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https://www.readbyqxmd.com/read/27909173/the-role-of-psychedelics-in-palliative-care-reconsidered-a-case-for-psilocybin
#1
Benjamin Kelmendi, Philip Corlett, Mohini Ranganathan, Cyril D'Souza, John H Krystal
No abstract text is available yet for this article.
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27909172/the-successful-return-of-psychedelics-to-psychiatry
#2
Herbert D Kleber
No abstract text is available yet for this article.
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27909166/back-to-the-future-research-renewed-on-the-clinical-utility-of-psychedelic-drugs
#3
Jeffrey A Lieberman, Daniel Shalev
No abstract text is available yet for this article.
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27888525/breaking-sad-unleashing-the-breakthrough-potential-of-ketamine-s-rapid-antidepressant-effects
#4
David Feifel
Preclinical Research The surprising results of a small clinical trial on the effects of low dose ketamine, a 65-year old anesthetic drug that is also used off-label for chronic pain and recreationally as a club drug, in eight depressed subjects unleashed the most significant advance in antidepressant drug development in decades. That study and subsequent ones have demonstrated that low dose, infused ketamine is able to induce a remission of depression in patients who have failed conventional medications, within 24 h...
November 26, 2016: Drug Development Research
https://www.readbyqxmd.com/read/27856684/psychedelics-in-the-treatment-of-unipolar-mood-disorders-a-systematic-review
#5
REVIEW
James Jh Rucker, Luke A Jelen, Sarah Flynn, Kyle D Frowde, Allan H Young
Unipolar mood disorders, including major depressive disorder and persistent depressive disorder (dysthymia), confer high rates of disability and mortality and a very high socioeconomic burden. Current treatment is suboptimal in most cases and there is little of note in the pharmaceutical development pipeline. The psychedelic drugs, including lysergic acid diethylamide and psilocybin, were used extensively in the treatment of mood disorders, and other psychiatric conditions, before their prohibition in the late 1960s...
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27852960/set-and-setting-psychedelics-and-the-placebo-response-an-extra-pharmacological-perspective-on-psychopharmacology
#6
REVIEW
Ido Hartogsohn
Placebo response theory and set and setting theory are two fields which examine how non-biological factors shape the response to therapy. Both consider factors such as expectancy, preparation and beliefs to be crucial for understanding the extra-pharmacological processes which shape the response to drugs. Yet there are also fundamental differences between the two theories. Set and setting concerns itself with response to psychoactive drugs only; placebo theory relates to all therapeutic interventions. Placebo theory is aimed at medical professionals; set and setting theory is aimed at professionals and drug users alike...
December 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27834144/evolutionary-considerations-on-the-emerging-subculture-of-the-e-psychonauts-and-the-novel-psychoactive-substances-a-comeback-to-the-shamanism
#7
Laura Orsolini, Paul St John-Smith, Daniel McQueen, Duccio Papanti, John Corkery, Fabrizio Schifano
BACKGROUND: Evolutionary research on drug abuse has hitherto been restricted to proximate studies, considering aetiology, mechanism, and ontogeny. However, in order to explain the recent emergency of a new behavioral pattern (e.g. 'the e-psychonaut style') of novel psychoactive substances' (NPS) intake, a complementary evolutionary model may be needed. OBJECTIVE: A range of evolutionary interpretations on the 'psychonaut style' and the recent emergency of NPS was here considered...
November 11, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27719438/the-associations-of-naturalistic-classic-psychedelic-use-mystical-experience-and-creative-problem-solving
#8
Noah W Sweat, Larry W Bates, Peter S Hendricks
Developing methods for improving creativity is of broad interest. Classic psychedelics may enhance creativity; however, the underlying mechanisms of action are unknown. This study was designed to assess whether a relationship exists between naturalistic classic psychedelic use and heightened creative problem-solving ability and if so, whether this is mediated by lifetime mystical experience. Participants (N = 68) completed a survey battery assessing lifetime mystical experience and circumstances surrounding the most memorable experience...
November 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27687776/australia-should-be-initiating-a-psychedelic-research-program-what-are-the-barriers
#9
Nigel Strauss, Stephen J Bright, Martin L Williams
No abstract text is available yet for this article.
September 28, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27649637/psychedelics-recruit-multiple-cellular-types-and-produce-complex-transcriptional-responses-within-the-brain
#10
David A Martin, Charles D Nichols
There has recently been a resurgence of interest in psychedelics, substances that profoundly alter perception and cognition and have recently demonstrated therapeutic efficacy to treat anxiety, depression, and addiction in the clinic. The receptor mechanisms that drive their molecular and behavioral effects involve activation of cortical serotonin 5-HT2A receptors, but the responses of specific cellular populations remain unknown. Here, we provide evidence that a small subset of 5-HT2A-expressing excitatory neurons is directly activated by psychedelics and subsequently recruits other select cell types including subpopulations of inhibitory somatostatin and parvalbumin GABAergic interneurons, as well as astrocytes, to produce distinct and regional responses...
September 2016: EBioMedicine
https://www.readbyqxmd.com/read/27631575/multivariate-optimization-of-the-hollow-fibre-liquid-phase-microextraction-of-muscimol-in-human-urine-samples
#11
Somandla Ncube, Anna Poliwoda, Hlanganani Tutu, Piotr Wieczorek, Luke Chimuka
A liquid phase microextraction based on hollow fibre followed by liquid chromatographic determination was developed for the extraction and quantitation of the hallucinogenic muscimol from urine samples. Method applicability on polar hallucinogens was also tested on two alkaloids, a psychedelic hallucinogen, tryptamine and a polar amino acid, tryptophan which exists in its charged state in the entire pH range. A multivariate design of experiments was used in which a half fractional factorial approach was applied to screen six factors (donor phase pH, acceptor phase HCl concentration, carrier composition, stirring rate, extraction time and salt content) for their extent of vitality in carrier mediated liquid microextractions...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27624312/commentary-the-entropic-brain-a-theory-of-conscious-states-informed-by-neuroimaging-research-with-psychedelic-drugs
#12
COMMENT
David Papo
No abstract text is available yet for this article.
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27503452/treating-addiction-perspectives-from-eeg-and-imaging-studies-on-psychedelics
#13
L F Tófoli, D B de Araujo
Despite reports of apparent benefits, social and political pressure beginning in the late 1960s effectively banned scientific inquiry into psychedelic substances. Covert examination of psychedelics persisted through the 1990s; the turn of the century and especially the past 10 years, however, has seen a resurgent interest in psychedelic substances (eg, LSD, ayahuasca, psilocybin). This chapter outlines relevant EEG and brain imaging studies evaluating the effects of psychedelics on the brain. This chapter also reviews evidence of the use of psychedelics as adjunct therapy for a number of psychiatric and addictive disorders...
2016: International Review of Neurobiology
https://www.readbyqxmd.com/read/27499488/acid-brothers-henry-beecher-timothy-leary-and-the-psychedelic-of-the-century
#14
Jonathan D Moreno
Henry Knowles Beecher, an icon of human research ethics, and Timothy Francis Leary, a guru of the counterculture, are bound together in history by the synthetic hallucinogen lysergic acid diethylamide (LSD). Both were associated with Harvard University during a critical period in their careers and of drastic social change. To all appearances the first was a paragon of the establishment and a constructive if complex hero, the second a rebel and a criminal, a rogue and a scoundrel. Although there is no evidence they ever met, Beecher's indirect struggle with Leary over control of the 20th century's most celebrated psychedelic was at the very heart of his views about the legitimate, responsible investigator...
2016: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/27496657/resting-state-network-specific-breakdown-of-functional-connectivity-during-ketamine-alteration-of-consciousness-in-volunteers
#15
Vincent Bonhomme, Audrey Vanhaudenhuyse, Athena Demertzi, Marie-Aurélie Bruno, Oceane Jaquet, Mohamed Ali Bahri, Alain Plenevaux, Melanie Boly, Pierre Boveroux, Andrea Soddu, Jean François Brichant, Pierre Maquet, Steven Laureys
BACKGROUND: Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control network, salience network (SALn), auditory network, sensorimotor network (SMn), and visual network sustain mentation. Ketamine modifies consciousness differently from other agents, producing psychedelic dreaming and no apparent interaction with the environment. The authors used functional magnetic resonance imaging to explore ketamine-induced changes in RSNs connectivity...
November 2016: Anesthesiology
https://www.readbyqxmd.com/read/27471468/a-model-for-the-application-of-target-controlled-intravenous-infusion-for-a-prolonged-immersive-dmt-psychedelic-experience
#16
Andrew R Gallimore, Rick J Strassman
The state of consciousness induced by N,N-dimethyltryptamine (DMT) is one of the most extraordinary of any naturally-occurring psychedelic substance. Users consistently report the complete replacement of normal subjective experience with a novel "alternate universe," often densely populated with a variety of strange objects and other highly complex visual content, including what appear to be sentient "beings." The phenomenology of the DMT state is of great interest to psychology and calls for rigorous academic enquiry...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27470427/measuring-the-subjective-revisiting-the-psychometric-properties-of-three-rating-scales-that-assess-the-acute-effects-of-hallucinogens
#17
José Carlos Bouso, Eduardo José Pedrero-Pérez, Sam Gandy, Miguel Ángel Alcázar-Córcoles
OBJECTIVE: In the present study we explored the psychometric properties of three widely used questionnaires to assess the subjective effects of hallucinogens: the Hallucinogen Rating Scale (HRS), the Mystical Experience Questionnaire (MEQ), and the Addiction Research Center Inventory (ARCI). METHODS: These three questionnaires were administered to a sample of 158 subjects (100 men) after taking ayahuasca, a hallucinogen whose main active component is N,N-dimethyltryptamine (DMT)...
September 2016: Human Psychopharmacology
https://www.readbyqxmd.com/read/27454674/clinical-applications-of-hallucinogens-a-review
#18
Albert Garcia-Romeu, Brennan Kersgaard, Peter H Addy
Hallucinogens fall into several different classes, as broadly defined by pharmacological mechanism of action, and chemical structure. These include psychedelics, entactogens, dissociatives, and other atypical hallucinogens. Although these classes do not share a common primary mechanism of action, they do exhibit important similarities in their ability to occasion temporary but profound alterations of consciousness, involving acute changes in somatic, perceptual, cognitive, and affective processes. Such effects likely contribute to their recreational use...
August 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27441452/long-term-follow-up-of-psilocybin-facilitated-smoking-cessation
#19
Matthew W Johnson, Albert Garcia-Romeu, Roland R Griffiths
BACKGROUND: A recent open-label pilot study (N = 15) found that two to three moderate to high doses (20 and 30 mg/70 kg) of the serotonin 2A receptor agonist, psilocybin, in combination with cognitive behavioral therapy (CBT) for smoking cessation, resulted in substantially higher 6-month smoking abstinence rates than are typically observed with other medications or CBT alone. OBJECTIVES: To assess long-term effects of a psilocybin-facilitated smoking cessation program at ≥12 months after psilocybin administration...
July 21, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27435062/ayahuasca-enhances-creative-divergent-thinking-while-decreasing-conventional-convergent-thinking
#20
K P C Kuypers, J Riba, M de la Fuente Revenga, S Barker, E L Theunissen, J G Ramaekers
INTRODUCTION: Ayahuasca is a South American psychotropic plant tea traditionally used in Amazonian shamanism. The tea contains the psychedelic 5-HT2A receptor agonist N,N-dimethyltryptamine (DMT), plus β-carboline alkaloids with monoamine oxidase-inhibiting properties. Increasing evidence from anecdotal reports and open-label studies indicates that ayahuasca may have therapeutic effects in treatment of substance use disorders and depression. A recent study on the psychological effects of ayahuasca found that the tea reduces judgmental processing and inner reactivity, classic goals of mindfulness psychotherapy...
September 2016: Psychopharmacology
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