keyword
https://read.qxmd.com/read/38300219/comparison-of-scheimpflug-and-anterior-segment-optical-coherence-tomography-imaging-parameters-for-japanese-patients-with-fuchs-endothelial-corneal-dystrophy-with-and-without-tcf4-repeat-expansions
#21
JOURNAL ARTICLE
Sayo Maeno, Yoshinori Oie, Ryota Koto, Nozomi Nishida, Arisa Yamashita, Michika Yoshioka, Chifune Kai, Takeshi Soma, Shizuka Koh, Masahito Yoshihara, Ryo Kawasaki, Vishal Jhanji, Masayuki Nakamori, Motokazu Tsujikawa, Kohji Nishida
PURPOSE: The aim of this study was to investigate the association between cytosine-thymine-guanine trinucleotide repeat (TNR) expansion in TCF4 and the clinical phenotypes of corneal densitometry or anterior segment morphology in Fuchs endothelial corneal dystrophy. METHODS: This retrospective cross-sectional study included 150 eyes from 75 Japanese consecutive patients with Fuchs endothelial corneal dystrophy. Cytosine-thymine-guanine repeat expansion of leukocyte-derived genomic DNA was analyzed through fragment analysis using polymerase chain reaction and triplet repeat primed polymerase chain reaction...
February 1, 2024: Cornea
https://read.qxmd.com/read/38281570/how-would-nature-see-our-corneal-triumphs-the-lxxix-edward-jackson-lecture
#22
JOURNAL ARTICLE
Gerrit R J Melles, Jack S Parker
PURPOSE: To describe discrepancies between clinical observation and current teachings in corneal endothelial disease, particularly in Fuchs endothelial dystrophy and its potential association with primary open angle glaucoma. DESIGN AND METHODS: Perspective on Fuchs dystrophy, a disorder that commonly presents with a compromised endothelium but minimal stromal edema, indicating that the corneal imbibition pressure is relatively 'too high'. RESULTS: The discrepancy between the relative lack of stromal edema in the absence of an endothelial cell layer can not be explained by the current theories involving a circulatory pumping mechanism over the endothelial cell layer, but may point to 1) secondary involvement of the corneal endothelium in Fuchs dystrophy; 2) separate hydration systems for maintaining the imbibition pressure (vertical static hydration) and corneal nutrition (horizontal dynamic hydration); 3) the cornea as net contributor of aqueous humor; 4) a close relationship between the corneal imbibition and intraocular pressure, with potentially a shared regulatory system; 5) a potential steroid-type hormone dependency of this regulatory system...
January 26, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38271677/letter-regarding-chatgpt-information-regarding-corneal-transplantation-and-fuchs-dystrophy
#23
JOURNAL ARTICLE
Hinpetch Daungsupawong, Viroj Wiwanitkit
No abstract text is available yet for this article.
January 25, 2024: Cornea
https://read.qxmd.com/read/38264539/the-role-of-rho-kinase-inhibitors-in-corneal-diseases
#24
REVIEW
Stefan Futterknecht, Eleftherios Chatzimichail, Konstantin Gugleta, Georgios D Panos, Zisis Gatzioufas
The cornea, as the outermost layer of the eye, plays a crucial role in vision by focusing light onto the retina. Various diseases and injuries can compromise its clarity, leading to impaired vision. This review aims to provide a thorough overview of the pharmacological properties, therapeutic potential and associated risks of Rho-associated protein kinase (ROCK) inhibitors in the management of corneal diseases. The article focuses on four key ROCK inhibitors: Y-27632, fasudil, ripasudil, and netarsudil, providing a comparative examination...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38252645/investigation-of-the-functional-impact-of-ched-and-fecd4-associated-slc4a11-mutations-in-human-corneal-endothelial-cells
#25
JOURNAL ARTICLE
Doug D Chung, Angela C Chen, Charlene H Choo, Wenlin Zhang, Dominic Williams, Christopher G Griffis, Paul Bonezzi, Kavya Jatavallabhula, Alapakkam P Sampath, Anthony J Aldave
Mutations in the solute linked carrier family 4 member 11 (SLC4A11) gene are associated with congenital hereditary endothelial dystrophy (CHED) and Fuchs corneal endothelial dystrophy type 4 (FECD4), both characterized by corneal endothelial cell (CEnC) dysfunction and/or cell loss leading to corneal edema and visual impairment. In this study, we characterize the impact of CHED-/FECD4-associated SLC4A11 mutations on CEnC function and SLC4A11 protein localization by generating and comparing human CEnC (hCEnC) lines expressing wild type SLC4A11 (SLC4A11WT) or mutant SLC4A11 harboring CHED-/FECD4-associated SLC4A11 mutations (SLC4A11MU)...
2024: PloS One
https://read.qxmd.com/read/38251647/comparison-of-pre-and-post-dmek-keratometry-and-total-keratometry-values-for-iol-power-calculations-in-eyes-undergoing-triple-dmek
#26
JOURNAL ARTICLE
Neal Rangu, David L Cooke, Aman Mittal, Thomas Reinhard, Katrin Wacker, Achim Langenbucher, Jascha A Wendelstein, Kamran M Riaz
PURPOSE: To evaluate prediction accuracy of pre- and post-DMEK keratometry (K) and total keratometry (TK) values for IOL power calculations in Fuchs endothelial corneal dystrophy (FECD) eyes undergoing DMEK with cataract surgery (triple DMEK). METHODS: Retrospective cross-sectional multicenter study of 55 FECD eyes (44 patients) that underwent triple DMEK between 2019 and 2022 between two centers in USA and Europe. Swept-source optical coherence tomography biometry (IOLMaster 700) was used for pre- and post-DMEK measurements...
January 22, 2024: Current Eye Research
https://read.qxmd.com/read/38206443/ctg18-1-expansion-in-transcription-factor-4-tcf4-in-corneal-graft-failure-preliminary-study
#27
JOURNAL ARTICLE
Ida Maria Westin, Andreas Viberg, Irina Golovleva, Berit Byström
Fuchs endothelial corneal dystrophy (FECD) is caused by a corneal endothelial cell loss, leading to corneal edema and visual impairment. The most significant genetic risk factor for FECD is an expansion of the CTG18.1 locus in transcription factor 4 (TCF4). The current treatment for severe FECD is corneal transplantation, with Descemet stripping automated keratoplasty (DSAEK) as a common surgical method. Although successful in most cases, the risk for transplant failure due to diverse causes must be considered...
January 11, 2024: Cell and Tissue Banking
https://read.qxmd.com/read/38176611/squishy-matters-corneal-mechanobiology-in-health-and-disease
#28
REVIEW
Sara M Thomasy, Brian C Leonard, Mark A Greiner, Jessica M Skeie, Vijay Krishna Raghunathan
The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces in order to maintain its structural integrity, barrier function, transparency and refractive power. Cells within the cornea sense and respond to various mechanical forces that fundamentally regulate their morphology and fate in development, homeostasis and pathophysiology. Corneal cells also dynamically regulate their extracellular matrix (ECM) with ensuing cell-ECM crosstalk as the matrix serves as a dynamic signaling reservoir providing biophysical and biochemical cues to corneal cells...
January 2, 2024: Progress in Retinal and Eye Research
https://read.qxmd.com/read/38171062/targeting-the-nrf2-pathway-a-promising-approach-for-corneal-endothelial-dysfunction
#29
REVIEW
Keith W Ward
Maintaining corneal endothelial function is required for vision, and corneal endothelial dysfunction is a major cause of visual deficits and blindness worldwide. To date there has been a dearth of innovation for therapeutics targeting the corneal endothelium. However, recent advances in understanding the role of oxidative stress and mitochondrial dysfunction have revealed potential avenues for the development of new therapies. This review summarizes recent developments in elucidating the role of the NRF2 pathway in corneal endothelial health and disease, focusing specifically on Fuchs' endothelial corneal dystrophy and the loss of corneal endothelial cells associated with cataract surgery...
February 2024: Current Opinion in Pharmacology
https://read.qxmd.com/read/38131576/trends-in-keratoplasty-from-central-and-northern-india-part-i-indications-for-keratoplasty
#30
JOURNAL ARTICLE
Gautam Parmar, Samrat Chatterjee, Neha Kapur, Sharad N Gomase, Ashi Khurana, Prashant Borde, Manisha Acharya, Virendra S Sangwan, Atanu Majumdar
PURPOSE: To report the indications for keratoplasty and analyze trends in two decades in India. METHODS: This was a retrospective review of eye bank registries of six tertiary eye care centers located in central and northern India from 2005 to 2021. The patterns of corneal pathology and changes in trends were analyzed. RESULTS: Between 2005 and 2021, 13223 corneal grafts were performed in the six collaborating tertiary eye care centers. The most common indication for keratoplasty in both decades was corneal ulcer (41...
January 1, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38128100/descemet-membrane-endothelial-keratoplasty-10-year-cell-loss-and-failure-rate-compared-with-descemet-stripping-endothelial-keratoplasty-and-penetrating-keratoplasty
#31
JOURNAL ARTICLE
Marianne O Price, Lauren Kanapka, Craig Kollman, Jonathan H Lass, Francis W Price
PURPOSE: The aim of this study was to assess long-term endothelial cell loss (ECL) and graft failure with Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping endothelial keratoplasty (DSEK) versus penetrating keratoplasty (PK) performed for the same indications (primarily Fuchs dystrophy and pseudophakic corneal edema) in the Cornea Donor Study. METHODS: This retrospective study included consecutive primary DMEK (529 recipients, 739 eyes) and DSEK cases (585 recipients, 748 eyes) with 1 or more endothelial cell density (ECD) measurements at 6 months to 16 years...
December 20, 2023: Cornea
https://read.qxmd.com/read/38127965/five-year-clinical-outcomes-of-107-consecutive-dmek-surgeries
#32
JOURNAL ARTICLE
Pierre Bichet, Rémi Moskwa, Christophe Goetz, Yinka Zevering, Jean-Charles Vermion, Jean-Marc Perone
PURPOSE: The long-term clinical outcomes, postoperative complications, and graft survival of Descemet-membrane endothelial keratoplasty (DMEK) remain poorly understood. We retrospectively assessed these variables in all consecutive eyes that underwent DMEK for any indication in 2014-2018. The findings were compared to the long-term DMEK studies of five other groups (3-10-year follow-up). METHODS: Patients underwent ophthalmological tests preoperatively, at 1, 3, 6, and 12 postoperative months, and then annually...
2023: PloS One
https://read.qxmd.com/read/38096202/transcriptomic-meta-analysis-reveals-err%C3%AE-mediated-oxidative-phosphorylation-is-downregulated-in-fuchs-endothelial-corneal-dystrophy
#33
JOURNAL ARTICLE
Xunzhi Zhang, Ashwani Kumar, Adwait A Sathe, V Vinod Mootha, Chao Xing
BACKGROUND: Late-onset Fuchs' endothelial corneal dystrophy (FECD) is a degenerative disease of cornea and the leading indication for corneal transplantation. Genetically, FECD patients can be categorized as with (RE+) or without (RE-) the CTG trinucleotide repeat expansion in the transcription factor 4 gene. The molecular mechanisms underlying FECD remain unclear, though there are plausible pathogenic models proposed for RE+ FECD. METHOD: In this study, we performed a meta-analysis on RNA sequencing datasets of FECD corneal endothelium including 3 RE+ datasets and 2 RE- datasets, aiming to compare the transcriptomic profiles of RE+ and RE- FECD...
2023: PloS One
https://read.qxmd.com/read/38091879/estrogen-genotoxicity-causes-preferential-development-of-fuchs-endothelial-corneal-dystrophy-in-females
#34
JOURNAL ARTICLE
Varun Kumar, Neha Deshpande, Mohit Parekh, Raymond Wong, Shazia Ashraf, Muhammad Zahid, Hanna Hui, Annie Miall, Sylvie Kimpton, Marianne O Price, Francis W Price, Frank J Gonzalez, Eleanor Rogan, Ula V Jurkunas
Fuchs endothelial corneal dystrophy (FECD) is a genetically complex, age-related, female-predominant disorder characterized by loss of post-mitotic corneal endothelial cells (CEnCs). Ultraviolet-A (UVA) light has been shown to recapitulate the morphological and molecular changes seen in FECD to a greater extent in females than males, by triggering CYP1B1 upregulation in females. Herein, we investigated the mechanism of greater CEnC susceptibility to UVA in females by studying estrogen metabolism in response to UVA in the cornea...
February 2024: Redox Biology
https://read.qxmd.com/read/38034859/non-apoptotic-regulated-cell-death-in-fuchs-endothelial-corneal-dystrophy
#35
JOURNAL ARTICLE
Saki Sakakura, Emi Inagaki, Tomoko Sayano, Risa Yamazaki, Noemi Fusaki, Shin Hatou, Masatoshi Hirayama, Kazuo Tsubota, Kazuno Negishi, Hideyuki Okano, Shigeto Shimmura
INTRODUCTION: Fuchs endothelial corneal dystrophy (FECD) is the leading cause of corneal blindness in developed countries. Corneal endothelial cells in FECD are susceptive to oxidative stress, leading to mitochondrial dysfunction and cell death. Oxidative stress causes many forms of cell death including parthanatos, which is characterized by translocation of apoptosis-inducing factor (AIF) to the nucleus with upregulation of poly (ADP-ribose) polymerase 1 (PARP-1) and poly (ADP-ribose) (PAR)...
December 2023: Regenerative Therapy
https://read.qxmd.com/read/38024683/targeting-the-expanded-tcf4-fuchs-endothelial-corneal-dystrophy-cug-repeat-with-morpholino-peptide-conjugates
#36
JOURNAL ARTICLE
Jiaxin Hu, Xiulong Shen, Mahboubeh Kheirabadi, Matthew D Streeter, Ziqing Qian, V Vinod Mootha, David R Corey
Fuchs' corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective curative treatment, but this surgery has limitations. A pharmacological intervention would complement surgery and be beneficial for many patients. FECD is caused by an expanded CUG repeat within intron 2 of the TCF4 RNA. Agents that recognize the expanded repeat can reverse the splicing defects associated with the disease. Successful drug development will require diverse strategies for optimizing the efficacy of anti-CUG oligomers...
November 14, 2023: ACS Omega
https://read.qxmd.com/read/38018729/-not-available
#37
REVIEW
Morten Brok Molbech Madsen, Anders Ivarsen, Jesper Hjortdal
Corneal grafting is performed approximately 650 times a year in Denmark. A summary of these procedures is given in this review. Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy are frequent indications for transplantation. Previously, penetrating keratoplasty was the technique of choice but is nowadays mainly used for combined stromal and endothelial pathology. Instead, techniques specifically replacing diseased layers are more common. The Danish Cornea Bank is the only center in Denmark which undertakes preparation and distribution of tissue...
November 27, 2023: Ugeskrift for Laeger
https://read.qxmd.com/read/38016014/quality-and-agreement-with-scientific-consensus-of-chatgpt-information-regarding-corneal-transplantation-and-fuchs-dystrophy
#38
JOURNAL ARTICLE
Kayson S Barclay, Jane Y You, Michael J Coleman, Priya M Mathews, Vincent L Ray, Kamran M Riaz, Joaquin O De Rojas, Aaron S Wang, Shelly H Watson, Ellen H Koo, Allen O Eghrari
PURPOSE: ChatGPT is a commonly used source of information by patients and clinicians. However, it can be prone to error and requires validation. We sought to assess the quality and accuracy of information regarding corneal transplantation and Fuchs dystrophy from 2 iterations of ChatGPT, and whether its answers improve over time. METHODS: A total of 10 corneal specialists collaborated to assess responses of the algorithm to 10 commonly asked questions related to endothelial keratoplasty and Fuchs dystrophy...
November 28, 2023: Cornea
https://read.qxmd.com/read/38007433/descemet-membrane-endothelial-keratoplasty-combined-with-presbyopia-correcting-and-toric-intraocular-lenses-a-narrative-review
#39
REVIEW
Marina Rodríguez-Calvo-de-Mora, Carlos Rocha-de-Lossada, Vito Romano, Manuel Rodríguez-Vallejo, Joaquín Fernández
Fuchs endothelial corneal dystrophy (FECD) is the leading indication for EK and may coexist with cataract and presbyopia. Notably, the outcomes of phacoemulsification in FECD patients are not as favorable as those in eyes without this condition. Historically, only monofocal intraocular lenses (IOLs) were recommended for these patients. However, recent reports have described the implantation of Premium-IOLs (such as Multifocal IOLs, Enhanced Depth of Focus IOLs, and Toric IOLs) in FECD eyes undergoing cataract surgery and Descemet membrane endothelial keratoplasty (DMEK)...
November 25, 2023: BMC Ophthalmology
https://read.qxmd.com/read/37986182/mediators-of-visual-acuity-in-descemet-membrane-endothelial-keratoplasty-and-ultrathin-descemet-stripping-automated-endothelial-keratoplasty
#40
JOURNAL ARTICLE
Charles C Lin, Winston D Chamberlain, Caitlin Kakigi, Benjamin F Arnold, Jennifer Rose-Nussbaumer
PURPOSE: The aim of this study was to investigate mediators of visual acuity in ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) compared with Descemet membrane endothelial keratoplasty (DMEK). METHODS: This was a prespecified secondary analysis of the Descemet Endothelial Thickness Comparison Trial, a prospective, randomized controlled trial comparing UT-DSAEK with DMEK. Subjects with Fuchs endothelial dystrophy or pseudophakic bullous keratopathy presenting to 2 academic centers were enrolled and randomized to either UT-DSAEK (n = 25 eyes) or DMEK (n = 25 eyes)...
November 21, 2023: Cornea
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