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https://www.readbyqxmd.com/read/29331554/potential-role-of-transfontanelle-ultrasound-for-infants-undergoing-modified-blalock-taussig-shunt
#1
Eun-Hee Kim, Ji-Hyun Lee, In-Kyung Song, Hee-Soo Kim, Young-Eun Jang, Woong-Han Kim, Jae-Gun Kwak, Jin-Tae Kim
OBJECTIVE: Transfontanelle ultrasound is a noninvasive method for assessing cerebral blood flow in neonates and infants. The authors applied this technique as a point-of-care tool, before and after modified Blalock-Taussig shunt procedure, to evaluate cerebral perfusion. DESIGN: Retrospective, observational study. SETTING: Tertiary care children's hospital. PARTICIPANTS: Ten infants undergoing modified Blalock-Taussig shunt procedure...
December 11, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29310561/endotoxin-activity-in-neonates-undergoing-cardiac-surgery-cohort-study
#2
Zaccaria Ricci, Simona Benegni, Cristiana Garisto, Isabella Favia, Roberta Haiberger, Luca Di Chiara
BACKGROUND: Endotoxemia in pediatric cardiac surgical patients is poorly understood. The endotoxin activity assay (EAA) levels were examined in neonates undergoing cardiac surgery in order to assess their reference levels and their association with other pre-, intra-, and postoperative risk factors for gut hypoperfusion. We finally observed if refeeding was associated with modification of endotoxin levels. METHODS: In a prospective cohort study, neonates undergoing surgery for correction or palliation were enrolled...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29296069/tuberous-sclerosis-presenting-as-neonatal-cyanosis-because-of-rhabdomyoma-causing-tricuspid-valve-obstruction-needing-a-blalock-taussig-shunt
#3
Monther Obeidat, Yazan Qawasmeh, Hani Tarawneh, Ibrahim Sawalhah, Ala'a Tawalbeh
We report a newborn female baby who presented at 6 hours of age with cyanosis without any signs of respiratory distress. Cardiovascular and systemic examination was unremarkable apart from cyanosis (saturation 75%). An echocardiogram showed multiple echogenic and homogeneous masses in the interventricular septum, one of which was big and protruding through the tricuspid valve causing right ventricular inflow obstruction. There was a small atrial septal defect (ASD) shunting right to left and patent ductus arteriosus (PDA) shunting left to right...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29284604/homozygous-familial-hypercholesterolemia-patients-with-identical-mutations-variably-express-the-ldlr-low-density-lipoprotein-receptor-implications-for-the-efficacy-of-evolocumab
#4
Aurélie Thedrez, Dirk J Blom, Stéphane Ramin-Mangata, Valentin Blanchard, Mikaël Croyal, Kevin Chemello, Brice Nativel, Matthieu Pichelin, Bertrand Cariou, Steeve Bourane, Lihua Tang, Michel Farnier, Frederick J Raal, Gilles Lambert
OBJECTIVE: Evolocumab, a PCSK9 (proprotein convertase subtilisin kexin type 9)-neutralizing antibody, lowers low-density lipoprotein cholesterol (LDL-C) in homozygous familial hypercholesterolemic (HoFH) patients with reduced LDLR (low-density lipoprotein receptor) function. However, their individual responses are highly variable, even among carriers of identical LDLR genetic defects. We aimed to elucidate why HoFH patients variably respond to PCSK9 inhibition. APPROACH AND RESULTS: Lymphocytes were isolated from 22 HoFH patients enrolled in the TAUSSIG trial...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29277357/french-guidelines-on-stereoelectroencephalography-seeg
#5
REVIEW
Jean Isnard, Delphine Taussig, Fabrice Bartolomei, Pierre Bourdillon, Hélène Catenoix, Francine Chassoux, Mathilde Chipaux, Stéphane Clémenceau, Sophie Colnat-Coulbois, Marie Denuelle, Stéphane Derrey, Bertrand Devaux, Georg Dorfmüller, Vianney Gilard, Marc Guenot, Anne-Sophie Job-Chapron, Elisabeth Landré, Axel Lebas, Louis Maillard, Aileen McGonigal, Lorella Minotti, Alexandra Montavont, Vincent Navarro, Anca Nica, Nicolas Reyns, Julia Scholly, Jean-Christophe Sol, William Szurhaj, Agnès Trebuchon, Louise Tyvaert, Maria Paola Valenti-Hirsch, Luc Valton, Jean-Pierre Vignal, Paul Sauleau
Stereoelectroencephalography (SEEG) was designed and developed in the 1960s in France by J. Talairach and J. Bancaud. It is an invasive method of exploration for drug-resistant focal epilepsies, offering the advantage of a tridimensional and temporally precise study of the epileptic discharge. It allows anatomo-electrical correlations and tailored surgeries. Whereas this method has been used for decades by experts in a limited number of European centers, the last ten years have seen increasing worldwide spread of its use...
December 22, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29274873/the-use-of-unfixed-bone-marrow-trephines-for-multicolour-flow-cytometry
#6
REVIEW
R Morilla, K Moss, V Nikolova, K Marquardt, S Duke, K Adamowska, L Fuller, A Taifoor, N Johnson, A Zeisig, A Morilla, A Atra, D C Taussig
An adequate bone marrow aspirate is essential for a rapid diagnosis of acute leukaemia by multicolour flow cytometry enabling the simultaneous assessment of multiple antigens on the cell surface as well as intracellular or nuclear ones. In the context of acute leukaemia, it is important to have a diagnosis of the blasts lineage as soon as possible to decide the appropriate treatment. This is sometimes delayed due to difficulties in of obtaining a bone marrow aspirate due to a "dry tap". In this study we evaluated retrospectively cell markers results by flow cytometry of unfixed bone marrow trephines of 65 patients with leukaemia at diagnosis and including a few after treatment...
December 21, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29241451/energetic-performance-analysis-of-staged-palliative-surgery-in-tricuspid-atresia-using-vector-flow-mapping
#7
Mao Kinoshita, Koichi Akiyama, Keiichi Itatani, Ayahiro Yamashita, Maki Ishii, Atsushi Kainuma, Yoshinobu Maeda, Takako Miyazaki, Masaaki Yamagishi, Teiji Sawa
BACKGROUND: Staged palliative surgery markedly shifts the balance of volume load on a single ventricle and pulmonary vascular bed. Blalock-Taussig shunt necessitates a single ventricle eject blood to both the systemic and pulmonary circulation. On the contrary, bidirectional cavopulmonary shunt release the single ventricle from pulmonary circulation. CASE PRESENTATION: We report a case of tricuspid atresia patient who underwent first palliative surgery and second palliative surgery...
December 14, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29216382/improving-crispr-cas-specificity-with-chemical-modifications-in-single-guide-rnas
#8
Daniel E Ryan, David Taussig, Israel Steinfeld, Smruti M Phadnis, Benjamin D Lunstad, Madhurima Singh, Xuan Vuong, Kenji D Okochi, Ryan McCaffrey, Magdalena Olesiak, Subhadeep Roy, Chong Wing Yung, Bo Curry, Jeffrey R Sampson, Laurakay Bruhn, Douglas J Dellinger
CRISPR systems have emerged as transformative tools for altering genomes in living cells with unprecedented ease, inspiring keen interest in increasing their specificity for perfectly matched targets. We have developed a novel approach for improving specificity by incorporating chemical modifications in guide RNAs (gRNAs) at specific sites in their DNA recognition sequence ('guide sequence') and systematically evaluating their on-target and off-target activities in biochemical DNA cleavage assays and cell-based assays...
December 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29174590/double-outlet-right-ventricle-with-subpulmonary-ventricular-septal-defect-taussig-bing-anomaly-and-other-complex-congenital-cardiac-malformations-in-an-american-quarter-horse-foal
#9
Rebecca Kohnken, Karsten Schober, Jennifer Godman, Alison Gardner, Tiffany Jenkins, Eric Schroeder, Peter Baker, Laura Dunbar
A 4-week-old American Quarter Horse colt presented with a recent history of diarrhea and decreased activity level. On initial physical examination, the animal was bright and alert and major findings were limited to a loud systolic heart murmur radiating widely over both sides of the thorax. While in the hospital, the clinical condition of the foal warranted further imaging to determine the cause and extent of cardiac disease. A variety of congenital cardiac malformations were identified during echocardiographic examination and autopsy, including a double outlet right ventricle and a subpulmonary interventricular septal defect (Taussig-Bing anomaly), ventricular inversion with atrioventricular discordance, tricuspid valve atresia, a septum primum interatrial septal defect, mitral valve dysplasia with a cleft in the septal mitral valve cusp, aortic, and subaortic stenosis, tubular hypoplasia of the ascending aorta and the aortic arch, a patent ductus arteriosus, an aberrant circumflex coronary artery, and aberrant left and right subclavian arteries...
November 21, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29124558/development-of-a-simple-device-enabling-percutaneous-flow-regulation-for-a-small-vascular-graft-for-a-blalock-taussig-shunt-capable-of-flow-regulation-complete-translation-of-a-review-article-originally-published-in-pediatric-cardiology-and-cardiac-surgery
#10
Yoshikazu Motohashi, Ryo Shimada, Tomoyasu Sasaki, Takahiro Katsumata, Kazunori Dan, Yasuhiro Tsutsui, Shintaro Nemoto
OBJECTIVES: The Blalock-Taussig shunt (BTS) operation is a cornerstone as initial palliative surgery for congenital heart disease with severely reduced pulmonary blood flow (PBF). The ideal PBF provided by BTS is crucial for an uneventful postoperative course, since excess PBF results in acute distress of the systemic circulation and insufficient PBF requires another BTS surgery. Therefore, the goal of this study was to develop a simple device to control the shunt graft flow percutaneously using a constrictor balloon connected to a subcutaneous port...
November 9, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29121836/retroesophageal-infracardiac-total-anomalous-pulmonary-venous-drainage
#11
Maria L Rodriguez, Christopher A Caldarone, Hadi Toeg, Gyaandeo Maharajh
This case report describes the management of a term baby, born cyanotic, who was preoperatively diagnosed to have an obstructed total anomalous pulmonary venous drainage (TAPVD) in association with a functionally univentricular heart. An urgent repair of the anomalous pulmonary venous drainage was done, and a modified Blalock-Taussig shunt was constructed. Intraoperative difficulties were encountered when the pulmonary venous confluence was not seen in the usual location in the posterior mediastinal space, anterior to the esophagus...
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29076145/durable-graft-versus-leukaemia-effects-without-donor-lymphocyte-infusions-results-of-a-phase-ii-study-of-sequential-t-replete-allogeneic-transplantation-for-high-risk-acute-myeloid-leukaemia-and-myelodysplasia
#12
Jeff K Davies, Sandra Hassan, Shah-Jalal Sarker, Caroline Besley, Heather Oakervee, Matthew Smith, David Taussig, John G Gribben, Jamie D Cavenagh
Allogeneic haematopoietic stem-cell transplantation remains the only curative treatment for relapsed/refractory acute myeloid leukaemia (AML) and high-risk myelodysplasia but has previously been limited to patients who achieve remission before transplant. New sequential approaches employing T-cell depleted transplantation directly after chemotherapy show promise but are burdened by viral infection and require donor lymphocyte infusions (DLI) to augment donor chimerism and graft-versus-leukaemia effects. T-replete transplantation in sequential approaches could reduce both viral infection and DLI usage...
October 26, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29067078/tetralogy-of-fallot-repair-in-patients-presenting-after-infancy-a-single-surgeon-experience
#13
Tariq Waqar, Muhammad Usman Riaz, Tania Mahar
OBJECTIVE: To determine the early surgical outcomes of Tetralogy of Fallot (TOF) repair in children and young adults operated after the age of one year. METHODS: In this retrospective study, 307 cases of primary repair of Tetralogy of Fallot were done between September 2012 to February 2017, at CPE Institute of cardiology, Multan. Out of 307 operated patients, 4 (1.3%) patients had previous modified Blalock Taussig shunts, 2 (0.6%) associated ASD with TOF, 3 (0...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29042354/a-comparison-between-patent-ductus-arteriosus-stent-and-modified-blalock-taussig-shunt-as-palliation-for-infants-with-ductal-dependent-pulmonary-blood-flow-insights-from-the-congenital-catheterization-research-collaborative
#14
Andrew C Glatz, Christopher J Petit, Bryan H Goldstein, Michael S Kelleman, Courtney E McCracken, Alicia McDonnell, Timothy Buckey, Christopher E Mascio, Subi Shashidharan, R Allen Ligon, Jingning Ao, Wendy Whiteside, W Jack Wallen, Christina M Metcalf, Varun Aggarwal, Hitesh Agrawal, Athar M Qureshi
Background -Infants with ductal-dependent pulmonary blood flow may undergo palliation with either a patent ductus arteriosus (PDA) stent or modified Blalock-Taussig (BT) shunt. A balanced multi-center comparison of these two approaches is lacking. Methods -Infants with ductal-dependent pulmonary blood flow, palliated with either PDA stent or BT shunt from 1/08 to 11/15, were reviewed from the four member centers of the Congenital Catheterization Research Collaborative. Outcomes were compared using propensity score adjustment to account for baseline differences between groups...
October 17, 2017: Circulation
https://www.readbyqxmd.com/read/29034732/pregnancy-and-childbearing-among-young-adults-who-experienced-foster-care
#15
Katie Massey Combs, Stephanie Begun, Deborah J Rinehart, Heather Taussig
This study explores rates of early pregnancy and parenthood among a sample of young adults ( N = 215), ages 18-22, with a history of foster care. The study also compares the educational attainment, financial resources, and homelessness experiences of young adults who became parents to those who did not. By age 21, 49% of the young women became pregnant, and 33% of young men reported getting someone pregnant. Over a quarter of participants experienced parenthood, which was associated with lower educational attainment, less employment, not having a checking or savings account, and a history of homelessness...
January 1, 2017: Child Maltreatment
https://www.readbyqxmd.com/read/28964410/association-of-shunt-type-with-arrhythmias-after-norwood-procedure
#16
Eric J Hall, Andrew H Smith, Frank A Fish, David P Bichell, Bret A Mettler, Kimberly Crum, Prince J Kannankeril, Andrew E Radbill
BACKGROUND: Transplant-free survival for single right ventricle (RV) lesions remains less than 70% at 3 years. Arrhythmia burden, influence of shunt type at Norwood procedure (RV-to-pulmonary artery shunt [RVPAS] versus Blalock-Taussig shunt [BTS]), and implications for mortality risk are not well defined. METHODS: The authors performed a single-center retrospective analysis of patients with single RV lesions enrolled in a prospective study of arrhythmias after congenital heart surgery...
September 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28948321/contralateral-pulmonary-hypertension-following-resuscitation-of-unilateral-ductal-origin-of-a-pulmonary-artery-a-multi-institutional-review
#17
Hitesh Agrawal, Christopher J Petit, Joaquim Miro, Carlos D Miranda, Damien Kenny, Henri Justino
In isolated unilateral ductal origin of a pulmonary artery (DOPA), intervention to establish reperfusion of the affected lung without direct re-anastomosis may lead to pulmonary hypertension (PH) in the contralateral lung. Multicenter retrospective review of patients with unilateral DOPA, who underwent palliation with a ductal stent (DS) or Blalock-Taussig (BT) shunt with subsequent development of PH in the contralateral lung, was conducted. Ten patients (4 females; median weight 3.2 kg, range 2.1-5.2) who underwent DS or BT shunt and developed contralateral PH were identified...
September 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28922269/extubation-failure-is-associated-with-increased-mortality-following-first-stage-single-ventricle-reconstruction-operation
#18
Thomas Scodellaro, Jane M McKenzie, Yves d'Udekem, Warwick Butt, Siva P Namachivayam
OBJECTIVES: To identify the prevalence, causes, risk factors, and outcomes associated with extubation failure following first stage single ventricle reconstruction surgery. DESIGN: Retrospective cohort analysis of neonates who underwent a first stage single ventricle reconstruction operation. Extubation failure was defined as endotracheal reintubation within 48 hours of first extubation attempt. SETTING: The Royal Children's Hospital, Melbourne...
December 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28915527/palliative-therapies-for-congenital-heart-disease-with-ductus-dependent-pulmonary-circulation
#19
Shi-Min Yuan
In neonates, the management of ductus dependent pulmonary circulation is challenging. There have been three palliative therapies for this lesion: the modified Blalock-Taussig shunt, ductal stenting and prostaglandin E infusions, for maintaining the ductal patency before definite operations. Debates remain with regard to the indications and disadvantages of three palliative therapies. The aim of this article is to give a brief review of these three palliative therapies.
September 15, 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28912041/postoperative-b-type-natriuretic-peptide-monitoring-for-the-assessment-of-the-magnitude-of-shunting-through-blalock-taussig-anastomoses
#20
Cristian Mirabile, Alessandra Mazzola, Liana Valeanu, Vanessa Lopez-Lopez, Claudio Barbanti, Camilla Biselli, Carole Hennequin, Sophie Malekzadeh-Milani, Mirela Bojan
BACKGROUND: The Modified Blalock-Taussig shunt (MBTS) is the most common palliative operation performed in patients with complex cardiac defects. Postoperative morbidity and mortality rates are high, mainly due to shunt thrombosis and over-shunting. Over-shunting may be difficult to identify postoperatively based on conventional criteria. Since plasma B-type natriuretic peptide (BNP) concentrations correlate with the magnitude of shunting in various left-to-right shunt cardiac defects, we investigated its ability to identify postoperative MBTS over-shunting...
December 15, 2017: International Journal of Cardiology
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