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Stuart Lubarsky, Valérie Dory, Sarkis Meterissian, Carole Lambert, Robert Gagnon
INTRODUCTION: In a script concordance test (SCT), examinees are asked to judge the effect of a new piece of clinical information on a proposed hypothesis. Answers are collected using a Likert-type scale (ranging from -2 to +2, with '0' indicating no effect), and compared with those of a reference panel of 'experts'. It has been argued, however, that SCT may be susceptible to the influences of gaming and guesswork. This study aims to address some of the mounting concern over the response process validity of SCT scores...
June 2018: Perspectives on Medical Education
Dezhi Li, Qian Liu, Zhifang Feng, Qi Zhang, Saran Feng
RATIONALE: Nephrogenic diabetes insipidus (NDI) rarely presents in the initial stage of acute lymphoblastic leukemia (ALL) and relapse due to renal infiltration is also rare. PATIENT CONCERNS: A 19-year-old man presented with weakness, polydipsia, and polyuria for 1 month. DIAGNOSES: NDI was diagnosed with insignificant response to a water deprivation test after stimulation with vasopressin injection. Bone marrow examination combined with immunophenotypic analysis, cerebrospinal cytology, and abdominal ultrasonography confirmed the diagnoses of precursor B cell ALL with renal infiltration...
June 2018: Medicine (Baltimore)
B G Guliev, B K Komyakov, A Yu Zaikin
INTRODUCTION: Renal hematomas (RH) are a rare complication of retrograde endoscopic lithotripsy (REL). This study aimed to investigate the incidence and causes of RH after REL in patients with ureteral stones of different locations. MATERIALS AND METHODS: From 2001 to 2016, 1214 REL were performed at the Urology Clinic of the Mechnikov NWSMU. The analyzes of patients who had RH after REL included the following parameters: age, gender, history of upper urinary tract (UUT) surgery and concomitant diseases (diabetes mellitus, hypertension), the baseline kidney function, the stone characteristics and the degree of hydronephrosis observed in the postoperative period, results of laboratory tests, ultrasound and spiral computed tomography (SCT) of the kidneys...
May 2018: Urologii︠a︡
Mojisola D Kupolati, Una E MacIntyre, Gerda J Gericke
Background: A theory-based contextual nutrition education manual (NEM) may enhance effective teaching of nutrition in schools. School nutrition education should lead to the realization of such benefits as improved health, scholarly achievement leading to manpower development and consequently the nation's development. The purpose of the study was to develop a contextual NEM for teachers of Grade 5 and 6 learners in the Bronkhorstspruit district, South Africa, and to assess teachers' perception on the use of the manual for teaching nutrition...
2018: Frontiers in Public Health
Marcin Kacper Uszynski, Blathin Casey, Sara Hayes, Stephen Gallagher, Helen Purtill, Robert W Motl, Susan Coote
Background: There is a growing body of evidence that physical activity (PA) improves symptoms of multiple sclerosis (MS). Despite the benefits of PA, people with MS are relatively inactive compared with their healthy counterparts. This study investigated associations between social cognitive theory (SCT) constructs and energy expenditure (EE) as an objective measure of PA in a sample of inactive people with MS. Methods: Participants (n = 65) completed several questionnaires and were assessed using standardized outcome measures as part of a cross-sectional analysis of baseline data from a randomized controlled trial (Step it Up)...
May 2018: International Journal of MS Care
Soo Ting Joyce Lim, Yuen Ching Angela Hui, Pei Kwee Lim, Chin Choo Evelyn Lim, Yen Yen Chia, Rashida Farhad Vasanwala
Aim: To measure skin thickness (ST) and skin + subcutaneous layer thickness (SCT) by ultrasound and estimate the risk of intramuscular injection (IM) with different needle lengths across injection sites according to age group. Method: Children recruited between 1 and 18 years with type 1 and 2 diabetes on insulin injections and divided into three age groups: 1-6 years, 7-12 years and 13-18 years. A portable ultrasound was used to measure ST and SCT at four injection sites on the abdomen, arm, thigh and buttock...
June 2018: Journal of Clinical & Translational Endocrinology
David W Niebuhr, Ligong Chen, Stephanie Shao, Jonathan Goldsmith, Celia Byrne, Darrell E Singer
Introduction: Sickle cell trait (SCT), the heterozygous carrier state for hemoglobin S, is present in an estimated 1.6% of all newborns and 7.3% in black individuals in the USA. SCT has long been considered a benign condition with anticipated normal life expectancy and no increased risk for chronic diseases. The medical literature is inconclusive on the potential association between SCT and chronic medical conditions (CMC) including chronic kidney disease, venous thromboembolism, and stroke...
June 8, 2018: Military Medicine
Alexander C Wilson, Dorothy V M Bishop
AIM: To test the hypothesis that sex chromosome trisomies (SCTs) are associated with reduced left lateralization for language. METHOD: Using a cross-sectional design, language laterality was measured during an animation description task using functional transcranial Doppler ultrasonography. Data were available for 75 children with an SCT (47,XXX females [n=26], 47,XXY males [n=25], 47,XYY males [n=24]; mean age 11y 4mo [SD 3y 10mo]) and 132 comparison children with typical karyotypes (69 males, 63 females; mean age 9y 1mo [SD 1y 7mo])...
June 10, 2018: Developmental Medicine and Child Neurology
Cédric Rossi, Julia Gilhodes, Marie Maerevoet, Charles Herbaux, Franck Morschhauser, Pauline Brice, Sylvain Garciaz, Cécile Borel, Loïc Ysebaert, Lucie Obéric, Julien Lazarovici, Bénédicte Deau, Jehan Dupuis, Adrien Chauchet, Julie Abraham, Fontanet Bijou, Aspasia Stamatoullas-Bastard, Jean-Valère Malfuson, Camille Golfier, Camille Laurent, Sarah Pericart, Alexandra Traverse-Glehen, Salim Kanoun, Thomas Filleron, René-Olivier Casasnovas, Hervé Ghesquières
Anti-PD-1 therapy provides high response rates in Hodgkin lymphoma (HL) patients who have relapsed or are refractory (R/R) to autologous stem cell transplantation (ASCT) and brentuximab vedotin (BV), but median progression free survival (PFS) is only one year. The efficacy of treatment following anti-PD-1 is not well known. We retrospectively investigated the efficacy of salvage therapies for unsatisfactory response to anti-PD-1 therapy, assessed by PET-CT according to the Lugano criteria, in 30 R/R HL patients...
June 8, 2018: American Journal of Hematology
Panagiotis Tsirigotis, Theodoros Vassilakopoulos, Ioannis Batsis, Zoi Bousiou, Konstantinos Gkirkas, Ioanna Sakellari, Panayotis Kaloyannidis, Paraskevi Roussou, Gerassimos A Pangalis, Maria Moschogiannis, George Vassilopoulos, Panagiotis Repousis, Aekaterini Megalakaki, Eurydiki Michalis, Christina Kalpadakis, Helen A Papadaki, Ioannis Kotsianidis, Eleftheria Hatzimichael, Alexandros Spyridonidis, Konstantinos Anargyrou, Elias Poulakidas, Panagiota Giannoullia, Ioannis Apostolidis, Maria Stamouli, Konstantinos Konstantopoulos, Vassiliki Pappa, Panayiotis Panayiotidis, Nikolaos Harhalakis, Achilles Anagnostopoulos, Maria Angelopoulou
The outcome of patients with relapsed/refractory classical Hodgkin lymphoma (R/R cHL) after autologous stem cell transplantation (auto-SCT) is poor. Recently, the anti-CD30 monoclonal antibody-drug conjugate, brentuximab vedotin (BV), has shown remarkable activity in the setting of R/R cHL. In the pivotal phase II study, BV produced an overall response rate of 75% and a median progression-free survival of 6.7 months. Although these results have been reproduced by large registry studies, the impact of BV on the overall survival (OS) of patients with R/R cHL has not been addressed so far...
June 8, 2018: Hematological Oncology
Nobuhiko Nakamura, Soranobu Ninomiya, Takuro Matsumoto, Hiroshi Nakamura, Junichi Kitagawa, Takeshi Hara, Masahito Shimizu, Hisashi Tsurumi
We herein report a case of long-lasting pure red cell aplasia (PRCA) after major ABO-incompatible allogeneic stem cell transplantation (SCT) for acute lymphoblastic leukemia. The patient needed red blood cell (RBC) transfusion every week after SCT. On day 236, he was diagnosed with odontogenic infection, and the serum levels of IL-6 were elevated to 12.1 pg/ml. After that, the numbers of reticulocyte rapidly began to increase, and RBC support was not needed from day 251. No standard care for PRCA following SCT has been established...
June 6, 2018: Internal Medicine
Mehdi Boukhechba, Sonia Baee, Alicia L Nobles, Jiaqi Gong, Kristen Wells, Laura E Barnes
Poor adherence to long-term therapies for chronic diseases, such as cancer, compromises effectiveness of treatment and increases the likelihood of disease progression, making medication adherence a critical issue in population health. While the field has documented many eers to adherence to medication, it has also come up with few efficacious solutions to medication adherence, indicating that new and innovative approaches are needed. In this paper, we evaluate medication-taking behaviors based on social cognitive theory (SCT), presenting patterns of adherence stratified across SCT constructs in 33 breast cancer survivors over an 8-month period...
March 2018: IEEE-EMBS International Conference on Biomedical and Health Informatics
Peter Esser, Katharina Kuba, Anja Mehnert, Christoffer Johansen, Andreas Hinz, Florian Lordick, Heide Götze
OBJECTIVES: Quality of life (QoL) has become an important tool to guide decision making in oncology. Given the heterogeneity among hematological cancer survivors, however, clinicians need comparative data across different subsets. METHODS: This study recruited survivors of hematological malignancies (≥ 2.5 years after diagnosis) from two German cancer registries. QoL was assessed with the EORTC QLQ-C30. The sample was stratified by cancer type, time since diagnosis, treatment with stem cell transplantation (SCT) and type of SCT...
June 1, 2018: European Journal of Haematology
Kalyana C Janga, Sheldon Greenberg, Phone Oo, Kavita Sharma, Umair Ahmed
A 26-year-old African American male with a history of congenital cerebral palsy, sickle cell trait, and intellectual disability presented with abdominal pain that started four hours prior to the hospital visit. The patient denied fever, chills, diarrhea, or any localized trauma. The patient was at a party at his community center last evening and danced for 2 hours, physically exerting himself more than usual. Labs revealed blood urea nitrogen (BUN) level of 41 mg/dL and creatinine (Cr) of 2.8 mg/dL which later increased to 4...
2018: Case Reports in Nephrology
Evelinda Baerends, Luuk J Oostveen, Casper T Smit, Marco Das, Ioannis Sechopoulos, Monique Brink, Frank de Lange, Mathias Prokop
OBJECTIVES: To compare contrast-to-noise ratios (CNRs) and iodine discrimination thresholds on iodine maps derived from dual energy CT (DECT) and subtraction CT (SCT). METHODS: A contrast-detail phantom experiment was performed with 2 to 15 mm diameter tubes containing water or iodinated contrast concentrations ranging from 0.5 mg/mL to 20 mg/mL. DECT scans were acquired at 100 kVp and at 140 kVp+Sn filtration. SCT scans were acquired at 100 kVp. Iodine maps were created by material decomposition (DECT) or by subtraction of water scans from iodine scans (SCT)...
May 28, 2018: European Radiology
Guido Lancman, Andrew Brunner, Ronald Hoffman, John Mascarenhas, Gabriela Hobbs
We retrospectively reviewed treatment outcomes for 57 patients with myeloproliferative neoplasms in blast phase (MPN-BP). The median overall survival (OS) of the entire cohort was 5.8 months. For patients receiving induction therapy, 67% achieved a complete response (CR) and 75% received stem cell transplantation (SCT). Median OS for all transplanted patients (n = 19) was not reached after a median follow-up of 19.2 months compared with 3.8 months in non-transplanted patients (p < 0.0001); patients who did not receive SCT after induction chemotherapy survived a median of 4...
May 21, 2018: Leukemia Research
Aditi Vedi, Richard Mitchell, Sunita Shanmuganathan, Cecilia Oswald, Glenn M Marshall, Toby Trahair, Siva Sivarajasingam, David S Ziegler
BACKGROUND: The treatment for pediatric acute myeloid leukemia (AML) has not changed significantly over the past 3 decades, yet outcomes have improved with cure rates increasing from 30% to over 60% of all newly diagnosed children over this period. This improvement in survival has been attributed to both treatment intensification and improved supportive care over the decades, although the precise impact of each remains unknown. PATIENTS AND METHODS: We retrospectively analyzed a unique cohort of 276 patients with de novo AML diagnosed in childhood, all treated with the same chemotherapy protocol over a 25-year period from 1986 to 2012...
May 22, 2018: Journal of Pediatric Hematology/oncology
Shi-Yuan Liu, Qiong Li, Ya-Feng Gu, Li Fan, Qing-Chu Li, Yi Xiao
To investigate the predictive value of size measurements of the solid components in pulmonary subsolid nodules with different CT window settings and to evaluate the degree of pathological malignancy in lung adenocarcinoma.  Methods: The preoperative chest CT images and pathological data of 125 patients were retrospectively evaluated. The analysis included 127 surgically resected lung adenocarcinomas that manifested as subsolid nodules. All subsolid nodules were divided into two groups: 69 in group A, including 22 adenocarcinomas in situ (AIS) and 47 minimally invasive adenocarcinomas (MIA); 58 in group B that included invasive pulmonary adenocarcinomas (IPA)...
May 23, 2018: British Journal of Radiology
Bahram Mohebbi, Azar Tol, Roya Sadeghi, Mehdi Yaseri, Negar Akbari Somar, Feleke Doyore Agide
Background: Misuse of antibiotics can be described as a failure to complete treatment, skipping of the doses and reuse of leftover medicines and overuse of antibiotics. Health education interventions are expected to enhance awareness and general belief on rational antibiotics use. Therefore, the study aimed to determine the efficacy of social cognitive theory (SCT)-based self-care intervention for rational antibiotic use. Methods: This randomized trial was conducted in a sample of 260 adults...
May 19, 2018: European Journal of Public Health
Mohammad Bagherniya, Firoozeh Mostafavi Darani, Manoj Sharma, Mohammad Reza Maracy, Ramesh Allipour Birgani, Golnaz Ranjbar, Ali Taghipour, Mohammad Safraian, Seyed Ali Keshavarz
BACKGROUND: Childhood obesity has become a global epidemic and physical inactivity and considered as one of the most important contributing factors. We aimed to evaluate a school-based physical activity intervention using social cognitive theory (SCT) to increase physical activity behavior in order to prevent obesity among overweight and obese adolescent girls. STUDY DESIGN: Randomized controlled trial study. METHODS: A seven-month randomized controlled trial based on SCT was implemented with 172 overweight and obese girl students (87 in intervention and 85 in control group), with the presence of their parents and teachers...
April 7, 2018: Journal of Research in Health Sciences
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