keyword
https://read.qxmd.com/read/38547214/from-opt-out-to-opt-in-consent-for-secondary-use-of-medical-data-and-residual-biomaterial-an-evaluation-using-the-re-aim-framework
#21
JOURNAL ARTICLE
Jennifer E Lutomski, Peggy Manders
BACKGROUND: Patient records, imaging, and residual biomaterial from clinical procedures are crucial resources for medical research. In the Netherlands, consent for secondary research has historically relied on opt-out consent. For ethical-legal experts who purport passive consent undermines patient autonomy, opt-in consent (wherein affirmative action is required) is seen as the preferred standard. To date, there is little empirical research exploring patient feasibility, organizational consequences, and the potential risks for research based on secondary data...
2024: PloS One
https://read.qxmd.com/read/38547180/assessing-the-quality-of-drinking-water-from-selected-water-sources-in-mbarara-city-south-western-uganda
#22
JOURNAL ARTICLE
Catherine N Abaasa, Savino Ayesiga, Julius B Lejju, Morgan Andama, Imelda K Tamwesigire, Joel Bazira, Frederick Byarugaba
This study assessed the physical, chemical, and microbiological quality with emphasis on risk score, source apportionment, geochemistry, feacal coliforms and water quality index of drinking water from selected water sources. A cross-sectional study was conducted in six villages in Mbarara city, south-western Uganda. Each selected source was inspected using a WHO-adopted sanitary inspection questionnaire. Each source's risk score was calculated. Thirty-seven samples were taken from one borehole, nine open dug wells, four rain harvest tanks, and twenty-three taps...
2024: PloS One
https://read.qxmd.com/read/38547136/confirming-the-attainment-of-maximal-oxygen-uptake-within-special-and-clinical-groups-a-systematic-review-and-meta-analysis-of-cardiopulmonary-exercise-test-and-verification-phase-protocols
#23
JOURNAL ARTICLE
Victor A B Costa, Adrian W Midgley, Julia K Baumgart, Sean Carroll, Todd A Astorino, Gustavo Z Schaun, Guilherme F Fonseca, Felipe A Cunha
BACKGROUND AND AIM: A plateau in oxygen uptake ([Formula: see text]) during an incremental cardiopulmonary exercise test (CPET) to volitional exhaustion appears less likely to occur in special and clinical populations. Secondary maximal oxygen uptake ([Formula: see text]) criteria have been shown to commonly underestimate the actual [Formula: see text]. The verification phase protocol might determine the occurrence of 'true' [Formula: see text] in these populations. The primary aim of the current study was to systematically review and provide a meta-analysis on the suitability of the verification phase for confirming 'true' [Formula: see text] in special and clinical groups...
2024: PloS One
https://read.qxmd.com/read/38547095/the-accuracy-of-different-calculation-methods-when-identifying-handgrip-strength-asymmetry-among-middle-aged-and-older-chinese-adults
#24
JOURNAL ARTICLE
Yilin Wang, Jing Wang, Binyou Wang, Jing Fu, Xiaoyan Chen
At present, there is no uniform standard mean of identifying handgrip strength (HGS) asymmetry based on maximum or average HGS values. Therefore, this study aimed to explore the accuracy of different calculation methods in the evaluation of HGS asymmetry. Using the maximum reading of two trials from both hands (Method A) as the reference standard, the accuracy of the HGS asymmetry identified by the average value of two trials of both hands (Method B) was determined by using various indicators, including specificity, sensitivity, the area under the receiver operating characteristic curve (AUC), positive, and negative predictive values...
2024: PloS One
https://read.qxmd.com/read/38547052/five-year-follow-up-of-polaris-01-phase-ii-trial-toripalimab-as-salvage-monotherapy-in-chinese-patients-with-advanced-melanoma
#25
JOURNAL ARTICLE
Bixia Tang, Rong Duan, Xiaoshi Zhang, Shuikui Qin, Di Wu, Jing Chen, Hong Yao, Zhihong Chi, Jun Guo, Xieqiao Yan
BACKGROUND: To investigate the efficacy and toxicity after long-term follow-up of anti-PD-1 antibody in advanced melanoma with predominantly acral and mucosal subtypes. METHODS AND PATIENTS: In the POLARIS-01 phase II trial, 128 Chinese patients with advanced melanoma refractory to standard therapy received toripalimab until disease progression or unacceptable toxicity for ≤2 years. For those who progressed after discontinuation due to 2-year treatment completion, rechallenge was allowed...
March 28, 2024: Oncologist
https://read.qxmd.com/read/38547047/validation-of-a-new-non-hyperemic-physiological-index-the-constant-resistance-ratio-crr
#26
JOURNAL ARTICLE
Chenguang Li, Jing Wu, Jiayan Lin, Yizhe Wu, Rende Xu, Juying Quian, William Kongto Hau, Emanuele Barbato, Nils J Johnson, Barry Hennigan, Colin Berry, Keith G Oldroyd, Liang Song, Junbo Ge
OBJECTIVES: The instantaneous wave-free ratio (iwFR) has limited availability. A new resting index called the constant-resistance ratio (cRR), which dynamically identifies cardiac intervals with constant and minimum resistance, has been developed; however, its diagnostic performance is unknown. The aim of this study was to validate the cRR by retrospectively calculating the cRR values from raw pressure waveforms of 2 publicly available datasets and compare them with those of the iwFR...
March 27, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38547030/expert-consensus-on-classification-and-performance-in-paralympic-powerlifting-a-delphi-study
#27
JOURNAL ARTICLE
Lorenzo Rum, Ruggero Romagnoli, Aldo Lazich, Tommaso Sciarra, Nicoletta Balletti, Maria Francesca Piacentini, Alessandro Boraschi, Elena Bergamini
BACKGROUND: In Paralympic sports, classification ensures fair competition by grouping athletes based on their impairments. The International Paralympic Committee has provided scientific principles to guide evidence-based classification procedures. In Paralympic Powerlifting (PPO), athletes compete in one class, divided by sex and bodyweight categories, overlooking impairment impact on performance. OBJECTIVE: This study aimed to establish a consensus among international PPO experts regarding classification and performance issues to guide future research...
March 25, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38547003/plain-language-summary-of-the-transform-study-primary-analysis-results-liso-cell-as-a-second-treatment-regimen-for-large-b-cell-lymphoma-following-failure-of-the-first-treatment-regimen
#28
REVIEW
Jeremy S Abramson, Scott R Solomon, Jon Arnason, Patrick B Johnston, Bertram Glass, Veronika Bachanova, Sami Ibrahimi, Stephan Mielke, Pim Mutsaers, Francisco Hernandez-Ilizaliturri, Koji Izutsu, Franck Morschhauser, Matthew Lunning, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Ken Ogasawara, Manali Kamdar
WHAT IS THIS SUMMARY ABOUT?: People diagnosed with a disease called large B-cell lymphoma (LBCL) may experience return, or early relapse, of their disease within the first year after receiving and responding to their first (first-line) treatment regimen. Others may have primary refractory disease, meaning that the disease either did not respond to first-line treatment at all or only responded for a very brief period. Second (second-line) treatment includes immunotherapy followed by high-dose chemotherapy and ASCT, which has the potential to cure LBCL...
March 28, 2024: Future Oncology
https://read.qxmd.com/read/38547000/mixed-supervision-of-histopathology-improves-prostate-cancer-classification-from-mri
#29
JOURNAL ARTICLE
Abhejit Rajagopal, Antonio C Westphalen, Nathan Velarde, Jeffry P Simko, Hao Nguyen, Thomas A Hope, Peder E Z Larson, Kirti Magudia
Non-invasive prostate cancer classification from MRI has the potential to revolutionize patient care by providing early detection of clinically significant disease, but has thus far shown limited positive predictive value. To address this, we present a image-based deep learning method to predict clinically significant prostate cancer from screening MRI in patients that subsequently underwent biopsy with results ranging from benign pathology to the highest grade tumors. Specifically, we demonstrate that mixed supervision via diverse histopathological ground truth improves classification performance despite the cost of reduced concordance with image-based segmentation...
March 28, 2024: IEEE Transactions on Medical Imaging
https://read.qxmd.com/read/38546960/a-prospective-study-of-zanubrutinib-a-bruton-tyrosine-kinase-inhibitor-in-relapsed-refractory-idiopathic-multicentric-castleman-disease
#30
JOURNAL ARTICLE
Lu Zhang, Yu-Han Gao, Si-Yuan Li, Hao Zhao, Miao-Yan Zhang, Yan-Ying Yu, Yan-Ting Liu, Jian Li
Relapsed and refractory (R/R) idiopathic multicentric Castleman disease (iMCD) is a clinical challenge with no standard treatment. In this preliminary clinical trial, we investigated the efficacy and safety profiles of a Bruton tyrosine kinase inhibitor (BTKi), zanubrutinib, in patients with R/R iMCD. The primary endpoint was the overall response rate at Week 12 according to the Castleman Disease Collaborative Network (CDCN) response criteria. The trial was terminated early due to a lack of treatment response in the first enrolled 5 patients...
March 28, 2024: International Journal of Hematology
https://read.qxmd.com/read/38546952/are-systematic-prostate-biopsy-still-necessary-in-biopsy-naive-men
#31
JOURNAL ARTICLE
Matthew Chau, Mitchell Barns, Owain Barratt, Kara McDermott, Melvyn Kuan, Patrick Teloken
PURPOSE: Multiparametric MRI and the transperineal approach have become standard in the diagnostic pathway for suspected prostate cancer. Targeting of MRI lesions is performed at most centers, but the routine use of systematic cores is controversial. We aim to assess the value of obtaining systematic cores in patients undergoing cognitive fusion targeted double-freehand transperineal prostate biopsy. MATERIALS AND METHODS: Patients who underwent a cognitive fusion, freehand TPB at a single tertiary urology service (Perth, Australia) between November 2020 and November 2021 were retrospectively reviewed...
March 28, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38546950/establishment-and-characterization-of-multiple-patient-derived-organoids-from-a-case-of-advanced-endometrial-cancer
#32
JOURNAL ARTICLE
Yoshiaki Maru, Mami Kohno, Kiyomi Suzuka, Akiko Odaka, Mari Masuda, Akinobu Araki, Makiko Itami, Naotake Tanaka, Yoshitaka Hippo
Patient-derived organoids (PDOs) retain the original tumor's characteristics to a large degree and allow direct evaluation of the drug sensitivity, thereby emerging as a valuable resource for both basic and preclinical researches. Whereas most past studies stereotypically adopted a single PDO as an avatar of the patient, it remains to be investigated whether this assumption can be justified even for the tumor with spatial diversity. To address this issue, we established and characterized multiple PDOs originating from various sites of a patient with advanced uterine carcinosarcoma (UCS)...
March 28, 2024: Human Cell
https://read.qxmd.com/read/38546944/a-phase-1-study-of-intravenous-egfr-erbituxedvsmit-in-children-with-solid-or-cns-tumours-expressing-epidermal-growth-factor-receptor
#33
JOURNAL ARTICLE
Louise Evans, Rick Walker, Jennifer MacDiarmid, Himanshu Brahmbhatt, Antoinette Anazodo, Geoffrey McCowage, Andrew J Gifford, Maria Kavallaris, Toby Trahair, David S Ziegler
BACKGROUND: Recurrent or refractory solid and central nervous system (CNS) tumours in paediatric patients have limited treatment options and carry a poor prognosis. The EnGeneIC Dream Vector (EDV) is a novel nanocell designed to deliver cytotoxic medication directly to the tumour. The epidermal growth factor receptor is expressed in several CNS and solid tumours and is the target for bispecific antibodies attached to the EDV. OBJECTIVE: To assess the safety and tolerability of EGFR-Erbitux receptor EnGeneIC Dream Vector with mitoxantrone (E EDVsMit ) in children with recurrent / refractory solid or CNS tumours expressing EGFR...
March 28, 2024: Targeted Oncology
https://read.qxmd.com/read/38546941/novel-clinical-trials-and-approaches-in-the-management-of-glioblastoma
#34
REVIEW
Allison R Valerius, Lauren M Webb, Ugur Sener
PURPOSE OF REVIEW: The purpose of this review is to discuss a wide variety of novel therapies recently studied or actively undergoing study in patients with glioblastoma. This review also discusses current and future strategies for improving clinical trial design in patients with glioblastoma to maximize efficacy in discovering effective treatments. RECENT FINDINGS: Over the years, there has been significant expansion in therapy modalities studied in patients with glioblastoma...
March 28, 2024: Current Oncology Reports
https://read.qxmd.com/read/38546937/observational-retrospective-study-in-patients-treated-with-galcanezumab-as-preventive-treatment-for-migraine-the-orygam-study
#35
JOURNAL ARTICLE
Samuel Díaz Insa, Ángel Guerrero, Javier Viguera, Vicente Medrano Martínez, Carlos Calle de Miguel, Jesús Porta-Etessam, Antonio Ciudad, Silvia Diaz-Cerezo, Ana Roncero Martín, Mercedes Núñez
INTRODUCTION: The efficacy of galcanezumab has been demonstrated in randomized controlled trials, but evidence about its use under clinical practice conditions is still limited. This study aimed to describe the characteristics of the patients treated with galcanezumab in routine clinical practice in Spain as well as treatment patterns, persistence, and effectiveness. METHODS: A retrospective chart review study was carried out in six hospitals. Information of adults with migraine, who started treatment with galcanezumab between November 2019 and September 2021, was analyzed until end or loss of follow-up...
March 28, 2024: Pain and Therapy
https://read.qxmd.com/read/38546932/evaluation-of-the-relationship-between-fdg-pet-hypometabolism-and-retinal-layer-thickness-in-patients-with-alzheimer-s-disease
#36
JOURNAL ARTICLE
Demet Duman Sastim, Gulcin Elboga, Umut Elboga, Kivanc Gungor
We aimed to investigate the diagnostic value of Optical coherence tomography (OCT) in Alzheimer's disease (AD) and to assess the correlation between OCT and fluorodeoxyglucose (FDG)-positron emission tomography (PET) which shows high diagnostic agreement with findings from postmortem histopathology-the gold standard method. Patients who were diagnosed with AD-related dementia were selected for the study. Patients with a mini mental test (MMT) score between 18 and 23 were included in the study (n = 31)...
March 28, 2024: Acta Neurologica Belgica
https://read.qxmd.com/read/38546914/hydrazone-containing-organotin-iv-complexes-synthesis-characterization-antimicrobial-antioxidant-activity-and-molecular-docking-studies
#37
JOURNAL ARTICLE
Bharti Taxak, Jai Devi, Binesh Kumar, Tanisha Arora
The diorganotin(IV) complexes (5-20) were synthesized in the present research from 4-fluorophenoxyacetic hydrazide and salicylaldehyde derivatives-based hydrazone ligands (1-4) to get an effective biological agent to combat microbial and oxidant deformities. Numerous spectral techniques such as (1 H, 13 C, 119 Sn) NMR, UV-Vis, IR, and mass spectrometry were executed to illuminate the composition of complexes. These techniques ascertained tridentate chelation of hydrazone ligands with tin metal through enolic, phenolic oxygens and imine nitrogen, revealing pentacoordinated geometry of the complexes...
March 28, 2024: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/38546900/risk-factors-and-the-nomogram-model-for-malnutrition-in-patients-with-nasopharyngeal-carcinoma
#38
JOURNAL ARTICLE
Pengpeng Wang, Xueling Huang, Yuanhang Liu, Li Xue, Chuanyi Ning, Li Jiang, Jieying Liu
BACKGROUND: For patients with nasopharyngeal carcinoma (NPC), the incidence of malnutrition is quite high, and malnutrition has severe effects on NPC patients. However, there is currently no recognized gold standard or specific nutritional assessment tool available to assess malnutrition in NPC patients. Our objective was to develop and verify a new nomogram model for NPC patients. METHODS: Data were collected from NPC patients. To evaluate risk factors for malnutrition, univariate and multivariate logistic regression analyses were used...
March 28, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38546889/enzyme-labeled-liquid-based-cytology-ellbc-a-new-noninvasive-diagnostic-method-for-bladder-cancers
#39
JOURNAL ARTICLE
Chao Jiang, Xiang Li, Ruilong Chen, Yongliu Yang, Yi Wang
BACKGROUND: Based on liquid-based cytology, we performed an enzyme histochemical staining using acid phosphatase as a marker and termed it ELLBC. The aim of this study was to investigate the value of ELLBC in the diagnosis of bladder cancer. METHODS: Fifty patients who were initially diagnosed with suspected bladder cancers (hematuria or bladder irritation symptoms, urinary ultrasound suggestive of bladder mass) at the Second Affiliated Hospital of Anhui Medical University (Anhui, China) from January 2022 to December 2022 were selected as the study subjects, all of whom underwent ELLBC, CC, and histopathology Histopathology was used as the gold standard to calculate the diagnostic efficacy of ELLBC, CC and ELLBC combined with CC in bladder cancer...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38546878/genome-based-classification-of-the-family-haloferacaceae-and-description-of-five-novel-species-of-halobaculum
#40
JOURNAL ARTICLE
Shun Tan, Ling-Rui Zhu, Qing-Ke Zhang, Xin-Yue Dong, Jing Hou, Heng-Lin Cui
The taxonomic status of some species of Halobellus, Haloferax, Halogranum, and Haloplanus within the family Haloferacaceae was elucidated by phylogenetic, phylogenomic, and comparative genomic analyses. The relative species of each genus should constitute a single species based on the overall genome-related indexes proposed for species demarcation. The cutoff values of AAI (72.1%), ANI (82.2%), and rpoB' gene similarity (90.7%) were proposed to differentiate genera within the family Haloferacaceae. According to these standards, a novel genus related to the genus Halobaculum was proposed to accommodate Halobaculum halophilum Gai3-2 T and Halobaculum salinum NJ-3-1 T ...
March 28, 2024: Extremophiles: Life Under Extreme Conditions
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