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https://www.readbyqxmd.com/read/29053831/effect-of-dietary-fiber-levels-on-performance-gizzard-development-intestinal-morphology-and-nutrient-utilization-in-meat-ducks-from-1-to-21-days-of-age
#1
H Y Han, K Y Zhang, X M Ding, S P Bai, Y H Luo, J P Wang, Q F Zeng
The objective of this experiment was to determine the effects of dietary fiber levels on growth performance, gizzard development, intestinal morphology, and nutrient utilization in Cherry Valley meat ducks. In total, 720 1-day-old ducklings were fed with starter diets (120 ducklings, 8 pens of 15 ducklings, on each diet) containing 6 levels of crude fiber (CF, 1.46, 3.09, 4.15, 6.18, 7.52, and 9.03%, based on analysis) for 21 d. Then, on d 22, ducks fed all of the starter diets were transferred to a grower diet (containing 4% CF) to examine the residual effect of starter dietary fiber levels until 35 d...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053713/a-longitudinal-study-of-facial-growth-of-southern-chinese-in-hong-kong-comprehensive-photogrammetric-analyses
#2
Yi Feng Wen, Hai Ming Wong, Colman Patrick McGrath
INTRODUCTION: Existing studies on facial growth were mostly cross-sectional in nature and only a limited number of facial measurements were investigated. The purposes of this study were to longitudinally investigate facial growth of Chinese in Hong Kong from 12 through 15 to 18 years of age and to compare the magnitude of growth changes between genders. METHODS AND FINDINGS: Standardized frontal and lateral facial photographs were taken from 266 (149 females and 117 males) and 265 (145 females and 120 males) participants, respectively, at all three age levels...
2017: PloS One
https://www.readbyqxmd.com/read/29053618/the-application-of-ultra-high-performance-liquid-chromatography-coupled-with-a-ltq-orbitrap-mass-technique-to-reveal-the-dynamic-accumulation-of-secondary-metabolites-in-licorice-under-aba-stress
#3
Da Li, Guojie Xu, Guangxi Ren, Yufeng Sun, Ying Huang, Chunsheng Liu
The traditional medicine licorice is the most widely consumed herbal product in the world. Although much research work on studying the changes in the active compounds of licorice has been reported, there are still many areas, such as the dynamic accumulation of secondary metabolites in licorice, that need to be further studied. In this study, the secondary metabolites from licorice under two different methods of stress were investigated by ultra-high-performance liquid chromatography coupled with hybrid linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MS)...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29053285/upper-bound-on-diffusivity
#4
Thomas Hartman, Sean A Hartnoll, Raghu Mahajan
The linear growth of operators in local quantum systems leads to an effective light cone even if the system is nonrelativistic. We show that the consistency of diffusive transport with this light cone places an upper bound on the diffusivity: D≲v^{2}τ_{eq}. The operator growth velocity v defines the light cone, and τ_{eq} is the local equilibration time scale, beyond which the dynamics of conserved densities is diffusive. We verify that the bound is obeyed in various weakly and strongly interacting theories...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29052944/differential-expression-of-the-three-alcanivorax-borkumensis-sk2-genes-coding-for-the-p450-cytochromes-involved-in-the-assimilation-of-hydrocarbons
#5
Emma Sevilla, Luis Yuste, Renata Moreno, Fernando Rojo
Alcanivorax borkumensis, a marine bacterium highly specialized in degrading linear and branched alkanes, plays a key ecological role in the removal of marine oil spills. It contains several alternative enzyme systems for terminal hydroxylation of alkanes, including three P450 cytochromes (P450-1, P450-2 and P450-3). The present work shows cytochrome P450-1 to be expressed from the promoter of the upstream gene fdx. Promoter Pfdx was more active when C8 -C18 n-alkanes or pristane were assimilated than when pyruvate was available...
October 20, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29051600/prediction-of-treatment-response-for-combined-chemo-and-radiation-therapy-for-non-small-cell-lung-cancer-patients-using-a-bio-mathematical-model
#6
Changran Geng, Harald Paganetti, Clemens Grassberger
The goal of this work was to develop a mathematical model to predict Kaplan-Meier survival curves for chemotherapy combined with radiation in Non-Small Cell Lung Cancer patients for use in clinical trial design. The Gompertz model was used to describe tumor growth, radiation effect was simulated by the linear-quadratic model with an α/β-ratio of 10, and chemotherapy effect was based on the log-cell kill model. To account for repopulation during treatment, we considered two independent methods: 1) kickoff-repopulation using exponential growth with a decreased volume doubling time, or 2) Gompertz-repopulation using the gradually accelerating growth rate with tumor shrinkage...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051317/expression-and-prognostic-significance-of-ect2-in-invasive-breast-cancer
#7
Hong-Kun Wang, Jian-Fang Liang, Hui-Xia Zheng, Hong Xiao
AIMS: To investigate the expression of epithelial cell transforming sequence 2 (ECT2) in invasive breast cancer and its prognostic significance. METHODS: ECT2 immunohistochemical detection was performed in 165 breast cancer specimens and 100 normal control tissues. Univariable and multivariable Cox proportional hazards regression model analysis was used to confirm independent prognostic factors. The PHREG procedure linear hypotheses testing method was used to analyse survival data...
October 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29050239/application-of-in-vivo-imaging-techniques-to-monitor-therapeutic-efficiency-of-plx4720-in-an-experimental-model-of-microsatellite-instable-colorectal-cancer
#8
Sarah Rohde, Tobias Lindner, Stefan Polei, Jan Stenzel, Luise Borufka, Sophie Achilles, Eric Hartmann, Falko Lange, Claudia Maletzki, Michael Linnebacher, Änne Glass, Sarah Marie Schwarzenböck, Jens Kurth, Alexander Hohn, Brigitte Vollmar, Bernd Joachim Krause, Robert Jaster
OBJECTIVES: Patient-derived tumor cell lines are a powerful tool to analyze the sensitivity of individual tumors to specific therapies in mice. An essential prerequisite for such an approach are reliable quantitative techniques to monitor tumor progression in vivo. METHODS: We have employed HROC24 cells, grown heterotopically in NMRI Foxn1(nu) mice, as a model of microsatellite instable colorectal cancer to investigate the therapeutic efficiencies of 5'-fluorouracil (5'-FU) and the mutant BRAF inhibitor PLX4720, a vemurafenib analogue, by three independent methods: external measurement by caliper, magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-((18)F)fluoro-D-glucose ((18)F-FDG)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049437/progression-of-stargardt-disease-as-determined-by-fundus-autofluorescence-in-the-retrospective-progression-of-stargardt-disease-study-progstar-report-no-9
#9
Rupert W Strauss, Beatriz Muñoz, Alexander Ho, Anamika Jha, Michel Michaelides, Artur V Cideciyan, Isabelle Audo, David G Birch, Amir H Hariri, Muneeswar G Nittala, SriniVas Sadda, Sheila West, Hendrik P N Scholl
Importance: Sensitive outcome measures for disease progression are needed for treatment trials of Stargardt disease. Objective: To describe the yearly progression rate of atrophic lesions in the retrospective Progression of Stargardt Disease study. Design, Setting, and Participants: A multicenter retrospective cohort study was conducted at tertiary referral centers in the United States and Europe. A total of 251 patients aged 6 years or older at baseline, harboring disease-causing variants in ABCA4 (OMIM 601691), enrolled in the study from 9 centers between August 2, 2013, and December 12, 2014; of these patients, 215 had at least 2 gradable fundus autofluorescence images with atrophic lesion(s) present in at least 1 eye...
October 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29048563/linear-discriminant-analysis-reveals-differences-in-root-architecture-in-wheat-seedlings-related-to-nitrogen-uptake-efficiency
#10
Kim Kenobi, Jonathan A Atkinson, Darren M Wells, Oorbessy Gaju, Jayalath G De Silva, M John Foulkes, Ian L Dryden, Andrew T A Wood, Malcolm J Bennett, Miriam Gifford
Root architecture impacts water and nutrient uptake efficiency. Identifying exactly which root architectural properties influence these agronomic traits can prove challenging. In this paper, approximately 300 wheat (Triticum aestivum) plants were divided into four groups using two binary classifications, high versus low nitrogen uptake efficiency (NUpE), and high versus low nitrate in the growth medium. The root system architecture for each wheat plant was captured using 16 quantitative variables. The multivariate analysis tool, linear discriminant analysis, was used to construct composite variables, each a linear combination of the original variables, such that the score of the plants on the new variables showed the maximum between-group variability...
October 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29046057/bile-duct-ligature-in-young-rats-a-revisited-animal-model-for-biliary-atresia
#11
Matias Garrido, Camila Escobar, Constanza Zamora, Carolina Rejas, Juan Varas, Mario Párraga, Sebastian San Martin, Sandra Montedónico
Biliary atresia leads to cirrhosis in the vast majority of patients and constitutes the first cause of paediatric liver transplantation. Animal models allow us to understand the molecular basis and natural history of diseases. The aim of this study is to describe a surgically created animal model of biliary atresia with emphasis in long-term liver function. Forty-two 3-week-old Sprague-Dawley rats were randomly divided into two groups: bile duct ligature (BDL) and control. The animals were sacrificed on the 2nd, 4th, and 6th postoperative weeks...
September 13, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29043046/among-tree-variability-and-feedback-effects-result-in-different-growth-responses-to-climate-change-at-the-upper-treeline-in-the-swiss-alps
#12
Matthias Jochner, Harald Bugmann, Magdalena Nötzli, Christof Bigler
Upper treeline ecotones are important life form boundaries and particularly sensitive to a warming climate. Changes in growth conditions at these ecotones have wide-ranging implications for the provision of ecosystem services in densely populated mountain regions like the European Alps. We quantify climate effects on short- and long-term tree growth responses, focusing on among-tree variability and potential feedback effects. Although among-tree variability is thought to be substantial, it has not been considered systematically yet in studies on growth-climate relationships...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29042227/pathogenetic-insights-from-quantification-of-the-cerebriform-connective-tissue-nevus-in-proteus-syndrome
#13
Neera R Nathan, Rachna Patel, Molly M Crenshaw, Marjorie J Lindhurst, Cara Olsen, Leslie G Biesecker, Kim M Keppler-Noreuil, Thomas N Darling
BACKGROUND: The plantar cerebriform connective tissue nevus (CCTN) is the most common and problematic cutaneous manifestation of Proteus syndrome. OBJECTIVE: To gain insights into CCTN pathogenesis and natural history. METHODS: The size and location of plantar CCTN was measured on 152 images from 22 individuals with Proteus syndrome by two independent, blinded reviewers. Average measures of plantar CCTN were transformed into a linear mixed model to estimate proportionate change in size with age...
October 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29039197/the-influence-of-the-grain-size-on-the-properties-of-ch3nh3pbi3-thin-films
#14
Oleksandra Shargaieva, Felix Lang, Joerg Rappich, Thomas Dittrich, Manuela Klaus, Matthias Meixner, Christoph Genzel, Norbert H Nickel
Hybrid perovskites have already shown a huge success as an absorber in solar cells, resulting in the skyrocketing rise of power conversion efficiency to more than η = 22%. Recently, it has been established that the crystal quality is one of the most important parameters to obtain devices with high efficiencies. However, the influence of the crystal quality on the material properties is not fully understood. Here, the influence of the morphology on electronic properties of CH3NH3PbI3 thin-films is investigated...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29038330/can-growth-hormone-treatment-improve-growth-in-children-with-severe-growth-failure-due-to-anorexia-nervosa-a-preliminary-pilot-study
#15
Juliane Leger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Catherine Doyen, Emmanuel Ecosse, Jean-Claude Carel, Marie-France Le Heuzey
BACKGROUND/AIMS: Growth failure is a difficult, but key aspect of care in children with anorexia nervosa (AN). The effects of hGH therapy have not been studied. The aim was to investigate the effect of hGH treatment on height velocity (HV) in children with AN. METHODS: We carried out a retrospective observational study. Ten girls diagnosed with AN at 10.0±1.9 years, with prolonged severe growth failure (HV <2.5 cm/year for at least 18 months) at the age of 13...
October 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29037382/influences-of-dietary-lipid-and-temperature-on-growth-fat-deposition-and-lipoprotein-lipase-expression-in-darkbarbel-catfish-pelteobagrus-vachellii
#16
Jun Qiang, Yi-Fan Tao, Jie He, Jin-Wen Bao, Hong-Xia Li, Wen-Bo Shi, Pao Xu, Yi-Lan Sun
Darkbarbel catfish (Pelteobagrus vachellii) is an important freshwater fish in China. Water temperature greatly influences the absorption and utilization of dietary lipid by fish. Response values (including growth, hepatic fat deposition, and gene expression) for darkbarbel catfish mediated by two factors (water temperature 20-34°C; dietary lipid level 2-17%) were the focus of this study. The relationship between the two factors and the response values was evaluated by the response surface method using the central composite design...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29036551/comparative-study-of-the-growth-and-nutritional-status-of-brazilian-and-nigerian-school-aged-children-with-sickle-cell-disease
#17
Samuel A Adegoke, Maria S Figueiredo, Adekunle D Adekile, Josefina A P Braga
Background: Comparative studies of patients in different sociogeographic/ecological zones may unravel potential environmental and nutritional factors influencing disease phenotype. In sickle cell disease (SCD), differential access to comprehensive care may influence their growth and nutritional status. Methods: From June 2015 to February 2016, steady-state nutritional parameters of 109 Brazilian and 95 Nigerian children with SCD attending routine clinic visits at Universidade Federal de São Paulo, Brazil and Obafemi Awolowo University Teaching Hospital, Ile-Ife (Ilesa unit), respectively, were compared...
September 28, 2017: International Health
https://www.readbyqxmd.com/read/29036196/understanding-the-antimicrobial-activity-of-selected-disinfectants-against-methicillin-resistant-staphylococcus-aureus-mrsa
#18
Ebrahim Aboualizadeh, Violet V Bumah, Daniela S Masson-Meyers, Janis T Eells, Carol J Hirschmugl, Chukuka S Enwemeka
Disinfectants and biocidal products have been widely used to combat Methicillin-resistant Staphylococcus aureus (MRSA) infections in homes and healthcare environments. Although disruption of cytoplasmic membrane integrity has been documented as the main bactericidal effect of biocides, little is known about the biochemical alterations induced by these chemical agents. In this study, we used Fourier transform infrared (FT-IR) spectroscopy and chemometric tools as an alternative non-destructive technique to determine the bactericidal effects of commonly used disinfectants against MRSA USA-300...
2017: PloS One
https://www.readbyqxmd.com/read/29034935/hedgehog-mesenchyme-gene-signature-identifies-bi-modal-prognosis-in-luminal-and-basal-breast-cancer-sub-types
#19
Wandaliz Torres-García, Maribella Domenech
Hedgehog signaling (Hh) has been shown to be hyper-activated in several cancers. However, active Hh signaling can promote or inhibit tumor growth; thus identification of markers beyond main canonical Hh target genes is needed to improve patient selection and clinical outcome in response to Hh inhibitors. Cancer-associated fibroblasts (CAFs) have been linked with tumor progression and beneficial response to Hh inhibitors. Thus, we hypothesized that genes associated with Hh-activated CAFs can be used for stratification of tumors that will benefit from Hh inhibitors...
October 16, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/29033377/proposed-treatment-paradigm-for-intracranial-chondrosarcomas-based-on-multidisciplinary-coordination
#20
Da Li, Jian-Cong Weng, Gui-Jun Zhang, Shu-Yu Hao, Jie Tang, Li-Wei Zhang, Liang Wang, Zhen Wu, Wang Jia, Jun-Ting Zhang
OBJECTIVES: There was no consensus regarding the treatment of intracranial chondrosarcoma (CSA). The study aimed to evaluate the adverse factors for progression-free survival (PFS) and overall survival (OS), and propose a treatment strategy for CSA. METHODS: The clinical chart and radiographic data of 106 consecutive cases (mesenchymal and conventional CSA in 18 and 88 patients, respectively) of surgically treated CSAs were retrospectively reviewed. RESULTS: Gross total resection was achieved in 43 patients (40...
October 12, 2017: World Neurosurgery
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