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Bone morphogenetic protein

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https://www.readbyqxmd.com/read/29932880/antagonizing-bone-morphogenetic-protein-4-attenuates-disease-progression-in-a-rat-model-of-amyotrophic-lateral-sclerosis
#1
Tomomi Shijo, Hitoshi Warita, Naoki Suzuki, Kensuke Ikeda, Shio Mitsuzawa, Tetsuya Akiyama, Hiroya Ono, Ayumi Nishiyama, Rumiko Izumi, Yasuo Kitajima, Masashi Aoki
Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative syndrome characterized by the systemic loss of motor neurons with prominent astrocytosis and microgliosis in the spinal cord and brain. Astrocytes play an essential role in maintaining extracellular microenvironments that surround motor neurons, and are activated by various insults. Growing evidence points to a non-cell autonomous neurotoxicity caused by chronic and sustained astrocytic activation in patients with neurodegenerative diseases, including ALS...
June 19, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29932237/effect-of-bone-morphogenetic-protein-9-on-osteoblast-differentiation-of-cells-grown-on-titanium-with-nanotopography
#2
Alann T P Souza, Barbara L S Bezerra, Fabiola S Oliveira, Gileade P Freitas, Rayana L Bighetti Trevisan, Paulo T Oliveira, Adalberto L Rosa, Marcio M Beloti
Among bone morphogenetic proteins (BMPs), BMP-9 has been described as one with higher osteogenic potential. Here, we aimed at evaluating the effect of BMP-9 on the osteoblast differentiation of cells grown on titanium (Ti) with nanotopography, a well-known osseoinductive surface. MC3T3-E1 cells were grown either in absence or presence of BMP-9 (20 nM) on Ti with nanotopography (Ti-Nano) or machined Ti (Ti-Machined) for up to 21 days to evaluate the gene expression of RUNX2, osterix, osteocalcin, bone sialoprotein, SMAD6 and SMAD4, protein expression of SMAD4, ALP activity and extracellular matrix mineralization...
June 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29931833/the-evolution-of-molluscs
#3
Andreas Wanninger, Tim Wollesen
Molluscs are extremely diverse invertebrate animals with a rich fossil record, highly divergent life cycles, and considerable economical and ecological importance. Key representatives include worm-like aplacophorans, armoured groups (e.g. polyplacophorans, gastropods, bivalves) and the highly complex cephalopods. Molluscan origins and evolution of their different phenotypes have largely remained unresolved, but significant progress has been made over recent years. Phylogenomic studies revealed a dichotomy of the phylum, resulting in Aculifera (shell-less aplacophorans and multi-shelled polyplacophorans) and Conchifera (all other, primarily uni-shelled groups)...
June 21, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29930977/regulation-of-gastric-lgr5-ve-cell-homeostasis-by-bone-morphogenetic-protein-bmp-signaling-and-inflammatory-stimuli
#4
Wei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Elise S Hibdon, Linda C Samuelson, Kathryn A Eaton, Andrea Todisco
Background & Aims: Gastric Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) cells exert important functions during injury and homeostasis. Bone morphogenetic protein (BMP) signaling regulates gastric inflammation and epithelial homeostasis. We investigated if BMP signaling controls the fate of Lgr5+ve cells during inflammation. Methods: The H + /K + -adenosine triphosphatase β-subunit promoter was used to express the BMP inhibitor noggin ( Nog ) in the stomach ( H + /K + -Nog mice)...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29929354/-in-vitro-differentiation-of-spermatogonial-stem-cell-with-testicular-cells-from-guangxi-bama-mini-pig
#5
Huimin Zhao, Junyu Nie, Xiangxing Zhu, Yangqing Lu, Xingwei Liang, Huiyan Xu, Xiaogan Yang, Yunkai Zhang, Kehuan Lu, Shengsheng Lu
In this study, we attempted to establish a culture system for in vitro spermatogenesis from spermatogonial stem cells (SSCs) of Bama Mini-pig. The dissociated testicular cells from one-month pig were co-cultured to mimic in vivo spermatogenesis. The testicular cells were seeded in Minimum Essential Media alpha (α-MEM) supplemented with KnockoutTM Serum Replacement (KSR). Three-dimensional (3D) colonies were formed after 10 days culture. The colonies showed positive staining for SSC-associated markers such as UCHL1, PLZF, THY1, OCT4, Dolichos biflorus agglutinin (DBA) and alkaline phosphatase (AP)...
June 21, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29928021/colon-organoid-formation-and-cryptogenesis-are-stimulated-by-growth-factors-secreted-from-myofibroblasts
#6
Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa, Antony Wilks Burgess
Although small intestinal epithelial stem cells form crypts when using intestinal culture conditions, colon stem cells usually form colonospheres. Colon mesenchymal cell feeder layers can stimulate colon crypts to form organoids and produce crypts. We have investigated whether conditioned medium from colon mesenchymal cells can also stimulate colonosphere and organoid cryptogenesis. We prepared conditioned medium (CM) from WEHI-YH2 cells (mouse colon myofibroblasts); the CM stimulated both colonosphere formation and organoid cryptogenesis in vitro...
2018: PloS One
https://www.readbyqxmd.com/read/29927820/acetyl-11-keto-%C3%AE-boswellic-acid-promotes-osteoblast-differentiation-by-inhibiting-tumor-necrosis-factor-%C3%AE-and-nuclear-factor-%C3%AE%C2%BAb-activity
#7
Fan Bai, Xuewu Chen, Hui Yang, Hong-Guang Xu
Tumor necrosis factor (TNF) -α plays a crucial role in rheumatoid arthritis (RA)-related bone loss disease. The main mechanism of action of RA induced bone loss is the significant inhibitory effect of TNF-α on osteoblast differentiation. TNF-α inhibits osteoblast differentiation mainly by activating nuclear factor (NF) -κB signaling pathway. Owing to the crucial role of TNF-α and NF-κB in the inhibition of osteoblast differentiation, they are considered as targets for the development of therapeutic drugs...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29926833/local-injection-of-bone-morphogenetic-protein-7-promotes-neuronal-regeneration-and-motor-function-recovery-after-acute-spinal-cord-injury
#8
Chen Chen, Guang-Chao Bai, Hong-Liang Jin, Kun Lei, Kuan-Xin Li
After spinal cord injury, the number of glial cells and motor neurons expressing bone morphogenetic protein 7 (BMP7) increases, indicating that upregulation of BMP7 can promote nerve repair. We, therefore, tested whether direct injection of BMP7 into acutely injured rat spinal cord can affect neurological recovery. Allen's impactor was used to create spinal cord injury at T10 . The injury site was then injected with 50 ng BMP7 (BMP7 group) or physiological saline (control group) for 7 consecutive days. Electrophysiological examination showed that the amplitude of N1 in motor evoked potentials (MEP) decreased after spinal cord injury...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29924384/glycans-in-stem-cell-regulation-from-drosophila-tissue-stem-cells-to-mammalian-pluripotent-stem-cells
#9
REVIEW
Shoko Nishihara
Cell surface glycans, which are tissue-specific and developmentally regulated, work as essential modulators in ligand-receptor interactions, binding to various signal ligands including Wnt, Hedgehog, fibroblast growth factors, epidermal growth factors, and bone morphogenetic proteins, as well as in cell-cell interactions and cell-extracellular matrix interactions. These signals are essential for the stemness and differentiation of various kinds of stem cells. In addition, the intracellular O-linked N-acetylglucosamine, a form of glycosylation found only on nuclear or cytoplasmic proteins, regulates core transcription factors of stemness and phosphorylation of downstream signal components...
June 20, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29922221/trauma-induced-heterotopic-ossification-regulates-the-blood-nerve-barrier
#10
REVIEW
Zbigniew Gugala, Elizabeth A Olmsted-Davis, Yuqing Xiong, Eleanor L Davis, Alan R Davis
De novo bone formation can occur in soft tissues as a result of traumatic injury. This process, known as heterotopic ossification (HO), has recently been linked to the peripheral nervous system. Studies suggest that HO may resemble neural crest-derived bone formation and is activated through the release of key bone matrix proteins leading to opening of the blood-nerve barrier (BNB). One of the first steps in this process is the activation of a neuro-inflammatory cascade, which results in migration of chondro-osseous progenitors, and other cells from both the endoneurial and perineurial regions of the peripheral nerves...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29922215/bone-morphogenetic-protein-bmp-3b-gene-depletion-causes-high-mortality-in-a-mouse-model-of-neonatal-hypoxic-ischemic-encephalopathy
#11
Yuko Ogawa, Masahiro Tsuji, Emi Tanaka, Mikiya Miyazato, Jun Hino
Bone morphogenetic proteins (BMPs) are a group of proteins that induce the formation of bone and the development of the nervous system. BMP-3b, also known as growth and differentiation factor 10, is a member of the BMPs that is highly expressed in the developing and adult brain. BMP-3b is therefore thought to play an important role in the brain even after physiological neurogenesis has completed. BMP-3b is induced in peri-infarct neurons in aged brains and is one of the most highly upregulated genes during the initiation of axonal sprouting...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29920660/dorsoventral-differences-in-camp-levels-and-correlated-changes-in-the-subcellular-distribution-of-the-pka-catalytic-domain-provide-further-evidence-that-pka-signaling-coordinates-dorsoventral-patterning-of-the-otocyst
#12
Sho Ohta, Gary C Schoenwolf
Dorsoventral (DV) patterning of the otocyst gives rise to formation of the morphologically and functionally complex membranous labyrinth composed of unique dorsal and ventral sensory organs. DV patterning results from extracellular signaling by secreted growth factors, which presumably form reciprocal concentration gradients across the DV axis of the otocyst. Previous work suggested a model in which two important growth factors, bone morphogenetic protein (BMP) and SHH, undergo crosstalk through an intersecting pathway to coordinate DV patterning...
June 19, 2018: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/29917272/enhancing-the-effects-of-exfoliated-carbon-nanofibers-using-bone-morphogenetic-protein-in-a-rat-spinal-fusion-model
#13
Naoki Notani, Masashi Miyazaki, Masahiro Toyoda, Shozo Kanezaki, Toshinobu Ishihara, Hiroshi Tsumura
Exfoliated carbon nanofibers (ExCNFs) are expected to serve as excellent scaffolds for promoting and guiding bone-tissue regeneration. We aimed to enhance the effects of ExCNFs using bone morphogenetic proteins (BMPs) and examined their feasibility and safety in clinical applications using a rat spinal fusion model. Group I (n = 15) animals were implanted with the control carrier; Group II (n = 16) animals were implanted with carrier containing 1 μg ExCNFs; Group III (n = 16) animals were implanted with carrier containing 1 μg recombinant human (rh) BMP-2; and Group IV (n = 17) animals were implanted with carrier containing 1 μg rhBMP-2 and 1 μg ExCNFs...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29915186/bmp-and-wnt-signalling-cooperate-through-lef1-in-the-neuronal-specification-of-adult-hippocampal-neural-stem-and-progenitor-cells
#14
Tomás Armenteros, Zoraida Andreu, Rafael Hortigüela, D Chichung Lie, Helena Mira
Neuronal production from neural stem cells persists during adulthood in the subgranular zone of the hippocampal dentate gyrus. Extracellular signals provided by the hippocampal microenvironment regulate the neuronal fate commitment of the stem cell progeny. To date, the identity of those signals and their crosstalk has been only partially resolved. Here we show that adult rat hippocampal neural stem and progenitor cells (AH-NSPCs) express receptors for bone morphogenetic proteins (BMPs) and that the BMP/P-Smad pathway is active in AH-NSPCs undergoing differentiation towards the neuronal lineage...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29912360/expression-levels-of-brown-beige-adipocyte-related-genes-in-fat-depots-of-vitamin-a-restricted-fattening-cattle
#15
Hsuan-Ju Chen, Tsubasa Ihara, Hidetugu Yoshioka, Erina Itoyama, Shoko Kitamura, Hiroshi Nagase, Hiroaki Murakami, Yoichiro Hoshino, Masaru Murakami, Shozo Tomonaga, Tohru Matsui, Masayuki Funaba
Brown/beige adipocytes dissipate energy as heat. We previously showed that brown/beige adipocytes are present in white adipose tissue (WAT) of fattening cattle. The present study examined the effect of vitamin A restriction on mRNA expression of brown/beige adipocyte-related genes. In Japan, fattening cattle are conventionally fed a vitamin A-restricted diet to improve beef marbling. Twelve Japanese Black steers aged 10 months were fed control feed (n=6) or vitamin A-restricted feed (n=6) for 20 months. Subcutaneous WAT (scWAT) and mesenteric WAT (mesWAT) were collected, and mRNA expression levels of molecules related to function of brown/beige adipocytes (Ucp1, Cidea, Dio2, Cox7a and Cox8b) as well as transcriptional regulators related to brown/beige adipogenesis (Zfp516, Nfia, Prdm16, and Pgc-1α) were evaluated...
June 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29909342/fak-and-bmp-9-synergistically-trigger-osteogenic-differentiation-and-bone-formation-of-adipose-derived-stem-cells-through-enhancing-wnt-%C3%AE-catenin-signaling
#16
Cheng Yuan, Xiaoli Gou, Jiang Deng, Zhijun Dong, Peng Ye, Zhenming Hu
BACKGROUNDS: Adipose derived stem cells (ADSCs) could undergo osteogenesis via focal adhesion kinase (FAK) and bone morphogenetic protein (BMP) 9 signals, both of which could affect Wnt-β-catenin signal, a signal pathway closely related to ADSCs osteogenesis. It's still enigma whether FAK and BMP-9 contribute to osteogenesis. Here, we examined the effect of FAK on BMP9-inducedosteogenic differentiation, unveiled the possible molecular mechanism underling this process. METHODS: In the present study, ADSCs were isolated and purified, and cells of passage 3 underwent virus mediated transfection to prepare ADSCs with stable FAK shRNA expression...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29908283/mir-378-and-bmp-smad-can-influence-the-proliferation-of-sheep-myoblast
#17
Zengkui Lu, Lixin Du, Ruizao Liu, Ran Di, Liping Zhang, Youji Ma, Qing Li, Enmin Liu, Mingxing Chu, Caihong Wei
MicroRNA (miRNA) is a sort of endogenous ~20-25 nt non-coding RNAs, and it can regulate a variety of biological events. We found the miR-378 may involve in regulating the muscle development of sheep during our previous research. However, the molecular mechanism of miR-378 regulating myoblast proliferation is still unclear. In this research, we predicted that BMP2 (Bone morphogenetic protein 2) was the target gene of miR-378 and the BMP-Smad signal pathway that BMP2 participated in playing an important role in the muscle development...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29907876/in-vitro-evaluation-of-a-lentiviral-two-step-transcriptional-amplification-system-using-gal4ff-transactivator-for-gene-therapy-applications-in-bone-repair
#18
Sofia Bougioukli, Osamu Sugiyama, Ram K Alluri, Robert Yoho, Daniel A Oakes, Jay R Lieberman
In this study, we developed a lentiviral two-step transcriptional amplification (TSTA) system expressing bone morphogenetic protein-2 (BMP-2) under the control of a GAL4FF transactivator to enhance gene expression and limit toxicity for bone repair applications. To this end human MSCs, isolated from bone marrow or adipose tissue, were transduced overnight with a LV-TSTA system (GAL4FF or GAL4vp16) expressing BMP-2 or GFP and evaluated in vitro for transduction efficiency, mean fluorescence intensity, cell viability, and BMP-2 production...
June 15, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29907569/arginine-methylation-of-smad7-by-prmt1-in-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-and-epithelial-stem-cell-generation
#19
Yoko Katsuno, Jian Qin, Juan A Oses-Prieto, Hongjun Wang, Olan Jackson-Weaver, Tingwei Zhang, Samy Lamouille, Jian Wu, A L L Burlingame, Jian Xu, Rik Derynck
The epithelial-to-mesenchymal transdifferentiation (EMT) is crucial for tissue differentiation in development, and drives essential steps in cancer and fibrosis. EMT is accompanied by reprogramming of gene expression, and has been associated with the epithelial stem cell state in normal and carcinoma cells. The cytokine TGF-β drives this program in cooperation with other signaling pathways and through TGF-β-activated Smad3 as major effector. TGF-β-induced Smad3 activation is inhibited by Smad7 and to a lesser extent by Smad6, and Smad6 and Smad7 both inhibit Smad1 and Smad5 activation in response to the TGF-β-related bone morphogenetic proteins (BMPs)...
June 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29905970/neurexin-superfamily-cell-membrane-receptor-contactin-associated-protein-like-4-cntnap4-is-involved-in-neural-egfl-like-1-nell-1-responsive-osteogenesis
#20
Chenshuang Li, Zhong Zheng, Pin Ha, Xiaoyan Chen, Wenlu Jiang, Shan Sun, Feng Chen, Greg Asatrian, Emily A Berthiaume, Jong Kil Kim, Eric C Chen, Shen Pang, Xinli Zhang, Kang Ting, Chia Soo
Contactin-associated protein-like 4 (Cntnap4) is a member of the neurexin superfamily of transmembrane molecules that have critical functions in neuronal cell communication. Cntnap4 knockout mice display decreased presynaptic gamma-aminobutyric acid (GABA) and increased dopamine release that is associated with severe, highly penetrant, repetitive, and perseverative movements commonly found in human autism spectrum disorder patients. However, no known function of Cntnap4 has been revealed besides the nervous system...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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