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Prurigo nodularis

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https://www.readbyqxmd.com/read/27891738/treatment-of-prurigo-nodularis-with-lenalidomide
#1
Lidia Ossorio-García, David Jiménez-Gallo, María Eugenia Rodríguez-Mateos, Cintia Arjona-Aguilera, Mario Linares-Barrios
Prurigo nodularis (PN) is an intensely pruriginous dermatological disorder whose treatment is challenging for dermatologists. It is characterized by eruptions of papules and hyperkeratotic nodules, some of which are eroded, on the extensor surfaces of the limbs. The most commonly used treatments for this condition are oral antihistamines and topical or systemic steroids. Thalidomide is an effective treatment option in cases of recalcitrant PN; however, its most frequent adverse effect is neurotoxicity, which often results in its discontinuation...
November 28, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27815548/de%C3%A2-novo-hiv-infection-diagnoses-in-a-department-of-dermatology-and-venereology-in-lisbon-portugal
#2
Pedro Mendes-Bastos, Ana Brasileiro, Eugénia Matos-Pires, Isaura Rodrigues, Cristina Marques, Vasco Coelho-Macias, Cândida Fernandes
BACKGROUND: Portugal has the highest prevalence rate of HIV infection in Western Europe. The proportion of patients with a late diagnosis, carried out in full-blown AIDS stage, remains high. Skin and mucous membrane manifestations are not rare in these patients. OBJECTIVE: A demographic, clinical, and laboratorial characterization of patients with de novo HIV infection diagnosis made in the Department of Dermatology and Venereology of a central hospital in Lisbon, Portugal...
November 4, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27617458/phototherapy-for-the-treatment-of-prurigo-nodularis-a-review
#3
Mio Nakamura, John Ym Koo
BACKGROUND/PURPOSE: Review the available literature on phototherapy for treatment of prurigo nodularis (PN). METHODS: Literature search was conducted on MEDLINE. RESULTS:  6 prospective trials, 2 retrospective studies, and 3 case series were found investigating efficacy and safety of phototherapy for treatment of PN. CONCLUSION: Although large randomized clinical trials are necessary, phototherapy appears to be a safe and efficacious treatment for PN, alone and in combination with other common treatment modalities for PN...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27613297/dermoscopy-in-general-dermatology-a-practical-overview
#4
REVIEW
Enzo Errichetti, Giuseppe Stinco
Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides and subacute cutaneous lupus erythematosus), papulosquamous/papulokeratotic dermatoses (lichen planus, pityriasis rosea, papulosquamous sarcoidosis, guttate psoriasis, pityriasis lichenoides chronica, classical pityriasis rubra pilaris, porokeratosis, lymphomatoid papulosis, papulosquamous chronic GVHD, parakeratosis variegata, Grover disease, Darier disease and BRAF-inhibitor-induced acantholytic dyskeratosis), facial inflammatory skin diseases (rosacea, seborrheic dermatitis, discoid lupus erythematosus, sarcoidosis, cutaneous leishmaniasis, lupus vulgaris, granuloma faciale and demodicidosis), acquired keratodermas (chronic hand eczema, palmar psoriasis, keratoderma due to mycosis fungoides, keratoderma resulting from pityriasis rubra pilaris, tinea manuum, palmar lichen planus and aquagenic palmar keratoderma), sclero-atrophic dermatoses (necrobiosis lipoidica, morphea and cutaneous lichen sclerosus), hypopigmented macular diseases (extragenital guttate lichen sclerosus, achromic pityriasis versicolor, guttate vitiligo, idiopathic guttate hypomelanosis, progressive macular hypomelanosis and postinflammatory hypopigmentations), hyperpigmented maculopapular diseases (pityriasis versicolor, lichen planus pigmentosus, Gougerot-Carteaud syndrome, Dowling-Degos disease, erythema ab igne, macular amyloidosis, lichen amyloidosus, friction melanosis, terra firma-forme dermatosis, urticaria pigmentosa and telangiectasia macularis eruptiva perstans), itchy papulonodular dermatoses (hypertrophic lichen planus, prurigo nodularis, nodular scabies and acquired perforating dermatosis), erythrodermas (due to psoriasis, atopic dermatitis, mycosis fungoides, pityriasis rubra pilaris and scabies), noninfectious balanitis (Zoon's plasma cell balanitis, psoriatic balanitis, seborrheic dermatitis and non-specific balanitis) and erythroplasia of Queyrat, inflammatory cicatricial alopecias (scalp discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia and folliculitis decalvans), nonscarring alopecias (alopecia areata, trichotillomania, androgenetic alopecia and telogen effluvium) and scaling disorders of the scalp (tinea capitis, scalp psoriasis, seborrheic dermatitis and pityriasis amiantacea)...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27578077/prurigo-nodularis-management
#5
Athanasios Tsianakas, Claudia Zeidler, Sonja Ständer
Characterized by the clinical presentation of individual to multiple symmetrically distributed, hyperkeratotic, and intensely itchy papules and nodules, prurigo nodularis (PN) is a rare disease that emerges in patients with chronic pruritus due to continuous scratching over a long period of time. The itching and scratching of the lesions contribute to the vicious cycle that makes this disease difficult to treat, thus reducing the quality of life of affected patients. The pathogenesis of PN is ambiguous, although immunoneuronal crosstalk is implicated...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27578074/itch-management-treatments-under-development
#6
Manuel Pedro Pereira, Sonja Ständer
Pruritus is a symptom arising from a plethora of dermatological, neurological, and systemic conditions. The pathophysiological mechanisms involved in the transmission of acute and chronic pruritus are of high complexity and not yet fully understood. Recent research has enhanced the understanding of these mechanisms, enabling the development of novel drugs. Specifically, new therapies for inflammatory dermatoses, uremic pruritus, cholestatic pruritus, cutaneous T-cell lymphoma, and prurigo nodularis are being tested in ongoing randomized clinical trials...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27511319/bullous-pemphigoid-developed-in-a-patient-with-prurigo-nodularis
#7
N Yoshimoto, H Ujiie, Y Hirata, K Izumi, W Nishie, H Shimizu
No abstract text is available yet for this article.
August 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27486591/systemic-methotrexate-for-prurigo-nodularis-and-keratoacanthomas-in-actinically-damaged-skin
#8
Amy Kalowitz Bieber, David E Cohen, Jennifer A Stein
No abstract text is available yet for this article.
May 2016: JAAD Case Reports
https://www.readbyqxmd.com/read/27473457/onychotillomania-an-underrecognized-disorder
#9
REVIEW
Evan A Rieder, Antonella Tosti
Onychotillomania is an uncommon and likely underreported condition in which patients repetitively manipulate the different constituents of the nail unit. Onychotillomania is characterized by a range of nonspecific findings, including bizarre morphology of the nail plate and damage to the nail bed and periungual skin. Histopathological changes are also nonspecific, but may be viewed as analogous to lichen simplex chronicus and prurigo nodularis of the skin. Clinical history is essential to making this diagnosis, as effective treatment modalities may focus on behavioral therapies and psychiatric medications...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27376752/-pruritus-in-systemic-diseases-common-and-rare-etiologies
#10
A E Kremer, T Mettang
Chronic pruritus is a symptom of various internal disorders. In contrast to dermatological diseases, pruritus does not present with primary skin alterations in these patients. However, intense scratching may cause secondary skin changes such as abrasion, excoriation, prurigo nodularis, or in rare cases even scaring. The most common internal medicine causes for chronic pruritus are chronic kidney disease, hepatobiliary and hematological disorders as well as adverse drug reactions. Pruritus is less commonly seen in patients with endocrine or metabolic diseases, malabsorption syndromes, infectious diseases and solid tumors...
August 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27349279/acquired-reactive-perforating-dermatosis-is-a-variant-of-prurigo-nodularis
#11
Roxane-Isabelle Kestner, Sonja Ständer, Nani Osada, Dan Ziegler, Dieter Metze
Patients with chronic pruritus may develop scratch-induced lesions with elevated borders and central necrosis. This so-called umbilicated type of prurigo (UP) is rare and is assumed to develop preferentially in the context of metabolic diseases. The aim of this study was to characterize UP in its clinical and histological dimension. Demographic and clinical data were collected from 23 patients with UP. Intensive light microscopical analysis of biopsied lesions was performed. Statistical comparison with previous results for prurigo nodularis (PN) showed that UP is clearly a subtype of PN...
June 28, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27289372/a-review-of-the-efficacy-of-thalidomide-and-lenalidomide-in-the-treatment-of-refractory-prurigo-nodularis
#12
REVIEW
Victoria M Lim, Eric L Maranda, Vivek Patel, Brian J Simmons, Joaquin J Jimenez
Prurigo nodularis (PN) is a chronic dermatoses characterized by intensely pruritic, excoriated, or lichenified nodules. Standard therapy includes corticosteroids, antihistamines, and phototherapy; however, treatment results are often inadequate or transient. Thalidomide and its analogue lenalidomide are immunomodulatory drugs that have successfully been used to treat refractory cases of PN. A systematic review was performed evaluating the use of thalidomide and lenalidomide for PN. Eighteen articles were included in this study in which a total of 106 patients were evaluated, of whom 76 (71...
September 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27222766/hypertrophic-lichen-planus-versus-prurigo-nodularis-a-dermoscopic-perspective
#13
Balachandra S Ankad, Savitha L Beergouder
BACKGROUND: Hypertrophic lichen planus (HLP) classically involves shin and ankles and is characterized by hyperkeratotic plaques and nodules. Prurigo nodularis (PN) is a chronic neurodermatitis that presents with intensely pruritic nodules. Histopathology of HLP and PN demonstrate epidermal hyperplasia, hypergranulosis, and compact hyperkeratosis. The dermis shows vertically arranged collagen fibers and an increased number of fibroblasts and capillaries in both conditions. Moreover, basal cell degeneration is confined to the tips of rete ridges, and band-like infiltration is conspicuously absent in HLP...
April 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27216284/chronic-pruritus-in-the-absence-of-skin-disease-pathophysiology-diagnosis-and-treatment
#14
REVIEW
Manuel P Pereira, Andreas E Kremer, Thomas Mettang, Sonja Ständer
Chronic pruritus arises not only from dermatoses, but also, in up to half of cases, from extracutaneous origins. A multitude of systemic, neurological, psychiatric, and somatoform conditions are associated with pruritus in the absence of skin disease. Moreover, pruritus is a frequently observed side effect of many drugs. It is therefore difficult for physicians to make a correct diagnosis. Chronic pruritus patients frequently present to the dermatologist with skin lesions secondary to a long-lasting scratching behavior, such as lichenification and prurigo nodularis...
August 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27207351/nodular-subtype-of-bullous-pemphigoid
#15
Björn Dangel, Lukas Kofler, Gisela Metzler
INTRODUCTION: Itching nodules and papules are common findings. A rare but important differential diagnosis is the nodular subtype of bullous pemphigoid. METHODS AND RESULTS: The investigators report a female patient presenting with strongly itching papules disseminated over her extremities and trunk. Physical examination revealed multiple erythematous, mostly excoriated papules and nodules on her back, abdomen, and extremities. Histology showed changes compatible with prurigo lesion, and immunofluorescence showed positive results for BP180 and BP230...
May 4, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27051775/prurigo-nodularis-after-acupuncture
#16
Timothy Hermosura Almazan, Jae Yeon Jung
No abstract text is available yet for this article.
November 2015: JAAD Case Reports
https://www.readbyqxmd.com/read/26848213/quality-of-life-and-economic-burden-in-recessive-dystrophic-epidermolysis-bullosa
#17
In Kyung Jeon, Hye Rang On, Soo-Chan Kim
BACKGROUND: Patients with recessive dystrophic epidermolysis bullosa (RDEB) exhibit blisters and erosions since birth, causing pain, pruritus and various complications. RDEB affects quality of life (QoL) in physical, emotional and social aspects. Furthermore, interminable dressing changes and supportive therapies impose a significant economic burden on the patient's family. OBJECTIVE: We assessed the QoL and economic burden in patients with RDEB. METHODS: Sixteen patients with RDEB were surveyed to assess the QoL and economic burden...
February 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/26588345/grape-cells-multinucleated-keratinocytes-in-noninfectious-dermatoses-case-series-and-review-of-the-literature
#18
REVIEW
Sarah A Sweeney, Daryl J Sulit, Erin G Adams, Katerina R Shvartsman, Ronald P Rapini
Multinucleated keratinocytes (also known as multinucleated epidermal giant cells) are a frequently overlooked histological finding in noninfectious inflammatory dermatoses. They are sometimes found in conditions characterized by chronic rubbing and pruritus, such as lichen simplex chronicus or prurigo nodularis, and may be a helpful clue in making the clinical diagnosis. This finding must be differentiated from other conditions characterized by multinucleated keratinocytes on histopathology, specifically herpes simplex, varicella zoster, or measles viral infections...
December 2015: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26585238/-treatment-of-chronic-itch-in-systemic-disease-current-standards
#19
T Mettang, S Ständer, A E Kremer
Chronic itch (CI) is a frequent and sometimes tormenting symptom in many skin and systemic diseases. In systemic diseases, it mostly appears on primarily unaffected skin. As a sequelae of intense scratching, secondary skin lesions such as excoriations, scars, and prurigo nodularis may occur. Due to the lack of valid pathogenetic concepts and good clinical trials, the therapy of CI remains mostly symptomatic. In Europe almost all drugs used to treat CI are not approved for this indication. CI is frequent in patients with chronic kidney diseases in advanced stages...
December 2015: Der Internist
https://www.readbyqxmd.com/read/26577510/thalidomide-for-the-treatment-of-chronic-refractory-pruritus
#20
REVIEW
Divya Sharma, Shawn G Kwatra
Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ineffective, thalidomide, an immunomodulator and neuromodulator, may be a useful alternative treatment. Considerable relief of chronic pruritus has been demonstrated with thalidomide in case reports, case series, and controlled trials...
February 2016: Journal of the American Academy of Dermatology
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