S Mazher Hussain, Leighton F Reed, Bradley A Krasnick, Gustavo Miranda-Carboni, Ryan C Fields, Ye Bi, Abul Elahi, Abidemi Ajidahun, Paxton V Dickson, Jeremiah L Deneve, William G Hawkins, David Shibata, Evan S Glazer
The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation. In order to understand the role of IL23, an interleukin associated with macrophage polarization, we investigated IL23 in the context of TGF-ß expression in PDAC. We hypothesized that IL23 expression is associated with metastatic development and survival in PDAC. We investigated IL23 and TGF-ß protein expression on resected PDAC patient tumor sections who were divided into short-term (<12 months) survivors and long-term (>30 months) survivors...
April 11, 2018: Scientific Reports