keyword
https://read.qxmd.com/read/38468528/xylazine-an-abused-tranq-dope-and-its-safety-concern
#1
JOURNAL ARTICLE
Sumel Ashique
A drug called Xylazine has gained notoriety in recent times, earning the nickname "zombie drug" due to reported alarming effects on its users. Although Xylazine is primarily intended for veterinary use as a sedative and muscle relaxant for animals, there have been growing concerns about its misuse among humans, particularly in the context of illicit drug use. However, it is essential to rely on accurate and evidence-based information when discussing the health risks associated with any substance, rather than resorting to sensationalized terms like "zombie drug...
March 11, 2024: Current Drug Safety
https://read.qxmd.com/read/38461638/the-walking-dead-are-zombie-firms-environmentally-and-socially-responsible-a-global-perspective
#2
JOURNAL ARTICLE
Asad Iqbal Mashwani, Rizwan Mushtaq, Ammar Ali Gull, Asad Ali Rind
This study examines the association between zombie firms and their environmental and social performance. Using a global dataset of listed firms from 49 countries between 2002 and 2019, we find that zombie firms perform poorly on environmental and social responsibility fronts. This finding supports the argument that zombie firms are characterized by consistent losses and that their existence is risky without external support. Zombie firms, while struggling for survival, may not be able to undertake environmental and social activities that require huge investments, thus falling behind other firms...
March 9, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38446291/-inside-out-of-mind-alternative-realities-dementia-and-graphic-medicine
#3
JOURNAL ARTICLE
Laboni Das, Sathyaraj Venkatesan
Graphic medicine, an interdisciplinary field situated at the crossroads of comics and healthcare, operates as a medium through which the intricate nature of experiences with illness can be articulated, challenging orthodox medical dogmatism in an engaging and accessible way. Combining the affordances of comics and the narrative power of storytelling, graphic medicine elucidates the socio-cultural stigmatization of dementia influenced by a multitude of discourses. Diverging from existing discourses that depict individuals with Alzheimer's disease (AD) as zombies, brain-dead, or empty shells, graphic memoirs reconstruct these reductive notions and represent them as imaginative, productive, and perceptive...
March 6, 2024: Journal of Medical Humanities
https://read.qxmd.com/read/38364357/media-framing-xylazine-as-a-zombie-drug-is-amplifying-stigma-onto-people-who-use-drugs
#4
JOURNAL ARTICLE
Jeanette M Bowles, Elizabeth C Copulsky, Megan K Reed
Amid increasing efforts to understand xylazine-associated harms, examining the potentially catastrophic role of stigma resulting from media outlets framing xylazine as the "zombie drug" is imperative. Zombies are cinematically depicted as soulless, dangerous, and required to be killed off entirely for public safety, making the "zombie" analogy especially grave amid the fatal overdose crisis. Xylazine is called the "zombie drug" due to its heavy sedative effect and associated-severely infected skin ulcers. We surmise that wide-scale media framing of xylazine as the "zombie drug" has increased stigmas onto people who use drugs as their likening to zombies reifies subhuman status...
February 15, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38352984/attack-of-zombie-reviews-jbi-evidence-synthesis-editors-discuss-the-commentary-definition-harms-and-prevention-of-redundant-systematic-reviews
#5
JOURNAL ARTICLE
Cindy Stern, Sonia Hines, Jo Leonardi-Bee, Jason Slyer, Sally Wilson, Judith Carrier, Ning Wang, Edoardo Aromataris
No abstract text is available yet for this article.
February 14, 2024: JBI evidence synthesis
https://read.qxmd.com/read/38326435/nutritional-status-of-zombi-pea-vigna-vexillata-as-influenced-by-plant-density-and-deblossoming
#6
JOURNAL ARTICLE
Srija Priyadarsini, Alok Nandi, Maniyam Nedunchezhiyan, Pushpajeet Choudhari, Saurabh Singh, Ajoy Pattnaik
Feeding billions, a healthy and nutritious diet in the era of climate change is a major challenge before plant breeders, geneticists and agronomist. In this context, the continuous search for adaptive and nutritious crops could be a better alternative to combat the problems of hunger and malnutrition. The zombi pea, a nutritious and underutilized leguminous vegetable, is one of such better alternatives to feed billions a nutritious food besides being a potential gene source for breeding abiotic stress resistant varieties...
February 7, 2024: Scientific Reports
https://read.qxmd.com/read/38279587/allogeneic-zombie-cell-as-off-the-shelf-vaccine-for-postsurgical-cancer-immunotherapy
#7
JOURNAL ARTICLE
Bo Li, Ping Zhang, Junlin Li, Rui Zhou, Minglu Zhou, Chendong Liu, Xi Liu, Liqiang Chen, Lian Li
Allogeneic tumor cell vaccines provide off-the-shelf convenience but lack patient specificity due to heterogeneity in tumor antigens. Here, allogeneic tumor cell corpses are converted into "zombie cells" capable of assimilating heterogeneous tumor by seizing cancer cells and spreading adjuvant infection. This causes pseudo-oncolysis of tumors, transforming them into immunogenic targets for enhanced phagocytosis. It is shown that in postoperative tumor models, localized delivery of premade "zombie cells" through stepwise gelation in resection cavity consolidates tumor surgery...
January 26, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38275386/cellular-senescence-in-liver-cancer-how-dying-cells-become-zombie-enemies
#8
REVIEW
Aurora Gazzillo, Camilla Volponi, Cristiana Soldani, Michela Anna Polidoro, Barbara Franceschini, Ana Lleo, Eduardo Bonavita, Matteo Donadon
Liver cancer represents the fourth leading cause of cancer-associated death worldwide. The heterogeneity of its tumor microenvironment (TME) is a major contributing factor of metastasis, relapse, and drug resistance. Regrettably, late diagnosis makes most liver cancer patients ineligible for surgery, and the frequent failure of non-surgical therapeutic options orientates clinical research to the investigation of new drugs. In this context, cellular senescence has been recently shown to play a pivotal role in the progression of chronic inflammatory liver diseases, ultimately leading to cancer...
December 21, 2023: Biomedicines
https://read.qxmd.com/read/38238992/zombie-leaves-novel-repurposing-of-senescent-fronds-in-the-tree-fern-cyathea-rojasiana-in-a-tropical-montane-forest
#9
JOURNAL ARTICLE
James W Dalling, Evidelio Garcia, Carlos Espinosa, Camila Pizano, Astrid Ferrer, Jéssica Lira Viana
No abstract text is available yet for this article.
January 18, 2024: Ecology
https://read.qxmd.com/read/38201932/unique-bioactives-from-zombie-fungus-cordyceps-as-promising-multitargeted-neuroprotective-agents
#10
REVIEW
Himadri Sharma, Niti Sharma, Seong Soo A An
Cordyceps , also known as "zombie fungus", is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a "zombie". These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma...
December 27, 2023: Nutrients
https://read.qxmd.com/read/38190315/can-removal-of-zombie-cells-revitalize-the-aging-cardiovascular-system
#11
JOURNAL ARTICLE
Seyed Soheil Saeedi Saravi, Mark W Feinberg
No abstract text is available yet for this article.
January 8, 2024: European Heart Journal
https://read.qxmd.com/read/38187707/spatial-genomics-of-aavs-reveals-mechanism-of-transcriptional-crosstalk-that-enables-targeted-delivery-of-large-genetic-cargo
#12
Gerard M Coughlin, Máté Borsos, Nathan Appling, Bre'Anna H Barcelona, Acacia M H Mayfield, Elisha D Mackey, Rana A Eser, Xinhong Chen, Sripriya Ravindra Kumar, Viviana Gradinaru
UNLABELLED: Integrating cell type-specific regulatory elements (e.g. enhancers) with recombinant adeno-associated viruses (AAVs) can provide broad and efficient genetic access to specific cell types. However, the packaging capacity of AAVs restricts the size of both the enhancers and the cargo that can be delivered. Transcriptional crosstalk offers a novel paradigm for cell type-specific expression of large cargo, by separating distally-acting regulatory elements into a second AAV genome...
December 24, 2023: bioRxiv
https://read.qxmd.com/read/38179068/rearing-zombie-flies-laboratory-culturing-of-the-behaviourally-manipulating-fungal-pathogen-entomophthora-muscae
#13
JOURNAL ARTICLE
Sam Edwards, Henrik H De Fine Licht
Insect pathogenic fungi (IPF) and insects have ubiquitous interactions in nature. The extent of these interkingdom host-pathogen interactions are both complex and diverse. Some IPF, notably of the order Entomophthorales, manipulate their species-specific host before death. The fungus-induced altered insect behaviours are sequential and can accurately be repeatedly characterised temporally, making them a valuable model for understanding the molecular and chemical underpinnings of behaviour and host-pathogen co-evolutionary biology...
June 2024: MethodsX
https://read.qxmd.com/read/38074754/a-linguistic-analysis-of-dehumanization-toward-substance-use-across-three-decades-of-news-articles
#14
Salvatore Giorgi, Daniel Roy Sadek Habib, Douglas Bellew, Garrick Sherman, Brenda Curtis
INTRODUCTION: Substances and the people who use them have been dehumanized for decades. As a result, lawmakers and healthcare providers have implemented policies that subjected millions to criminalization, incarceration, and inadequate resources to support health and wellbeing. While there have been recent shifts in public opinion on issues such as legalization, in the case of marijuana in the U.S., or addiction as a disease, dehumanization and stigma are still leading barriers for individuals seeking treatment...
2023: Frontiers in Public Health
https://read.qxmd.com/read/38066183/how-to-slay-your-zombies
#15
A R Siders, Nicola Ulibarri, Amanda E Cravens, Rebecca L Nelson
No abstract text is available yet for this article.
December 8, 2023: Nature
https://read.qxmd.com/read/38059853/microbial-pathogens-at-the-movies
#16
JOURNAL ARTICLE
Manuel Sánchez-Angulo
Usually, show business depicts viruses, bacteria, and other microorganisms as one of the worse menaces to mankind. Entertainment movies influence the way audiences understand and perceive these topics. Few films accurately portray the science of microbiology and its social implications. Movies and TV series often feature outbreaks of deadly diseases and the efforts of scientists and medical professionals to contain them. But entertainment movies can also be used to educate the public about the importance and the impact that microorganisms have on our lives, helping to increase public awareness and appreciation of the world of microbiology...
December 6, 2023: FEMS Microbiology Letters
https://read.qxmd.com/read/38045062/orange-derived-extracellular-vesicles-nanodrugs-for-efficient-treatment-of-ovarian-cancer-assisted-by-transcytosis-effect
#17
JOURNAL ARTICLE
Feng Long, Yao Pan, Jinheng Li, Suinan Sha, Xiubo Shi, Haoyan Guo, Chuanqing Huang, Qian Xiao, Chao Fan, Xingmei Zhang, Jun-Bing Fan, Ying Wang
Extracellular vesicles (EVs) have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size, biocompatibility, and high stability. Herein, we demonstrate orange-derived extracellular vesicles (OEV) nanodrugs (DN@OEV) by modifying cRGD-targeted doxorubicin (DOX) nanoparticles (DN) onto the surface of OEV, enabling significantly enhancing tumor accumulation and penetration, thereby efficiently inhibiting the growth of ovarian cancer. The obtained DN@OEV enabled to inducement of greater transcytosis capability in ovarian cancer cells, which presented the average above 10-fold transcytosis effect compared with individual DN...
December 2023: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/37991156/zombie-cats-on-the-quantum-classical-frontier-wigner-moyal-and-semiclassical-limit-dynamics-of-quantum-coherence-in-molecules
#18
JOURNAL ARTICLE
Austin T Green, Craig C Martens
In this paper, we investigate the time evolution of quantum coherence-the off-diagonal elements of the density matrix of a multistate quantum system-from the perspective of the Wigner-Moyal formalism. This approach provides an exact phase space representation of quantum mechanics. We consider the coherent evolution of nuclear wavepackets in a molecule with two electronic states. For harmonic potentials, the problem is analytically soluble for both a fully quantum mechanical description and a semiclassical description...
November 28, 2023: Journal of Chemical Physics
https://read.qxmd.com/read/37969549/expression-of-trematode-induced-zombie-ant-behavior-is-strongly-associated-with-temperature
#19
JOURNAL ARTICLE
Simone Nordstrand Gasque, Brian Lund Fredensborg
Parasite-induced modification of host behavior increasing transmission to a next host is a common phenomenon. However, field-based studies are rare, and the role of environmental factors in eliciting host behavioral modification is often not considered. We examined the effects of temperature, relative humidity (RH), time of day, date, and an irradiation proxy on behavioral modification of the ant Formica polyctena (Förster, 1850) by the brain-encysting lancet liver fluke Dicrocoelium dendriticum (Rudolphi, 1819)...
2023: Behavioral Ecology
https://read.qxmd.com/read/37946493/-maladi-nanm-maladi-zonbi-maladi-lalin-a-qualitative-study-of-cultural-concepts-of-distress-in-northern-haiti
#20
JOURNAL ARTICLE
Michael Galvin, Guesly Michel, Edny Pierre, Eurine Manguira, Jude Mary Cénat
Cultural Concepts of Distress (CCDs) are culturally constructed diagnostic categories that exist within a specific society or culture. While several studies have assessed CCDs around the world, few studies have examined them in Haiti. This qualitative study examines manifestations of anxiety and depression via "sent spirits" in the form of maladi nanm ("Soul disorder") and maladi zonbi ("Zombie disorder"), and bipolar disorder in the form of maladi lalin ("Moon disorder"). Examples of CCDs were recorded as part of a study which interviewed 96 outpatients at the first mental health center in northern Haiti...
November 9, 2023: Transcultural Psychiatry
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