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https://www.readbyqxmd.com/read/29245186/endothelial-dysfunction-in-early-systemic-lupus-erythematosus-patients-and-controls-without-previous-cardiovascular-events
#1
Mara Taraborelli, Edoardo Sciatti, Ivano Bonadei, Vincenzo Terlizzi, Micaela Fredi, Roberta Zani, Giovanni Cancarini, Angela Tincani, Franco Franceschini, Enrico Vizzardi, Ilaria Cavazzana
OBJECTIVES: To assess the prevalence and risk factors for endothelial dysfunction detected by peripheral artery tonometry in systemic lupus erythematosus patients with early disease without cardiovascular disease and risk factors. METHODS: All the consecutive adult lupus patients, with a disease duration less than 5 years, seen in our Hospital from December 2014 to March 2016 were considered. We excluded patients with any history of cardiovascular disease or risk factors possibly affecting peripheral artery tonometry...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245183/increased-expression-and-modulated-regulatory-activity-of-co-inhibitory-receptors-pd-1-tigit-and-tim-3-in-lymphocytes-of-systemic-sclerosis-patients
#2
Michelle Fleury, Anna C Belkina, Elizabeth A Proctor, Christopher Zammitti, Robert W Simms, Douglas A Lauffenburger, Jennifer E Snyder-Cappione, Robert Lafyatis, Hans Dooms
OBJECTIVE: Immune dysfunction is an important component of the disease process underlying Systemic Sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. Here, we measured the expression and function of the co-inhibitory receptors (co-IRs) PD-1, TIGIT, TIM-3, and LAG-3 in lymphocyte subsets from the peripheral blood of SSc patients. METHODS: Co-IR expression levels on immune cell subsets were analyzed using a 16-color flow cytometry panel...
December 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29245178/transcriptional-regulation-of-cd4-t-cell-differentiation-in-experimentally-induced-arthritis-and-rheumatoid-arthritis
#3
REVIEW
Yuya Kondo, Masahiro Yokosawa, Shunta Kaneko, Kotona Furuyama, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by infiltration of the joint synovium by activated inflammatory cells. CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathological process. In general, CD4+ T cells differentiate into various T helper (Th) cell subsets and acquire the functional characterization to respond to specific pathogens, and also mediated some autoimmune disorders such as RA. Because the differentiation of Th cell subsets is determined by the expression of specific transcription factors in response to cytokine environment, these transcription factors is considered to have a role in pathology of RA...
December 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29245177/microplastics-as-an-emerging-threat-to-terrestrial-ecosystems
#4
Anderson Abel de Souza Machado, Werner Kloas, Christiane Zarfl, Stefan Hempel, Matthias C Rillig
Microplastics (plastics < 5 mm, including nanoplastics which are < 0.1 μm) originate from the fragmentation of large plastic litter or from direct environmental emission. Their potential impacts in terrestrial ecosystems remain largely unexplored despite numerous reported effects on marine organisms. Most plastics arriving in the oceans were produced, used, and often disposed on land. Hence, it is within terrestrial systems that microplastics might first interact with biota eliciting ecologically relevant impacts...
December 15, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29245170/-consequences-of-a-failed-project-introduction-and-management-of-a-hospitalization-substituting-treatment-model
#5
Uwe Peters
This article is a report on a psychiatric project introducing services that substitute in-patient treatment and a new control and management system. The implementation of the project was a failure. Nevertheless, the project has made a contribution to further development of community-based psychiatry. Design, organization and course of the project are described and analyzed from the point of view of the communal actors involved. Effects going beyond the time course of the project have been taken into consideration...
December 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29245157/dynamic-cellular-complexity-of-anoxygenic-phototrophic-sulfur-bacteria-in-the-chemocline-of-meromictic-lake-cadagno
#6
Francesco Danza, Nicola Storelli, Samuele Roman, Samuel Lüdin, Mauro Tonolla
The meromictic Lake Cadagno is characterized by a compact chemocline with high concentrations of anoxygenic phototrophic purple sulfur bacteria (PSB) and green sulfur bacteria (GSB). The co-occurrence of phylogenetically distant bacterial groups such as PSB and GSB in the same ecological niche, makes the chemocline of Lake Cadagno an ideal system for studying the conditions and consequences of coexistence of photosynthetic bacteria populations. In this study, we applied flow cytometry (FCM) as a fast tool to identify metabolic changes due to the production and consumption of inclusion bodies such as sulfur globules (SGBs), and follow population dynamics of closely related anoxygenic photosynthetic sulfur bacteria in their natural environment...
2017: PloS One
https://www.readbyqxmd.com/read/29245151/substantial-enhancement-of-anaerobic-pyridine-bio-mineralization-by-electrical-stimulation
#7
Xinbai Jiang, Jinyou Shen, Kaichun Xu, Dan Chen, Yang Mu, Xiuyun Sun, Weiqing Han, Jiansheng Li, Lianjun Wang
Due to highly recalcitrant and toxicological nature of pyridine, the conventional anaerobic bioprocess is often limited by low removal rate and poor process stability. In this study, an electricity-assisted anaerobic system was developed in order to enhance biodegradation of pyridine from wastewater. The results showed that the performance and stability of the anaerobic reactor was remarkably improved for pyridine biodegradation with the applied direct current of 0.3 mA, where the efficiencies of pyridine and total organic carbon removal as well as NH4+-N formation were as high as 100...
December 5, 2017: Water Research
https://www.readbyqxmd.com/read/29245144/the-myorobot-a-novel-automated-biomechatronics-system-to-assess-voltage-ca2-biosensors-and-active-passive-biomechanics-in-muscle-and-biomaterials
#8
M Haug, B Reischl, G Prölß, C Pollmann, T Buckert, C Keidel, S Schürmann, M Hock, S Rupitsch, M Heckel, T Pöschel, T Scheibel, C Haynl, L Kiriaev, S I Head, O Friedrich
We engineered an automated biomechatronics system, MyoRobot, for robust objective and versatile assessment of muscle or polymer materials (bio-)mechanics. It covers multiple levels of muscle biosensor assessment, e.g. membrane voltage or contractile apparatus Ca2+ ion responses (force resolution 1µN, 0-10mN for the given sensor; [Ca2+] range ~ 100nM-25µM). It replaces previously tedious manual protocols to obtain exhaustive information on active/passive biomechanical properties across various morphological tissue levels...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29245143/functionalization-of-protein-crystals-with-metal-ions-complexes-and-nanoparticles
#9
REVIEW
Satoshi Abe, Basudev Maity, Takafumi Ueno
Self-assembled proteins have specific functions in biology. With inspiration provided by natural protein systems, several artificial protein assemblies have been constructed via site-specific mutations or metal coordination, which have important applications in catalysis, material and bio-supramolecular chemistry. Similar to natural protein assemblies, protein crystals have been recognized as protein assemblies formed of densely-packed monomeric proteins. Protein crystals can be functionalized with metal ions, metal complexes or nanoparticles via soaking, co-crystallization, creating new metal binding sites by site-specific mutations...
December 12, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29245134/phosphorus-recovery-and-reuse-by-pyrolysis-applications-for-agriculture-and-environment
#10
REVIEW
Daquan Sun, Lauren Hale, Gourango Kar, Raju Soolanayakanahally, Sina Adl
Phosphorus ore extraction for soil fertilization supports the demand of modern agriculture, but extractable resource limitations, due to scarcity, impose a P reuse and recycling research agenda. Here we propose to integrate biochar production (pyrogenic carbon) with municipal and agricultural waste management systems, to recover and reuse phosphorous that would otherwise be lost from the ecological food web. A meta-analysis and available data on total P in biochar indicated that P-enriched feedstocks include animal manure, human excreta, and plant-biomass collected from P-polluted sites...
December 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29245133/source-identification-and-ecological-impact-evaluation-of-pahs-in-urban-river-sediments-a-case-study-in-taiwan
#11
Y T Tu, J H Ou, D C W Tsang, C D Dong, C W Chen, C M Kao
The Love River and Ho-Jin River, two major urban rivers in Kaohsiung City, Taiwan, are moderately to heavily polluted because different types of improperly treated wastewaters are discharged into the rivers. In this study, sediment and river water samples were collected from two rivers to investigate the river water quality and accumulation of polycyclic aromatic hydrocarbons (PAHs) in sediments. The spatial distribution, composition, and source appointment of PAHs of the sediments were examined. The impacts of PAHs on ecological system were assessed using toxic equivalence quotient (TEQ) of potentially carcinogenic PAHs (TEQcarc) and sediment quality guidelines...
December 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/29245132/transcriptome-analysis-reveals-novel-insights-into-the-response-to-pb-exposure-in-phanerochaete-chrysosporium
#12
Chao Huang, Rongzhong Wang, Guangming Zeng, Danlian Huang, Cui Lai, Jiachao Zhang, Zhihua Xiao, Jia Wan, Piao Xu, Xiaomin Gong, Wenjing Xue, Xiaoya Ren
Metals released into the environment continue to be of concern for human health. Using white-rot fungi as biosorbents for heavy metals removal is an attractive alternative owing to its good performance and low cost. However, the molecular mechanism underlying heavy metal tolerance in white-rot fungi has not yet been fully elucidated. This study identified and analyzed the lead (Pb)-induced transcriptional changes in Phanerochaete chrysosporium, a well-known heavy metal hyperaccumulating white-rot fungus. The results confirmed its outstanding ability in Pb tolerance and effective defense system...
December 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/29245131/premagnetization-enhancing-the-reactivity-of-fe0-passivated-fe0-system-for-high-concentration-p-nitrophenol-removal-in-aqueous-solution
#13
Yi Ren, Jun Li, Leiduo Lai, Bo Lai
In order to strengthen the treatment efficiency of Fe0 based system for high concentration wastewater treatment, Fe0 particles were passivated by concentrated nitric acid, and a premagnetization Fe0/(passivated Fe0) system was setup for high concentration p-nitrophenol (PNP) removal in this study. The significant parameters of this system were optimized. Under the optimal conditions, the premagnetization Fe0/(passivated Fe0) system could obtain high kobs value for PNP removal (0.100 min-1) and COD removal (15...
December 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/29245125/delayed-type-hypersensitivity-to-metals-in-connective-tissue-diseases-and-fibromyalgia
#14
REVIEW
Geir Bjørklund, Maryam Dadar, Jan Aaseth
Rheumatic diseases include a group of autoimmune disorders with environmental and genetic etiology that are characterized as a subgroup of connective tissue diseases (CTD). Rheumatoid arthritis (RA) often involves the small joints of the hands in a symmetrical fashion that can lead to loss of joint function, and RA, as well as Sjögren's syndrome (SS) and other rheumatic diseases, are often accompanied by sensitivity to metals. Numerous investigations on metal sensitivity were evaluated in this review. A detailed metal exposure history was collected by different evaluation of studies...
December 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/29245123/the-gdnf-family-a-role-in-cancer
#15
REVIEW
Graeme C Fielder, Teresa Wen-Shan Yang, Mahalakshmi Razdan, Yan Li, Jun Lu, Jo K Perry, Peter E Lobie, Dong-Xu Liu
The glial cell line-derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, neurturin, artemin, and persephin plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis. Here we review our current understanding of GFL biology, and supported by recent progress in the area, we examine their emerging role in endocrine-related and other non-hormone-dependent solid neoplasms. The ability of GFLs to elicit actions that resemble those perturbed in an oncogenic phenotype, alongside mounting evidence of GFL involvement in tumor progression, presents novel opportunities for therapeutic intervention...
December 12, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29245105/autoimmune-encephalitis-with-gabaa-receptor-antibodies-in-a-10-year-old-girl
#16
Magdalena Figlerowicz, Paweł Kemnitz, Anna Mania, Katarzyna Mazur-Melewska, Emila Tomczak, Karolina Kuls, Katarzyna Jończyk-Potoczna, Francesc Graus, Wojciech Służewski
Recent studies have indicated that some cases of nonparaneoplastic autoimmune encephalitis in children can be caused by a systemic autoimmune disorder that generates autoantibodies to cell membrane proteins. We describe the clinical features of a 10-year-old girl with autoimmune encephalitis with autoantibodies against the GABAA receptor in whom type 1 diabetes mellitus developed during the course of the disease. The diagnosis was based on the progressive course of disease, pleocytosis in the cerebrospinal fluid (CSF), inflammatory changes in the brain and autoantibodies against the GABAA receptor detected in serum (absent in CSF)...
December 12, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29245070/blood-brain-barrier-permeability-and-neuroprotective-effects-of-three-main-alkaloids-from-the-fruits-of-euodia-rutaecarpa-with-mdck-phamdr-cell-monolayer-and-pc12-cell-line
#17
Yi-Nan Zhang, Yan-Fang Yang, Xiu-Wei Yang
The fruits of Euodia rutaecarpa (Euodiae Fructus, EF), the widely used traditional Chinese medicine, have various central nervous system effects. Alkaloids following as evodiamine (EDM), rutaecarpine (RCP) and dehydroevodiamine (DEDM) are the major substances in EF. The MDCK-pHaMDR cell monolayer model was utilized as a blood-brain barrier (BBB) surrogate model to study their BBB permeability. The transport samples were analyzed by high performance liquid chromatography and the apparent permeability coefficients (Papp) were calculated...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29245069/aqueous-extract-of-triphala-inhibits-cancer-cell-proliferation-through-perturbation-of-microtubule-assembly-dynamics
#18
Sanith Cheriyamundath, Tejashree Mahaddalkar, Shreyada N Save, Sinjan Choudhary, Ramakrishna V Hosur, Manu Lopus
Triphala (Trl) is an ayurvedic formulation used for treating disorders of the digestive, respiratory, and nervous systems. Its anticancer properties have also been documented. We studied effects of Trl on tubulin, a target protein for several anticancer drugs, and systematically elucidated a possible antiproliferative mechanism of action of Trl. Trl inhibited proliferation of HeLa (cervical adenocarcinoma), PANC-1 (pancreatic adenocarcinoma), and MDA-MB-231 (triple-negative breast carcinoma) cells in microgram quantities and strongly suppressed the clonogenicity of HeLa cells...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29245067/lin28a-functionally-modulates-bupivacaine-induced-dorsal-root-ganglion-neuron-apoptosis-through-trka-activation
#19
Liangsheng Yu, Yuanxu Jiang, Bin Tang
PURPOSE: Lin-28 Homolog A gene (Lin28a) is an important regulator in nerve system. In this study, we investigated the functional mechanism of Lin28a during the process of bupivacaine (BUP)-induced neuronal apoptosis of spinal cord dorsal root ganglion neurons (DRGNs). METHODS: Young mouse DRGNs were cultured in vitro and treated with series concentrations of BUP. Apoptosis was evaluated by TUNEL assay. Corresponding Lin28a mRNA and protein expressions were evaluated by qRT-PCR and western blot (WB) assays...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29245050/nanog-restores-the-impaired-myogenic-differentiation-potential-of-skeletal-myoblasts-after-multiple-population-doublings
#20
Aref Shahini, Debanik Choudhury, Mohammadnabi Asmani, Ruogang Zhao, Pedro Lei, Stelios T Andreadis
Adult skeletal muscle regeneration relies on the activity of satellite cells residing in the skeletal muscle niche. However, systemic and intrinsic factors decrease the myogenic differentiation potential of satellite cells thereby impairing muscle regeneration. Here we present data showing that late passage C2C12 myoblasts exhibited significantly impaired myogenic differentiation potential that was accompanied by impaired expression of myogenic regulatory factors (Myf5, MyoD, Myogenin, and MRF4) and members of myocyte enhancer factor 2 family...
December 2, 2017: Stem Cell Research
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