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https://www.readbyqxmd.com/read/28106085/the-%C3%AE-globin-replicator-greatly-enhances-the-potential-of-s-mar-based-episomal-vectors-for-gene-transfer-into-human-haematopoietic-progenitor-cells
#1
Eleana F Stavrou, Vassileios M Lazaris, Aristeidis Giannakopoulos, Eirini Papapetrou, Alexandros Spyridonidis, Nikolas C Zoumbos, Antonis Gkountis, Aglaia Athanassiadou
Specific human chromosomal elements enhance the performance of episomal gene-transfer vectors. S/MAR-based episomal vector pEPI-eGFP transfects CD34(+) haematopoietic cells, but only transiently. To address this issue we reinforced (1) transgene transcription by replacing the CMV promoter driving eGFP with the EF1/HTLV or SFFV promoters to produce vectors pEPI-EF1/HTLV and pEPI-SFFV, respectively; and (2) plasmid replication by inserting the replication-Initiation Region (IR) from the β-globin locus into vector pEPI-SFFV to produce vector pEP-IR...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28104487/comparison-of-a-special-designed-high-intensity-coil-to-a-standard-round-coil-tms-setting
#2
Andrea Szelényi, Julia Wölfle, Igor Fischer, Hans-Jakob Steiger, Michael Sabel
BACKGROUND: Routine diagnostic Transcranial Magnetic Stimulation (TMS) is performed with a round coil (RC) for cranial and spinal root stimulation, being less successful for motor evoked potentials (MEP) of lower limb muscles. MEP elicited with a special configured flat figure-of-eight coil designed for high intensity stimulation (HI-coil) were compared to RC with regard to handling, efficiency, and physiological properties of MEP. NEW METHODS: MEP elicited with HI-coil and 9-cm diameter RC for cortical, spinal and peripheral stimulation (PES) were compared for Motor threshold (MT), latencies and amplitudes of bilateral Abductor pollicis brevis (APB) and Abductor hallucis muscles (AH)...
January 16, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28101727/reliable-prediction-of-adsorption-isotherms-via-genetic-algorithm-molecular-simulation
#3
L LoftiKatooli, A Shahsavand
Conventional molecular simulation techniques such as grand canonical Monte Carlo (GCMC) strictly rely on purely random search inside the simulation box for predicting the adsorption isotherms. This blind search is usually extremely time demanding for providing a faithful approximation of the real isotherm and in some cases may lead to non-optimal solutions. A novel approach is presented in this article which does not use any of the classical steps of the standard GCMC method, such as displacement, insertation, and removal...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28101541/inner-salt-shaped-small-molecular-photosensitizer-with-extremely-enhanced-two-photon-absorption-for-mitochondrial-targeted-photodynamic-therapy
#4
Wenbo Hu, Tingchao He, Rongcui Jiang, Jun Yin, Lin Li, Xiaomei Lu, Hui Zhao, Lei Zhang, Ling Huang, Handong Sun, Wei Huang, Quli Fan
Herein, we experimentally and theoretically demonstrate an unprecedentedly enhanced two-photon absorption in a small organic molecule by a simple introduction of an inner salt-shaped structure. Moreover, such an inner salt-shaped small molecule also exhibits superior singlet oxygen quantum yield and fascinating structure-inherent mitochondrial-targeting ability for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway.
January 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28100249/intraoperative-radiation-therapy-iort-in-soft-tissue-sarcoma
#5
REVIEW
Falk Roeder, Robert Krempien
Soft-tissue sarcoma (STS) represent a rare tumor entity, accounting for less than 1% of adult malignancies. The cornerstone of curative intent treatment is surgery with free margins, although the extent of the surgical approach has been subject to change in the last decades. Multimodal approaches usually including radiation therapy have replaced extensive surgical procedures in order to preserve functionality while maintaining adequate local control. However, the possibility to apply adequate radiation doses by external beam radiation therapy (EBRT) can be limited in some situation especially in case of directly adjacent organs at risk with low radiation tolerance...
January 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28098443/fe-cluster-pushing-electrons-to-n-doped-graphitic-layers-with-fe3c-fe-hybrid-nanostructure-to-enhance-o2-reduction-catalysis-of-zn-air-batteries
#6
Jie Yang, Jiangtao Hu, Mouyi Weng, Rui Tan, Lei-Lei Tian, Jinlong Yang, Joseph Amine, Jia-Xin Zheng, Haibiao Chen, Feng Pan
Non-noble metal catalysts with oxygen reduction reaction (ORR) performance comparable or even superior to that of Pt are extremely important for metal-air batteries and fuel cells. Here we report a simple and controllable strategy to synthesize Fe-cluster embedded in Fe3C nanoparticles (designated as Fe3C(Fe)) encased in nitrogen-doped Graphitic Layers (NDGL) with graphitic shells as a novel hybrid nanostructure as an effective ORR catalyst by directly pyrolyzing a mixture of Prussian blue (PB) and glucose...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28098393/clinical-and-histopathological-features-of-cutaneous-nontuberculous-mycobacterial-infection-a-review-of-13-cases
#7
Jing Jing Li, Rohan Beresford, Janet Fyfe, Christopher Henderson
BACKGROUND: The incidence of cutaneous nontuberculous mycobacterial (NTM) infection has increased in recent decades due to widespread use of immunosuppressive therapy and better detection methods. The histopathology of cutaneous NTM infection is not pathognomic and the organisms are slow and difficult to culture, making diagnosis challenging. METHODS: We reviewed the clinical and histopathological features of 13 cases of cutaneous NTM infection, and performed panmycobacterial polymerase chain reaction (PCR) on the paraffin blocks...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28096589/water-cooled-radiofrequency-neuroablation-for-sacroiliac-joint-dysfunctional-pain
#8
Binay Kumar Biswas, Samarjit Dey, Saumya Biswas, Varinder Kumar Mohan
Sacroiliac (SI) joint dysfunction is a common source of chronic low-back pain. Recent evidences from different parts of the world suggest that cooled radiofrequency (RF) neuroablation of sacral nerves supplying SI joints has superior pain alleviating properties than available existing treatment options for SI joint dysfunctional pain. A 35-year-old male had intractable bilateral SI joint pain (numeric rating scale [NRS] - 9/10) with poor treatment response to intra-articular steroid therapy. Bilateral water cooled = RF was applied for neuroablation of nerves supplying both SI joints...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28090748/electrochemically-driven-transformation-of-amorphous-carbons-to-crystalline-graphite-nanoflakes-a-facile-and-mild-graphitization-method
#9
Junjun Peng, Nanqing Chen, Rui He, Zhiyong Wang, Sheng Dai, Xianbo Jin
Although, in the carbon family, graphite is the most thermodynamically stable allotrope, conversion of other carbon allotropes, even amorphous carbons, into graphite is extremely hard. We report a simple electrochemical route for the graphitization of amorphous carbons through cathodic polarization in molten CaCl2 at temperatures of about 1100 K, which generates porous graphite comprising petaloid nanoflakes. This nanostructured graphite allows fast and reversible intercalation/deintercalation of anions, promising a superior cathode material for batteries...
January 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28089898/exercise-guidelines-to-promote-cardiometabolic-health-in-spinal-cord-injured-humans-time-to-raise-the-intensity
#10
Tom E Nightingale, Richard S Metcalfe, Niels Bj Vollaard, James L J Bilzon
Spinal cord injury (SCI) is a life changing event that, as a result of paralysis, negatively influences habitual levels of physical activity and hence cardiometabolic health. Performing regular structured exercise therefore appears extremely important in persons with SCI. However, exercise options are mainly limited to the upper-body, which involves a smaller activated muscle mass compared to the mainly leg-based activities commonly performed by non-disabled individuals. Current exercise guidelines for SCI focus predominantly on relative short durations of moderate-intensity aerobic arm cranking exercise, yet contemporary evidence suggests this is not sufficient to induce meaningful improvements in risk factors for the prevention of cardiometabolic disease in this population...
January 12, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28077311/cortical-thickness-increases-after-simultaneous-interpretation-training
#11
Alexis Hervais-Adelman, Barbara Moser-Mercer, Micah M Murray, Narly Golestani
Simultaneous interpretation is a complex cognitive task that not only demands multilingual language processing, but also requires application of extreme levels of domain-general cognitive control. We used MRI to longitudinally measure cortical thickness in simultaneous interpretation trainees before and after a Master's program in conference interpreting. We compared them to multilingual control participants scanned at the same interval of time. Increases in cortical thickness were specific to trainee interpreters...
January 9, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28074807/isolated-persistent-left-superior-vena-cava-a-case-report-and-its-clinical-implications
#12
Samarjit Bisoyi, Usha Jagannathan, Anjan Kumar Dash, Sabyasachi Tripathy, Raghunath Mohapatra, Naba Kumar Pattnaik, Satyajit Sahu, Debashish Nayak
The venous anomaly of a persistent left superior vena cava (PLSVC) affects 0.3%-0.5% of the general population. PLSVC with absent right superior vena cava, also termed as "isolated PLSVC," is an extremely rare venous anomaly. Almost half of the patients with isolated PLSVC have cardiac anomalies in the form of atrial septal defect, endocardial cushion defects, or tetralogy of Fallot. Isolated PLSVC is usually innocuous. Its discovery, however, has important clinical implications. It can pose clinical difficulties with central venous access, cardiothoracic surgeries, and pacemaker implantation...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28072809/optimal-angle-of-contralateral-oblique-view-in-cervical-interlaminar-epidural-injection-depending-on-the-needle-tip-position
#13
Jun Young Park, Myung-Hwan Karm, Doo Hwan Kim, Jae-Young Lee, Hye-Joo Yun, Jeong Hun Suh
BACKGROUND: Chronic neck and upper extremity pain associated with cervical origin is common, and cervical interlaminar epidural steroid injections (CILESIs) are frequently used to manage the symptoms of cervical spinal disorders. However, CILESIs are associated with risks such as dural puncture and cord injury. OBJECTIVES: We aimed to determine the optimal needle tip visualization, in order to minimize CILESIs-induced complications. STUDY DESIGN: Retrospective observational study...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072648/locking-cap-designs-improve-fatigue-properties-of-polyaxial-screws-in-upper-extremity-applications
#14
Surena Namdari, Samir Mehta, Ann Tierney, Michael W Hast
OBJECTIVES: This study sought to examine fatigue characteristics of two polyaxial locking screw designs: locking cap (LC) and cross-threaded (CT). The goal was to compare LC and CT implants at 0, 10, and 15 degrees of angulation to determine the effect of locking mechanism on screw-plate interface failure. The hypothesis was LC implants would have superior fatigue properties in comparison to CT designs and that increased angulation of the screw would have a negative impact on the fatigue life of CT implants, but would not have any effect on LC implants...
January 4, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28068542/cost-effective-surface-modification-for-galinstan%C3%A2-lyophobicity
#15
Shantanu Shrikant Kadlaskar, Jun Hyeon Yoo, Abhijeet, Jeong Bong Lee, Wonjae Choi
In this paper we investigate the feasibility of using a cost-effective fabrication method based on sandblasting, chemical etching and spray coating processes, to render common surfaces to be non-wettable by Galinstan®. Although Galinstan® is a non-toxic liquid metal alternative to mercury, the viscoelastic and extremely wetting characteristics of Galinstan® have been the major bottleneck limiting the wide applicability of the gallium-based liquid metal. This paper tries to accomplish non-wettability to Galinstan® by combining surface texture and chemistry with the unique property of Galinstan®, that is, its high surface tension and yield strength that prevent the penetration of the liquid metal into surface asperities...
December 28, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28068242/cost-effectiveness-analysis-of-preoperative-versus-postoperative-radiation-therapy-in-extremity-soft-tissue-sarcoma
#16
Xuanlu M Qu, Alexander V Louie, Jonathan Ashman, Nabil Wasif
PURPOSE: Surgery combined with radiation therapy (RT) is the cornerstone of multidisciplinary management of extremity soft tissue sarcoma (STS). Although RT can be given in either the preoperative or the postoperative setting with similar local recurrence and survival outcomes, the side effect profiles, costs, and long-term functional outcomes are different. The aim of this study was to use decision analysis to determine optimal sequencing of RT with surgery in patients with extremity STS...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28067352/an-ultrastable-zirconium-phosphonate-framework-as-bifunctional-catalyst-for-highly-active-co2-chemical-transformation
#17
Chao-Ying Gao, Jing Ai, Hong-Rui Tian, Dai Wu, Zhong-Ming Sun
A zirconium-phosphonate network, as a bifunctional catalyst for carbon dioxide (CO2)/epoxide coupling reaction, exhibits very high activity that is superior to most documented metal-organic framework (MOF)-based catalysts. Furthermore, it possesses extraordinary tolerance to extremely harsh conditions, such as aqua regia. This paper describes the use of metal phosphonate as a new MOF applied to CO2 transformation.
January 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28065876/three-dimensional-anatomy-of-the-white-matter-fibers-of-the-temporal-lobe-surgical-implications
#18
L Pescatori, M P Tropeano, A Manfreda, R Delfini, A Santoro
BACKGROUND: The aim of this work is to describe in detail the complex three-dimensional organization of the white matter of the temporal lobe and discuss the surgical implications of the approaches to lesions located into the mesial temporal region and within the temporal horn and the atrium of the lateral ventricles. METHODS: Sixteen human cerebral hemispheres fixed in a 10% formalin solution for at least 40 days were studied. After removal of the arachnoid membrane, the hemispheres were frozen at -15 C° for at least 15 days , and the Klingler' technique which consist in the microscopic dissection and progressive identification of white matter fibers was performed...
January 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28060814/glenohumeral-joint-kinematics-following-clavicular-fracture-and-repairs
#19
Claudio Rosso, Michael Nasr, Kempland C Walley, Ethan R Harlow, Babak Haghpanah, Ashkan Vaziri, Arun J Ramappa, Ara Nazarian, Joseph P DeAngelis
BACKGROUND: The purpose of this biomechanical study was to determine the effect of shortened clavicle malunion on the center of rotation of the glenohumeral (GH) joint, and the capacity of repair to restore baseline kinematics. METHODS: Six shoulders underwent automated abduction (ABD) and abbreviated throwing motion (ATM) using a 7-DoF automated upper extremity testing system in combination with an infrared motion capture system to measure the center of rotation of the GH joint...
2017: PloS One
https://www.readbyqxmd.com/read/28060477/in-situ-localized-growth-of-ordered-metal-oxide-hollow-sphere-array-on-microheater-platform-for-sensitive-ultra-fast-gas-sensing
#20
Ameya Rao, Hu Long, Anna Harley-Trochimczyk, Thang Pham, Alex Zettl, Carlo Carraro, Roya Maboudian
A simple and versatile strategy is presented for the localized on-chip synthesis of an ordered metal oxide hollow sphere array directly on a low power microheater platform to form a closely integrated miniaturized gas sensor. Selective microheater surface modification through fluorinated monolayer self-assembly and its subsequent microheater-induced thermal decomposition enables the position-controlled deposition of an ordered two-dimensional colloidal sphere array, which serves as a sacrificial template for metal oxide growth via homogeneous chemical precipitation; this strategy ensures control in both the morphology and placement of the sensing material on only the active heated area of the microheater platform, providing a major advantage over other methods of presynthesized nanomaterial integration via suspension coating or printing...
January 13, 2017: ACS Applied Materials & Interfaces
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