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https://www.readbyqxmd.com/read/28549157/exposure-to-acute-psychosocial-stress-disrupts-the-luteinizing-hormone-surge-independent-of-estrous-cycle-alterations-in-female-mice
#1
Elizabeth R Wagenmaker, Suzanne M Moenter
The disruptive effects of severe stress on reproductive function are well documented, but surprisingly few studies exist that demonstrate milder psychosocial stressors interfere with the ovarian cycle in females. We hypothesized repeated application of psychosocial stress would disrupt estrous cycles in mice. Mice were transferred to a new cage, transported to a new room and restrained (2h) for 21 consecutive days. Contrary to our hypothesis, this paradigm did not affect estrous cycles. We next tested the hypothesis that a single exposure to mild stress disrupts a specific aspect of the cycle: the proestrous luteinizing hormone (LH) surge...
May 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28549101/loneliness-and-objectively-measured-physical-capability-in-middle-aged-adults
#2
Rikke Lund, Jelena Laban, Gitte L Petersen, Agnete Dissing, Åse Marie Hansen, Naja H Rod
Loneliness is associated with poor functional ability in older people. Little is known about this association in the middle-aged. The aim is to investigate if perceived loneliness is associated with lower physical capability among middle-aged men and women and if the associations of loneliness with physical capability interact with socioeconomic position and cohabitation status. 5224 participants from Copenhagen Aging and Midlife Biobank (CAMB) aged 49-62 years (mean age 54) were included. Handgrip strength (measured by a dynamometer) and maximal number of chair rises in 30 s was recorded...
May 25, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28549024/the-epidemiology-of-hospital-death-following-pediatric-severe-sepsis-when-why-and-how-children-with-sepsis-die
#3
Scott L Weiss, Fran Balamuth, Josey Hensley, Julie C Fitzgerald, Jenny Bush, Vinay M Nadkarni, Neal J Thomas, Mark Hall, Jennifer Muszynski
OBJECTIVE: The epidemiology of in-hospital death after pediatric sepsis has not been well characterized. We investigated the timing, cause, mode, and attribution of death in children with severe sepsis, hypothesizing that refractory shock leading to early death is rare in the current era. DESIGN: Retrospective observational study. SETTING: Emergency departments and ICUs at two academic children's hospitals. PATIENTS: Seventy-nine patients less than 18 years old treated for severe sepsis/septic shock in 2012-2013 who died prior to hospital discharge...
May 25, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28548829/fused-pentagon-configuration-dependent-electron-transfer-of-monotitanium-encapsulated-fullerenes
#4
Jing-Shuang Dang, Wei-Wei Wang, Jia-Jia Zheng, Xiang Zhao, Shigeru Nagase
We introduce monotitanium-based endohedral metallofullerenes (EMFs) using density functional theory calculations. Isomeric C64 fullerenes are initially employed as hosts, and Ti@C64 species show novel features on the electronic structures. Energetically, the preference of titanium residing on triple-fused-pentagon subunits is proposed in theory. More importantly, different from current knowledge on mono-EMFs, electron transfer between titanium and carbon cages is not unified but is essentially dependent on the pentagon distribution of the binding sites, giving rise to variations of the cationic titanium of Ti@C64...
May 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28548524/topologically-enforced-bifurcations-in-superconducting-circuits
#5
G Engelhardt, M Benito, G Platero, T Brandes
The relationship of topological insulators and superconductors and the field of nonlinear dynamics is widely unexplored. To address this subject, we adopt the linear coupling geometry of the Su-Schrieffer-Heeger model, a paradigmatic example for a topological insulator, and render it nonlinearly in the context of superconducting circuits. As a consequence, the system exhibits topologically enforced bifurcations as a function of the topological control parameter, which finally gives rise to chaotic dynamics, separating phases that exhibit clear topological features...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28546660/can-we-deliver-better
#6
REVIEW
Ajay Rane, Jay Iyer, Harsha Ananthram, Thomas Currie
Human childbirth has been described as an "obstetrical dilemma". Evolution favours enlargement of the foetal brain, whilst bipedal locomotion demands a reduction in pelvic breadth for improvements in biomechanical efficiency. The result of this conflict is a human pelvis incongruous with the dynamics of childbirth. Acute genital distortion at delivery can inflict lasting damage to female pelvic function. Pelvic organ prolapse, urinary, faecal incontinence and sexual dysfunction are long-term sequelae rarely discussed at antenatal care, impacting upon the expectant mother's ability to make an informed decision...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28545844/rise-and-fall-of-the-two-visual-systems-theory
#7
Yves Rossetti, Laure Pisella, Robert D McIntosh
Among the many dissociations describing the visual system, the dual theory of two visual systems, respectively dedicated to perception and action, has yielded a lot of support. There are psychophysical, anatomical and neuropsychological arguments in favor of this theory. Several behavioral studies that used sensory and motor psychophysical parameters observed differences between perceptive and motor responses. The anatomical network of the visual system in the non-human primate was very readily organized according to two major pathways, dorsal and ventral...
May 22, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28545394/agennt-annotation-of-enzyme-families-by-means-of-refined-neighborhood-networks
#8
Florian Kandlinger, Maximilian G Plach, Rainer Merkl
BACKGROUND: Large enzyme families may contain functionally diverse members that give rise to clusters in a sequence similarity network (SSN). In prokaryotes, the genome neighborhood of a gene-product is indicative of its function and thus, a genome neighborhood network (GNN) deduced for an SSN provides strong clues to the specific function of enzymes constituting the different clusters. The Enzyme Function Initiative ( http://enzymefunction.org/ ) offers services that compute SSNs and GNNs...
May 25, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28545257/the-reactive-sulfur-species-concept-15-years-on
#9
REVIEW
Gregory I Giles, Muhammad Jawad Nasim, Wesam Ali, Claus Jacob
Fifteen years ago, in 2001, the concept of "Reactive Sulfur Species" or RSS was advocated as a working hypothesis. Since then various organic as well as inorganic RSS have attracted considerable interest and stimulated many new and often unexpected avenues in research and product development. During this time, it has become apparent that molecules with sulfur-containing functional groups are not just the passive "victims" of oxidative stress or simple conveyors of signals in cells, but can also be stressors in their own right, with pivotal roles in cellular function and homeostasis...
May 23, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28545123/predictability-of-arousal-in-mouse-slow-wave-sleep-by-accelerometer-data
#10
Gustavo Zampier Dos Santos Lima, Sergio Roberto Lopes, Thiago Lima Prado, Bruno Lobao-Soares, George C do Nascimento, John Fontenele-Araujo, Gilberto Corso
Arousals can be roughly characterized by punctual intrusions of wakefulness into sleep. In a standard perspective, using human electroencephalography (EEG) data, arousals are associated to slow-wave rhythms and K-complex brain activity. The physiological mechanisms that give rise to arousals during sleep are not yet fully understood. Moreover, subtle body movement patterns, which may characterize arousals both in human and in animals, are usually not detectable by eye perception and are not in general present in sleep studies...
2017: PloS One
https://www.readbyqxmd.com/read/28544612/ecology-adaptation-and-function-of-methane-sulfidic-spring-water-biofilm-microorganisms-including-a-strain-of-anaerobic-fungus-mucor-hiemalis
#11
Enamul Hoque, Johannes Fritscher
Ecological aspects, adaptation, and some functions of a special biofilm and its unique key anaerobic fungus Mucor hiemalis strain EH11 isolated from a pristine spring (Künzing, Bavaria, Germany) are described. The spring's pure nature is characterized by, for example, bubbling methane, marine-salinity, mild hydrothermal (~19.1°C), sulfidic, and reductive-anoxic (Eh : -241 to -253 mV, O2 : ≤ 0.1 mg/L) conditions. It is geoecologically located at the border zone between Bavarian Forest (crystalline rocky mountains) and the moor-like Danube River valley, where geological displacements bring the spring's water from the deeper layers of former marine sources up to the surface...
May 24, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28544444/review-of-the-ecosystem-service-implications-of-mangrove-encroachment-into-salt-marshes
#12
REVIEW
Jeffrey J Kelleway, Kyle Cavanaugh, Kerrylee Rogers, Ilka C Feller, Emilie Ens, Cheryl Doughty, Neil Saintilan
Salt marsh and mangrove have been recognized as being among the most valuable ecosystem types globally in terms of their supply of ecosystem services and support for human livelihoods. These coastal ecosystems are also susceptible to the impacts of climate change and rising sea levels, with evidence of global shifts in the distribution of mangroves, including encroachment into salt marshes. The encroachment of woody mangrove shrubs and trees into herbaceous salt marshes may represent a substantial change in ecosystem structure, although resulting impacts on ecosystem functions and service provisions are largely unknown...
May 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28543976/structure-induced-switching-of-the-band-gap-charge-order-and-correlation-strength-in-ternary-vanadium-oxide-bronzes
#13
Thomas Tolhurst, Justin Andrews, Brett Leedahl, Peter Marley, Sarbajit Banerjee, Alexander Moewes
Recently, V2O5 nanowires have been synthesized as several different polymorphs, and as correlated bronzes with cations intercalated between the layers of edge- and corner-sharing VO6 octahedra. Unlike extended crystals, which tend to be plagued by substantial local variations in stoichiometry, nanowires of correlated bronzes exhibit precise charge ordering, thereby giving rise to pronounced electron correlation effects. These developments have greatly broadened the scope of research, and promise applications in several frontier electronic devices that make use of novel computing vectors...
May 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543642/bidirectional-superior-cavopulmonary-anastomosis-with-or-without-cardiopulmonary-bypass-a-randomized-study
#14
Sachin Talwar, Anish Gupta, Ashima Nehra, Neeti Makhija, Poonam Malhotra Kapoor, Vishnubhatla Sreenivas, Shiv Kumar Choudhary, Balram Airan
OBJECTIVES: This study aims to compare the bidirectional superior cavopulmonary anastomosis (BDG) with or without cardiopulmonary bypass (CPB). METHODS: 100 patients undergoing BDG were randomized into two groups: Off-CPB or on-CPB groups. All patients underwent near-infrared spectrophotometry (NIRS) and bispectral index (BIS) monitoring and pre- and postoperative serum 100 beta protein measurements (Sβ100) and neuro-cognitive evaluation. Postoperative intensive care unit (ICU) parameters were also studied...
May 21, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28542952/compensatory-and-decompensatory-alterations-in-cardiomyocyte-ca-2-dynamics-in-hearts-with-diastolic-dysfunction-following-aortic-banding
#15
Sara Gattoni, Åsmund Treu Røe, Jan Magnus Aronsen, Ivar Sjaastad, William E Louch, Nicolas P Smith, Steven A Niederer
KEY POINTS: At the cellular level cardiac hypertrophy causes remodelling, leading to changes in ionic channel, pump and exchanger densities and kinetics. Previous studies have focused on quantifying changes in channels, pumps and exchangers without quantitatively linking these changes with emergent cellular scale functionality. Two biophysical cardiac cell models were created, parameterized and validated and are able to simulate electrophysiology and calcium dynamics in myocytes from control sham operated rats and aortic-banded rats exhibiting diastolic dysfunction...
May 21, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28542423/plasmid-free-crispr-cas9-genome-editing-in-plasmodium-falciparum-confirms-mutations-conferring-resistance-to-the-dihydroisoquinolone-clinical-candidate-sj733
#16
Emily D Crawford, Jenai Quan, Jeremy A Horst, Daniel Ebert, Wesley Wu, Joseph L DeRisi
Genetic manipulation of the deadly malaria parasite Plasmodium falciparum remains challenging, but the rise of CRISPR/Cas9-based genome editing tools is increasing the feasibility of altering this parasite's genome in order to study its biology. Of particular interest is the investigation of drug targets and drug resistance mechanisms, which have major implications for fighting malaria. We present a new method for introducing drug resistance mutations in P. falciparum without the use of plasmids or the need for cloning homologous recombination templates...
2017: PloS One
https://www.readbyqxmd.com/read/28541654/stable-1t-mose2-and-carbon-nanotubes-hybridized-flexible-film-binder-free-and-high-performance-li-ion-anode
#17
Ting Xiang, Shi Tao, Weiyu Xu, Qi Fang, Chuanqiang Wu, Daobin Liu, Yu Zhou, Adnan Khalil, Zahir Muhammad, Wangsheng Chu, Zhonghui Wang, Hongfa Xiang, Qin Liu, Li Song
Two-dimensional stable metallic 1T-MoSe2 with expanded interlayer spacing of 10.0 Å in-situ grown on SWCNTs film is fabricated via a one-step solvothermal method. Combined with X-ray absorption near-edge structures, our characterizations reveals that such 1T-MoSe2 and single-walled carbon nanotubes (abbreviated as 1T-MoSe2/SWCNTs) hybridized structure can provide strong electrical and chemical coupling between 1T-MoSe2 nanosheets and SWCNTs film in a form of C-O-Mo bonding, which is significantly benefiting a high-efficiency electron/ion transport pathway and structural stability, thus directly enabling high performance lithium-storage properties...
May 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28541593/clinical-and-prognostic-relevancy-of-left-ventricular-trabeculation-assessed-by-cardiac-magnetic-resonance-in-patients-with-dilated-cardiomyopathy
#18
Łukasz Mazurkiewicz, Joanna Petryka, Mateusz Śpiewak, Barbara Miłosz-Wieczorek, Łukasz A Małek, Anna Jasińska, Ewelina Jarmus, Magdalena Marczak, Jolanta Misko, Jacek Grzybowski
BACKGROUND AND AIM: We sought to search for factors that are associated with the magnitude of trabeculation by cardiac magnetic resonance (CMR), and evaluate the impact of trabeculations on outcomes in patients with dilated cardiomyopathy (DCM). METHODS: We evaluated clinical profiles and outcomes of 276 subjects with DCM (age - 33,2+/-13,3 years, 160 males). Trabeculation was quantified as trabeculated/total myocardial mass ratio (TM/M). Subjects were stratified into 3 subgroups (A, B, and C) according to the tertiles of rising TM/M values (33% ranges)...
May 25, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28540884/effect-of-fluorescein-angiography-on-renal-functions-in-type-2-diabetes-patients-a-pilot-study
#19
Waleed H Almalki, Ashraf Nabiel Abdalla, Ahmed F Elkeraie, Ahmed M Abdelhadi, Mahmoud Elrggal, Mohamed E Elrggal
Fluorescein angiography (FA) is an important tool for the diagnosis and management of diabetic retinopathy. However, the safety of fluorescein sodium on renal functions is not fully understood. One hundred type 2 diabetes patients, within the Ophthalmology Outpatient Clinic at Alexandria Main University Hospital, Egypt, were enrolled in this prospective observational study to determine the safety of FA on renal function. Serum creatinine and cystatin C were measured pre- and 2 days post-FA. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) was measured pre- and 4 hours post-FA...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28539995/the-effect-of-luteinizing-hormone-reducing-agent-on-anxiety-and-novel-object-recognition-memory-in-gonadectomized-rats
#20
Paria Arfa-Fatollahkhani, Arezo Nahavandi, Hossein Abtahi, Shabnam Anjidani, Sahar Borhani, Seyed Behnam Jameie, Mohammad Shabani, Saeed Mehrzadi, Ali Shahbazi
INTRODUCTION: Mood disorders such as anxiety and depression are common following menopause and andropause. Lack of sex steroid hormones is suggested as the primary cause of these disturbances. The level of luteinizing hormone (LH) would also rise 3-4 times than normal in these people. The potential effects of LH on mood and cognitive symptoms following menopause and andropause are still unknown. This study aimed to investigate the effect of increased LH on novel object discrimination (NOD) memory and anxiety like behavior in gonadectomized rats...
March 2017: Basic and Clinical Neuroscience
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