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https://www.readbyqxmd.com/read/22518155/the-role-of-atoh1-in-mucous-cell-metaplasia
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Yoshihisa Nakamura, Yuki Hamajima, Masahiro Komori, Makoto Yokota, Motohiko Suzuki, Jizhen Lin
A key issue in otitis media is mucous cell metaplasia which is responsible for mucous hypersecretion and persistence of the disease. However, little is known about the molecular mechanisms of mucous cell metaplasia in otitis media. Numerous studies of intestinal epithelial homeostasis have shown that Atonal homolog 1 (Atoh1), a basic helix-loop-helix (bHLH) transcription factor, is essential for the intestinal goblet cell differentiation. On the other hand, SAM-pointed domain-containing Ets transcription factor (SPDEF), a member of the "Ets" transcription factor family, has been reported to trigger the mucous cell metaplasia of pulmonary infectious diseases or athsma...
2012: International Journal of Otolaryngology
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