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https://www.readbyqxmd.com/read/29475102/predictors-of-benzodiazepine-use-in-a-transdiagnostic-sample-of-panic-disorder-social-anxiety-disorder-and-obsessive-compulsive-disorder-patients
#1
Luana D Laurito, Carla P Loureiro, Rafaela V Dias, Paula Vigne, Gabriela B de Menezes, Rafael C Freire, Ulrich Stangier, Leonardo F Fontenelle
We investigated the rates of current and past benzodiazepine (BZD) use in a sample of 102 subjects attending specialized anxiety disorder clinics, including panic disorder (PD; N = 36), social anxiety disorder (SAD; N = 28) and obsessive-compulsive disorder (OCD; N = 38) patients. Almost 56% of the entire sample was using BZDs at the moment of the assessment, and 74.5% described having used them at some point during their lifetimes. The duration of psychiatric treatment and a lifetime history of PD, but not any other "transdiagnostic" measure of severity (such as the Panic and Agoraphobia Scale, the Social Phobia Inventory, the Dimensional Obsessive-Compulsive Scale, the Anxiety Sensitivity Index-36, and the Beck Inventories) were independent risk factors for current prescription of BZDs...
February 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29473781/prediction-of-depression-and-anxiety-via-patient-assessed-tremor-severity-not-physician-reported-motor-symptom-severity-in-patients-with-parkinson-s-disease-or-essential-tremor-who-have-undergone-deep-brain-stimulation
#2
Rebecca L Achey, Erin Yamamoto, Daniel Sexton, Christine Hammer, Bryan S Lee, Robert S Butler, Nicolas R Thompson, Sean J Nagel, Andre G Machado, Darlene A Lobel
OBJECTIVE Deep brain stimulation (DBS) is an effective therapy for movement disorders such as idiopathic Parkinson's disease (PD) and essential tremor (ET). However, some patients who demonstrate benefit on objective motor function tests do not experience postoperative improvement in depression or anxiety, 2 important components of quality of life (QOL). Thus, to examine other possible explanations for the lack of a post-DBS correlation between improved objective motor function and decreased depression or anxiety, the authors investigated whether patient perceptions of motor symptom severity might contribute to disease-associated depression and anxiety...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29473112/a-study-of-sensory-dysregulation-in-children-with-tic-disorders
#3
Hana Weisman, Shula Parush, Alan Apter, Silvana Fennig, Noa Benaroya-Milshtein, Tamar Steinberg
Disrupted somatosensory processing characterized by over- or under- responsiveness to environmental stimuli plays an important, yet often overlooked, role in typical development and is aberrant in various neurodevelopmental disorders. These dysfunctional somatosensory processes have been conceptualized as an entity termed somatosensory dysregulation (SMD). Since Tourette syndrome (TS) is a prototypical example of developmental psychopathological disorder, we hypothesised that SMD would be a feature found in children suffering from the disorder...
February 23, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29471423/predictive-models-of-cognitive-fatigue-in-multiple-sclerosis
#4
Jason A Berard, Andra M Smith, Lisa A S Walker
Objective: Cognitive fatigue (CF) can be defined as decreased performance with sustained cognitive effort. The present study examined the interrelatedness of disease severity, fatigue, depression, and sleep quality in order to evaluate their predictive roles of CF in MS. Four theoretical models examining these variables were assessed. Methods: Fifty-eight individuals with a diagnosis of MS were recruited. CF was measured by examining last third versus first third performance on the Paced Auditory Serial Addition Test (PASAT)...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29471022/temporal-lobe-epilepsy-induced-neurodegeneration-and-cognitive-deficits-implications-for-aging
#5
REVIEW
Vrinda M, Arun S, Srikumar B N, Bindu M Kutty, Shankaranarayana Rao B S
Epilepsy is a neurological condition associated with seizures, neurodegeneration, circuit reorganization, and other structural and functional abnormalities. These elements ultimately lead to behavioural alterations such as anxiety, depression, and importantly cognitive impairment like learning disability and memory impairment. These factors can attribute to acceleration of aging and cognitive impairment in middle-aged people, which is otherwise evident in dementia and Alzheimer's disease among elderly people...
February 19, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29470472/ethnic-and-sex-related-differences-in-pain-characteristics-psychological-distress-and-pain-related-disability-in-patients-attending-a-new-zealand-teaching-hospital-pain-service
#6
Andrea Burri, David Rice, Nicola Kluger, Michal Kluger
AIM: The aim of the present observational study was to provide a description of the demographic, psychological and pain characteristics of patients attending the Waitemata Pain Services (WPS), Auckland, New Zealand. METHOD: Data were collected via a comprehensive paper-pencil questionnaire handed out to 798 consecutive new patients seen at the WPS over a four-year period. RESULTS: 32.3% attending the WPS were men and 67.7% women, with a mean age of 52...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29470092/the-stroop-test-as-a-measure-of-performance-validity-in-adults-clinically-referred-for-neuropsychological-assessment
#7
Laszlo A Erdodi, Sanya Sagar, Kristian Seke, Brandon G Zuccato, Eben S Schwartz, Robert M Roth
This study was designed to develop performance validity indicators embedded within the Delis-Kaplan Executive Function Systems (D-KEFS) version of the Stroop task. Archival data from a mixed clinical sample of 132 patients (50% male; MAge = 43.4; MEducation = 14.1) clinically referred for neuropsychological assessment were analyzed. Criterion measures included the Warrington Recognition Memory Test-Words and 2 composites based on several independent validity indicators. An age-corrected scaled score ≤6 on any of the 4 trials reliably differentiated psychometrically defined credible and noncredible response sets with high specificity (...
February 22, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29467497/altered-taok2-activity-causes-autism-related-neurodevelopmental-and-cognitive-abnormalities-through-rhoa-signaling
#8
Melanie Richter, Nadeem Murtaza, Robin Scharrenberg, Sean H White, Ole Johanns, Susan Walker, Ryan K C Yuen, Birgit Schwanke, Bianca Bedürftig, Melad Henis, Sarah Scharf, Vanessa Kraus, Ronja Dörk, Jakob Hellmann, Zsuzsa Lindenmaier, Jacob Ellegood, Henrike Hartung, Vickie Kwan, Jan Sedlacik, Jens Fiehler, Michaela Schweizer, Jason P Lerch, Ileana L Hanganu-Opatz, Fabio Morellini, Stephen W Scherer, Karun K Singh, Froylan Calderon de Anda
Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 is one of several genes in the 16p11.2 microdeletion region, but whether it contributes to NDDs is unknown. We performed behavioral analysis on Taok2 heterozygous (Het) and knockout (KO) mice and found gene dosage-dependent impairments in cognition, anxiety, and social interaction. Taok2 Het and KO mice also have dosage-dependent abnormalities in brain size and neural connectivity in multiple regions, deficits in cortical layering, dendrite and synapse formation, and reduced excitatory neurotransmission...
February 21, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29467308/comparing-the-antiseizure-and-neuroprotective-efficacy-of-ly293558-diazepam-caramiphen-and-ly293558-caramiphen-combination-against-soman-in-a-rat-model-relevant-to-the-pediatric-population
#9
James P Apland, Vassiliki Aroniadou-Anderjaska, Taiza H Figueiredo, Volodymyr I Pidoplichko, Katia Rossetti, Maria F M Braga
The currently FDA-approved anticonvulsant for the treatment of status epilepticus (SE) induced by nerve agents is the benzodiazepine diazepam. However, diazepam does not appear to offer neuroprotective benefits. This is particularly concerning with respect to the protection of children, because in the developing brain, synaptic transmission mediated via GABAA receptors, the target of diazepam, is still weak. In the present study, we exposed 21-day-old male rats to 1.2xLD50 soman, and compared the antiseizure, anti-lethality, and neuroprotective efficacy of diazepam (10 mg/kg), LY293558 (an AMPA/GluK1 receptor antagonist; 15 mg/kg), caramiphen (an antimuscarinic with NMDA receptor-antagonistic properties; 50 mg/kg), and LY293558 (15 mg/kg)+caramiphen (50 mg/kg), administered 1 h post-exposure...
February 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29466546/association-of-hidradenitis-suppurativa-with-body-image
#10
Sylke Schneider-Burrus, Agata Jost, Eva Milena Johanna Peters, Ellen Witte-Haendel, Wolfram Sterry, Robert Sabat
Importance: Hidradenitis suppurativa (HS) leads to disfigurement and painful eruptions in terminal hair follicles of the intertriginous skin, mainly of axillary, genitofemoral, and perianal sites. It is associated with an excessive impairment of quality of life, psychiatric disorders, and sexual distress. Body image impairment has been linked to depression and anxiety and has been described for some dermatologic disorders but has not yet been investigated in patients with HS. Objectives: To investigate whether body image is diminished in patients with HS and whether disease severity, age at onset, disease duration, obesity, depression, and anxiety are linked to body image impairment...
February 21, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29465354/self-reported-childhood-maltreatment-lifelong-traumatic-events-and-mental-disorders-in-american-and-israeli-rheumatoid-arthritis-patients
#11
Rona Merdler-Rabinowicz, Ayal Hassidim, Raneen Hellou, Ilan Merdler, Winfried Hauser, Jacob N Ablin
OBJECTIVES: Psychological stress is thought to play a major role in the development and exacerbation of autoimmune diseases in general, as well as in rheumatoid arthritis (RA) in particular. The aims of the current study are to compare retrospective self-reports of childhood maltreatment and lifetime major life/traumatic experiences of American and Israeli RA patients, using standardised instruments, while adjusting for concomitant mental disorders and psychological distress, in order to rule out their part in the subjective reports, thus addressing the trans-cultural robustness of the association between childhood maltreatment, traumatic experiences and RA...
February 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29464577/behavioral-consequences-of-children-with-sleep-disordered-breathing-after-adenotonsillectomy
#12
Ji Yoon Kim, Chang Ho Lee, Hyoung-Mi Kim
BACKGROUND: Adenotonsillectomy (AT) has been an effective treatment for sleep-disordered breathing (SDB) in children, and several studies described the risk of postoperative weight gain and obesity in children treated with AT. The present study aimed to evaluate behavioral improvements in children with SDB one year after adenotonsillectomy and to investigate an influence of postoperative weight gain on behaviors. METHODS: The study included 170 children aged 5-11 years who underwent adenotonsillectomy for SDB and 150 controls...
February 20, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29464188/glycine-receptor-modulating-antibody-predicting-treatable-stiff-person-spectrum-disorders
#13
Shannon R Hinson, A Sebastian Lopez-Chiriboga, James H Bower, Joseph Y Matsumoto, Anhar Hassan, Eati Basal, Vanda A Lennon, Sean J Pittock, Andrew McKeon
Background: Glycine receptor alpha-1 subunit (GlyRα1)-immunoglobulin G (IgG) is diagnostic of stiff-person syndrome (SPS) spectrum but has been reported detectable in other neurologic diseases for which significance is less certain. Methods: To assess GlyRα1-IgGs as biomarkers of SPS spectrum among patients and controls, specimens were tested using cell-based assays (binding [4°C] and modulating [antigen endocytosing, 37°C]). Medical records of seropositive patients were reviewed...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29463384/the-evaluation-of-depression-in-multiple-sclerosis-using-the-newly-proposed-multiple-sclerosis-depression-rating-scale
#14
U Palm, M A Chalah, A Créange, J-P Lefaucheur, S S Ayache
Fatigue and depression are frequent symptoms in multiple sclerosis (MS). Both are overlapping and shadowing each other and may impair the quality of life. For detection of depression symptoms in MS, the Multiple Sclerosis Depression Rating Scale (MSDRS) has been proposed recently. Here, we compare the performance of MSDRS in MS patients with and without fatigue to that of established rating scales, i.e. Hospital Anxiety and Depression Scale and Beck Depression Inventory. Twenty-nine MS patients were screened for fatigue and depression symptoms...
February 17, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29463164/apolipoprotein-e-apoe-%C3%AE%C2%B54-genotype-is-associated-with-elevated-psychiatric-distress-in-veterans-with-a-history-of-mild-to-moderate-traumatic-brain-injury
#15
Victoria C Merritt, Alexandra L Clark, Scott F Sorg, Nicole D Evangelista, Madeleine Werhane, Mark W Bondi, Dawn M Schiehser, Lisa Delano-Wood
Since few studies have examined the relationship between the APOE gene and clinical outcomes following military-related traumatic brain injury (TBI), we aimed to determine whether the ε4 allele of the APOE gene influences neuropsychiatric symptoms in Veterans with a history of mild to moderate TBI. Participants included 133 Veterans (TBI=79, military controls [MC]=54) who underwent APOE genotyping and were divided into ε4+ (TBI=18, MC=15) and ε4- (TBI=61, MC=39) groups. All participants underwent evaluation of psychological distress using the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and PTSD Checklist-Military Version (PCL-M)...
February 20, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29463132/long-term-metabolic-cage-housing-increases-anxiety-depression-related-behaviours-in-adult-male-rats
#16
Zafer Sahin, Hatice Solak, Aynur Koc, Raviye Ozen Koca, Alpaslan Ozkurkculer, Pinar Cakan, Zulfikare Isik Solak Gormus, Selim Kutlu, Haluk Kelestimur
There are several reports on unfavourable effects of metabolic cage housing on animal welfare mainly due to the characteristic structures of these cages such as single housing and grid flooring. This study was aimed to compare the effects of long-term metabolic cage housing and conventional housing (normal grouped housing in standard cages) on the anxiety/depression-like behaviours in male rats. Anxiety/depression-related behaviours were evaluated by use of forced swimming test and open field test. Swimming and climbing were significantly lower and immobility duration higher in the metabolic cage group...
February 20, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29462503/efficacy-of-a-spanish-language-self-administered-stress-management-training-intervention-for-latinas-undergoing-chemotherapy
#17
Aasha I Hoogland, Suzanne C Lechner, Brian D Gonzalez, Brent J Small, Dinorah M Tyson, Yasmin Asvat, Anna Barata, Maria F Gomez, Yvelise Rodriguez, Heather S L Jim, Michael H Antoni, Paul B Jacobsen, Cathy D Meade
BACKGROUND: Cancer patients often report increased stress during chemotherapy. Stress management training has been shown to reduce this adverse outcome, but few interventions exist for Spanish-speaking Hispanic and Latina women (Latinas). METHODS: Following community feedback (including focus groups/in-depth interviews), we transcreated the Spanish-Language Self-Administered Stress Management Training (SL-SAT) intervention based on our previously developed and implemented English-based intervention...
February 20, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29462222/cross-sectional-survey-of-the-burden-of-illness-of-rosacea-by-erythema-severity
#18
Julie Harper, James Q Del Rosso, Ilia L Ferrusi
Rosacea is a chronic skin condition characterized by persistent central facial erythema. To explore the burden of illness of rosacea in US adults, a cross-sectional web-based survey was conducted. Participants answered questions on sociodemographics, clinical characteristics, bothersome symptoms, coping and avoidance behaviors, self-perceptions, and health care resource utilization, and completed 2 quality of life instruments, the 21-item rosacea-specific quality of life questionnaire (RosaQoL) and the 36-item Short Form Health Survey (SF-36)...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29462110/strain-differences-in-the-susceptibility-to-the-gut-brain-axis-and-neurobehavioural-alterations-induced-by-maternal-immune-activation-in-mice
#19
Livia H Morais, Daniela Felice, Anna V Golubeva, Gerard Moloney, Timothy G Dinan, John F Cryan
There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher susceptibility to neurodevelopmental abnormalities. The maternal immune activation (MIA) rodent model is a valuable tool for elucidating the basis of this interaction. We induced MIA with polyinosinic-polycytidylic acid (poly I:C) at gestational day 12...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29461908/improving-early-palliative-care-with-a-scalable-stepped-peer-navigator-and-social-work-intervention-a-single-arm-clinical-trial
#20
David B Bekelman, Rachel Johnson-Koenke, Daniel W Bowles, Stacy M Fischer
BACKGROUND: Patients with cancer could benefit from early primary (i.e., basic) palliative care. Scalable models of care delivery are needed. OBJECTIVE: Examine the feasibility of a stepped peer navigator and social work intervention developed to improve palliative care outcomes. DESIGN: Single-arm prospective clinical trial. The peer navigator educated patients to advocate for pain and symptom management with their healthcare providers, motivated patients to pursue advance care planning, and discussed the role of hospice...
February 20, 2018: Journal of Palliative Medicine
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