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https://www.readbyqxmd.com/read/28437538/effects-of-diagnosis-by-newborn-screening-for-cystic-fibrosis-on-weight-and-length-in-the-first-year-of-life
#1
Daniel H Leung, Sonya L Heltshe, Drucy Borowitz, Daniel Gelfond, Margaret Kloster, James E Heubi, Michael Stalvey, Bonnie W Ramsey
Importance: Since the implementation of universal newborn screening (NBS) for cystic fibrosis (CF), the timing and magnitude of growth deficiency or its association with correlates of disease among infants with CF who underwent NBS has not been well described. Objective: To examine incremental weight gain, linear growth, and clinical features in the first year of life among infants with CF who underwent NBS. Design, Setting, and Participants: The Baby Observational and Nutrition Study (BONUS), a multicenter, longitudinal, observational cohort study, was conducted during regular CF clinic visits in the first 12 months of life at 28 US Cystic Fibrosis Foundation-accredited Care Centers from January 7, 2012, through May 31, 2015...
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28431557/the-effect-of-vitamin-b12-supplementation-in-nepalese-infants-on-growth-and-development-study-protocol-for-a-randomized-controlled-trial
#2
Tor A Strand, Manjeswori Ulak, Ram K Chandyo, Ingrid Kvestad, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha, Prakash S Shrestha
BACKGROUND: Vitamin B12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B12 is crucial for normal cell division and differentiation, and it is necessary for the development and myelination of the central nervous system. The aim of the present study is to measure the effect of daily supplementation of vitamin B12 on the neurodevelopment and growth of young children in Nepal. METHODS/DESIGN: We are conducting an individually randomized, double-blind, placebo-controlled trial with 600 marginally stunted children 6-11 months old (length for age less than -1 z-score)...
April 21, 2017: Trials
https://www.readbyqxmd.com/read/28430018/characterization-of-canna-yellow-mottle-virus-in-a-new-host-alpinia-purpurata-in-hawaii
#3
Jingxin Zhang, Kishore K Dey, Birun Lin, Wayne B Borth, Michael J Melzer, Diane Sether, Yanan Wang, I-Chin Wang, Huifang Shen, Xiaoming Pu, Dayuan Sun, John S Hu
Canna yellow mottle virus (CaYMV) is an important badnavirus infecting Canna spp. worldwide. This is the first report of CaYMV in flowering ginger (Alpinia purpurata) in Hawaii, where it is associated with yellow mottling and necrosis of leaves, vein streaking, and stunted plants. We have sequenced CaYMV in A. purpurata (CaYMV-Ap) using a combination of next-generation sequencing and traditional Sanger sequencing techniques. The complete genome of CaYMV-Ap was 7,120 bp with an organization typical of other Badnavirus species...
April 21, 2017: Phytopathology
https://www.readbyqxmd.com/read/28429911/inequality-in-malnutrition-by-maternal-education-levels-in-early-childhood-the-prospective-cohort-of-thai-children-pctc
#4
Seo Ah Hong, Pattanee Winichagoon, Aroonsri Mongkolchati
BACKGROUND AND OBJECTIVES: As tackling socioeconomic inequality in child malnutrition still remains one of the greatest challenges in developing countries, we examined maternal educational differences in malnutrition and the magnitude of its inequality among 4,198 children from the Prospective Cohort study of Thai Children (PCTC). METHODS AND STUDY DESIGN: Prevalence of stunting, underweight, and wasting from birth to 24 months was calculated using the new WHO growth chart...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429467/conditional-random-slope-a-new-approach-for-estimating-individual-child-growth-velocity-in-epidemiological-research
#5
Michael Leung, Diego G Bassani, Amy Racine-Poon, Anna Goldenberg, Syed Asad Ali, Gagandeep Kang, Prasanna S Premkumar, Daniel E Roth
OBJECTIVES: Conditioning child growth measures on baseline accounts for regression to the mean (RTM). Here, we present the "conditional random slope" (CRS) model, based on a linear-mixed effects model that incorporates a baseline-time interaction term that can accommodate multiple data points for a child while also directly accounting for RTM. METHODS: In two birth cohorts, we applied five approaches to estimate child growth velocities from 0 to 12 months to assess the effect of increasing data density (number of measures per child) on the magnitude of RTM of unconditional estimates, and the correlation and concordance between the CRS and four alternative metrics...
April 21, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28426828/consumption-of-fortified-infant-foods-reduces-dietary-diversity-but-has-a-positive-effect-on-subsequent-growth-in-infants-from-sumedang-district-indonesia
#6
Aly Diana, Simonette R Mallard, Jillian J Haszard, Dwi Monik Purnamasari, Ikrimah Nurulazmi, Pratami D Herliani, Gaga I Nugraha, Rosalind S Gibson, Lisa Houghton
Stunting and underweight among under-five children in Indonesia are common, raising public health concerns. Whether inappropriate complementary feeding (CF) practices compromise optimal growth during late infancy in Indonesia is uncertain. Therefore we characterized and evaluated CF practices in Indonesian infants and investigated their relationship with subsequent growth. We enrolled breastfed infants at 6 months of age (n = 230); and followed them at 9 (n = 202) and 12 months of age (n = 190). We collected socio-demographic and anthropometric data and two-day in-home weighed food records...
2017: PloS One
https://www.readbyqxmd.com/read/28424091/investigations-into-the-association-between-soil-transmitted-helminth-infections-haemoglobin-and-child-development-indices-in-manufahi-district-timor-leste
#7
Suzy J Campbell, Susana V Nery, Catherine A D'Este, Darren J Gray, James S McCarthy, Rebecca J Traub, Ross M Andrews, Stacey Llewellyn, Andrew J Vallely, Gail M Williams, Archie C A Clements
BACKGROUND: Timor-Leste has a high prevalence of soil-transmitted helminth (STH) infections. High proportions of the population have been reported as being anaemic, and extremely high proportions of children as stunted or wasted. There have been no published analyses of the contributions of STH to these morbidity outcomes in Timor-Leste. METHODS: Using baseline cross-sectional data from 24 communities (18 communities enrolled in a cluster randomised controlled trial, and identically-collected data from six additional communities), analyses of the association between STH infections and community haemoglobin and child development indices were undertaken...
April 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28422940/body-composition-at-birth-and-height-at-2-years-a-prospective-cohort-study-among-children-in-jimma-ethiopia
#8
Bitiya Admassu, Jonatan C Wells, Tsinuel Girma, Gregers S Andersen, Victor Owino, Tefera Belachew, Kim F Michaelsen, Mubarek Abera, Rasmus Wibaek, Henrik Friis, Pernille Kæstel
BACKGROUND: Low birth weight is associated with childhood stunting, but equivalent associations for birth body composition (BC) remain unknown. OBJECTIVE: To assess associations of BC with height-for-age Z score (HAZ) at 2 years of age. METHODS: In a prospective cohort study, fat mass (FM) and fat-free mass (FFM) were measured using air-displacement plethysmography within 48 h of birth. Linear regression models were applied to study the relationship between BC at birth and HAZ at 24 months (±3 months)...
April 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28421143/the-dual-burden-of-malnutrition-and-associated-dietary-and-lifestyle-habits-among-lebanese-school-age-children-living-in-orphanages-in-north-lebanon
#9
Germine El-Kassas, Fouad Ziade
Childhood is a crucial period affecting physical and intellectual development. Although children living in orphanages are among the most vulnerable groups at risk of malnutrition, there is scarcity of data concerning their nutritional status in Lebanon. To investigate these data, a cross-sectional survey was conducted including a sample of 153 institutionalized children aged 5-14 years from all orphanages in Tripoli. Nutritional status was assessed using anthropometric, clinical, and dietary tools. Interpretation of anthropometric data showed that 13...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28420431/injuries-in-extreme-sports
#10
REVIEW
Lior Laver, Ioannis P Pengas, Omer Mei-Dan
Extreme sports (ES) are usually pursued in remote locations with little or no access to medical care with the athlete competing against oneself or the forces of nature. They involve high speed, height, real or perceived danger, a high level of physical exertion, spectacular stunts, and heightened risk element or death.Popularity for such sports has increased exponentially over the past two decades with dedicated TV channels, Internet sites, high-rating competitions, and high-profile sponsors drawing more participants...
April 18, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28417875/influence-of-malnutrition-upon-all-cause-mortality-among-children-in-swaziland
#11
Paula Acevedo, María Teresa García Esteban, Noemí Lopez-Ejeda, Amador Gómez, María Dolores Marrodán
OBJECTIVE: To analyze the effect of the type of malnutrition, sex, age and the presence of edema upon all-cause mortality in children under 5 years of age. MATERIAL AND METHODS: A cross-sectional study was conducted during 2010 and 2011 in Swaziland. Sex, age, weight and height were taken to classify nutritional status according to the 2006 WHO growth standards: stunting (low height for age), wasting (low weight for height or low body mass index for age) and underweight (low weight for age)...
April 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28417161/ift54-regulates-ift20-stability-but-is-not-essential-for-tubulin-transport-during-ciliogenesis
#12
Xin Zhu, Yinwen Liang, Feng Gao, Junmin Pan
Intraflagellar transport (IFT) is required for ciliogenesis by ferrying ciliary components using IFT complexes as cargo adaptors. IFT54 is a component of the IFT-B complex and is also associated with cytoplasmic microtubules (MTs). Loss of IFT54 impairs cilia assembly as well as cytoplasmic MT dynamics. The N-terminal calponin homology (CH) domain of IFT54 interacts with tubulins/MTs and has been proposed to transport tubulin during ciliogenesis, whereas the C-terminal coiled-coil (CC) domain binds IFT20. However, the precise function of these domains in vivo is not well understood...
April 17, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28416560/horizontal-schools-based-health-programme-in-rural-kenya
#13
James Bogie, Ben Eder, Dan Magnus, Onguko David Amonje, Martina Gant
BACKGROUND: Primary school children in low-income countries are at risk of many diseases and poor health affects attendance, cognition and ability to learn. Developing school health and nutrition strategies has been extensively highlighted as a global priority, with a particular focus on complex programme design. However, such programmes are relatively untested in low-income settings. METHOD: We implemented a complex school health and nutrition programme in two schools in Western Kenya over 3 years...
April 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28414102/parental-knowledge-of-trampoline-safety-in-children
#14
S Beno, A Ackery, K Colaco, K Boutis
OBJECTIVES: Recreational trampoline use is increasing in popularity, with a resulting increase in significant trampoline-related injuries in children. Parents are the best advocates for the safety of their children during recreational trampoline use. Our primary objective was to determine the proportion of parents who were aware of five key recommendations for safer recreational trampoline use in children. METHODS: This was a cross-sectional survey of parents whose children presented to a tertiary care pediatric emergency department (ED) with an extremity injury...
April 13, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28410435/small-area-estimation-of-child-undernutrition-in-ethiopian-woredas
#15
Thomas Pave Sohnesen, Alemayehu Azeze Ambel, Peter Fisker, Colin Andrews, Qaiser Khan
Reducing child undernutrition is a key social policy objective of the Ethiopian government. Despite substantial reduction over the last decade and a half, child undernutrition is still high; with 48 percent of children either stunted, underweight or wasted, undernutrition remains an important child health challenge. The existing literature highlights that targeting of efforts to reduce undernutrition in Ethiopia is inefficient, in part due to lack of data and updated information. This paper remedies some of this shortfall by estimating levels of stunting and underweight in each woreda for 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28408936/household-food-insecurity-and-its-association-with-nutritional-status-of-children-6-59-months-of-age-in-east-badawacho-district-south-ethiopia
#16
Bealu Betebo, Tekle Ejajo, Fissahaye Alemseged, Desalegn Massa
Background. Ethiopia has one of the highest child malnutrition rates in the world. Food insecurity is one of the determinant factors of malnutrition in developing countries; however its role remains unclear. Objective. To assess household food insecurity and its association with the nutritional status of children 6-59 months of age in East Badawacho District, South Ethiopia. Methods. A community based cross-sectional study was conducted from February 20 to 30, 2014 on a sample of 508 mother/child pairs of 6-59-month-old children...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28408745/sumoylation-of-foxp1-regulates-transcriptional-repression-via-ctbp1-to-drive-dendritic-morphogenesis
#17
Daniel L Rocca, Kevin A Wilkinson, Jeremy M Henley
Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated. Here, we show that FOXP1 SUMOylation at lysine 670 is required for recruiting the co-repressor CtBP1 and transcriptional repression. FOXP1 SUMOylation is tightly controlled by neuronal activity, in which synapse to nucleus signalling, mediated via NMDAR and L-type calcium channels, results in rapid FOXP1 deSUMOylation...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28396284/identification-of-a-nanovirus-alphasatellite-complex-in-sophora-alopecuroides
#18
Jahangir Heydarnejad, Mehdi Kamali, Hossain Massumi, Anders Kvarnheden, Maketalena F Male, Simona Kraberger, Daisy Stainton, Darren P Martin, Arvind Varsani
Viruses in the genus Nanovirus of the family Nanoviridae generally have eight individually encapsidated circular genome components and have been predominantly found infecting Fabaceae plants in Europe, Australia, Africa and Asia. For over a decade Sophora alopecuroides L. (Fabaceae) plants have been observed across Iran displaying dwarfing, yellowing, stunted leaves and yellow vein banding. Using a high-throughput sequencing approach, sequences were identified within one such plant that had similarities to nanovirus genome components...
April 8, 2017: Virus Research
https://www.readbyqxmd.com/read/28395198/propagation-and-some-physiological-effects-of-citrus-bark-cracking-viroid-and-apple-fruit-crinkle-viroid-in-multiple-infected-hop-humulus-lupulus-l
#19
J Matoušek, K Siglová, J Jakše, S Radišek, Joseph R J Brass, T Tsushima, T Guček, G S Duraisamy, T Sano, G Steger
The hop metabolome important for the brewing industry and for medical purposes is endangered worldwide due to multiple viroid infections affecting hop physiology. Combinatorial biolistic hop inoculation with Citrus bark cracking viroid (CBCVd), Apple fruit crinkle viroid (AFCVd), Hop latent viroid, and Hop stunt viroid (HSVd) showed a low CBCVd compatibility with HSVd, while all other viroid combinations were highly compatible. Unlike to other viroids, single CBCVd propagation showed a significant excess of (-) over (+) strands in hop, tomato, and Nicotiana benthamiana, but not in citruses...
March 27, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28392409/a-rapid-isothermal-assay-for-the-detection-of-hop-stunt-viroid-in-hop-plants-humulus-lupulus-and-its-application-in-disease-surveys
#20
Madhu Kappagantu, Dan Edward V Villamor, Jeff M Bullock, Kenneth C Eastwell
Hop stunt disease caused by Hop stunt viroid (HSVd) is a growing threat to hop cultivation globally. HSVd spreads mainly by use of contaminated planting material and by mechanical means. Thorough testing of hop yards and removal of infected bines are critical components of efforts to control the spread of the disease. Reverse transcription-polymerase chain reaction (RT-PCR) has become the primary technique used for HSVd detection; however, sample handling and analysis are technically challenging. In this study, a robust reverse transcription-recombinase polymerase amplification (RT-RPA) assay was developed to facilitate analysis of multiple samples...
April 7, 2017: Journal of Virological Methods
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