keyword
MENU ▼
Read by QxMD icon Read
search

Psychedelic

keyword
https://www.readbyqxmd.com/read/29923178/effects-of-psilocybin-therapy-on-personality-structure
#1
D Erritzoe, L Roseman, M M Nour, K MacLean, M Kaelen, D J Nutt, R L Carhart-Harris
OBJECTIVE: To explore whether psilocybin with psychological support modulates personality parameters in patients suffering from treatment-resistant depression (TRD). METHOD: Twenty patients with moderate or severe, unipolar, TRD received oral psilocybin (10 and 25 mg, one week apart) in a supportive setting. Personality was assessed at baseline and at 3-month follow-up using the Revised NEO Personality Inventory (NEO-PI-R), the subjective psilocybin experience with Altered State of Consciousness (ASC) scale, and depressive symptoms with QIDS-SR16...
June 19, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29917056/sustained-activation-of-postsynaptic-5-ht2a-receptors-gates-plasticity-at-prefrontal-cortex-synapses
#2
Coralie Berthoux, Alexander Barre, Joël Bockaert, Philippe Marin, Carine Bécamel
The prefrontal cortex (PFC) plays a key role in many high-level cognitive processes. It is densely innervated by serotonergic neurons originating from the dorsal and median raphe nuclei, which profoundly influence PFC activity. Among the 5-HT receptors abundantly expressed in PFC, 5-HT2A receptors located in dendrites of layer V pyramidal neurons control neuronal excitability and mediate the psychotropic effects of psychedelic hallucinogens, but their impact on glutamatergic transmission and synaptic plasticity remains poorly characterized...
June 16, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29910745/psychedelic-fauna-for-psychonaut-hunters-a-mini-review
#3
REVIEW
Laura Orsolini, Michela Ciccarese, Duccio Papanti, Domenico De Berardis, Amira Guirguis, John M Corkery, Fabrizio Schifano
Currently different classes of psychoactive substances are easily available for abuse, including several hundred novel psychoactive substances (NPS). Some of these drugs occur naturally in plants and animals or are chemically modified from plant or animal compounds and have been abused by humans over millennia. Recently, the occurrence of a new "drug culture" (e.g., psychonauts) who consume a great variety of NPS with hallucinogenic/psychedelic properties, facilitated the development of a new "psychedelic trend" toward the consumption of substances contained in some species of animals ("psychedelic fauna")...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29903051/rapid-antidepressant-effects-of-the-psychedelic-ayahuasca-in-treatment-resistant-depression-a-randomized-placebo-controlled-trial
#4
Fernanda Palhano-Fontes, Dayanna Barreto, Heloisa Onias, Katia C Andrade, Morgana M Novaes, Jessica A Pessoa, Sergio A Mota-Rolim, Flávia L Osório, Rafael Sanches, Rafael G Dos Santos, Luís Fernando Tófoli, Gabriela de Oliveira Silveira, Mauricio Yonamine, Jordi Riba, Francisco R Santos, Antonio A Silva-Junior, João C Alchieri, Nicole L Galvão-Coelho, Bruno Lobão-Soares, Jaime E C Hallak, Emerson Arcoverde, João P Maia-de-Oliveira, Dráulio B Araújo
BACKGROUND: Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. METHODS: To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating scale at baseline, and at 1 (D1), 2 (D2), and 7 (D7) days after dosing...
June 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29898390/psychedelics-promote-structural-and-functional-neural-plasticity
#5
Calvin Ly, Alexandra C Greb, Lindsay P Cameron, Jonathan M Wong, Eden V Barragan, Paige C Wilson, Kyle F Burbach, Sina Soltanzadeh Zarandi, Alexander Sood, Michael R Paddy, Whitney C Duim, Megan Y Dennis, A Kimberley McAllister, Kassandra M Ori-McKenney, John A Gray, David E Olson
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast-acting antidepressant properties of the dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo. These changes in neuronal structure are accompanied by increased synapse number and function, as measured by fluorescence microscopy and electrophysiology...
June 12, 2018: Cell Reports
https://www.readbyqxmd.com/read/29885421/some-distorted-thoughts-about-ketamine-as-a-psychedelic-and-a-novel-hypothesis-based-on-nmda-receptor-mediated-synaptic-plasticity
#6
REVIEW
Rachael Ingram, Heather Kang, Stafford Lightman, David E Jane, Zuner A Bortolotto, Graham L Collingridge, David Lodge, Arturas Volianskis
Ketamine, a channel blocking NMDA receptor antagonist, is used off-label for its psychedelic effects, which may arise from a combination of several inter-related actions. Firstly, reductions of the contribution of NMDA receptors to afferent information from external and internal sensory inputs may distort sensations and their processing in higher brain centres. Secondly, reductions of NMDA receptor-mediated excitation of GABAergic interneurons can result in glutamatergic overactivity. Thirdly, limbic cortical disinhibition may indirectly enhance dopaminergic and serotonergic activity...
June 6, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29867608/cortisol-modulation-by-ayahuasca-in-patients-with-treatment-resistant-depression-and-healthy-controls
#7
Ana C de Menezes Galvão, Raíssa N de Almeida, Erick A Dos Santos Silva, Fúlvio A M Freire, Fernanda Palhano-Fontes, Heloisa Onias, Emerson Arcoverde, João P Maia-de-Oliveira, Dráulio B de Araújo, Bruno Lobão-Soares, Nicole L Galvão-Coelho
Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29863323/psychedelics-and-personality
#8
Marc Aixalà, Rafael G Dos Santos, Jaime E C Hallak, José Carlos Bouso
In the past decade, an increasing number of clinical trials are reporting evidence that psychedelics or serotonergic hallucinogens (such as lysergic acid diethylamide, psilocybin, and ayahuasca/dimethyltryptamine) could be effective in the treatment of mood, anxiety, and substance use disorders. The mechanisms responsible for these effects are not fully understood but seem to involve changes in bran dynamics in areas rich in serotonergic 5-HT2A receptors and in personality. In the present text, we present a brief and critical overview of the current research in this field, pointing out both promises and limitations of these studies...
June 4, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29860647/-may-all-be-shattered-into-god-mary-barnes-and-her-journey-through-madness-in-kingsley-hall
#9
Adrian Chapman
Contributing to renewed scholarly interest in R. D. Laing and his circle, and in the radical therapeutic community of Kingsley Hall, London (1965-1970), this article offers the first article-length reading of Mary Barnes' and Joseph Berke's Mary Barnes: Two Accounts of a Journey through Madness. This text offers views of anti-psychiatry 'on the ground' that critique the 1960s utopianism of Laing's championing of madness as a metanoic, quasi-psychedelic voyage. Barnes' story, too, reveals tensions within the anti-psychiatric movement...
June 2, 2018: Journal of Medical Humanities
https://www.readbyqxmd.com/read/29859447/assessing-the-longitudinal-stability-of-latent-classes-of-substance-use-among-gay-bisexual-and-other-men-who-have-sex-with-men
#10
Kiffer G Card, Heather L Armstrong, Allison Carter, Zishan Cui, Lu Wang, Julia Zhu, Nathan J Lachowsky, David M Moore, Robert S Hogg, Eric A Roth
BACKGROUND: Association between substance use and HIV-risk among gay and bisexual men (GBM) is well documented. However, their substance use patterns are diverse, and it is unknown whether self-reported use patterns are stable over time. METHODS: Sexually-active GBM, aged >16 years, were recruited in Metro Vancouver using respondent-driven sampling and followed across 5 study visits at six-month intervals (n = 449). To identify distinct patterns of substance use and their longitudinal stability, Latent Transition Analysis (LTA) was conducted for drugs reported by at least 30 participants...
May 22, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29850881/monoamine-transporter-and-receptor-interaction-profiles-in-vitro-predict-reported-human-doses-of-novel-psychoactive-stimulants-and-psychedelics
#11
Dino Luethi, Matthias E Liechti
Background: Pharmacological profiles of new psychoactive substances (NPSs) can be established rapidly in vitro and provide information on potential psychoactive effects in humans. The present study investigated whether specific in vitro monoamine transporter and receptor interactions can predict effective psychoactive doses in humans. Methods: We correlated previously assessed in vitro data of stimulants and psychedelics with human doses that are reported on the Internet and in books...
May 29, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29847089/dark-classics-in-chemical-neuroscience-mescaline
#12
Bruce Cassels, Patricio Sáez-Briones
Archeological studies in the USA, Mexico and Peru suggest that mescaline, as a cactus constituent, has been used for more than 6000 years. Although it is a widespread cactus alkaloid, it is present in high concentrations in few species, notably the North American peyote (Lophophora williamsii) and the South American wachuma (Trichocereus pachanoi, T. peruvianus and T. bridgesii). Spanish 16th century chroniclers considered these cacti "diabolic", leading to their prohibition, but their use persisted to our days and has been spreading for the last 150 years...
May 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29807492/psychedelic-use-and-intimate-partner-violence-the-role-of-emotion-regulation
#13
Michelle S Thiessen, Zach Walsh, Brian M Bird, Adele Lafrance
BACKGROUND: Recent evidence suggests that psychedelic use predicts reduced perpetration of intimate partner violence among men involved in the criminal justice system. However, the extent to which this association generalizes to community samples has not been examined, and potential mechanisms underlying this association have not been directly explored. AIMS: The present study examined the association between lifetime psychedelic use and intimate partner violence among a community sample of men and women...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29790360/-current-and-future-pharmacotherapy-of-severe-psychiatric-disorders
#14
Eva Češková
Despite of tremendous development in CNS research, current treatment is suboptimal especially in severe mental disorders. In medicine, there are two main methods of improving the healthcare provided: seeking new treatment procedures and perfecting (optimizing) the existing ones. Optimization of treatment includes not only practical tools such as therapeutic drug monitoring, but also implementation of general trends into the clinical practice. New pharmacological options include drugs aimed at other than monoaminergic systems and old drugs used before the psychopharmacological era...
2018: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29763291/classics-in-neuroimaging-the-serotonergic-2a-receptor-system-from-discovery-to-modern-molecular-imaging
#15
Elina T L'Estrade, Hanne D Hansen, Maria Erlandsson, Tomas G Ohlsson, Gitte M Knudsen, Matthias M Herth
Already in 1953, Woolley and Shaw speculated that serotonin could be involved in a range of central nervous system (CNS) disorders. Lysergic acid diethylamide (LSD) displayed an important role in this respect. It was used not only to antagonize biological effects of serotonin and to study the system itself, but also to identify serotonergic subtype receptors. The 5-HT2A receptor was discovered in the 1970s and identified as the responsible receptor mediating psychedelic effects of LSD. The development of positron emission tomography (PET) allowed to study this receptor system in vivo...
May 15, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29755349/ibogaine-acute-administration-in-rats-promotes-wakefulness-long-lasting-rem-sleep-suppression-and-a-distinctive-motor-profile
#16
Joaquín González, José P Prieto, Paola Rodríguez, Matías Cavelli, Luciana Benedetto, Alejandra Mondino, Mariana Pazos, Gustavo Seoane, Ignacio Carrera, Cecilia Scorza, Pablo Torterolo
Ibogaine is a potent psychedelic alkaloid that has been the focus of intense research because of its intriguing anti-addictive properties. According to anecdotic reports, ibogaine has been originally classified as an oneirogenic psychedelic; i.e., induces a dream-like cognitive activity while awake. However, the effects of ibogaine administration on wakefulness (W) and sleep have not been thoroughly assessed. The main aim of our study was to characterize the acute effects of ibogaine administration on W and sleep...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29753748/the-abuse-potential-of-medical-psilocybin-according-to-the-8-factors-of-the-controlled-substances-act
#17
REVIEW
Matthew W Johnson, Roland R Griffiths, Peter S Hendricks, Jack E Henningfield
This review assesses the abuse potential of medically-administered psilocybin, following the structure of the 8 factors of the US Controlled Substances Act (CSA). Research suggests the potential safety and efficacy of psilocybin in treating cancer-related psychiatric distress and substance use disorders, setting the occasion for this review. A more extensive assessment of abuse potential according to an 8 factor analysis would eventually be required to guide appropriate schedule placement. Psilocybin, like other 5-HT2A agonist classic psychedelics, has limited reinforcing effects, supporting marginal, transient non-human self-administration...
May 10, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29740355/assessment-of-alcohol-and-tobacco-use-disorders-among-religious-users-of-ayahuasca
#18
Paulo Cesar Ribeiro Barbosa, Luís F Tófoli, Michael P Bogenschutz, Robert Hoy, Lais F Berro, Eduardo A V Marinho, Kelsy N Areco, Michael J Winkelman
The aims of this study were to assess the impact of ceremonial use of ayahuasca -a psychedelic brew containing N,N-dimethyltryptamine (DMT) and β-carboline -and attendance at União do Vegetal (UDV) meetings on substance abuse; here we report the findings related to alcohol and tobacco use disorder. A total of 1,947 members of UDV 18+ years old were evaluated in terms of years of membership and ceremonial attendance during the previous 12 months. Participants were recruited from 10 states from all major regions of Brazil...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29740267/indolethylamine-n-methyltransferase-polymorphisms-genetic-and-biochemical-approaches-for-study-of-endogenous-n-n-dimethyltryptamine
#19
REVIEW
Jon G Dean
N,N -dimethyltryptamine (DMT) is a powerful serotonergic psychedelic whose exogenous administration elicits striking psychedelic effects in humans. Studies have identified DMT and analogous compounds (e.g., 5-hydroxy-DMT, 5-methoxy-DMT) alongside of an enzyme capable of synthesizing DMT endogenously from tryptamine, indolethylamine- N -methyltransferase (INMT), in human and several other mammalian tissues. Subsequently, multiple hypotheses for the physiological role of endogenous DMT have emerged, from proposed immunomodulatory functions to an emphasis on the overlap between the mental states generated by exogenous DMT and naturally occurring altered states of consciousness; e...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29728331/3-4-methylenedioxymethamphetamine-mdma-assisted-psychotherapy-for-post-traumatic-stress-disorder-in-military-veterans-firefighters-and-police-officers-a-randomised-double-blind-dose-response-phase-2-clinical-trial
#20
Michael C Mithoefer, Ann T Mithoefer, Allison A Feduccia, Lisa Jerome, Mark Wagner, Joy Wymer, Julie Holland, Scott Hamilton, Berra Yazar-Klosinski, Amy Emerson, Rick Doblin
BACKGROUND: Post-traumatic stress disorder (PTSD) is prevalent in military personnel and first responders, many of whom do not respond to currently available treatments. This study aimed to assess the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for treating chronic PTSD in this population. METHODS: We did a randomised, double-blind, dose-response, phase 2 trial at an outpatient psychiatric clinic in the USA. We included service personnel who were 18 years or older, with chronic PTSD duration of 6 months or more, and who had a Clinician-Administered PTSD Scale (CAPS-IV) total score of 50 or greater...
April 30, 2018: Lancet Psychiatry
keyword
keyword
12941
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"