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Neurocysticercosis burden

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https://www.readbyqxmd.com/read/27880878/neurocysticercosis-infection-and-disease-a-review
#1
REVIEW
Lucy Gripper, Susan C Welburn
Neurocysticercosis (NCC) is the most common parasitic disease of the human central nervous system (CNS), a pleomorphic disease with a diverse array of clinical manifestations. The infection is pleomorphic and dependent on a complex range of interconnecting factors, including number and size of the cysticerci, their stage of development and localisation within the brain with resulting difficulties in accurate diagnosis and staging of the disease. This review examines the factors that contribute to the accurate assessment of NCC distribution and transmission that are critical to achieving robust disease burden calculations...
November 20, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27794094/neurocysticercosis-in-bhutan-a-cross-sectional-study-in-people-with-epilepsy
#2
Kate Brizzi, Sonam Pelden, Tshokey Tshokey, Damber K Nirola, Megan B Diamond, Joshua P Klein, Lhab Tshering, Sonam Deki, Dechen Nidup, Veronica Bruno, Pierre Dorny, Hector Hugo Garcia, Farrah J Mateen
BACKGROUND: We sought to provide an assessment of the burden of neurocysticercosis among people with epilepsy (PWE) in Bhutan and evaluate the yield of various tests for Taenia solium. METHODS: PWE were enrolled at the National Referral Hospital in Thimphu (2014-2015). Serum was tested for anti-Taenia solium IgG using ELISA (Ab-ELISA), enzyme-linked immunoelectrotransfer blot (EITB), and parasite antigen. Results were compared to brain MRI. Participants were categorized as definite neurocysticercosis (MRI and EITB positive), probable neurocysticercosis (MRI or EITB positive), or without neurocysticercosis...
September 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27697089/human-cysticercosis-in-portugal-long-gone-or-still-contemporary
#3
M Vilhena, A G Fonseca, S Dias, J Marques DA Silva, J Torgal
Cysticercosis, a leading cause of acquired epilepsy in developing countries, has been controlled or eradicated in industrialized countries. This paradigm has recently been challenged, with human neurocysticercosis (NCC) being increasingly diagnosed in these countries. In order to assess the NCC burden in Portugal, a retrospective study on NCC hospitalizations (2006-2013) was conducted based on the national database on hospital morbidity: 357 hospitalized cases were detected. NCC was most frequent in the following age groups: 20-64 years (n = 197, 55·2%) >64 years (n = 111, 31·1%), and <20 years (n = 49, 13·7%)...
October 4, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27642465/neurocysticercosis-among-patients-with-first-time-seizure-in-northern-namibia
#4
Innocent Lule Segamwenge, Ngalyuka Paul Kioko, Celia Mukulu, Ogunsina Jacob, Wanzira Humphrey, Josephine Augustinus
INTRODUCTION: Neurocysticercosis is a common cause of seizures in low resource countries. There is a paucity of data regarding the extent of this infection in Namibia. There are multiple causes of First-time seizure including electrolyte abnormalities, infections, trauma, drugs, alcohol and many times no apparent cause can be found. We sought to describe the burden of Neurocysticercosis among individuals with a first-time seizure in Namibia. METHODS: We recruited 221 patients with a First-time seizure who presented to the Intermediate Hospital Oshakati between August 2012 and March 2014...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27493081/host-th1-th2-immune-response-to-taenia-solium-cyst-antigens-in-relation-to-cyst-burden-of-neurocysticercosis
#5
J Tharmalingam, A T Prabhakar, P Gangadaran, P Dorny, J Vercruysse, P Geldhof, V Rajshekhar, M Alexander, A Oommen
Neurocysticercosis (NCC), Taenia solium larval infection of the brain, is an important cause of acquired seizures in endemic countries, which relate to number, location and degenerating cysts in the brain. Multicyst infections are common in endemic countries although single-cyst infection prevails in India. Single-cyst infections in an endemic country suggest a role for host immunity limiting the infection. This study examined ex vivo CD4(+) T cells and in vitro Th1 and Th2 cytokine responses to T. solium cyst antigens of peripheral blood mononuclear cells of healthy subjects from endemic and nonendemic regions and of single- and multicyst-infected patients for association with cyst burden of NCC...
October 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27332553/reduced-leukocyte-infiltration-in-absence-of-eosinophils-correlates-with-decreased-tissue-damage-and-disease-susceptibility-in-%C3%AE-dblgata-mice-during-murine-neurocysticercosis
#6
Pramod K Mishra, Qun Li, Luis E Munoz, Chris A Mares, Elizabeth G Morris, Judy M Teale, Astrid E Cardona
Neurocysticercosis (NCC) is one of the most common helminth parasitic diseases of the central nervous system (CNS) and the leading cause of acquired epilepsy worldwide. NCC is caused by the presence of the metacestode larvae of the tapeworm Taenia solium within brain tissues. NCC patients exhibit a long asymptomatic phase followed by a phase of symptoms including increased intra-cranial pressure and seizures. While the asymptomatic phase is attributed to the immunosuppressive capabilities of viable T. solium parasites, release of antigens by dying organisms induce strong immune responses and associated symptoms...
June 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27250121/pulmonary-neuroendocrine-carcinoma-mimicking-neurocysticercosis-a-case-report
#7
John C Lam, Stephen R Robinson, Andrew Schell, Stephen Vaughan
BACKGROUND: Neurocysticercosis occurs when the eggs of the pork tapeworm (Taenia solium) migrate and hatch into larvae within the central nervous system. Neurocysticercosis is the most common cause of seizures in the developing world and is characterized on brain imaging by cysts in different stages of evolution. In Canada, cases of neurocysticercosis are rare and most of these patients acquire the disease outside of Canada. We report the case of a patient with multiple intracranial lesions whose history and diagnostic imaging were consistent with neurocysticercosis...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27054160/data-and-the-associated-r-code-used-to-estimate-health-and-economic-burden-of-neurocysticercosis-in-india
#8
B B Singh, M S Khatkar, J P S Gill, N K Dhand
This article contains epidemiological, demographic and other data used for estimating health and economic burden of neurocysticercosis (NCC)-associated active epilepsy in India [1]. Most of the data are embedded in the R-code used for analyses so that the reader is able to replicate the results or adapt the code to their own data. However, data used to conduct sensitivity analyses to evaluate the effect of changing important input values such as prevalence and per capita income on health and economic impact of NCC in India are included in tables...
June 2016: Data in Brief
https://www.readbyqxmd.com/read/26802489/estimation-of-the-health-and-economic-burden-of-neurocysticercosis-in-india
#9
B B Singh, M S Khatkar, J P S Gill, N K Dhand
Taenia solium is an endemic parasite in India which occurs in two forms in humans: cysticercosis (infection of soft tissues) and taeniosis (intestinal infection). Neurocysticercosis (NCC) is the most severe form of cysticercosis in which cysts develop in the central nervous system. This study was conducted to estimate health and economic impact due to human NCC-associated active epilepsy in India. Input data were sourced from published research literature, census data and other official records. Economic losses due to NCC-associated active epilepsy were estimated based on cost of treatment, hospitalisation and severe injury as well as loss of income...
January 20, 2016: Acta Tropica
https://www.readbyqxmd.com/read/26580325/global-research-priorities-for-infections-that-affect-the-nervous-system
#10
REVIEW
Chandy C John, Hélène Carabin, Silvia M Montano, Paul Bangirana, Joseph R Zunt, Phillip K Peterson
Infections that cause significant nervous system morbidity globally include viral (for example, HIV, rabies, Japanese encephalitis virus, herpes simplex virus, varicella zoster virus, cytomegalovirus, dengue virus and chikungunya virus), bacterial (for example, tuberculosis, syphilis, bacterial meningitis and sepsis), fungal (for example, cryptococcal meningitis) and parasitic (for example, malaria, neurocysticercosis, neuroschistosomiasis and soil-transmitted helminths) infections. The neurological, cognitive, behavioural or mental health problems caused by the infections probably affect millions of children and adults in low- and middle-income countries...
November 19, 2015: Nature
https://www.readbyqxmd.com/read/26527895/managing-neurocysticercosis-challenges-and-solutions
#11
REVIEW
Yannick Fogoum Fogang, Abdoul Aziz Savadogo, Massaman Camara, Dènahin Hinnoutondji Toffa, Anna Basse, Adjaratou Djeynabou Sow, Mouhamadou Mansour Ndiaye
Taenia solium neurocysticercosis (NCC) is a major cause of neurological morbidity in the world. Variability in the neuropathology and clinical presentation of NCC often make it difficult to diagnose and manage. Diagnosis of NCC can be challenging especially in endemic and resource-limited countries where laboratory and imaging techniques are often lacking. NCC management can also be challenging as current treatment options are limited and involve symptomatic agents, antiparasitic agents, or surgery. Although antiparasitic treatment probably reduces the number of active lesions and long-term seizure frequency, its efficacy is limited and strategies to improve treatment regimens are warranted...
2015: International Journal of General Medicine
https://www.readbyqxmd.com/read/26519884/neurocysticercosis-in-a-rural-population-with-extensive-pig-production-in-ang%C3%A3-nia-district-tete-province-mozambique
#12
Yunus Amade Assane, Chiara Trevisan, Clara Maria Schutte, Emilia Virginia Noormahomed, Maria Vang Johansen, Pascal Magnussen
Neurocysticercosis (NCC) is an important neurological disease in countries with high prevalence of Taenia solium infection and is emerging as a serious public health and economic problem. The aim of this study was to estimate the prevalence of NCC in Angónia district, Tete province, Mozambique based on: prevalence of human T. solium cysticercosis assessed by antigen Enzyme-linked Immunosorbent Assay (Ag-ELISA) seropositivity, history of epilepsy, and brain computed tomography (CT) scan results. A cross sectional study was conducted between September and November 2007 in Angónia district...
October 28, 2015: Acta Tropica
https://www.readbyqxmd.com/read/26336013/immune-response-to-taenia-solium-cysticerci-after-anti-parasitic-therapy
#13
Aloukick K Singh, Satyendra K Singh, Amrita Singh, Kamlesh K Gupta, Jahanarah Khatoon, Amit Prasad, Ravi P Rai, Rakesh K Gupta, Mukesh Tripathi, Nuzhat Husain, Kashi N Prasad
Albendazole is the drug of choice for Taenia solium infection. Concomitant administration of steroid has been advocated to avoid adverse reactions to albendazole therapy in neurocysticercosis. Some T. solium cysticerci (larvae) respond to albendazole therapy while others do not and the reasons remain unexplained. We hypothesise that the immune response differs between treatment responder and non-responder cysticerci and this may determine the outcome. Twenty swine naturally infected with T. solium were purchased from the market and the infection was confirmed by magnetic resonance imaging...
October 2015: International Journal for Parasitology
https://www.readbyqxmd.com/read/26155476/imaging-and-serological-evidence-of-neurocysticercosis-among-patients-with-seizures-in-odisha-an-unexplored-eastern-coastal-province-in-india
#14
Priyadarshi Soumyaranjan Sahu, Shubhransu Patro, Payod Kumar Jena, Santosh Kumar Swain, Bidyut Kumar Das
INTRODUCTION: Neurocysticercosis being a potential to human transmitted disease, is the major cause of seizures and a public health problem in tropical countries. Though India is known to be highly endemic, there are many provinces where reports are still unavailable thereby underestimating its actual burden. MATERIALS AND METHODS: Anti-Cysticercus IgG antibodies in sera from cases presenting with seizures were screened by ELISA in a preliminary study in Odisha state which is a province in Eastern coastal India that was never explored before...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25516827/repurposing-drugs-for-the-treatment-and-control-of-helminth-infections
#15
REVIEW
Gordana Panic, Urs Duthaler, Benjamin Speich, Jennifer Keiser
Helminth infections are responsible for a considerable public health burden, yet the current drug armamentarium is small. Given the high cost of drug discovery and development, the high failure rates and the long duration to develop novel treatments, drug repurposing circumvents these obstacles by finding new uses for compounds other than those they were initially intended to treat. In the present review, we summarize in vivo and clinical trial findings testing clinical candidates and marketed drugs against schistosomes, food-borne trematodes, soil-transmitted helminths, Strongyloides stercoralis, the major human filariases lymphatic filariasis and onchocerciasis, taeniasis, neurocysticercosis and echinococcosis...
December 2014: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/25327193/-hospital-care-expenses-caused-by-acute-fascioliasis-cystic-echinococcosis-and-neurocysticercosis-in-santiago-chile
#16
COMPARATIVE STUDY
Alberto Fica, Thomas Weitzel
BACKGROUND: Acute fascioliasis (FA), cystic echinococcosis (CE) and neurocysticercosis (NCC) are three endemic parasitic diseases in Chile for whom there is scarce information about the economic impact they represent during management at the hospital. AIMS: To quantify and compare hospital care expenses caused by these three endemic helminth infections in a Chilean hospital. METHODS: Retrospective analysis of hospital costs at a referral hospital in Santiago between 2006 and 2010...
August 2014: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/24999157/efficacy-of-combined-antiparasitic-therapy-with-praziquantel-and-albendazole-for-neurocysticercosis-a-double-blind-randomised-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Hector H Garcia, Isidro Gonzales, Andres G Lescano, Javier A Bustos, Mirko Zimic, Diego Escalante, Herbert Saavedra, Martin Gavidia, Lourdes Rodriguez, Enrique Najar, Hugo Umeres, E Javier Pretell
BACKGROUND: Neurocysticercosis causes a substantial burden of seizure disorders worldwide. Treatment with either praziquantel or albendazole has suboptimum efficacy. We aimed to establish whether combination of these drugs would increase cysticidal efficacy and whether complete cyst resolution results in fewer seizures. We added an increased dose albendazole group to establish a potential effect of increased albendazole concentrations. METHODS: In this double-blind, placebo-controlled, phase 3 trial, patients with viable intraparenchymal neurocysticercosis were randomly assigned to receive 10 days of combined albendazole (15 mg/kg per day) plus praziquantel (50 mg/kg per day), standard albendazole (15 mg/kg per day), or increased dose albendazole (22·5 mg/kg per day)...
August 2014: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/24992686/feasibility-of-a-lateral-flow-test-for-neurocysticercosis-using-novel-up-converting-nanomaterials-and-a-lightweight-strip-analyzer
#18
Paul L A M Corstjens, Claudia J de Dood, Jeffrey W Priest, Hans J Tanke, Sukwan Handali
UNLABELLED: Neurocysticercosis is a frequent parasitic infection of the human brain, occurring in most of the world, and requires imaging of the brain to diagnose. To determine the burden of disease and to simplify diagnosis, a field-friendly rapid lateral flow (LF) based antibody screening test was developed. The assay utilizes novel nano-sized up-converting phosphor (UCP) reporter particles in combination with a portable lightweight analyzer and detects antibodies in serum samples reactive with bacterial-expressed recombinant (r) T24H, a marker for detecting neurocysticercosis cases...
July 2014: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/24957954/neurocysticercosis-the-effectiveness-of-the-cysticidal-treatment-could-be-influenced-by-the-host-immunity
#19
Graciela Cárdenas, Gladis Fragoso, Marcos Rosetti, Laura Uribe-Figueroa, Claudia Rangel-Escareño, Brenda Saenz, Marisela Hernández, Edda Sciutto, Agnes Fleury
Neurocysticercosis, a clinically and radiologically pleomorphic parasitic disease, is still endemic to most non-developed countries of Latin America, Africa, and Asia. Anti-helminthic drugs (AHD) are generally effective and rapidly destroy parenchymal cysticerci. In contrast, several cycles of AHD are frequently necessary to damage extraparenchymally located parasites. The present study was designed to evaluate whether differences in the immunological profile of the patients is involved in the diversity of the response to AHD...
December 2014: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/24863516/the-relationship-between-neurocysticercosis-and-epilepsy-an-endless-debate
#20
REVIEW
Arturo Carpio, Matthew L Romo
Neurocysticercosis (NC), or cerebral infection with Taenia solium, is an important public health problem worldwide. Among the neurological sequelae of NC, seizures have been described as the most common symptom. Acute symptomatic seizures often result from degeneration of a viable cyst; however, not all of these patients with acute or provoked seizures will develop epilepsy (i.e., recurrent unprovoked seizures). Because of the high prevalence of epilepsy and NC, a causal, as well as incidental relationship between the two may exist...
May 2014: Arquivos de Neuro-psiquiatria
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