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https://www.readbyqxmd.com/read/28351091/plasma-betatrophin-levels-of-subjects-classified-with-normal-impaired-and-diabetic-glucose-tolerance-and-subjects-with-impaired-fasting-glucose
#1
Sibel Ozyazgan, Burak Onal, Eda Merve Kurtulus, Hafize Uzun, Gokhan Akkan, Dildar Konukoglu
This study was aimed to investigate whether betatrophin shows glucose intolerance or not. To access the plasma betatrophin levels after basal and glucose load, groups were classified as normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetic glucose tolerance (DGT) according to WHO 2012 criteria. An oral glucose tolerance test was performed on age-matched subjects (n=220) with a body mass index (BMI)<27 kg/m(2). Subjects were categorized as normoglycemic (n=55), IFG (n=50), IGT (n=60), and DM (n=55) according to the WHO criteria...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351089/leptin-and-its-receptors-in-human-placenta-of-small-adequate-and-large-for-gestational-age-newborns
#2
Maria-Luisa Lazo-de-la-Vega-Monroy, Martha I González-Domínguez, Silvio Zaina, Myrna Sabanero, Leonel Daza-Benítez, Juan Manuel Malacara, Gloria Barbosa-Sabanero
Alterations in birth weight impact postnatal outcome and adult metabolic health. Therefore, fetal growth regulation is crucial for preventing chronic metabolic diseases. Leptin has been suggested to play an important role in placental and fetal growth, albeit its specific mechanisms of action have not been elucidated. The aim of this study was to analyze leptin concentrations in placenta, cord blood, and maternal blood of SGA, AGA, and LGA (small, adequate and large for gestational age, respectively) newborns, as well as placental leptin receptor (LEPRa and LEPRb) protein expression...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351080/is-really-crocus-sativus-as-effective-as-citalopram-in-the-treatment-of-depression
#3
Konstantinos N Fountoulakis
No abstract text is available yet for this article.
March 28, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28351067/do-medical-students-narrative-representations-of-the-good-doctor-change-over-time-comparing-humanism-essays-from-a-national-contest-in-1999-and-2013
#4
Pooja C Rutberg, Brandy King, Elizabeth Gaufberg, Pamela Brett-MacLean, Perry Dinardo, Richard M Frankel
PURPOSE: To explore medical students' conceptions of "the good doctor" at two points in time separated by 14 years. METHOD: The authors conducted qualitative analysis of narrative-based essays. Following a constant comparative method, an emergent relational coding scheme was developed which the authors used to characterize 110 essays submitted to the Arnold P. Gold Foundation Humanism in Medicine Essay Contest in 1999 (n = 50) and 2013 (n = 60) in response to the prompt, "Who is the good doctor?" RESULTS: The authors identified five relational themes as guiding the day-to-day work and lives of physicians: doctor-patient, doctor-self, doctor-learner, doctor-colleague, and doctor-system/society/profession...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351059/sonographic-markers-in-the-prediction-of-fetal-complex-gastroschisis
#5
Walkyria S Andrade, Maria L Brizot, Agatha S Rodrigues, Ana C Tannuri, Vera L Krebs, Estela N Nishie, Rossana P V Francisco, Marcelo Zugaib
OBJECTIVE: To investigate the ultrasound (US) markers predictive of complex gastroschisis (CG), mortality, and morbidity in fetuses with gastroschisis. MATERIALS AND METHODS: This was a retrospective cohort study of 186 pregnancies with isolated fetal gastroschisis. Eight US markers were analyzed. The predictions and associations of US markers with CG, mortality, and morbidity were assessed. Combinations of US markers predictive of CG were investigated. RESULTS: Extra-abdominal bowel dilatation (EABD), intra-abdominal bowel dilatation (IABD), and polyhydramnios were predictive of CG...
March 29, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28351037/impact-of-laser-power-and-firing-angle-on-coagulation-efficiency-in-laser-treatment-for-twin-twin-transfusion-syndrome-an-ex-vivo-placenta-study
#6
Joost Akkermans, Loes van der Donk, Suzanne H P Peeters, Sjoerd van Tuijl, Johanna M Middeldorp, Enrico Lopriore, Dick Oepkes
OBJECTIVE: To assess the impact of laser power and firing angle on coagulation efficiency for closing placental anastomoses in the treatment of twin-twin transfusion syndrome. METHODS: We used an ex vivo blood-perfused human placenta model to compare time to complete coagulation using 30 vs. 50 W of neodymium-doped yttrium aluminum garnet laser power and using a firing angle of 90° vs. 45°. Placentas were perfused with pig blood at 5 mL/min. Differences were analyzed using independent-samples t test, Mann-Whitney U test, or χ2 test as appropriate...
March 29, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28351035/resting-state-functional-connectivity-changes-associated-with-visuospatial-cognitive-deficits-in-patients-with-mild-alzheimer-disease
#7
Rakesh Balachandar, Srikala Bharath, John P John, Himanshu Joshi, Shilpa Sadanand, Jitender Saini, Keshav J Kumar, Mathew Varghese
BACKGROUND/AIMS: Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive disconnection of various brain networks leading to neuropsychological impairment. Pathology in the visual association areas has been documented in presymptomatic AD and therefore we aimed at examining the relationship between brain connectivity and visuospatial (VS) cognitive deficits in early AD. METHODS: Tests for VS working memory, episodic memory and construction were used to classify patients with AD (n = 48) as having severe VS deficits (n = 12, female = 4) or mild deficits (n = 11, female = 4)...
March 29, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28351022/reference-values-and-factors-associated-with-musculoskeletal-symptoms-in-healthy-adolescents-and-adults
#8
Jennifer N Baldwin, Marnee J McKay, Niamh Moloney, Claire E Hiller, Elizabeth J Nightingale, Joshua Burns
BACKGROUND: Insufficient attention has been given to individuals who report musculoskeletal symptoms yet experience minimal disability. OBJECTIVES: To examine musculoskeletal symptoms among healthy individuals, and compare demographic, psychological and physical factors between individuals with and without symptoms. DESIGN: Cross-sectional observational study. METHOD: Data were from the 1000 Norms Project which recruited 1000 individuals aged 3-101 years...
March 23, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28351018/profiles-of-amino-acids-and-biogenic-amines-in-the-plasma-of-cri-du-chat-patients
#9
Danielle Zildeana Sousa Furtado, Fernando Brunale Vilela de Moura Leite, Cleber Nunes Barreto, Bernadete Faria, Leticia Dias Lima Jedlicka, Elisângela de Jesus Silva, Heron Dominguez Torres da Silva, Etelvino Jose Henriques Bechara, Nilson Antonio Assunção
Cri-du-chat syndrome (CDCS) is a rare innate disease attributed to chromosome 5p deletion characterized by a cat-like cry, craniofacial malformation, and altered behavior of affected children. Metabolomic analysis and a chemometric approach allow description of the metabolic profile of CDCS as compared to normal subjects. In the present work, UHPLC/MS was employed to analyze blood samples withdrawn from CDCS carriers (n=18) and normal parental subjects (n=18), all aged 0-34 years, aiming to set up a representative CDCS profile constructed from 33 targeted amino acids and biogenic amines...
March 21, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28351015/optimization-for-zeolite-regeneration-and-nitrogen-removal-performance-of-a-hypochlorite-chloride-regenerant
#10
Wei Zhang, Zhen Zhou, Ying An, Silu Du, Danian Ruan, Chengyue Zhao, Ning Ren, Xiaoce Tian
Simultaneous zeolites regeneration and nitrogen removal were investigated by using a mixed solution of NaClO and NaCl (NaClO-NaCl solution), and effects of the regenerant on ammonium removal performance and textural properties of zeolites were analyzed by long-term adsorption and regeneration operations. Mixed NaClO-NaCl solution removed more NH4(+) exchanged on zeolites and converted more of them to nitrogen than using NaClO or NaCl solution alone. Response surface methodological analysis indicated that molar ratio of hypochlorite and nitrogen (ClO(-)/N), NaCl concentration and pH value all had significant effects on zeolites regeneration and NH4(+) conversion to nitrogen, and the optimum condition was obtained at ClO(-)/N of 1...
March 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28351009/the-influence-of-citrate-and-oxalate-on-99-tc-vii-cs-np-v-and-u-vi-sorption-to-a-savannah-river-site-soil
#11
D Montgomery, K Barber, N Edayilam, K Oqujiuba, S Young, T Biotidara, A Gathers, M Danjaji, N Tharayil, N Martinez, B Powell
Batch sorption experiments were conducted with 0.5-50 ppb (99)Tc, (133)Cs, (237)Np and U in the presence and absence of citrate and/or oxalate in a 25 g/L Savannah River Site (SRS) soil suspension. Citrate and oxalate were the ligands of choice due to their relevancy to plant exudates, the nuclides were selected for their wide range of biogeochemical behavior, and the soil from SRS was selected as a model Department of Energy (DOE) site soil. Batch samples were continually mixed on a rotary shaker and maintained at a pH of approximately 5...
March 25, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28351004/temporal-changes-in-the-prevalence-of-disordered-eating-behaviors-among-adolescents-living-in-the-metropolitan-area-of-rio-de-janeiro-brazil
#12
Danilo Dias Santana, Erica Guimarães Barros, Rosana Salles da Costa, Gloria Valeria da Veiga
To investigate temporal changes in the prevalence of disordered eating behaviors among adolescents, and their association with socio demographic factors and overweight. Using probability sampling, two population-based cross-sectional surveys were conducted: one in 2005 (n=511) and the other in 2010 (n=314). The frequency of disordered eating behaviors (binge eating, strict dieting or fasting and compensatory behaviors) was investigated using a self-administered questionnaire. The presence of binge eating increased by 18...
March 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28350991/serum-proteases-potentiate-bmp-induced-cell-cycle-re-entry-of-dedifferentiating-muscle-cells-during-newt-limb-regeneration
#13
Ines Wagner, Heng Wang, Philipp M Weissert, Werner L Straube, Anna Shevchenko, Marc Gentzel, Goncalo Brito, Akira Tazaki, Catarina Oliveira, Takuji Sugiura, Andrej Shevchenko, András Simon, David N Drechsel, Elly M Tanaka
Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic proteins (BMPs) and mature BMPs that have been further cleaved by serum proteases induce cell cycle entry by dedifferentiating newt muscle cells. Protease-activated BMP4/7 heterodimers that are present in serum strongly induced myotube cell cycle re-entry with protease cleavage yielding a 30-fold potency increase of BMP4/7 compared with canonical BMP4/7...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350977/small-bowel-obstruction-caused-by-anisakis-and-meckel-s-diverticulum-a-rare-case
#14
G Carbotta, R Laforgia, Michele Milella, M G Sederino, M Minafra, F Fortarezza, D Piscitelli, N Palasciano
INTRODUCTION: Anisakiasis is a parasitic infection caused by the ingestion of raw fish contaminated by larval nematodes of Anisakis species. Intestinal or extraintestinal manifestations are rated to > 4% and >1% respectively. PRESENTATION OF CASE: A 61-year old patient was admitted to our General Surgical and Emergency Unit because of sudden abdominal pain, vomit and constipation. He had eaten raw fish 3 days before admission. Laboratory data showed high levels of WBC and PCR...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350976/neuroendocrine-tumor-of-the-common-bile-duct-case-report
#15
C Raspanti, N Falco, V Silvestri, G Rotolo, S Bonventre, G Gulotta
Neuroendocrine tumors (NET) are a very heterogeneous group of neoplasms; in recent years we have seen an increase in their incidence (3.65 /100.000/year). They can be associated with hereditary endocrine syndromes (MEN, Von Hippel Lindau); they can occur at any age and the incidence is slightly higher in men than women. The aetiology of the neuroendocrine tumors is unclear; in most cases, inflammation of the bile ducts may be the underlying cause and for this reason, the initial patient's evaluation should be focused on the different aspects concerning the oncological one and the possible sequelae of the biliary obstructions that can evolve in biliary sepsis...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350975/long-lasting-postoperative-ileus-after-surgery-for-intestinal-obstruction-due-to-left-paraduodenal-hernia-lpdh-case-report
#16
A Volpi, P Ialongo, A Panebianco, R Lozito, A Prestera, R Laforgia, C Punzo, N Palasciano
Left paraduodenal hernia is a rare congenital anomaly which arises from an error of rotation of the midgut; sometimes can be responsible for intestinal occlusion, that require surgery. In many cases of literature a prompt diagnosis and therapy reduced morbidity and mortality and almost all patients were discharged on 4th or 5th postoperative day (POD). We report a case of a 59 years old patient who underwent surgery for intestinal obstruction due to a massive left paraduodeneal hernia, that had a very long period (20 days) of postoperative ileus...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350973/is-it-really-useful-the-harmonic-scalpel-in-axillary-dissection-for-locally-advanced-breast-cancer-a-case-series
#17
G Militello, P De Marco, N Falco, K Kabhuli, A Mascolino, L Licari, R Tutino, G Cocorullo, G Gulotta
BACKGROUND: The seroma is one of the most common complications in the axillary lymph nodal dissection (different surgical approaches have been tried to reduce the seroma incidence). In our study we evaluate the outcome of patients using or not the ultrasonic scalpel (Harmonic scalpel) according to a standardized surgical technique. PATIENTS AND METHODS: From January 2011 to December 2015 120 patients underwent axillary dissection for breast cancer. Patients were divided in two groups: patients belonging to the first group underwent Harmonic scalpel dissection and patients belonging to the second group underwent classical dissection...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350972/open-sphincter-preserving-surgery-of-extraperitoneal-rectal-cancer-without-primary-stoma-and-fast-track-protocol
#18
G Pappalardo, S Coiro, F De Lucia, A Giannella, F Ruffolo, F M Frattaroli
AIM: Fast track protocol (FTP) showed to improve perioperative care. The study aims to evaluate the impact of the FTP in the open extraperitoneal rectal cancer (ERC) surgical treatment without a primary derivative stoma (DS) and the QoL in patients with or without a secondary DS. PATIENTS AND METHODS: 50 patients affected by ERC were enrolled and operated on with open low anterior resection without a primary DS. They were randomized in two groups: one was treated perioperativelly in the traditional way (group T), the other using a modif ed FTP (group FT)...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350970/mannheim-peritonitis-index-mpi-and-elderly-population-prognostic-evaluation-in-acute-secondary-peritonitis
#19
G Salamone, L Licari, N Falco, G Augello, R Tutino, S Campanella, G Guercio, G Gulotta
INTRODUCTION: Acute Secondary Peritonitis due to abdominal visceral perforation is characterized by high mortality and morbidity risk. Risk stratification allows prognosis prediction to adopt the best surgical treatment and clinical care support therapy. In Western countries elderly people represent a significant percentage of population Aim. Evaluation of Mannheim Peritonitis Index (MPI) and consideration upon old people. PATIENTS AND METHODS: Retrospective study on 104 patients admitted and operated for "Acute Secondary Peritonitis due to visceral perforation"...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350948/bending-the-cost-curve-establishing-value-in-spine-surgery
#20
Scott L Parker, Silky Chotai, Clinton J Devin, Lindsay Tetreault, Thomas E Mroz, Darrel S Brodke, Michael G Fehlings, Matthew J McGirt
BACKGROUND: As publically promoted by all stakeholders in health care reform, prospective outcomes registry platforms lie at the center of all current evidence-driven value-based models. OBJECTIVE: To demonstrate the variability in outcomes and cost at population level and individual patient level for patients undergoing spine surgery for degenerative diseases. METHODS: Retrospective analysis of prospective longitudinal spine registry data was conducted...
March 1, 2017: Neurosurgery
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