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https://www.readbyqxmd.com/read/28323987/fibroblast-growth-factor-23-mineral-metabolism-and-adiposity-in-normal-kidney-function
#1
Sarah Zaheer, Ian H de Boer, Matthew Allison, Jenifer M Brown, Bruce M Psaty, Cassianne Robinson-Cohen, Erin D Michos, Joachim H Ix, Bryan Kestenbaum, David Siscovick, Anand Vaidya
Context: Obesity is associated with poor bone mineralization and quality. Fibroblast growth factor 23 (FGF23) plays an important role in calcium, phosphate, and skeletal physiology. Objective: To test the hypothesis that greater adiposity results in higher FGF23 levels among individuals with normal estimated glomerular filtration rate (eGFR). Design, Setting, Participants: Cross-sectional analyses among participants of the Multi-Ethnic Study of Atherosclerosis with eGFR ≥60 mL/min/1...
January 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323960/fgf23-is-not-associated-with-age-related-changes-in-phosphate-but-enhances-renal-calcium-reabsorption-in-girls
#2
Deborah M Mitchell, Harald Jüppner, Sherri-Ann M Burnett-Bowie
Context: Fibroblast growth factor 23 (FGF23) is a critical determinant of phosphate homeostasis. The role of FGF23, however, in regulating physiologic changes in serum phosphate and renal phosphate handling across childhood is not well-described. In addition, animal models have suggested a role for FGF23 in regulating renal calcium excretion. Objective: To assess changes in FGF23 concentrations across childhood in relation to changes in mineral ions and hormones of mineral ion homeostasis...
January 31, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323917/gh-treatment-in-children-with-prader-willi-syndrome-3-years-longitudinal-data-in-prepubertal-children-and-adult-height-data-from-kigs-database
#3
N E Bakker, A Lindberg, J Heissler, H A Wollmann, C Camacho-Hübner, A C Hokken-Koelega
Context: Longitudinal data of children with Prader-Willi syndrome (PWS) treated with Genotropin were registered in Pfizer-International-Growth-Database (KIGS). Objective: Evaluate efficacy and safety of GH-treatment in a unique large group of children with PWS. Design: Longitudinal data registered in KIGS, from 1987-2012. Setting: Worldwide retrospective cohort study. Patients: 522 prepubertal children treated with GH for 3 years and 173 children who had reached adult height...
February 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323913/accrual-of-bone-mass-in-children-and-adolescents-with-cystic-fibrosis
#4
Sonakshi Sharma, Mirjana Jaksic, Sheryl Fenwick, Catherine Byrnes, Tim Cundy
Context: Low bone density is a recognised complication of cystic fibrosis (CF). Hypothesis: Accrual of bone mass is most impaired in the sickest children, as judged by nutritional status and pulmonary function. Design: Retrospective analysis of correlation between lumbar spine BMD, BMI and FEV1 z-score in children and adolescents with CF. Setting: Specialist CF service at a pediatric hospital. Patients: 60 participants aged 5...
February 22, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323889/towards-a-critical-evaluation-of-an-empirical-and-volume-based-solvation-function-for-ligand-docking
#5
Heloisa S Muniz, Alessandro S Nascimento
Molecular docking is an important tool for the discovery of new biologically active molecules given that the receptor structure is known. An excellent environment for the development of new methods and improvement of the current methods is being provided by the rapid growth in the number of proteins with known structure. The evaluation of the solvation energies outstands among the challenges for the modeling of the receptor-ligand interactions, especially in the context of molecular docking where a fast, though accurate, evaluation is ought to be achieved...
2017: PloS One
https://www.readbyqxmd.com/read/28323413/designing-morphology-in-epitaxial-silicon-nanowires-the-role-of-gold-surface-chemistry-and-phosphorus-doping
#6
Seokhyoung Kim, David J Hill, Christopher W Pinion, Joseph D Christesen, James R McBride, James F Cahoon
Vertically-aligned semiconductor nanowires (NWs) have many potential applications for NW-based technologies, ranging from solar cells to intracellular sensors. Aligned NWs can be fabricated by top-down etching of planar wafers or synthesized from the bottom-up using the vapor-liquid-solid (VLS) mechanism to induce epitaxial growth on lattice-matched substrates. The VLS process permits the modulation of dopants along the NW growth axis, which, if combined with dopant-dependent wet-chemical etching, can be used to encode precise morphology...
March 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28319904/sensitivity-enhancement-of-graphene-zinc-oxide-nanocomposite-based-electrochemical-impedance-genosensor-for-single-stranded-rna-detection
#7
Sze Shin Low, Hwei-San Loh, Jian Sheng Boey, Poi Sim Khiew, Wee Siong Chiu, Michelle T T Tan
An efficient electrochemical impedance genosensing platform has been constructed based on graphene/zinc oxide nanocomposite produced via a facile and green approach. Highly pristine graphene was synthesised from graphite through liquid phase sonication and then mixed with zinc acetate hexahydrate for the synthesis of graphene/zinc oxide nanocomposite by solvothermal growth. The as-synthesised graphene/zinc oxide nanocomposite was characterised with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy and X-ray diffractometry (XRD) to evaluate its morphology, crystallinity, composition and purity...
February 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319746/predicting-biphasic-responses-in-binary-mixtures-pelargonic-acid-versus-glyphosate
#8
Regina G Belz, Hans-Peter Piepho
Predicting hormesis in mixtures is challenging, but essential considering that chemical exposures often occur in mixtures and at low doses. This study investigated mixture effects with two herbicides prone to induce hormesis and to interact, namely pelargonic acid versus glyphosate. Five independent mixture experiments were conducted in vitro to assess effects on root growth of lettuce. Mixture effects on the dose were analyzed using classical joint-action models in terms of deviation from the reference model of concentration addition...
March 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319661/atomistic-insights-into-nucleation-and-formation-of-hexagonal-boron-nitride-on-ni-from-first-principles-based-reactive-molecular-dynamics-simulations
#9
Song Liu, Adri C T van Duin, Diana M van Duin, Bin Liu, James H Edgar
Atomistic-scale insights into the growth of a continuous, atomically thin hexagonal boron nitride (hBN) lattice from elemental boron and nitrogen on Ni substrates were obtained from multi-scale modeling combining density functional theory (DFT) and reactive molecular dynamics (rMD). The quantum mechanical calculations focused on the adsorption and reaction energetics for the hBN building-block species, i.e., atomic B, N, BxNy (x, y = 1-2), on Ni(111) and Ni(211), and the diffusion pathways of elemental B and N on these slab model surfaces and in the sublayer...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28318888/characterization-of-the-lung-parenchyma-using-ultrasound-multiple-scattering
#10
Kaustav Mohanty, John Blackwell, Thomas Egan, Marie Muller
The purpose of the study described here was to showcase the application of ultrasound to quantitative characterization of the micro-architecture of the lung parenchyma to predict the extent of pulmonary edema. The lung parenchyma is a highly complex and diffusive medium for which ultrasound techniques have remained qualitative. The approach presented here is based on ultrasound multiple scattering and exploits the complexity of ultrasound propagation in the lung structure. The experimental setup consisted of a linear transducer array with an 8-MHz central frequency placed in contact with the lung surface...
March 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28318259/ammonia-borane-clusters-energetics-of-dihydrogen-bonding-cooperativity-and-role-of-electrostatics
#11
Kunduchi Periya Vijayalakshmi, Cherumuttathu H Suresh
Cluster formation of ammonia borane (NH3BH3) driven by non-covalent H...H dihydrogen interaction is investigated at M06L/6-311+G(d,p) level density functional theory. For clusters containing up to six monomers, ladder, cyclic, stacked, cross-stacked, end-on, mixed and hexagonal configurations have been screened for their energetic stability. In the dimer, 7.94 kcal/mol stabilization energy per monomer (E(m)) is observed. Compared to ladder and cyclic configurations, a tetramer consisting of stacked dimer units is more stable by 3...
March 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28316275/central-growth-factor-loaded-depots-in-bone-tissue-engineering-scaffolds-for-enhanced-cell-attraction
#12
Mandy Quade, Sven Knaack, Ashwini Rahul Akkineni, Anastasia Gabrielyan, Anja Lode, Angela Roesen-Wolff, Michael Gelinsky
Tissue engineering, i.e. the application of stem and progenitor cells in combination with an engineered extracellular matrix, is a promising strategy for bone regeneration. However, its success is limited by the lack of vascularization after implantation. The concept of in situ tissue engineering envisages the recruitment of cells necessary for tissue regeneration from the host environment foregoing ex vivo cell seeding of the scaffold. In this study, we developed a novel scaffold system for enhanced cell attraction which is based on biomimetic mineralized collagen scaffolds equipped with a central biopolymer depot loaded with chemotactic agents...
March 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28315890/evidence-for-the-effects-of-complementary-feeding-interventions-on-the-growth-of-infants-and-young-children-in-low-and-middle-income-countries
#13
Rebecca A Heidkamp
As momentum for investment in early childhood nutrition grows, so does the evidence base for the effectiveness of interventions to improve complementary feeding in low- and middle-income countries (LMIC), where the risk of early growth faltering is high. The aim of this chapter is to review the current state of the evidence for the impact of two categories of interventions (nutrition education alone and provision of food or nutrient supplements with or without education) on linear and ponderal growth of children aged 6-23 months in LMIC...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28315809/identifying-attendance-patterns-in-a-smoking-cessation-treatment-and-their-relationships-with-quit-success
#14
Jolene Jacquart, Santiago Papini, Michelle L Davis, David Rosenfield, Mark B Powers, Georita M Frierson, Lindsey B Hopkins, Scarlett O Baird, Bess H Marcus, Timothy S Church, Michael W Otto, Michael J Zvolensky, Jasper A J Smits
BACKGROUND: While important for substance use outcomes, knowledge about treatment attendance patterns, and their relation with clinical outcomes is limited. We examined the association between attendance patterns and smoking outcomes in a randomized, controlled smoking cessation intervention trial. METHODS: In addition to standard smoking cessation treatment, participants were randomized to 15 weeks of an exercise intervention (n=72) or an education control condition (n=64)...
March 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28315698/worldwide-demography-of-centenarians
#15
REVIEW
Jean-Marie Robine, Sarah Cubaynes
The global number of centenarians should strongly increase during the 21 st century. According to the Population Division of the United Nations it should reach more than 25 million people in 2100. To better understand the dynamics of the emergence and growth of the centenarian population, we focused on four European countries having long chronological series and high quality data about centenarians, Denmark, France, Sweden, and Switzerland, and Japan which has had the highest life expectancy at birth for several years...
March 15, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28314990/an-apparent-clinical-pharmacokinetic-drug-drug-interaction-between-bevacizumab-and-the-anti-placental-growth-factor-monoclonal-antibody-ro5323441-via-a-target-trapping-mechanism
#16
Ka Wang, Franziska Schaedeli Stark, Tilman Schlothauer, Angelika Lahr, Valerie Cosson, Jianguo Zhi, Kai Habben, Jean Tessier, Eginhard Schick, Roland F Staack, Oliver Krieter
PURPOSE: RO5323441 is a humanized anti-placental growth factor (PlGF) monoclonal antibody that has shown preclinical activity in several cancer models. The objective of this analysis is to examine the pharmacokinetic (PK) results from four Phase I studies that have been conducted with RO5323441 (n = 61) and to report an apparent drug-drug interaction observed when RO5323441 was administered in combination with bevacizumab. METHODS: The four Phase I studies were a multiple-ascending dose study in 23 patients with solid tumors (Study 1), an open-label study in seven patients with colorectal/ovarian cancer (Study 2), a sorafenib combination study in nine patients with hepatocellular carcinoma (Study 3), and a bevacizumab combination study in 22 patients with recurrent glioblastoma (Study 4)...
March 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28314842/performance-of-mid-treatment-breast-ultrasound-and-axillary-ultrasound-in-predicting-response-to-neoadjuvant-chemotherapy-by-breast-cancer-subtype
#17
Rosalind P Candelaria, Roland L Bassett, William Fraser Symmans, Maheshwari Ramineni, Stacy L Moulder, Henry M Kuerer, Alastair M Thompson, Wei Tse Yang
BACKGROUND: The primary objective was to determine whether mid-treatment ultrasound measurements of index breast tumors and index axillary nodes of different cancer subtypes associate with residual cancer burden (RCB). METHODS: Patients with invasive breast cancer who underwent neoadjuvant chemotherapy and had pre-treatment and mid-treatment breast and axillary ultrasound were included in this single-institution, retrospective cohort study. Linear regression analysis assessed associations between RCB with (a) change in index breast tumor size, (b) change in index node size, and (c) absolute number of abnormal nodes at mid-treatment...
March 17, 2017: Oncologist
https://www.readbyqxmd.com/read/28306299/graviton-mass-might-reduce-tension-between-early-and-late-time-cosmological-data
#18
Antonio De Felice, Shinji Mukohyama
The standard cold dark matter model with a cosmological constant (Λ-CDM) predicts a growth of structures which tends to be higher than the values of redshift space distortion (RSD) measurements if the cosmological parameters are fixed by the cosmic microwave background data. In this Letter, we point out that this discrepancy can be resolved or understood if we assume that the graviton has a small but nonzero mass. In the context of the minimal theory of massive gravity (MTMG), due to infrared Lorentz violations measurable only at present cosmological scales, the graviton acquires a mass without being haunted by unwanted extra degrees of freedom...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28303556/serum-fibroblast-growth-factor-1-is-associated-with-the-decreased-risk-of-obesity-in-human
#19
Jinzhou Zhu, Yuming Wang, Kefu Zhu, Jianguo Gao, Xingyong Wan, Xunlei Pang, Sujuan Fei
As a transducer of PPARγ signaling, recent evidence supports that fibroblast growth factor 1 (FGF1) mediates adipose tissue remodeling and insulin sensitivity. This study is to assess the role of serum FGF1 in obesity. A hospital-based case-control study of 154 subjects was conducted. Serum level of FGF1 was measured by enzyme-linked immunosorbent assay. The serum level of FGF1 in the lean (119.0 [103.1-146.1] pg/ml) was higher than it in the subjects with overweight/obesity (111.9 [80.3-127.4] pg/ml, P=0...
March 16, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28303422/efficacy-of-the-fun-for-wellness-online-intervention-to-promote-multidimensional-well-being-a-randomized-controlled-trial
#20
Nicholas D Myers, Isaac Prilleltensky, Ora Prilleltensky, Adam McMahon, Samantha Dietz, Carolyn L Rubenstein
Subjective well-being refers to people's level of satisfaction with life as a whole and with multiple dimensions within it. Interventions that promote subjective well-being are important because there is evidence that physical health, mental health, substance use, and health care costs may be related to subjective well-being. Fun For Wellness (FFW) is a new online universal intervention designed to promote growth in multiple dimensions of subjective well-being. The purpose of this study was to provide an initial evaluation of the efficacy of FFW to increase subjective well-being in multiple dimensions in a universal sample...
March 16, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
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