Hannah L Cornman, Jaya Manjunath, Sriya V Reddy, Jackson Adams, Ahmad Rajeh, Christeen Samuel, Aaron Bao, Ryan Zhao, Emily Z Ma, Jason Shumsky, Thomas W Pritchard, Brenda Umenita Imo, Alexander L Kollhoff, Kevin K Lee, Weiying Lu, Selina Yossef, Madan M Kwatra, Shawn G Kwatra
Prurigo nodularis (PN) is a chronic inflammatory skin disease that is associated with variability in peripheral blood eosinophil levels and response to T-helper 2 targeted therapies (Th2). Our objective was to determine whether circulating immune profiles with respect to type 2 inflammation differ by race and peripheral blood eosinophil count. Plasma from 56 PN patients and 13 matched healthy controls was assayed for 54 inflammatory biomarkers. We compared biomarker levels between PN and HCs, among PN patients based on absolute eosinophil count, and across racial groups in PN...
April 6, 2024: Scientific Reports