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HMGA2

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https://www.readbyqxmd.com/read/28337375/hmga2-regulates-cd44-expression-to-promote-gastric-cancer-cell-motility-and-sphere-formation
#1
Junying Sun, Baocun Sun, Dongwang Zhu, Xiulan Zhao, Yanhui Zhang, Xueyi Dong, Na Che, Jing Li, Fang Liu, Nan Zhao, Danfang Zhang, Tieju Liu, Xian Lin
High mobility group AT-hook 2 (HMGA2) is a transcriptional modulator that mediates motility and self-renewal in cancer stem cells. Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC contains a population of stem-like cells that promote tumor invasion and resistance to therapy. In the current study, we investigated the expression of HMGA2 and the cancer stem cell marker CD44 in 200 GC samples and found that HMGA2 and CD44 were significantly associated with distant metastasis, histological differentiation and poor prognosis in GC patients...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28289824/a-mirna-signature-for-an-environmental-heterocyclic-amine-defined-by-a-multi-organ-carcinogenicity-bioassay-in-the-rat
#2
Ying-Shiuan Chen, Rong Wang, Wan-Mohaiza Dashwood, Christiane V Löhr, David E Williams, Emily Ho, Susanne Mertens-Talcott, Roderick H Dashwood
Heterocyclic amines (HCAs) produced during high-temperature cooking have been studied extensively in terms of their genotoxic/genetic effects, but recent work has implicated epigenetic mechanisms involving non-coding RNAs. Colon tumors induced in the rat by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) have altered microRNA (miRNA) signatures linked to dysregulated pluripotency factors, such as c-Myc and Krüppel-like factor 4 (KLF4). We tested the hypothesis that dysregulated miRNAs from PhIP-induced colon tumors would provide a "PhIP signature" for use in other target organs obtained from a 1-year carcinogenicity bioassay in the rat...
March 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28228139/hmga2-immunostaining-is-a-straightforward-technique-which-helps-to-distinguish-pulmonary-fat-forming-lesions-from-normal-adipose-tissue-in-small-biopsies-a-retrospective-observational-study-about-a-series-of-13-lung-biopsies
#3
Nicolas Piton, Émilie Angot, Florent Marguet, Jean-Christophe Sabourin
BACKGROUND: A tracheobronchial lesion observed during an endoscopic examination is usually sampled by the pulmonologist and sent to the pathologist for microscopic examination. Adipocytes may be observed in the lamina propria of tracheobronchial biopsies, which may complicate diagnosis of sampled lesions because these adipose cells may be part of the lesion (lipoma or pulmonary hamartoma), but may also be a normal component of the bronchial mucosa. Because endoscopic samples frequently miss their target, adipocytes observed in such biopsies usually lead to uncertainty regarding diagnosis...
February 23, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28222152/alteration-of-the-exdna-profile-in-blood-serum-of-llc-bearing-mice-under-the-decrease-of-tumour-invasion-potential-by-bovine-pancreatic-dnase-i-treatment
#4
Ludmila A Alekseeva, Nadezhda L Mironova, Evgenyi V Brenner, Alexander M Kurilshikov, Olga A Patutina, Marina A Zenkova
Taking into account recently obtained data indicating the participation of circulating extracellular DNA (exDNA) in tumorigenesis, enzymes with deoxyribonucleic activity have again been considered as potential antitumour and antimetastatic drugs. Previously, using murine Lewis lung carcinoma and hepatocellular carcinoma A1 tumour models, we have shown the antimetastatic activity of bovine DNase I, which correlates with an increase of DNase activity and a decrease of exDNA concentration in the blood serum of tumour-bearing mice...
2017: PloS One
https://www.readbyqxmd.com/read/28219208/-expression-and-clinical-significance-of-hmga2-in-renal-carcinoma
#5
Y Liu, Q Z Fu, L Pu, L L Song, G Y Lyu, J Liu, Zhenlong Wang, Ziming Wang
Objective: To detect the high mobility group A2 (HMGA2) expression in renal carcinoma, and to explore the relationship with clinicopathological features and its significance for prognosis. Methods: 50 renal carcinoma specimens, 50 corresponding adjacent normal kidney tissue samples, and 40 benign renal tumor specimens were used in this study. The expressions of HMGA2 mRNA and protein were detected by RT-PCR, Western blot and immunohistochemical assays, and its relationship with clinicopathological features and prognosis in the renal carcinoma patients was analyzed...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28169242/increased-expression-of-high-mobility-group-a2-a-novel-independent-indicator-of-poor-prognosis-in-patients-with-esophageal-squamous-cell-carcinoma
#6
Rongna Wei, Zhiqun Shang, Jing Leng, Lihong Cui
PURPOSE: Although high-mobility group A2 (HMGA2) protein has been reported to participate in cancer progression and metastasis, its clinical relationship with tumor invasion, lymph node metastasis, and prognosis in esophageal squamous cell carcinoma (ESCC) remains unclear. The purpose of this study is to analyze the clinical and prognostic significance of HMGA2 in ESCC patients after curative resection. MATERIALS AND METHODS: The expression of HMGA2 protein was evaluated by using immunohistochemistry in a tissue microarray (TMA) containing ESCC lesions and adjacent normal esophageal epithelial tissues from 96 patients who had undergone curative resection...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28159956/microrna-495-inhibits-gastric-cancer-cell-migration-and-invasion-possibly-via-targeting-high-mobility-group-at-hook-2-hmga2
#7
Huashe Wang, Zhipeng Jiang, Honglei Chen, Xiaobin Wu, Jun Xiang, Junsheng Peng
BACKGROUND Gastric cancer is one of the most common malignancies, and has a high mortality rate. miR-495 acts as a suppressor in some cancers and HMGA2 (high mobility group AT-hook 2) is a facilitator for cell growth and epithelial-mesenchymal transition (EMT), but little is known about their effect in gastric cancer. This study aimed to investigate the role and mechanism of miR-495 in gastric cancer. MATERIAL AND METHODS miR-495 levels were quantitatively analyzed in gastric cancer tissue and GES-1, SGC-7901, BGC-823, and HGC-27 cell lines by qRT-PCR...
February 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28152577/complementary-actions-of-dopamine-d2-receptor-agonist-and-anti-vegf-therapy-on-tumoral-vessel-normalization-in-a-transgenic-mouse-model
#8
Norbert Chauvet, Nicola Romanò, Chrystel Lafont, Anne Guillou, Evelyne Galibert, Xavier Bonnefont, Paul Le Tissier, Monica Fedele, Alfredo Fusco, Patrice Mollard, Nathalie Coutry
Angiogenesis contributes in multiple ways to disease progression in tumors and reduces treatment efficiency. Molecular therapies targeting Vegf signaling combined with chemotherapy or other drugs exhibit promising results to improve efficacy of treatment. Dopamine has been recently proposed to be a novel safe anti-angiogenic drug that stabilizes abnormal blood vessels and increases therapeutic efficacy. Here, we aimed to identify a treatment to normalize tumoral vessels and restore normal blood perfusion in tumor tissue with a Vegf receptor inhibitor and/or a ligand of dopamine G protein-coupled receptor D2 (D2R)...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28123643/gsk3%C3%AE-activity-is-essential-for-senescence-associated-heterochromatin-foci-sahf-formation-induced-by-hmga2-in-wi38-cells
#9
Xi Shi, Baoqing Tian, Chi Ma, Lingxia Liu, Na Zhang, Yuan Na, Jing Li, Jun Lu, Yuehua Qiao
Cellular senescence is an irreversible form of cell cycle arrest, which is often characterized by domains of facultative heterochromatin substructures also known as senescence-associated heterochromatin foci (SAHF). SAHF assembly is likely mediated through the downregulation of the Wnt pathway, which inhibits Glycogen Synthase Kinase 3 Beta (GSK3β) in cells undergoing replicative senescence. Alternatively, High Mobility Group AT-Hook 2 (HMGA2) can also induce SAHF formation in primary cells, through a process in which the involved cell signaling pathway is unknown...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28121923/identifying-key-stage-specific-genes-and-transcription-factors-for-gastric-cancer-based-on-rna-sequencing-data
#10
Yan Wang
BACKGROUND: To identify gastric cancer (GC)-associated genes and transcription factors (TFs) using RNA-sequencing (RNA-seq) data of Asians. MATERIALS AND METHODS: The RNA-seq data (GSE36968) were downloaded from Gene Expression Omnibus database, including 6 noncancerous gastric tissue samples, 5 stage I GC samples, 5 stage II GC samples, 8 stage III GC samples, and 6 stage IV GC samples. The gene expression values in each sample were calculated using Cuffdiff. Following, stage-specific genes were identified by 1-way analysis of variance and hierarchical clustering analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28119367/hmga2-foxl2-axis-regulates-metastases-and-epithelial-to-mesenchymal-transition-of-chemo-resistant-gastric-cancer
#11
Jiaqiang Dong, Rui Wang, Gui Ren, Xiaowei Li, Jingbo Wang, Yi Sun, Jie Liang, Yongzan Nie, Kaichun Wu, Bin Feng, Yulong Shang, Daiming Fan
Purpose Chemo-resistance is the main cause of treatment failure in cancer and is associated with distant metastases and epithelial-to-mesenchymal transition (EMT). This study aimed to explore the mechanism of metastases and EMT in chemo-resistant gastric cancer (GC). Experimental Design A key molecular pathway was identified via gene profiling and a bioinformatic analysis in a chemo-resistant GC model. The roles of FOXL2, HMGA2 and ITGA2 were validated via loss-of-function and gain-of-function experiments in vitro and in an orthotopic GC animal model...
January 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28057739/aberrant-let7a-hmga2-signaling-activity-with-unique-clinical-phenotype-in-jak2-mutated-myeloproliferative-neoplasms
#12
Chih-Cheng Chen, Jie-Yu You, Jrhau Lung, Cih-En Huang, Yi-Yang Chen, Yu-Wei Leu, Hsing-Ying Ho, Chian-Pei Li, Chang-Hsien Lu, Kuan-Der Lee, Chia-Chen Hsu, Jyh-Pyng Gau
High mobility group AT-hook 2 (HMGA2) is an architectural transcriptional factor that is negatively regulated by Let-7 microRNA through binding to its 3-untranslated region (3-UTR). Transgenic mice expressing HMGA2 with a truncation of its 3-UTR has been shown to exhibit a myeloproliferative phenotype. To decipher the Let-7-HMGA2 axis in myeloproliferative neoplasms (MPN), we employed an in vitro model supplemented with clinical correlation. Ba/F3 cells with inducible JAK2V617F expression (Ton.JAK2.V617F cells) showed up-regulation of HMGA2 with concurrent let-7a repression...
January 5, 2017: Haematologica
https://www.readbyqxmd.com/read/27986804/dwarfism-and-altered-craniofacial-development-in-rabbits-is-caused-by-a-12-1-kb-deletion-at-the-hmga2-locus
#13
Miguel Carneiro, Dou Hu, John Archer, Chungang Feng, Sandra Afonso, Congying Chen, José A Blanco-Aguiar, Hervé Garreau, Samuel Boucher, Paula G Ferreira, Nuno Ferrand, Carl-Johan Rubin, Leif Andersson
The dwarf phenotype characterizes the smallest of rabbit breeds and is governed largely by the effects of a single dwarfing allele with an incompletely dominant effect on growth. Dwarf rabbits typically weigh under 1 kg and have altered craniofacial morphology. The dwarf allele is recessive lethal and dwarf homozygotes die within a few days of birth. The dwarf phenotype is expressed in heterozygous individuals and rabbits from dwarf breeds homozygous for the wild-type allele are normal, although smaller when compared to other breeds...
February 2017: Genetics
https://www.readbyqxmd.com/read/27956228/genome-wide-crispr-screen-identifies-regulators-of-mitogen-activated-protein-kinase-as-suppressors-of-liver-tumors-in-mice
#14
Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela Park, Yotsawat Pomyen, Soren Hough, Zachary Kennedy, Andrew Fischer, Hao Yin, Daniel G Anderson, Darryl Conte, Lars Zender, Xin Wei Wang, Snorri Thorgeirsson, Zhiping Weng, Wen Xue
BACKGROUND & AIMS: It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing. METHODS: We performed a genome-wide CRISPR/Cas9-based knockout screen of P53-null mouse embryonic liver progenitor cells that overexpressed MYC. We infected p53(-/-);Myc;Cas9 hepatocytes with the mGeCKOa lentiviral library of 67,000 single-guide RNAs (sgRNAs), targeting 20,611 mouse genes, and transplanted the transduced cells subcutaneously into nude mice...
December 10, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27940362/stat3-stimulates-adipogenic-stem-cell-proliferation-and-cooperates-with-hmga2-during-the-early-stage-of-differentiation-to-promote-adipogenesis
#15
Yanyan Yuan, Yang Xi, Jiayi Chen, Pan Zhu, Jinyu Kang, Zuquan Zou, Fuyan Wang, Shizhong Bu
Signal transducer and activator of transcription 3 (STAT3) is abundantly expressed in the adipose tissue of obese mice and humans, but the role of STAT3 in adipogenesis is still not fully understood. In the present study, we discovered an activation of STAT3 during the early differentiation stage of mouse 3T3-L1 preadipocytes. Stat3 knockdown using siRNA blocked cell cycle progression of both preadipoctes and early differentiating cells. Moreover, accumulation of lipid droplets was inhibited by Stat3 knockdown...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27932890/high-expression-of-hmga2-predicts-poor-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#16
Ning Na, Tujie Si, Zhengyu Huang, Bin Miao, Liangqing Hong, Heng Li, Jiang Qiu, Jianguang Qiu
High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery. The expression of HMGA2 was evaluated retrospectively by immunohistochemistry (IHC) in 162 patients with ccRCC who underwent nephrectomy in 2003 and 2004...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27929737/long-noncoding-rna-hit000218960-promotes-papillary-thyroid-cancer-oncogenesis-and-tumor-progression-by-upregulating-the-expression-of-high-mobility-group-at-hook-2-hmga2-gene
#17
Tao Li, Xiao-Dong Yang, Chun-Xiang Ye, Zhan-Long Shen, Yang Yang, Bo Wang, Peng Guo, Zhi-Dong Gao, Ying-Jiang Ye, Ke-Wei Jiang, Shan Wang
Accumulating evidence suggests that long noncoding RNAs (lncRNAs) play an important role in oncogenesis and tumor progression. However, our knowledge of lncRNAs in thyroid cancer is still limited. To explore the crucial lncRNAs involved in oncogenesis of papillary thyroid cancer (PTC), we acquired data of differentially expressed lncRNAs between PTC tissues and paired adjacent noncancerous thyroid tissues through lncRNA microarray. In the microarray data, we observed that a newly identified lncRNA, HIT000218960, was significantly upregulated in PTC tissues and associated with a well-known oncogene, high mobility group AT-hook 2 (HMGA2) gene...
January 17, 2017: Cell Cycle
https://www.readbyqxmd.com/read/27928058/identification-of-senescence-associated-circular-rnas-sac-rnas-reveals-senescence-suppressor-circpvt1
#18
Amaresh C Panda, Ioannis Grammatikakis, Kyoung Mi Kim, Supriyo De, Jennifer L Martindale, Rachel Munk, Xiaoling Yang, Kotb Abdelmohsen, Myriam Gorospe
Using RNA sequencing (RNA-Seq), we compared the expression patterns of circular RNAs in proliferating (early-passage) and senescent (late-passage) human diploid WI-38 fibroblasts. Among the differentially expressed senescence-associated circRNAs (which we termed 'SAC-RNAs'), we identified CircPVT1, generated by circularization of an exon of the PVT1 gene, as a circular RNA showing markedly reduced levels in senescent fibroblasts. Reducing CircPVT1 levels in proliferating fibroblasts triggered senescence, as determined by a rise in senescence-associated β-galactosidase activity, higher abundance of CDKN1A/P21 and TP53, and reduced cell proliferation...
December 7, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27920151/lin28-is-induced-in-primed-embryonic-stem-cells-and-regulates-let-7-independent-events
#19
Silvia Parisi, Fabiana Passaro, Luigi Russo, Anna Musto, Angelica Navarra, Simona Romano, Giuseppe Petrosino, Tommaso Russo
Lin28 RNA-binding proteins play important roles in pluripotent stem cells, but the regulation of their expression and the mechanisms underlying their functions are still not definitively understood. Here we address the above-mentioned issues in the first steps of mouse embryonic stem cell (ESC) differentiation. We observed that the expression of Lin28 genes is transiently induced soon after the exit of ESCs from the naive ground state and that this induction is due to the Hmga2-dependent engagement of Otx2 with enhancers present at both Lin28 gene loci...
December 5, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27917442/polymorphisms-in-ten-candidate-genes-are-associated-with-conformational-and-locomotive-traits-in-spanish-purebred-horses
#20
Natalia Sevane, Susana Dunner, Ana Boado, Javier Cañon
The Spanish Purebred horses, also known as Andalusian horses, compete to the highest standards in international dressage events. Gait and conformation could be used as early selection criteria to detect young horses with promising dressage ability. Although the genetic background of equine size variation has been recently uncovered, the genetic basis of horse conformational and locomotive traits is not known, hampered by the complex genetic architecture underlying quantitative traits and the lack of phenotypic data...
December 5, 2016: Journal of Applied Genetics
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