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https://www.readbyqxmd.com/read/29187545/novel-insect-specific-eilat-virus-based-chimeric-vaccine-candidates-provide-durable-mono-and-multi-valent-single-dose-protection-against-lethal-alphavirus-challenge
#1
Jesse H Erasmus, Robert L Seymour, Jason T Kaelber, Dal Y Kim, Grace Leal, Michael B Sherman, Ilya Frolov, Wah Chiu, Scott C Weaver, Farooq Nasar
Most alphaviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates including birds, rodents, equids, humans and nonhuman primates. Recently, a host-restricted, mosquito-borne alphavirus, Eilat virus (EILV), was described with an inability to infect vertebrate cells based on defective attachment and/or entry as well as a lack of genomic RNA replication. We investigated the utilization of EILV recombinant technology as a vaccine platform against eastern (EEEV) and Venezuelan equine encephalitis viruses (VEEV), two important pathogens of humans and domesticated animals...
November 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29161110/biotechnological-applications-of-an-insect-specific-alphavirus
#2
Jesse H Erasmus, Scott C Weaver
The coupling of viral and arthropod host diversity, with evolving methods of virus discovery, has resulted in the identification and classification of a growing number of novel insect-specific viruses (ISVs) that appear to be evolutionarily related to many human pathogens but have either lost or have yet to gain the ability to replicate in vertebrates. The discovery of ISVs has raised many questions as to the origin and evolution of many human pathogenic viruses and points to the role that arthropods may play in this evolutionary process...
November 21, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29052980/decabromodiphenyl-ether-decabde-in-electrical-and-electronic-equipment-in-japan-stock-emission-and-substitution-evaluation
#3
Mianqiang Xue, Liang Zhou, Naoya Kojima, Takashi Machimura, Akihiro Tokai
DecaBDE has been widely used as flame retardant in electrical and electronic equipment (EEE). It has recently been listed in Annex A of the Stockholm Convention. The time series flow, stock, and emission of DecaBDE in EEE in Japan were quantified. On this basis, a risk/risk trade-off analysis of substituting DecaBDE with triphenyl phosphate (TPhP) that is one possible phosphorus-based alternative was conducted. The stock of DecaBDE reached a maximum of ∼42 000 t in 1995. Even though the demand flow was negligible in 2030, the stock was modeled to be still ∼470 t...
October 31, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29047412/wetland-characteristics-linked-to-broad-scale-patterns-in-culiseta-melanura-abundance-and-eastern-equine-encephalitis-virus-infection
#4
Nicholas K Skaff, Philip M Armstrong, Theodore G Andreadis, Kendra S Cheruvelil
BACKGROUND: Eastern equine encephalitis virus (EEEV) is an expanding mosquito-borne threat to humans and domestic animal populations in the northeastern United States. Outbreaks of EEEV are challenging to predict due to spatial and temporal uncertainty in the abundance and viral infection of Cs. melanura, the principal enzootic vector. EEEV activity may be closely linked to wetlands because they provide essential habitat for mosquito vectors and avian reservoir hosts. However, wetlands are not homogeneous and can vary by vegetation, connectivity, size, and inundation patterns...
October 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29030119/weee-plastic-sorting-for-bromine-essential-to-enforce-eu-regulation
#5
Pierre Hennebert, Montserrat Filella
The plastics of waste of electric and electronic equipment (WEEE) are improved for fire safety by flame retardants, and particularly brominated flame retardants (BFR). As waste, the management of these plastic fractions must comply with the update of the regulation of waste hazard classification (2014, 2017), the publication of a technical standard on management of WEEE (2015), and a restriction of use for decabromodiphenylether in the product regulation (2017). Data of bromine (n=4283) and BFR concentrations (n=98) in plastics from electric and electronic equipment (EEE), and from WEEE processing facilities before and after sorting for bromine in four sites in France have been studied for chemical composition and for regulatory classification...
October 10, 2017: Waste Management
https://www.readbyqxmd.com/read/28956525/emerging-arboviruses-in-quebec-canada-assessing-public-health-risk-by-serology-in-humans-horses-and-pet-dogs
#6
J P Rocheleau, P Michel, L R Lindsay, M Drebot, A Dibernardo, N H Ogden, A Fortin, J Arsenault
Periodic outbreaks of West Nile virus (WNV), Eastern equine encephalitis virus (EEEV) and to a lesser extent, California serogroup viruses (CSGV), have been reported in parts of Canada in the last decade. This study was designed to provide a broad assessment of arboviral activity in Quebec, Canada, by conducting serological surveys for these arboviruses in 196 horses, 1442 dogs and 485 humans. Sera were screened by a competitive enzyme linked immunosorbent assay and positive samples confirmed by plaque reduction neutralisation tests...
October 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28923116/wing-variation-in-culex-nigripalpus-diptera-culicidae-in-urban-parks
#7
Gabriela Cristina de Carvalho, Daniel Pagotto Vendrami, Mauro Toledo Marrelli, André Barretto Bruno Wilke
BACKGROUND: Culex nigripalpus has a wide geographical distribution and is found in North and South America. Females are considered primary vectors for several arboviruses, including Saint Louis encephalitis virus, Venezuelan equine encephalitis virus and Eastern equine encephalitis virus, as well as a potential vector of West Nile virus. In view of the epidemiological importance of this mosquito and its high abundance, this study sought to investigate wing variation in Cx. nigripalpus populations from urban parks in the city of São Paulo, Brazil...
September 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28842921/development-of-high-throughput-and-high-sensitivity-capillary-gel-electrophoresis-platform-method-for-western-eastern-and-venezuelan-equine-encephalitis-wevee-virus-like-particles-vlps-purity-determination-and-characterization
#8
Deepika Gollapudi, Diane L Wycuff, Richard M Schwartz, Jonathan W Cooper, K C Cheng
In this paper, we describe development of a high-throughput, highly sensitive method based on Lab Chip CGE-SDS platform for purity determination and characterization of virus-like particle (VLP) vaccines. A capillary gel electrophoresis approach requiring about 41 s per sample for analysis and demonstrating sensitivity to protein initial concentrations as low as 20 μg/mL, this method has been used previously to evaluate monoclonal antibodies, but this application for lot release assay of VLPs using this platform is unique...
October 2017: Electrophoresis
https://www.readbyqxmd.com/read/28832509/statistical-qos-guaranteed-energy-efficiency-optimization-for-energy-harvesting-wireless-sensor-networks
#9
Ya Gao, Wenchi Cheng, Hailin Zhang
Energy harvesting, which offers a never-ending energy supply, has emerged as a prominent technology to prolong the lifetime and reduce costs for the battery-powered wireless sensor networks. However, how to improve the energy efficiency while guaranteeing the quality of service (QoS) for energy harvesting based wireless sensor networks is still an open problem. In this paper, we develop statistical delay-bounded QoS-driven power control policies to maximize the effective energy efficiency (EEE), which is defined as the spectrum efficiency under given specified QoS constraints per unit harvested energy, for energy harvesting based wireless sensor networks...
August 23, 2017: Sensors
https://www.readbyqxmd.com/read/28757222/internet-of-things-and-big-data-as-potential-solutions-to-the-problems-in-waste-electrical-and-electronic-equipment-management-an-exploratory-study
#10
Fu Gu, Buqing Ma, Jianfeng Guo, Peter A Summers, Philip Hall
Management of Waste Electrical and Electronic Equipment (WEEE) is a vital part in solid waste management, there are still some difficult issues require attentionss. This paper investigates the potential of applying Internet of Things (IoT) and Big Data as the solutions to the WEEE management problems. The massive data generated during the production, consumption and disposal of Electrical and Electronic Equipment (EEE) fits the characteristics of Big Data. Through using the state-of-the-art communication technologies, the IoT derives the WEEE "Big Data" from the life cycle of EEE, and the Big Data technologies process the WEEE "Big Data" for supporting decision making in WEEE management...
July 27, 2017: Waste Management
https://www.readbyqxmd.com/read/28754695/eastern-equine-encephalitis
#11
Daniel Berlin, Ahmed I Gilani, Amrit K Grewal, Mary Fowkes
We describe a patient who died from a fulminant presentation of encephalitis. After an exhaustive search, we found no treatable cause. Postmortem PCR analysis of brain tissue led to a diagnosis of eastern equine encephalitis. We have identified several clinical pearls that may assist others in making the diagnosis earlier in the disease course.
October 2017: Practical Neurology
https://www.readbyqxmd.com/read/28722628/serologic-evidence-of-various-arboviruses-detected-in-white-tailed-deer-odocoileus-virginianus-in-the-united-states
#12
Kerri Pedersen, Eryu Wang, Scott C Weaver, Paul C Wolf, Adam R Randall, Kyle R Van Why, Amelia P A Travassos Da Rosa, Thomas Gidlewski
White-tailed deer (Odocoileus virginianus) are an abundant mammal with a wide geographic distribution in the United States, which make them good sentinels for monitoring arboviral activity across the country. Exposure to various arboviruses has been detected in white-tailed deer, typically in conjunction with another diagnostic finding. To better assess the exposure of white-tailed deer to seven arboviruses, we tested 1,508 sera collected from 2010 to 2016 for antibodies to eastern equine encephalitis (2.5%), Powassan (4...
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28669496/using-choice-architecture-to-exploit-a-university-distinct-urban-mine
#13
REVIEW
Xavier Pierron, Ian D Williams, Peter J Shaw, Victoria Cleaver
There are widespread concerns regarding the potential future scarcity of ferrous and non-ferrous materials. However, there are already potentially rich reserves of secondary materials via high ownership of Electrical and Electronic Equipment (EEE) in economically-developed nations. Young people are particularly high consumers of EEE, thus university students and campuses may present an opportunity to harness this potential. University Distinct Urban Mines (DUM) may be used to exemplify how potential reserves of secondary metals may be exploited, and could contribute to the transition from a linear to a circular economy...
June 29, 2017: Waste Management
https://www.readbyqxmd.com/read/28620281/inhibition-of-the-mitochondrial-glutamate-carrier-slc25a22-in-astrocytes-leads-to-intracellular-glutamate-accumulation
#14
Emmanuelle Goubert, Yanina Mircheva, Francesco M Lasorsa, Christophe Melon, Emanuela Profilo, Julie Sutera, Hélène Becq, Ferdinando Palmieri, Luigi Palmieri, Laurent Aniksztejn, Florence Molinari
The solute carrier family 25 (SLC25) drives the import of a large diversity of metabolites into mitochondria, a key cellular structure involved in many metabolic functions. Mutations of the mitochondrial glutamate carrier SLC25A22 (also named GC1) have been identified in early epileptic encephalopathy (EEE) and migrating partial seizures in infancy (MPSI) but the pathophysiological mechanism of GC1 deficiency is still unknown, hampered by the absence of an in vivo model. This carrier is mainly expressed in astrocytes and is the principal gate for glutamate entry into mitochondria...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28511269/the-role-of-birds-in-arboviral-disease-surveillance-in-harris-county-and-the-city-of-houston-texas
#15
Lauren Wilkerson, Martin Reyna Nava, Cheryl Battle-Freeman, Amelia Travassos da Rosa, Hilda Guzman, Robert Tesh, Mustapha Debboun
Avian arboviral surveillance is an integral part of any disease-based integrated mosquito control program. The Harris County Public Health Mosquito and Vector Control Division has performed arboviral surveillance in the wild birds of Harris County and the City of Houston since 1965. Blood samples from live trapped birds were tested for arboviral antibodies to West Nile virus (WNV), St. Louis encephalitis, Eastern equine encephalitis, and Western equine encephalitis. A dead bird surveillance program was created in 2002 with the arrival of WNV in Harris County...
January 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/28480291/fatal-eastern-equine-encephalitis-in-a-patient-on-maintenance-rituximab-a-case-report
#16
Isaac H Solomon, Pedro D S C Ciarlini, Sandro Santagata, Asim A Ahmed, Umberto De Girolami, Sashank Prasad, Shibani S Mukerji
A 63-year-old woman on rituximab maintenance for follicular lymphoma presented with headaches, vomiting, and fever, and was diagnosed with eastern equine encephalomyelitis by cerebrospinal fluid polymerase chain reaction. Eastern equine encephalomyelitis immunoglobulin (Ig)G/IgM remained negative due to rituximab treatment, and magnetic resonance imaging showed minimal abnormalities, making this a diagnostically challenging case. Despite therapy with intravenous Ig, the patient rapidly declined and died on hospital day 12...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28468889/hypervariable-domain-of-eastern-equine-encephalitis-virus-nsp3-redundantly-utilizes-multiple-cellular-proteins-for-replication-complex-assembly
#17
Ilya Frolov, Dal Young Kim, Maryna Akhrymuk, James A Mobley, Elena I Frolova
Eastern equine encephalitis virus (EEEV) is a representative member of the New World alphaviruses. It is pathogenic for a variety of vertebrate hosts, in which EEEV induces a highly debilitating disease, and the outcomes are frequently lethal. Despite a significant public health threat, the molecular mechanism of EEEV replication and interaction with hosts is poorly understood. Our previously published data and those of other teams have demonstrated that hypervariable domains (HVDs) of the alphavirus nsP3 protein interact with virus-specific host factors and play critical roles in assembly of viral replication complexes (vRCs)...
July 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28412098/supply-and-demand-of-some-critical-metals-and-present-status-of-their-recycling-in-weee
#18
REVIEW
Shengen Zhang, Yunji Ding, Bo Liu, Chein-Chi Chang
New development and technological innovations make electrical and electronic equipment (EEE) more functional by using an increasing number of metals, particularly the critical metals (e.g. rare and precious metals) with specialized properties. As millions of people in emerging economies adopt a modern lifestyle, the demand for critical metals is soaring. However, the increasing demand causes the crisis of their supply because of their simple deficiency in the Earth's crust or geopolitical constraints which might create political issues for their supply...
April 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28399216/emergent-and-reemergent-arboviruses-in-south-america-and-the-caribbean-why-so-many-and-why-now
#19
Carlos Brisola Marcondes, Marta Contigiani, Raquel Miranda Gleiser
Varios arbovirus han emergido y/o reemergido en el Nuevo Mundo en las últimas décadas. Los virus Zika y chikungunya, anteriormente restringidos a África y quizás Asia, invadieron el continente, causando gran preocupación; además siguen ocurriendo brotes causados por el virus dengue en casi todos los países, con millones de casos por año. El virus West Nile invadió rápidamente América del Norte, y ya se han encontrado casos en América Central y del Sur. Otros arbovirus, como Mayaro y el virus de la encefalitis equina del este han aumentado su actividad y se han encontrado en nuevas regiones...
May 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28384059/potential-sympatric-vectors-and-mammalian-hosts-of-venezuelan-equine-encephalitis-virus-in-southern-mexico
#20
Jesús Sotomayor-Bonilla, Carlos Antonio Abella-Medrano, Andrea Chaves, Paulina Álvarez-Mendizábal, Óscar Rico-Chávez, Sergio Ibáñez-Bernal, Melinda K Rostal, Rafael Ojeda-Flores, Arturo Barbachano-Guerrero, Gustavo Gutiérrez-Espeleta, A Alonso Aguirre, Peter Daszak, Gerardo Suzán
Arboviruses are important zoonotic agents with complex transmission cycles and are not well understood because they may involve many vectors and hosts. We studied sympatric wild mammals and hematophagous mosquitoes having the potential to act as hosts and vectors in two areas of southern Mexico. Mosquitoes, bats, and rodents were captured in Calakmul (Campeche) and Montes Azules (Chiapas), between November 2010 and August 2011. Spleen samples from 146 bats and 14 rodents were tested for molecular evidence of Venezuelan equine encephalitis virus (VEEV), eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV), and West Nile virus (WNV) using PCR protocols...
July 2017: Journal of Wildlife Diseases
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