
Hui-Meng Lu, Xiao-Li Lu, Jia-Hui Zhai, Ren-Bin Zhou, Yan-Li Qin, Jing-Di Li, Chen-Yan Zhang, Jian-Yu Shi
It is important to design insecticides having both low drug resistance and less undesirable toxicity for desert locust control. Specific GPCRs of Schistocerca gregaria, especially β-adrenergic-like octopamine receptor (SgOctβR), can be considered as its potential effective insecticide targets. However, either the unavailability of SgOctβR's structure or the inadequate capability of its sequence lead the development of insecticide for Schistocerca gregaria meets its plateau. To relax this difficulty, this paper develops a promising progressive structure simulation from SgOctβR's sequence, to its predicted structure of SgOctβR in vacuum, to its conformation as well as its complex with endogenous ligand octopamine in a solvent-membrane system...
July 27, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28822272/b24n24-fullerene-as-a-carrier-for-5-fluorouracil-anti-cancer-drug-delivery-dft-studies
#10
Mehrnoosh Khodam Hazrati, Zahra Javanshir, Zargham Bagheri
It has been previously indicated that BN nanostructures may be nontoxic and biocompatible. Here the potential application of a B24N24 is explored as a drug delivery system for anti-cancer 5-fluorouracil based on the density functional theory. This drug prefers to attach via its oxygen atoms to the B atoms of the cluster with adsorption energy about -11.90kcalmol(-1) based on the dispersion corrected B3LYP level of theory. To make the cluster more appropriate for drug delivery, we replaced a B atom by Si or Al atom to improve the interaction strength...
August 9, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28822269/correlation-of-cholinergic-drug-induced-quenching-of-acetylcholinesterase-bound-thioflavin-t-fluorescence-with-their-inhibition-activity
#11
Mullah Muhaiminul Islam, Mostofa Ataur Rohman, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, Sivaprasad Mitra
The development of new acetylcholinesterase inhibitors (AChEIs) and subsequent assay of their inhibition efficiency is considered to be a key step for AD treatment. The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation...
August 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28822263/the-most-important-factor-in-producing-clubhead-speed-in-golf
#12
Christopher Joyce
Substantial experiential research into x-factor, and to a lesser extent crunch-factor has been undertaken with the aim of increasing clubhead speed. However, a direct comparison of the golf swing kinematics associated with each 'factor' has not, and possible differences when using a driver compared to an iron. Fifteen low handicap male golfers who displayed a modern swing had their golf swing kinematic data measured when hitting their own driver and five-iron, using a 10-camera motion analysis system operating at 250Hz...
August 16, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28822257/performance-of-a-monolith-biotrickling-filter-treating-high-concentrations-of-h2s-from-mimic-biogas-and-elemental-sulfur-plugging-control-using-pigging
#13
Xintong Qiu, Marc A Deshusses
A novel biotrickling filter using a 3D-printed honeycomb-monolith as its filter bed has been proposed and studied in this work and a solution to bed-clogging problems using pigging was demonstrated. The inlet H2S concentration in the mimic biogas was controlled around 1000 ppmv and the empty bed gas residence time (EBRT) was 41 s corresponding to a loading rate of 127 g S-H2S m(-3) h(-1). The influence of different H2S/O2 ratios on the removal performance and fate of sulfur end-products was investigated...
August 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28822253/clout-or-doubt-perspectives-on-an-infant-mental-health-service-for-young-children-placed-in-foster-care-due-to-abuse-and-neglect
#14
Fiona Turner-Halliday, Gary Kainth, Genevieve Young-Southward, Richard Cotmore, Nicholas Watson, Lynn McMahon, Helen Minnis
Despite knowledge about the profound effects of child abuse and neglect, we know little about how best to assess whether maltreated children should return home. The effectiveness of the New Orleans Intervention Model (NIM) is being tested in a randomized controlled trial where the comparison is social work 'services as usual.' The future trial results will tell us which approach produces the best outcomes for children; meanwhile qualitative process evaluation is generating intriguing findings about the perceived impact of NIM on decision-making about childrens' futures...
August 16, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28822252/removal-of-gadolinium-a-neutron-poison-from-the-moderator-system-of-nuclear-reactors
#15
A L Rufus, Padma S Kumar, K Jeena, S Velmurugan
Gadolinium as gadolinium nitrate is used as neutron poison in the moderator system for regulating and controlling the power generation of Pressurized Heavy Water Reactors (PHWR) and proposed to be used in Advanced Heavy Water Reactors (AHWR) owing to its high neutron absorption cross section. Removal of the added gadolinium nitrate (Gd(3+) and NO3(-)) from the system after its intended use is done using ion exchange resins. In the present investigation, attempts have been made to optimize the ion exchange process for generation of low radioactive waste and maximize utilization of the ion exchange resins by employing different types of resins and different modes of operation...
August 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28822225/altered-thymocyte-and-t-cell-development-in-neonatal-mice-with-hyperoxia-induced-lung-injury
#16
Sowmya Angusamy, Tamer Mansour, Mohammed Abdulmageed, Rachel Han, Brian C Schutte, John LaPres, Jack R Harkema, Said A Omar
BACKGROUND: The adaptive immune system of neonates is relatively underdeveloped. The thymus is an essential organ for adaptive T cell development and might be affected during the natural course of oxygen induced lung injury. The effect of prolonged hyperoxia on the thymus, thymocyte and T cell development, and its proliferation has not been studied extensively. METHODS: Neonatal mice were exposed to 85% oxygen (hyperoxia) or room air (normoxia) up to 28 days. Flow cytometry using surface markers were used to assay for thymocyte development and proliferation...
August 19, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28822222/biomechanical-comparison-of-a-novel-monocortical-and-two-common-bicortical-external-fixation-systems-regarding-rigidity-and-dynamic-stability
#17
Patrick A Varady, Markus Greinwald, Peter Augat
AIM: To biomechanically compare a monocortical single frame external fixator (Orthofix UNYCO) with two bicortical fixator systems (dual frame: Stryker Hoffmann and single frame: Synthes LEF) with respect to system rigidity and stability under cyclic loading. METHODS: The fixator systems were assessed for axial rigidity under loads which would occur clinically during fixator application and dynamic stability (cyclic fatigue) under loads which would occur in the first week postoperatively...
August 19, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28822218/locally-produced-xenin-and-the-neurotensinergic-system-in-pancreatic-islet-function-and-%C3%AE-cell-survival
#18
Dawood Khan, Srividya Vasu, R Charlotte Moffett, Victor A Gault, Peter R Flatt, Nigel Irwin
Modulation of neuropeptide receptors is important for pancreatic β-cell function. Here, islet distribution and effects of the neurotensin (NT) receptor modulators, xenin and NT, was examined. Xenin, but not NT, significantly improved glucose disposal and insulin secretion, in mice. However, both peptides stimulated insulin secretion from rodent β-cells at 5.6 mM glucose, with xenin having similar insulinotropic actions at 16.7 mM glucose. In contrast, NT inhibited glucose-induced insulin secretion. Similar observations were made in human 1...
August 28, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28822217/using-a-novel-technology-for-disaster-staff-notification
#19
Stephen C Morris, Janice K Pelley, Steven H Mitchell
Notification of backup staff and determining their ability to augment frontline staff is a major component of any disaster plan. However, the communication and organization of this effort has many challenges. These include communication system overload, the disaster setting, disrupted transportation, and staffing impacts on normal operations. An optimal disaster notification system must have the ability to be modified to include all hazards and the unique environment in which the plan is being made. This article highlights a unique disaster staff notification system using a novel technology, an outside administrator, and a multilayer system of redundant communication...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28822213/liberia-national-disaster-preparedness-coordination-exercise-implementing-lessons-learned-from-the-west-african-disaster-preparedness-initiative
#20
Melinda J Morton Hamer, Paul L Reed, Jane D Greulich, Charles W Beadling
OBJECTIVE: In light of the recent Ebola outbreak, there is a critical need for effective disaster management systems in Liberia and other West African nations. To this end, the West Africa Disaster Preparedness Initiative held a disaster management exercise in conjunction with the Liberian national government on November 24-25, 2015. DESIGN: During this tabletop exercise (TTX), interactions within and between the 15 counties and the Liberian national government were conducted and observed to refine and validate the county and national standard operating procedures (SOPs)...
January 2017: American Journal of Disaster Medicine
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