Yu-Bo Hu, Xi Deng, Lu Liu, Can-Can Cao, Ya-Wen Su, Zhen-Jie Gao, Xin Cheng, Deshan Kong, Qi Li, Yan-Wei Shi, Xiao-Guang Wang, Xiaojing Ye, Hu Zhao
Methamphetamine, a commonly abused drug, is known for its high relapse rate. The persistence of addictive memories associated with methamphetamine poses a significant challenge in preventing relapse. Memory retrieval and subsequent reconsolidation provide an opportunity to disrupt addictive memories. However, the key node in the brain network involved in methamphetamine-associated memory retrieval has not been clearly defined. In this study, using the conditioned place preference in male mice, whole brain c-FOS mapping and functional connectivity analysis, together with chemogenetic manipulations of neural circuits, we identified the medial prefrontal cortex (mPFC) as a critical hub that integrates inputs from the retrosplenial cortex and the ventral tegmental area to support both the expression and reconsolidation of methamphetamine-associated memory during its retrieval...
May 10, 2024: Neuropsychopharmacology