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https://www.readbyqxmd.com/read/29780359/the-mitotic-and-metabolic-effects-of-phosphatidic-acid-in-the-primary-muscle-cells-of-turbot-scophthalmus-maximus
#1
Tingting Wang, Xuan Wang, Huihui Zhou, Haowen Jiang, Kangsen Mai, Gen He
Searching for nutraceuticals and understanding the underlying mechanism that promote fish growth is at high demand for aquaculture industry. In this study, the modulatory effects of soy phosphatidic acids (PA) on cell proliferation, nutrient sensing, and metabolic pathways were systematically examined in primary muscle cells of turbot ( Scophthalmus maximus ). PA was found to stimulate cell proliferation and promote G1/S phase transition through activation of target of rapamycin signaling pathway. The expression of myogenic regulatory factors, including myoD and follistatin , was upregulated, while that of myogenin and myostatin was downregulated by PA...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#2
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29752426/protein-engineering-on-human-recombinant-follistatin-enhancing-pharmacokinetic-characteristics-for-therapeutic-application
#3
Chuan Shen, Andrea Iskenderian, Dianna Lundberg, Tao He, Kathleen Palmieri, Robert Crooker, Qingwei Deng, Matthew Traylor, Sheng Gu, Haojing Rong, David Ehmann, Brian Pescatore, Bettina Strack-Logue, Alla Romashko, George Baviello, John Gill, Bohong Zhang, Muthuraman Meiyappan, Clark Pan, Angela W Norton
Follistatin (FS) is an important regulatory protein, a natural antagonist for transforming growth factor beta family members activin and myostatin. The diverse biological roles of the activin and myostatin signaling pathways make FS a promising therapeutic target for treating human diseases exhibiting inflammation, fibrosis and muscle disorders, such as Duchenne muscular dystrophy. However, rapid heparin-mediated hepatic clearance of FS limits its therapeutic potential. We targeted the heparin binding loop of FS for site-directed mutagenesis to improve clearance parameters...
May 11, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29741932/to-hypertrophy-and-beyond-myostatin-and-its-association-to-intermuscular-adipose-tissue-with-exercise-and-aging
#4
Kevin Andrew Murach
No abstract text is available yet for this article.
May 9, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29740785/regulation-of-myostatin-expression-is-associated-with-growth-and-muscle-development-in-commercial-broiler-and-dmc-muscle
#5
Tengfei Dou, Zhengtian Li, Kun Wang, Lixian Liu, Hua Rong, Zhiqiang Xu, Ying Huang, Dahai Gu, Xiaobo Chen, Wenyuan Hu, Jiarong Zhang, Sumei Zhao, Markandeya Jois, Qihua Li, Changrong Ge, Marinus F W Te Pas, Junjing Jia
Myostatin is a negative regulator of skeletal muscle growth. Muscle tissue is the largest tissue in the body and influences body growth. Commercial Avian broiler chickens are selected for high growth rate and muscularity. Daweishan mini chickens are a slow growing small-sized chicken breed. We investigated the relations between muscle (breast and leg) myostatin mRNA expression and body and muscle growth. Twenty chickens per breed were slaughtered at 0, 30, 60, 90, 120, and 150 days of age. Body and muscle weights were higher at all times in Avian chickens...
May 8, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29731967/anti-cachectic-effect-of-antrodia-cinnamomea-extract-in-lung-tumor-bearing-mice-under-chemotherapy
#6
Meng-Chuan Chen, Wen-Lin Hsu, Tz-Chong Chou
Skeletal muscle atrophy, the most characteristic feature of cancer cachexia, often occurs in patients with cancer undergoing chemotherapy. Antrodia cinnamomea (AC) a widely used edible medical fungus, exhibits hepatoprotective, anti-inflammatory and anticancer activities. In this study, we investigated whether combined treatment with the ethonolic extract of AC ameliorates cachexia symptoms, especially muscle wasting, in lung tumor-bearing mice treated with chemotherapy. Our results revealed that gemcitabine and cisplatin-induced severe body weight loss and skeletal muscle atrophy in the mice with cancer were greatly attenuated after AC extract administration...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29730709/lysine-supplement-benefits-the-growth-performance-protein-synthesis-and-muscle-development-of-megalobrama-amblycephala-fed-diets-with-fish-meal-replaced-by-rice-protein-concentrate
#7
Wan-Cun Cai, Wen-Bin Liu, Guang-Zhen Jiang, Kai-Zhou Wang, Cun-Xin Sun, Xiang-Fei Li
This study aimed to investigate the effects of lysine supplement on the growth performance of blunt snout bream Megalobrama amblycephala fed diets with fish meal (FM) replaced by rice protein concentrate (RPC) with the potential mechanisms characterized. Fish were fed three diets, including the FM diet (containing FM), the RPC diet (FM replaced by RPC), and the MRPC diet (the RPC diet supplemented with lysine) for 8 weeks. Weight gain, protein efficiency ratio, and nitrogen and energy utilization of fish fed the FM diet were all significantly higher than those of the RPC treatment, but they showed no statistical difference with those of the MRPC group...
May 5, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29723585/platycodon-grandiflorum-derived-saponin-enhances-exercise-function-skeletal-muscle-protein-synthesis-and-mitochondrial-function
#8
Yong An Kim, Sun Woo Jin, Suck Hoon Oh, Gi Ho Lee, Hoa Thi Pham, Jae Ho Choi, Young Chul Chung, Wang Lok Lee, Sang Kyum Kim, Hye Gwang Jeong
Lower physical performance is an important risk factor in hypokinetic-related chronic disease, metabolic syndrome, and muscle atrophy. Our previous research demonstrated that Platycodon grandiflorum-derived saponin (PS) protects against eccentric exercise-induced muscle damage and mitochondrial function-related peroxisomal acyl-coenzme A oxidase (ACOX-1) and carnitine palmitoyltransferase (CPT-1) in high-fat diet-induced non-alcoholic steatohepatitis, and it inhibits osteoclast differentiation. However, the effects of PS on physical performance remain unknown...
April 30, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29718700/relationship-between-intermuscular-adipose-tissue-infiltration-and-myostatin-before-and-after-aerobic-exercise-training
#9
Adam R Konopka, Christopher A Wolff, Miranda K Suer, Matthew P Harber
Intermuscular adipose tissue (IMAT) is associated with impaired skeletal muscle contractile and metabolic function. Myostatin and downstream signaling proteins such as cyclin-dependent kinase 2 (CDK2) contribute to the regulation of adipose and skeletal muscle mass in cell culture and animals models but this relationship remains incompletely understood in humans. The purpose of this study was to determine if the infiltration of IMAT was associated with skeletal muscle myostatin and downstream proteins before and after 12-weeks of aerobic exercise training (AET) in healthy older women (OW; 69{plus minus}2y), older men (OM; 74{plus minus}3y) and young men (YM; 20{plus minus}1y)...
May 2, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29709011/muscle-wasting-in-osteoarthritis-model-induced-by-anterior-cruciate-ligament-transection
#10
Jordana Miranda de Souza Silva, Paulo Vinicius Gil Alabarse, Vivian de Oliveira Nunes Teixeira, Eduarda Correa Freitas, Francine Hehn de Oliveira, Rafael Mendonça da Silva Chakr, Ricardo Machado Xavier
This study aimed to investigate the molecular pathways involved in muscle wasting in an animal model of osteoarthritis (OA) induced by anterior cruciate ligament transection (ACLT) in rats. Reduction of protein syntheses, increased proteolysis and impaired muscle regeneration are important pathways related to muscle wasting, and myogenin, MyoD, myostatin and MuRF-1 are some of their markers. Female Wistar rats were allocated into two groups: OA (submitted to the ACLT) and SHAM (submitted to surgery without ACLT)...
2018: PloS One
https://www.readbyqxmd.com/read/29648516/the-phosphodiesterase-4-inhibitor-roflumilast-reverts-proteolysis-in-skeletal-muscle-cells-of-patients-with-copd-cachexia
#11
Esther Barreiro, Ester Puig-Vilanova, Anna Salazar-Degracia, Sergi Pascual-Guardia, Carme Casadevall, Joaquim Gea
Peripheral muscle weakness and mass loss are characteristic features in severe COPD. We hypothesized that the phosphodiesterase-4 inhibitor roflumilast-induced cAMP may ameliorate proteolysis and metabolism in skeletal muscles of COPD patients with severe muscle wasting. In myogenic precursor cells (isolated from muscle biopsies and cultured up to obtain differentiated myotubes) from 10 severe COPD patients and 10 healthy controls, which were treated with 1 microM roflumilast N-oxide (RNO) for three time-cohorts (1h, 6h, and 24h), genes of antioxidant defense and oxidative stress marker, myogenesis and muscle metabolism, proteolysis (tyrosine release assay) and ubiquitin-proteasome system markers, autophagy, and myosin isoforms were analyzed using RT-PCR and immunoblotting...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29615742/systemic-and-specific-effects-of-antihypertensive-and-lipid-lowering-medication-on-plasma-protein-biomarkers-for-cardiovascular-diseases
#12
Stefan Enroth, Varun Maturi, Malin Berggrund, Sofia Bosdotter Enroth, Aristidis Moustakas, Åsa Johansson, Ulf Gyllensten
A large fraction of the adult population is on lifelong medication for cardiovascular disorders, but the metabolic consequences are largely unknown. This study determines the effects of common anti-hypertensive and lipid lowering drugs on circulating plasma protein biomarkers. We studied 425 proteins in plasma together with anthropometric and lifestyle variables, and the genetic profile in a cross-sectional cohort. We found 8406 covariate-protein associations, and a two-stage GWAS identified 17253 SNPs to be associated with 109 proteins...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615416/the-drosophila-tgf-beta-activin-like-ligands-dawdle-and-myoglianin-appear-to-modulate-adult-lifespan-through-regulation-of-26s-proteasome-function-in-adult-muscle
#13
Shaughna Langerak, Myung-Jun Kim, Hannah Lamberg, Michael Godinez, Mackenzie Main, Lindsey Winslow, Michael B O'Connor, Changqi C Zhu
The Drosophila Activin signaling pathway employs at least three separate ligands, Activin-β (Actβ), Dawdle (Daw), and Myoglianin (Myo), to regulate several general aspects of fruit fly larval development including cell proliferation, neuronal remodeling, and metabolism. Here we provide experimental evidence indicating that both Daw and Myo are anti-ageing factors in adult fruit flies. Knockdown of Myo or Daw in adult fruit flies reduced mean lifespan, while overexpression of either ligand in adult muscle tissues but not in adipose tissues enhanced mean lifespan...
April 3, 2018: Biology Open
https://www.readbyqxmd.com/read/29609073/comparative-assessment-of-heat-stress-induced-changes-in-carcass-traits-plasma-leptin-profile-and-skeletal-muscle-myostatin-and-hsp70-gene-expression-patterns-between-indigenous-osmanabadi-and-salem-black-goat-breeds
#14
P R Archana, V Sejian, Wilfred Ruban, M Bagath, G Krishnan, J Aleena, G B Manjunathareddy, V Beena, Raghavendra Bhatta
The primary objective of the study was to compare the impact of heat stress on meat production characteristics of Osmanabadi and Salem Black breed goats based on changes in carcass characteristics, meat quality attributes, plasma leptin concentration, skeletal muscle myostatin and heat shock protein 70 (HSP70) gene expression patterns. The goats were randomly distributed into four groups: OSC (n = 6; Osmanabadi Control), OSHS (n = 6; Osmanabadi Heat Stress), SBC (n = 6; Salem Black Control) and SBHS (n = 6; Salem Black Heat Stress)...
March 24, 2018: Meat Science
https://www.readbyqxmd.com/read/29595876/exercise-mitigates-the-effects-of-hyperhomocysteinemia-on-adverse-muscle-remodeling
#15
Lee J Winchester, Sudhakar Veeranki, Sathnur Pushpakumar, Suresh C Tyagi
Hyperhomocysteinemia (HHcy) is known for causing inflammation and vascular remodeling, particularly through production of reactive oxygen species (ROS) and matrix metalloproteinase-9 (MMP-9) activation. Although its effect on the skeletal muscle is unclear, HHcy can cause skeletal muscle weakness and functional impairment by induction of inflammatory mediators and macrophage mediated injury. Exercise has been shown to reduce homocysteine levels and therefore, could serve as a promising intervention for HHcy...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29582582/mirna-23a-27a-attenuates-muscle-atrophy-and-renal-fibrosis-through-muscle-kidney-crosstalk
#16
Aiqing Zhang, Min Li, Bin Wang, Janet D Klein, S Russ Price, Xiaonan H Wang
BACKGROUND: The treatment of muscle wasting is accompanied by benefits in other organs, possibly resulting from muscle-organ crosstalk. However, how the muscle communicates with these organs is less understood. Two microRNAs (miRs), miR-23a and miR-27a, are located together in a gene cluster and regulate proteins that are involved in the atrophy process. MiR-23a/27a has been shown to reduce muscle wasting and act as an anti-fibrotic agent. We hypothesized that intramuscular injection of miR-23a/27a would counteract both muscle wasting and renal fibrosis lesions in a streptozotocin-induced diabetic model...
March 26, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29566437/effects-of-bimagrumab-an-activin-receptor-type-ii-inhibitor-on-pituitary-neurohormonal-axes
#17
Tania Garito, Marjorie Zakaria, Dimitris A Papanicolaou, Yifang Li, Pascale Pinot, Olivier Petricoul, Didier Laurent, Daniel Rooks, Juan Carlos Rondon, Ronenn Roubenoff
BACKGROUND: Bimagrumab is a human monoclonal antibody inhibitor of activin type II receptors (ActRII), with anabolic action on skeletal muscle mass by blocking binding of myostatin and other negative regulators of muscle growth. Bimagrumab is under evaluation for muscle wasting and associated functional loss in hip fracture and sarcopenia, and in obesity. Bimagrumab also blocks other endogenous ActRII ligands, such as activins, which act on the neurohormonal axes, pituitary, gonads and adrenal glands...
March 22, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29558345/irisin-and-myostatin-responses-to-acute-high-intensity-interval-exercise-in-humans
#18
Banu Kabak, Muaz Belviranli, Nilsel Okudan
Background The purpose of this study was to investigate irisin and myostatin responses to acute high-intensity interval exercise. Materials and methods Ten male professional kick-boxers aged between 18 and 24 years and 10 sedentary males with similar age and body weight participated in the present study. Participants performed 4 × 30-s Wingate test separated with 4 min of rest. Blood samples were taken immediately before and after exercise, and 3 and 6 h of recovery. Results and conclusion At rest, irisin levels were higher in the kick-boxers (p < 0...
March 20, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29556895/efficient-genome-editing-in-cultured-cells-and-embryos-of-debao-pig-and-swamp-buffalo-using-the-crispr-cas9-system
#19
Xiaoping Su, Kuiqing Cui, Shanshan Du, Hongli Li, Fenghua Lu, Deshun Shi, Qingyou Liu
Myostatin (MSTN), a protein encoded by growth differentiation factor 8 (GDF8), is primarily expressed in skeletal muscle and negatively regulates the development and regeneration of muscle. Accordingly, myostatin-deficient animals exhibit a double-muscling phenotype. The CRISPR/Cas9 system has proven to be an efficient genome-editing tool and has been applied to gene modification in cells from many model organisms such as Drosophila melanogaster, zebrafish, mouse, rat, sheep, and human. Here, we edited the GDF8 gene in fibroblasts and embryos of Debao pig and swamp buffalo using the CRISPR/Cas9 system...
May 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29546591/endoplasmic-reticulum-stress-induces-myostatin-high-molecular-weight-aggregates-and-impairs-mature-myostatin-secretion
#20
Rishibha Sachdev, Karin Kappes-Horn, Lydia Paulsen, Yvonne Duernberger, Catharina Pleschka, Philip Denner, Bishwajit Kundu, Jens Reimann, Ina Vorberg
Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disorder in the elderly with no defined etiology or effective therapy. Endoplasmic reticulum stress and deposition of myostatin, a secreted negative regulator of muscle growth, have been implicated in disease pathology. The myostatin signaling pathway has emerged as a major target for symptomatic treatment of muscle atrophy. Here, we systematically analyzed the maturation and secretion of myostatin precursor MstnPP and its metabolites in a human muscle cell line...
March 15, 2018: Molecular Neurobiology
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