keyword
https://read.qxmd.com/read/38531068/real-world-effectiveness-of-ustekinumab-in-ulcerative-colitis-in-a-united-states-multicenter-cohort-consortium
#21
JOURNAL ARTICLE
Andres J Yarur, Ryan Ungaro, Katherine Huang, Wenfei Wang, Priya Sasankan, Mir Zulqarnain, Amanda M Johnson, Geoffrey Bader, Carl Kay, Nicholas Costable, David Dulaney, Marc Fenster, Poonam Beniwal-Patel, Gaurav Syal, Anish Patel, Edward Loftus, Joel Pekow, Benjamin Cohen, Parakkal Deepak
BACKGROUND: Pivotal trials have shown that ustekinumab is effective in ulcerative colitis (UC). However, the population included in these trials do not represent the cohort of patients treated in the real world. In this study, we aimed to describe the effectiveness and safety of ustekinumab in a clinical cohort of patients with UC. METHODS: We performed a multicenter retrospective cohort study and included patients with active UC starting ustekinumab. Variables collected included demographics, clinical data, and disease activity (measured using partial Mayo score [PMS] and endoscopic Mayo score) at follow-up...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38530797/geraniin-alleviates-inflammation-in-caco-2-cells-and-dextran-sulfate-sodium-induced-colitis-mice-by-targeting-il-1%C3%AE
#22
JOURNAL ARTICLE
Hae-Ri Lee, Young-Jin Jeong, Sun-Ae Park, Hee Jung Kim, Tae-Hwe Heo
IL-1β is an important cytokine implicated in the progression of inflammatory bowel disease (IBD) and intestinal barrier dysfunction. The polyphenolic compound, geraniin, possesses bioactive properties, such as antitumor, antioxidant, anti-inflammatory, antihypertensive, and antiviral activities; however, its IL-1β-targeted anticolitis activity remains unclear. Here, we evaluated the inhibitory effect of geraniin in IL-1β-stimulated Caco-2 cells and a dextran sulfate sodium (DSS)-induced colitis mouse model...
March 26, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38530500/effect-of-tofacitinib-on-one-year-colectomy-risk-in-anti-tnf-refractory-ulcerative-colitis-a-prospective-multicenter-italian-study
#23
JOURNAL ARTICLE
Anna Maria Carvalhas Gabrielli, Francesca Ferretti, Camilla Maria Monico, Enrico Tombetti, Giovanni Maconi, Samanta Romeo, Nicole Piazza O Sed, Flavio Caprioli, Anna Maria Mazzola, Saverio Alicante, Roberto Bertè, Elisabetta Lolli, Maria Lia Scribano, Elisabetta Buscarini, Chiara Ricci, Stefania Carmagnola, Sandro Ardizzone, Rosanna Cannatelli
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor recently approved to induce and maintain remission in ulcerative colitis (UC). AIMS: Considering the number of anti-TNF non-responders, this study aims to assess the effectiveness and safety of tofacitinib in a cohort of multi-failure patients with moderate-to-severe UC at 52 weeks. METHODS: From January 2021 to March 2023, we performed a prospective multicenter study observing adult patients with moderate-to-severe UC starting tofacitinib after an anti-TNF failure for a 52-week-long period...
March 26, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38530319/serum-fibroblast-growth-factor-19-level-correlates-inversely-with-clinical-and-endoscopic-activity-of-inflammatory-bowel-disease
#24
JOURNAL ARTICLE
Agata Łukawska, Agata Mulak
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic condition with relapsing-remitting course. Diarrhea and abdominal pain are the most common IBD symptoms. Fibroblast growth factor 19 (FGF19) is an endocrine factor that inhibits hepatic bile acid production and may be used as a diagnostic marker for bile acid malabsorption. OBJECTIVES: To assess serum FGF19 levels in active and inactive phases of IBD and find a potential correlation between FGF19 and disease activity...
March 26, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38529957/pan-enteric-capsule-endoscopy-to-characterize-crohn-s-disease-phenotypes-and-predict-clinical-outcomes-in-children-and-adults-the-bomiro-study
#25
JOURNAL ARTICLE
Salvatore Oliva, Silvio Veraldi, Giusy Russo, Marina Aloi, Fernando Rizzello, Paolo Gionchetti, Patrizia Alvisi, Flavio Labriola, Maurizio Vecchi, Pini Eidler, Luca Elli, Nikolas Dussias, Gian Eugenio Tontini, Carlo Calabrese
BACKGROUND: Pan-enteric capsule endoscopy (PCE) provides useful information for the management of Crohn's disease (CD), especially in children. No study has evaluated the ability of PCE to characterize CD phenotypes and outcomes in children and adults. METHODS: In a prospective multicenter observational study, we recruited patients with CD >6 years from 4 centers in Italy. Patients underwent clinical, biomarker assessment and PCE. Lesions were graded using the PCE system...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38529506/senolytic-car-t-cells-reverse-aging-associated-defects-in-intestinal-regeneration-and-fitness
#26
Onur Eskiocak, Saria Chowdhury, Vyom Shah, Emmanuella Nnuji-John, Charlie Chung, Jacob A Boyer, Alexander S Harris, Jill Habel, Michel Sadelain, Semir Beyaz, Corina Amor
Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature of the aging process, little is known about the in vivo effects of senescent cells on intestinal fitness. Here, we identify the accumulation of senescent cells in the aging gut and, by harnessing senolytic CAR T cells to eliminate them, we uncover their detrimental impact on epithelial integrity and overall intestinal homeostasis in natural aging, injury and colitis...
March 22, 2024: bioRxiv
https://read.qxmd.com/read/38529272/mannose-enhances-intestinal-immune-barrier-function-and-dextran-sulfate-sodium-salt-induced-colitis-in-mice-by-regulating-intestinal-microbiota
#27
JOURNAL ARTICLE
Yi Yang, Qiming Ma, Qingyu Wang, Lifeng Zhao, Hengshan Liu, Yanjun Chen
BACKGROUND: Inflammatory bowel disease (IBD) greatly affects human quality of life. Mannose has been reported to be used to treat IBD, but the mechanism is currently unknown. METHODS: C57/BL mice were used as research subjects, and the mouse acute colitis model was induced using dextran sulfate sodium salt (DSS). After oral administration of mannose, the body weights and disease activity index (DAI) scores of the mice were observed. The colon lengths, histopathological sections, fecal content microbial sequencing, colon epithelial inflammatory genes, and tight junction protein Occludin-1 expression levels were measured...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529201/the-role-of-inflammatory-biomarkers-in-mediating-the-effect-of-inflammatory-bowel-disease-on-nonmalignant-digestive-system-diseases-a-multivariable-mendelian-randomized-study
#28
JOURNAL ARTICLE
Shu Zhou, Qi Sun, Ning Gao, Zekai Hu, Junjun Jia, Jiangwei Song, Guocong Xu, Aiqiang Dong, Weiliang Xia, Jiafeng Wu
BACKGROUND: While observation studies have shown a positive correlation between inflammatory bowel disease (IBD) and the risk of nonmalignant digestive system diseases, a definitive causal relationship has not yet been clearly established. METHODS: Mendelian randomization (MR) was employed to investigate the potential causal association between genetic susceptibility to IBD and nonmalignant gastrointestinal diseases. Genetic variants were extracted as instrumental variables (IVs) from a genome-wide association study (GWAS) meta-analysis, which included 12,194 cases of Crohn's disease (CD) and 28,072 control cases of European ancestry...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38529188/erratum-pde9-inhibitor-pf-04447943-attenuates-dss-induced-colitis-by-suppressing-oxidative-stress-inflammation-and-regulating-t-cell-polarization
#29
(no author information available yet)
[This corrects the article DOI: 10.3389/fphar.2021.643215.].
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38529083/laparoscopy-assisted-restorative-proctocolectomy-with-ileal-pouch-anal-anastomosis-in-middle-colic-artery-ligation-immediately-before-specimen-removal
#30
JOURNAL ARTICLE
Keiji Matsuda, Yojiro Hashiguchi, Tamuro Hayama, Kurara Hayashi, Toshiya Miyata, Kentaro Asako, Yoshihisa Fukushima, Ryu Shimada, Kensuke Kaneko, Keijiro Nozawa, Hiroki Ochiai, Takatsugu Yamamoto
INTRODUCTION: Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the surgical procedure for ulcerative colitis (UC). Intestinal ischemia may occur if the main blood vessels are ligated at an early stage of this surgery. Considering that the blood flow in the large intestine can be maintained by preserving the middle colic artery, we have used a new IPAA method: ligating the middle colic artery immediately before removal of the specimens ("M-method"). Here, we evaluated the M-method's clinical outcomes...
2024: Inflammatory Intestinal Diseases
https://read.qxmd.com/read/38528993/intestinal-flora-imbalance-induced-by-antibiotic-use-in-rats
#31
JOURNAL ARTICLE
Guojun Tong, Hai Qian, Dongli Li, Jing Li, Jing Chen, Xiongfeng Li, Zhenhua Tan
AIM: This study aims to explore the effect of different doses of antibiotics on rats in order to observe alterations in their fecal microbiota, inflammatory changes in the colonic mucosa and four types of inflammatory markers in blood serum. METHODS: Our methodology involved separating 84 female Sprague Dawley rats into groups A-G, with each group consisting of 12 rats. We collected the rat feces for analysis, using a distinct medium for bacterial cultivation and counting colonies under a microscope...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38528940/risk-of-primary-gastrointestinal-lymphoma-in-patients-with-inflammatory-conditions-exposed-to-tumor-necrosis-factor-alpha-inhibitors-and-immunomodulators-a-case-control-study
#32
JOURNAL ARTICLE
Manuel B Braga-Neto, Jason Nasser, Xiao Xing Iris Wang, William Scott Harmsen, Laura E Raffals, Michael Camilleri, Victor Chedid
INTRODUCTION: The aim of this case-control study was to determine if exposure to tumor necrosis factor alpha inhibitors (TNFIs) or immunomodulators (thiopurines or methotrexate) was associated with development of primary gastrointestinal lymphoma (PGIL) in patients with chronic inflammatory conditions. METHODS: Patients with PGIL and controls evaluated at a tertiary care center over 20 years were matched 1:3 using a medical record informatics search engine based on their chronic inflammatory condition (Crohn's disease [CD], ulcerative colitis [UC], rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and duration of follow-up...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38528736/nonextractable-polyphenols-from-fu-brick-tea-alleviates-ulcerative-colitis-by-controlling-colon-microbiota-targeted-release-to-inhibit-intestinal-inflammation-in-mice
#33
JOURNAL ARTICLE
Chengcheng Yang, Wuqi Yang, Yu Wang, Yao Du, Tong Zhao, Hongjun Shao, Daoyuan Ren, Xingbin Yang
This study was designed to elucidate the colon microbiota-targeted release of nonextractable bound polyphenols (NEPs) derived from Fu brick tea and to further identify the possible anti-inflammatory mechanism in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mice. 1.5% DSS drinking water-induced C57BL/6J mice were fed rodent chow supplemented with or without 8% NEPs or dietary fibers (DFs) for 37 days. The bound p -hydroxybenzoic acid and quercetin in NEPs were liberated up to 590.5 ± 70...
March 25, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38528729/indole-3-acetic-acid-alleviates-dss-induced-colitis-by-promoting-the-production-of-r-equol-from-bifidobacterium-pseudolongum
#34
JOURNAL ARTICLE
Miaomiao Li, Xue Han, Lijun Sun, Xinjuan Liu, Weizhen Zhang, Jianyu Hao
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence of IBD is driven by the complex interactions of multiple factors. The objective of this study was to evaluate the therapeutic effects of IAA in colitis. METHOD: C57/BL6 mice were administered 2.5% DSS in drinking water to induce colitis. IAA, Bifidobacterium pseudolongum, and R-equol were administered by oral gavage and fed a regular diet...
2024: Gut Microbes
https://read.qxmd.com/read/38528541/protective-effect-of-synbiotic-combination-of-lactobacillus-plantarum-sc-5-and-olive-oil-extract-tyrosol-in-a-murine-model-of-ulcerative-colitis
#35
JOURNAL ARTICLE
Fazheng Yu, Xueyu Hu, HongLin Ren, Xiaoxu Wang, Ruoran Shi, Jian Guo, Jiang Chang, Xiaoshi Zhou, Yuanyuan Jin, Yansong Li, Zengshan Liu, Pan Hu
BACKGROUND: Ulcerative colitisis (UC) classified as a form of inflammatory bowel diseases (IBD) characterized by chronic, nonspecific, and recurrent symptoms with a poor prognosis. Common clinical manifestations of UC include diarrhea, fecal bleeding, and abdominal pain. Even though anti-inflammatory drugs can help alleviate symptoms of IBD, their long-term use is limited due to potential side effects. Therefore, alternative approaches for the treatment and prevention of inflammation in UC are crucial...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528540/association-between-inflammatory-bowel-disease-and-cancer-risk-evidence-triangulation-from-genetic-correlation-mendelian-randomization-and-colocalization-analyses-across-east-asian-and-european-populations
#36
JOURNAL ARTICLE
Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang
BACKGROUND: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have been inconsistent and may face the bias of confounding and reverse causality. The potential causal relationships between IBD and the risk of cancers remain largely unclear. METHODS: We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR), and colocalization analyses using summary genome-wide association study (GWAS) data across East Asian and European populations to evaluate the causal relationships between IBD and cancers...
March 25, 2024: BMC Medicine
https://read.qxmd.com/read/38527801/extracellular-sombrero-vesicles-are-hallmarks-of-eosinophilic-cytolytic-degranulation-in-tissue-sites-of-human-diseases
#37
JOURNAL ARTICLE
Vitor H Neves, Cinthia Palazzi, Kássia K Malta, Kennedy Bonjour, Felipe Kneip, Felipe F Dias, Josiane S Neves, Peter F Weller, Rossana C N Melo
Eosinophil sombrero vesicles (EoSVs) are large tubular carriers resident in the cytoplasm of human eosinophils, identifiable by transmission electron microscopy (TEM), and important for immune mediator transport. Increased EoSV formation occurs in activated eosinophils in vitro and in vivo. In tissue sites of eosinophilic cytolytic inflammation, extracellular EoSVs are noted, but their frequency and significance in eosinophil-associated diseases (EADs) remain unclear. Here, we performed comprehensive quantitative TEM analyses and electron tomography to investigate the numbers, density, integrity, and three-dimensional (3D) structure of EoSVs in different biopsy tissues from five prototypic EADs (eosinophilic chronic rhinosinusitis/nasal sinuses, ulcerative colitis/intestines, hypereosinophilic syndrome/skin, dermatitis/skin, and schistosomiasis/rectum)...
March 25, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38527677/colon-targeted-hydroxyethyl-starch-curcumin-microspheres-with-high-loading-capacity-ameliorate-ulcerative-colitis-via-alleviating-oxidative-stress-regulating-inflammation-and-modulating-gut-microbiota
#38
JOURNAL ARTICLE
Da Huang, Yongming Wang, Chenlan Xu, Minglang Zou, Yangcan Ming, Fang Luo, Zhenjin Xu, Ying Miao, Na Wang, Zhenyu Lin, Zuquan Weng
Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HC-MSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19...
March 23, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38527451/analysis-of-the-medication-persistence-rate-for-and-adherence-to-oral-5-aminosalicylic-acid-preparations-in-japanese-patients-with-ulcerative-colitis-study-using-a-nationwide-claims-database
#39
JOURNAL ARTICLE
Takumi Ota, Takahiro Takebe, Yutaka Shimizu, Takashi Orido, Hiroyuki Tanaka, Shiro Nakamura
Introduction 5-aminosalicylic acid (5-ASA) is the first-line drug for the treatment of mild-to-moderate ulcerative colitis (UC). Three oral sustained-release formulations are often used. However, no unified view of their actual use in routine medical practice has been presented to date. Methods Using a health insurance claims database, we extracted patients with an initial diagnosis of mild-to-moderate UC during the period from December 1, 2017 to March 31, 2022. For the three types of oral 5-ASA formulation, we calculated and compared descriptive statistics of medication persistence rates (MPR), proportions of days covered (PDC) and adherence proportion (PDC ≥ 80%) in the extracted population...
March 25, 2024: Digestion
https://read.qxmd.com/read/38526945/comparing-the-efficacy-of-vedolizumab-between-males-and-females-a-post-hoc-analysis-of-gemini-1-and-varsity
#40
JOURNAL ARTICLE
Tarun Chhibba, Emily C L Wong, Walter Reinisch, Laura Targownik, Neeraj Narula
Vedolizumab is a first-line treatment option for ulcerative colitis. There are differences in incidence of ulcerative colitis between males and females, but whether sex affects treatment outcomes is less clear. We examined sex-based differences in patients with ulcerative colitis initiated on vedolizumab from two major randomized controlled trials (RCTs). We conducted a post-hoc analysis on participants with ulcerative colitis from the VARSITY and GEMINI-1 RCTs who received vedolizumab. Outcomes of interest were rates of clinical improvement, clinical remission, and endoscopic improvement at weeks 6, 14, and 52 in male and female participants, as were differences in concentrations of trough vedolizumab and C-reactive protein; 1009 persons in GEMINI-1 and VARSITY trials were included...
March 22, 2024: European Journal of Gastroenterology & Hepatology
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