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https://www.readbyqxmd.com/read/29909593/imaging-of-kingella-kingae-musculoskeletal-infections-in-children-a-series-of-5-cases
#1
Jie C Nguyen, Susan L Rebsamen, Michael J Tuite, J Muse Davis, Humberto G Rosas
PURPOSE: Kingella kingae musculoskeletal infections continue to be under-diagnosed and there remains a paucity of literature on its imaging features. The purpose of this manuscript is to review the imaging, clinical, and laboratory findings of microbiology-proven K. kingae infections. MATERIALS AND METHODS: A retrospective review of musculoskeletal infections between January 1, 2013 and Dec 31, 2016 yielded 134 patients from whom 5 patients had confirmed K. kingae infections (3 boys and 2 girls, mean age of 16 months, range 9-38 months)...
June 16, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29909592/combined-strategy-of-transcription-factor-manipulation-and-%C3%AE-glucosidase-gene-overexpression-in-trichoderma-reesei-and-its-application-in-lignocellulose-bioconversion
#2
Ying Xia, Lirong Yang, Liming Xia
The industrial application of Trichoderma reesei has been greatly limited by insufficient β-glucosidase activity in its cellulase system. In this study, a novel β-glucosidase expression cassette was constructed and integrated at the target site in T. reesei ZU-02, which achieved the overexpression of β-glucosidase gene and in situ disruption of the cellulase transcriptional repressor ACE1. The resulting transformants showed significant increase in both β-glucosidase activity (BGA) and filter paper activity (FPA)...
June 16, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29909583/clinical-and-radiographical-ten-years-long-term-outcome-of-microfracture-vs-autologous-chondrocyte-implantation-a-matched-pair-analysis
#3
Robert Ossendorff, Kilian Franke, Benjamin Erdle, Markus Uhl, Norbert P Südkamp, Gian M Salzmann
PURPOSE: To compare the clinical and radiographical long-term outcome of microfracture (MFX) and first-generation periosteum-covered autologous chondrocyte implantation (ACI-P). METHODS: All subjects (n = 86) who had been treated with knee joint ACI-P or microfracture (n = 76) with a post-operative follow-up of at least ten years were selected. Clinical pre- and post-operative outcomes were analyzed by numeric analog scale (NAS) for pain, Lysholm, Tegner, IKDC, and KOOS score...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909579/martin-vahlensieck-and-maximilian-reiser-eds-mri-of-the-musculoskeletal-system-second-edition-thieme-verlags-gruppe-stuttgart-2018-isbn-978-3-13-116-572-5
#4
Antonio D'Addio, Luigi Mansi
No abstract text is available yet for this article.
June 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29909561/molecular-genetic-analysis-for-periodic-fever-syndromes-a-supplemental-role-for-the-diagnosis-of-adult-onset-still-s-disease
#5
Hongbin Li, Irina Abramova, Sandra Chesoni, Qingping Yao
Adult-onset Still's disease (AOSD) represents a systemic autoinflammatory disease (SAID), and its diagnostic criteria are clinical without genetic testing. Given shared manifestations between AOSD and hereditary SAIDs, molecular analysis may help differentiate these diseases. A PubMed literature search was conducted using key words "adult-onset Still's disease," "autoinflammatory disease," and "genetic mutation" between 1970 and February 2018. Articles on genetic mutations in the genes MEFV, TNFRSF1A, mevalonate kinase, or NOD2 for hereditary SAIDs in AOSD/systemic onset juvenile idiopathic arthritis (SJIA) patients were reviewed and analyzed...
June 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29909554/handling-times-and-saturating-transmission-functions-in-a-snail-worm-symbiosis
#6
Skylar R Hopkins, Cari M McGregor, Lisa K Belden, Jeremy M Wojdak
All dynamic species interaction models contain an assumption that describes how contact rates scale with population density. Choosing an appropriate contact-density function is important, because different functions have different implications for population dynamics and stability. However, this choice can be challenging, because there are many possible functions, and most are phenomenological and thus difficult to relate to underlying ecological processes. Using one such phenomenological function, we described a nonlinear relationship between field transmission rates and host density in a common snail-oligochaete symbiosis...
June 16, 2018: Oecologia
https://www.readbyqxmd.com/read/29909551/combined-use-of-leptin-and-mechanical-stress-has-osteogenic-effects-on-ossification-of-the-posterior-longitudinal-ligament
#7
Shuai Chen, Haifeng Zhu, Gangliang Wang, Ziang Xie, Jiying Wang, Jian Chen
PURPOSE: To evaluate the effects of leptin/leptin receptor (LepR) combined with mechanical stress on the development of ossification of the posterior longitudinal ligament (OPLL), which is a disease characterized by ectopic bone formation of the posterior longitudinal ligament (PLL) and can lead to radiculopathy and myelopathy. METHODS: Six human samples of the PLL were analyzed for the expression of leptin and LepR by RT-PCR and western blotting. PLL cells were stimulated with leptin and mechanical stress delivered via a Flexcell tension system, and osteogenic differentiation was evaluated by RT-PCR and western blotting analysis of osteogenic marker expression as well as by alkaline phosphatase (ALP) staining and alizarin red S staining...
June 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29909533/intermittent-micro-aeration-control-of-methane-emissions-from-an-integrated-vertical-flow-constructed-wetland-during-agricultural-domestic-wastewater-treatment
#8
Xiaoling Liu, Ke Zhang, Liangqian Fan, Hongbing Luo, Mingshu Jiang, Bruce C Anderson, Mei Li, Bo Huang, Lijuan Yu, Guozhu He, Jingting Wang, Aiping Pu
It is very important to control methane emissions to mitigate global warming. An intermittent micro-aeration control system was used to control methane emissions from an integrated vertical-flow constructed wetland (IVCW) to treat agricultural domestic wastewater pollution in this study. The optimized intermittent micro-aeration conditions were a 20-min aeration time and 340-min non-aeration time, 3.9 m3  h-1 aeration intensity, evenly distributed micro-aeration diffusers at the tank bottom, and an aeration period of every 6 h...
June 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909522/why-don-t-segregated-roma-do-more-for-their-health-an-explanatory-framework-from-an-ethnographic-study-in-slovakia
#9
Andrej Belak, Andrea Madarasova Geckova, Jitse P van Dijk, Sijmen A Reijneveld
OBJECTIVES: The health status of segregated Roma is poor. To understand why segregated Roma engage in health-endangering practices, we explored their nonadherence to clinical and public health recommendations. METHODS: We examined one segregated Roma settlement of 260 inhabitants in Slovakia. To obtain qualitative data on local-level mechanisms supporting Roma nonadherence, we combined ethnography and systematic interviewing over 10 years. We then performed a qualitative content analysis based on sociological and public health theories...
June 16, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29909518/the-african-indigenous-lens-of-understanding-spirituality-reflection-on-key-emerging-concepts-from-a-reviewed-literature
#10
Chioma Ohajunwa, Gubela Mji
In this paper, we will present a reflection on reviewed literature on African indigenous understanding of spirituality, highlighting the influence of this concept on notions of the self, motivation and well-being. The indigenous understanding of spirituality is central to the understanding of the self as distinct, but positioned within the relational-collective self. This African indigenous perception of the self is grounded within the autonomous experience of the tenets of spirituality, which is explored in this paper through the lens of self-determination theory...
June 16, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29909509/utilization-of-public-system-for-gastric-bands-placed-by-private-providers-a-4-year-population-based-analysis-in-ontario-canada
#11
Kristel Lobo Prabhu, Allan Okrainec, Azusa Maeda, Refik Saskin, David Urbach, Chaim M Bell, Timothy D Jackson
Laparoscopic adjustable gastric band (LAGB) placement remains a common bariatric procedure. While LAGB procedure is performed within private clinics in most Canadian provinces, public health care is often utilized for LAGB-related reoperations. We identified 642 gastric band removal procedures performed in Ontario from 2011 to 2014 using population-level administrative data. The number of procedures performed increased annually from 101 in 2011 to 220 in 2014. Notably, 54.7% of the patients required laparotomy, and 17...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29909504/anderson-fabry-disease-in-heart-failure
#12
REVIEW
M M Akhtar, P M Elliott
Anderson-Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene that result in deficiency of the enzyme alpha-galactosidase A. The worldwide incidence of Fabry's disease is reported to be in the range of 1 in 40,000-117,000, although this value may be a significant underestimate given under recognition of symptoms and delayed or missed diagnosis. Deficiency in alpha-galactosidase A causes an accumulation of neutral glycosphingolipids such as globotriaosylceramide (Gb3) in lysosomes within various tissues including the vascular endothelium, kidneys, heart, eyes, skin and nervous system...
June 16, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29909495/the-neuro-immune-regulators-niregs-promote-tissue-resilience-a-vital-component-of-the-host-s-defense-strategy-against-neuroinflammation
#13
REVIEW
Yosra Bedoui, Jim W Neal, Philippe Gasque
An effective protective inflammatory response in the brain is crucial for the clearance of pathogens (e.g. microbes, amyloid fibrils, prionSC ) and should be closely regulated. However, the CNS seems to have limited tissue resilience to withstand the detrimental effects of uncontrolled inflammation compromising functional recovery and tissue repair. Newly described neuro-immune-regulators (NIREGs) are functionally related proteins regulating the severity and duration of the host inflammatory response. NIREGs such as CD200, CD47 and CX3CL1 are vital for increasing tissue resilience and are constitutively expressed by neurons...
June 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29909492/modelling-glioma-invasion-using-3d-bioprinting-and-scaffold-free-3d-culture
#14
Derek M van Pel, Kaori Harada, Dandan Song, Christian C Naus, Wun Chey Sin
Glioma is a highly aggressive form of brain cancer, with some subtypes having 5-year survival rates of less than 5%. Tumour cell invasion into the surrounding parenchyma seems to be the primary driver of these poor outcomes, as most gliomas recur within 2 cm of the original surgically-resected tumour. Many current approaches to the development of anticancer therapy attempt to target genetic weaknesses in a particular cancer, but may not take into account the microenvironment experienced by a tumour and the patient-specific genetic differences in susceptibility to treatment...
June 16, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29909483/understanding-patient-reported-outcome-measures-in-huntington-disease-at-what-point-is-cognitive-impairment-related-to-poor-measurement-reliability
#15
N E Carlozzi, S Schilling, A L Kratz, J S Paulsen, S Frank, J C Stout
PURPOSE: Symptom progression in Huntington disease (HD) is associated with cognitive decline which may interfere with the self-report of symptoms. Unfortunately, data to support or refute the psychometric reliability of patient-reported outcomes (PROs) as HD progresses are limited. This is problematic given that PROs are increasingly recognized as important measures of efficacy for new treatments. METHODS: We examined PRO data from the HDQLIFE Measurement System (Speech Difficulties; Swallowing Difficulties; Chorea) in 509 individuals with premanifest, early-stage, or late-stage HD...
June 16, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29909475/stress-genes-and-hypertension-contribution-of-the-isiah-rat-strain-study
#16
REVIEW
Olga E Redina, Arcady L Markel
PURPOSE OF REVIEW: Acute psychoemotional stress is one of the causes of a sharp increase in blood pressure. However, the question if the stress may promote the hypertensive disease development is still open. This review aims, firstly, to show that the genetically determined enhanced responsiveness to stress is linked to sustained hypertension development and, secondly, to characterize the main physiological mechanisms and genetic factors implicated in the pathogenesis of stress-sensitive hypertension...
June 16, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29909474/the-chimeric-genes-in-the-hybrid-lineage-of-carassius-auratus-cuvieri-%C3%A2-%C3%A3-carassius-auratus-red-var-%C3%A2
#17
Qingfeng Liu, Yanhua Qi, Qiuli Liang, Xiujuan Xu, Fangzhou Hu, Jing Wang, Jun Xiao, Shi Wang, Wuhui Li, Min Tao, Qinbo Qin, Rurong Zhao, Zhanzhou Yao, Shaojun Liu
Hybridization can combine the genomes of different strains or species, which leads to changes of genotype and phenotype in the hybrids. In this study, we aimed to investigate the genetic variations of hybrids (WR-F1 and WR-F2 ) derived from the intraspecific hybridization of white crucian carp (Carassius auratus cuvieri, WCC, ♀) and red crucian carp (Carassius auratus red var., RCC, ♂). Here, we compared the orthologous genes in the liver transcriptomes of hybrids with those of WCC and RCC, and classified the orthologous genes into eight gene patterns within three categories (chimera, mutant, and biparental origin genes)...
June 13, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29909473/rational-design-for-fungal-laccase-production-in-the-model-host-aspergillus-nidulans
#18
Wei Li, Jingwen Yu, Zixin Li, Wen-Bing Yin
Laccases, multicopper oxidoreductases, are mainly produced in white-rot fungi and are considered as ideal green catalysts in industrial and biotechnological applications. However, the development of laccases is limited due to the slow growth of natural laccase producing strains and the low expression levels of laccases. In this study, we designed three regulation strategies for laccase gene expression in the model fungus Aspergillus nidulans. By introducing various promoters in front of the laccase gene pslcc from the white-rot fungus Pycnoporus sanguineus, we found that the laccase gene with the original promoter had effective expression in A...
June 12, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29909460/modulation-of-brain-ace-and-ace2-may-be-a-promising-protective-strategy-against-cerebral-ischemia-reperfusion-injury-an-experimental-trial-in-rats
#19
Maha Mohammed Abdel-Fattah, Basim Anwar Shehata Messiha, Ahmed Mohamed Mansour
The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological homeostasis and disease progression. We evaluated the protective effects of the angiotensin receptor blocker (ARB) telmisartan and the angiotensin-converting enzyme 2 (ACE2) activator xanthenone on experimental cerebral ischemia/reperfusion (I/R) injury. Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p...
June 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29909453/m-6-a-rna-methylation-controls-neural-development-and-is-involved-in-human-diseases
#20
REVIEW
Kunzhao Du, Longbin Zhang, Trevor Lee, Tao Sun
RNA modifications are involved in many aspects of biological functions. N6-methyladenosine (m6 A) is one of the most important forms of RNA methylation and plays a vital role in regulating gene expression, protein translation, cell behaviors, and physiological conditions in many species, including humans. The dynamic and reversible modification of m6 A is conducted by three elements: methyltransferases ("writers"), such as methyltransferase-like protein 3 (METTL3) and METTL14; m6 A-binding proteins ("readers"), such as the YTH domain family proteins (YTHDFs) and YTH domain-containing protein 1 (YTHDC1); and demethylases ("erasers"), such as fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5)...
June 16, 2018: Molecular Neurobiology
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