Gino Castillo, Lizbeth Fustamante, Ana D Delgado-Kamiche, Rogger P Camen-Orozco, Taryn Clark, Edson Bernal, Jemima Morales-Alvarez, Maria Ferrufino, Javier Mamani-Palomino, Javier A Bustos, Hector H Garcia, Cesar M Gavidia, Robert H Gilman, Manuela Verastegui
Despite being a leading cause of acquired seizures in endemic regions, the pathological mechanisms of neurocysticercosis are still poorly understood. This study aims to investigate the impact of anthelmintic treatment on neuropathological features in a rat model of neurocysticercosis. Rats were intracranially infected with Taenia solium oncospheres and treated with albendazole + praziquantel (ABZ), oxfendazole + praziquantel (OXF), or untreated placebo (UT) for 7 days. Following the last dose of treatment, brain tissues were evaluated at 24 h and 2 months...
January 11, 2024: Brain Pathology