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JOURNAL ARTICLE
Marwa Mahmoud Awad, Rehab M El-Gohary, Sarah Ibrahim, Muhammad Tarek Abdel Ghafar, Eman E Farghal, Alshimaa Aboalsoud, Rehab Ahmed Ahmed El-Shaer
Growing evidence suggests that phosphoinositide 3-kinase (PI3K) and adenosine monophosphate-activated protein kinase (AMPK) signaling cascades are critical in ulcerative colitis (UC) pathophysiology by influencing gut mucosal inflammation. Recently, the coloprotective properties of dipeptidyl peptidase-IV (DPP-IV) inhibitors have emerged. Thus, this study assessed for the first time the potential mitigating impact of a DPP-IV inhibitor, vildagliptin (Vilda), on oxazolone (OXZ)-induced colitis in rats, targeting the role of PI3K/AKT/mTOR and AMPK/Nrf2 pathways...
April 22, 2024: International Immunopharmacology
#2
JOURNAL ARTICLE
Asma Qasim Rahman, Reiadh Kamal Al-Kamali
Recurrent Aphthous stomatitis (RAS) is common oral mucosal condition. The pathophysiology of RAS is affected by a variety of variables, including microbial, genetic, immunological and local and systemic diseases. Interleukin IL-1β, a cytokine that promotes inflammation, has been found in high concentrations in the circulation of RAS. The goal of current investigation was to determine whether RAS is connected with polymorphisms of the IL-1β 542 T>A gene. A total of 60 RAS patients and 30 controls were included in the study...
March 31, 2024: Cellular and Molecular Biology
#3
JOURNAL ARTICLE
S Y Wang, S J Zhang, H F Meng, H Q Xu, Z X Guo, J F Yan, J L Gao, L N Niu, S L Wang, K Jiao
BACKGROUND: Oral submucous fibrosis (OSF) is a precancerous lesion characterized by fibrous tissue deposition, the incidence of which correlates positively with the frequency of betel nut chewing. Prolonged betel nut chewing can damage the integrity of the oral mucosal epithelium, leading to chronic inflammation and local immunological derangement. However, currently, the underlying cellular events driving fibrogenesis and dysfunction are incompletely understood, such that OSF has few treatment options with limited therapeutic effectiveness...
April 23, 2024: Stem Cell Research & Therapy
#4
Zhongwei Zhang, Izumi Tanaka, Rika Nakahashi-Ouchida, Peter B Ernst, Hiroshi Kiyono, Yosuke Kurashima
No abstract text is available yet for this article.
April 22, 2024: Seminars in Immunopathology
#5
JOURNAL ARTICLE
Valentina Eberlein, Sophia Rosencrantz, Julia Finkensieper, Joana Kira Besecke, Yaser Mansuroglu, Jan-Christopher Kamp, Franziska Lange, Jennifer Dressman, Simone Schopf, Christina Hesse, Martin Thoma, Jasmin Fertey, Sebastian Ulbert, Thomas Grunwald
The respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections associated with numerous hospitalizations. Recently, intramuscular (i.m.) vaccines against RSV have been approved for elderly and pregnant women. Noninvasive mucosal vaccination, e.g., by inhalation, offers an alternative against respiratory pathogens like RSV. Effective mucosal vaccines induce local immune responses, potentially resulting in the efficient and fast elimination of respiratory viruses after natural infection...
2024: Frontiers in Immunology
#6
JOURNAL ARTICLE
Hussein Muttaleb Asfoor, Atyaf Saied Hamied
Candida species are a normal human flora in humans' digestive and reproductive systems, oral cavity, skin, and mucosal surfaces. This study aimed to detect the immunological role of Candida infection by using some immunological markers. The results of levels in serum showed high concentrations of IgA (56.20 ± 12 pg/ml,29.55 ± 4.5 pg/ml respectively) and IgG (12.05 ± 3.218 pg/ml, 3.836 ± 1.23 pg/ml respectively) in mice infected with C...
April 18, 2024: Cytokine
#7
JOURNAL ARTICLE
Pablo Canales-Herrerias, Mathieu Uzzan, Akihiro Seki, Rafael S Czepielewski, Bram Verstockt, Alexandra E Livanos, Fiona Raso, Alexandra Dunn, Daniel Dai, Andrew Wang, Zainab Al-Taie, Jerome Martin, Thomas Laurent, Huaibin M Ko, Minami Tokuyama, Michael Tankelevich, Hadar Meringer, Francesca Cossarini, Divya Jha, Azra Krek, John D Paulsen, Matthew D Taylor, Mohammad Zuber Nakadar, Joshua Wong, Emma C Erlich, Rachel L Mintz, Emily J Onufer, Beth A Helmink, Keshav Sharma, Adam Rosenstein, Danielle Ganjian, Grace Chung, Travis Dawson, Julius Juarez, Vijay Yajnik, Andrea Cerutti, Jeremiah J Faith, Mayte Suarez-Farinas, Carmen Argmann, Francesca Petralia, Gwendalyn J Randolph, Alexandros D Polydorides, Andrea Reboldi, Jean-Frederic Colombel, Saurabh Mehandru
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7+ ) plasmablasts in circulation of VDZ-treated patients suggested that VDZ targets gut-associated lymphoid tissue (GALT). Anti-α4β7 blockade in wild-type and photoconvertible (KikGR) mice confirmed a loss of GALT size and cellularity because of impaired cellular entry...
April 19, 2024: Science Immunology
#8
JOURNAL ARTICLE
Gohar Shaghayegh, Clare Cooksley, George Bouras, Beula Subashini Panchatcharam, Sholeh Feizi, Shari Javadian, Mahnaz Ramezanpour, Kevin Aaron Fenix, Peter-John Wormald, Alkis James Psaltis, Sarah Vreugde
Staphylococcus aureus mucosal biofilms are associated with recalcitrant chronic rhinosinusitis (CRS). However, S. aureus colonisation of sinus mucosa is frequent in the absence of mucosal inflammation. This questions the relevance of S. aureus biofilms in CRS etiopathogenesis. This study aimed to investigate whether strain-level variation in in vitro-grown S. aureus biofilm properties relates to CRS disease severity, in vitro toxicity, and immune B cell responses in sinonasal tissue from CRS patients and non-CRS controls...
April 16, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#9
REVIEW
Changlin Wen, Dan Chen, Rao Zhong, Xi Peng
Inflammatory bowel disease (IBD) research often relies on animal models to study the etiology, pathophysiology, and management of IBD. Among these models, rats and mice are frequently employed due to their practicality and genetic manipulability. However, for studies aiming to closely mimic human pathology, non-human primates such as monkeys and dogs offer valuable physiological parallels. Guinea pigs, while less commonly used, present unique advantages for investigating the intricate interplay between neurological and immunological factors in IBD...
2024: Gastroenterology Report
#10
JOURNAL ARTICLE
Osamu Imataki, Shunsuke Yoshida, Tomoya Ishida, Haruyuki Fujita, Makiko Uemura
A literature review does not provide information about the safety of autologous hematopoietic stem cell transplantation (HSCT) in a recipient who has previously received allogeneic HSCT. We treated a 69-year-old woman with diffuse large B cell lymphoma. The patient received autologous stem cell transplantation (ASCT) in the second complete remission of malignant lymphoma. The patient had undergone allogeneic hematopoietic SCT (allo-HSCT) for chronic myeloid leukemia 20 years ago. Chronic myeloid leukemia had been in complete remission for the previous 20 years...
April 2024: EJHaem
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JOURNAL ARTICLE
Kate L Seib, Basil Donovan, Caroline Thng, David A Lewis, Anna McNulty, Christopher K Fairley, Barbara Yeung, Fengyi Jin, Doug Fraser, Benjamin R Bavinton, Matthew Law, Marcus Y Chen, Eric P F Chow, David M Whiley, Brent Mackie, Michael P Jennings, Amy V Jennison, Monica M Lahra, Andrew E Grulich
INTRODUCTION: Gonorrhoea, the sexually transmissible infection caused by Neisseria gonorrhoeae , has a substantial impact on sexual and reproductive health globally with an estimated 82 million new infections each year worldwide. N. gonorrhoeae antimicrobial resistance continues to escalate, and disease control is largely reliant on effective therapy as there is no proven effective gonococcal vaccine available. However, there is increasing evidence from observational cohort studies that the serogroup B meningococcal vaccine four-component meningitis B vaccine (4CMenB) (Bexsero), licensed to prevent invasive disease caused by Neisseria meningitidis , may provide cross-protection against the closely related bacterium N...
April 16, 2024: BMJ Open
#12
JOURNAL ARTICLE
Eimear K Ryan, Christy Clutter, Conor De Barra, Benjamin J Jenkins, Simon O'Shaughnessy, Odhrán K Ryan, Chloe McKenna, Helen M Heneghan, Fiona Walsh, David K Finlay, Linda V Sinclair, Nicholas Jones, Daniel T Leung, Donal O'Shea, Andrew E Hogan
Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production. The metabolic and nutritional requirements for optimal MAIT cell effector responses are still emerging. Iron is an important micronutrient and is essential for cellular fitness, in particular cellular metabolism...
April 15, 2024: Journal of Immunology
#13
JOURNAL ARTICLE
Qiang Shao, Lin Sun
C1q/tumor necrosis factor-related protein 3 (CTRP3) has been demonstrated to play a protective role in mice with severe acute pancreatitis (SAP). However, its clinical significance in SAP remains unknown. This study was conducted to explore the clinical values of serum C1q/tumor necrosis factor-related protein 3 (CTRP3) level in the diagnosis of cardiac dysfunction (CD) and intestinal mucosal barrier dysfunction (IMBD) in SAP. Through RT-qPCR, we observed decreased CTRP3 level in the serum of SAP patients. Serum CTRP3 level was correlated with C-reactive protein, procalcitonin, creatine, modified computed tomography severity index score, and Acute Physiology and Chronic Health Evaluation II score...
2024: Critical Reviews in Immunology
#14
JOURNAL ARTICLE
Hend Alqedari, Khaled Altabtbaei, Josh L Espinoza, Saadoun Bin-Hasan, Mohammad Alghounaim, Abdullah Alawady, Abdullah Altabtabae, Sarah AlJamaan, Sriraman Devarajan, Tahreer AlShammari, Mohammed Ben Eid, Michele Matsuoka, Hyesun Jang, Christopher L Dupont, Marcelo Freire
Established evidence indicates that oral microbiota plays a crucial role in modulating host immune responses to viral infection. Following severe acute respiratory syndrome coronavirus 2, there are coordinated microbiome and inflammatory responses within the mucosal and systemic compartments that are unknown. The specific roles the oral microbiota and inflammatory cytokines play in the pathogenesis of coronavirus disease 2019 (COVID-19) are yet to be explored. Here, we evaluated the relationships between the salivary microbiome and host parameters in different groups of COVID-19 severity based on their oxygen requirement...
April 2024: PNAS Nexus
#15
JOURNAL ARTICLE
Ling Zhao, Xinxin Hou, Yuanyuan Feng, Yingru Zhang, Shiyun Shao, Xinnan Wu, Junfeng Jim Zhang, Zhaozhou Zhang
Purpose: Mounting evidence indicates that psychological stress adversely affects cancer progression including tumor growth and metastasis. The aim of this study was to investigate the role of chronic stress-induced microbiome perturbation in colorectal cancer (CRC) progression. Methods: Chronic restraint stress (CRS) was used to establish the chronic stress mouse model, behavioral tests were used for the CRS model evaluation. Subcutaneous xenograft model and lung metastasis model were established to investigate the growth and metastasis of CRC promoted by CRS exposure...
2024: International Journal of Medical Sciences
#16
JOURNAL ARTICLE
Sebastian Malmqvist, Reuben Clark, Gunnar Johannsen, Annsofi Johannsen, Elisabeth A Boström, Ronaldo Lira-Junior
Peri-implantitis and periodontitis are common oral inflammatory diseases, which seem to exhibit critical differences in some of their molecular features. Thus, we assessed the immune cell composition of peri-implantitis and periodontitis lesions and the corresponding inflammatory profile in soft tissues and crevicular fluid. Peri-implantitis, periodontitis and control patients were recruited (n=62), and soft tissue biopsies were collected during surgery. Crevicular fluid around implant or tooth was collected...
April 15, 2024: Clinical and Experimental Immunology
#17
JOURNAL ARTICLE
Emily L Parsons, Jisung S Kim, Allison M W Malloy
Infection of the respiratory tract with respiratory syncytial virus (RSV) is common and occurs repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and the elderly. Effective anti-viral therapeutics are not available and therefore prevention has been the primary strategy for reducing the disease burden. Our current understanding of respiratory mucosal cell biology and the immune response within the respiratory tract is inadequate to prevent infection caused by a pathogen like RSV that does not disseminate outside of this environment...
March 26, 2024: Cellular Immunology
#18
JOURNAL ARTICLE
Amira Isaac, Marcel W Keddeas, Abeer A Abd Elhady, Sara M Khatab, Shimaa A Elgohary, Hosam S El Baz
Ulcerative colitis is a chronic immune-mediated inflammatory condition of large intestine that is frequently associated with inflammation of the rectum but often extends proximally to involve other areas of the colon. The ultimate target of therapy is complete healing in the form of clinical remission, complete endoscopic and histological healing, and transmural healing for which endoscopy is mandatory. Colonoscopy may not always be applicable due to possible complications in active ulcerative colitis. Therefore, non-invasive biomarkers are needed to avoid the disadvantageous complications of invasive diagnostic procedures...
April 2024: Egyptian Journal of Immunology
#19
JOURNAL ARTICLE
Tingting Li, Xiaojun Zhou, Qian Zhang, Qi Miao, Owen L Woodman, Yuguo Chen, Chengxue Qin
Excessive inflammatory responses are the main characteristic of ulcerative colitis (UC). Activation of formyl peptide receptor 1 (FPR1) has been found to promote the proliferation and migration of epithelial cells, but its role and therapeutic potential in UC remain unclear. This study observed an increased expression of FPR1 in a mouse model of colitis. Interestingly, FPR1 deficiency exacerbated UC and increased the secretion of the pro-inflammatory mediator from immune cells (e.g., macrophages), S100a8, a member of the damage-associated molecular patterns (DAMPs)...
April 11, 2024: Mucosal Immunology
#20
JOURNAL ARTICLE
Loredana Vesci, Grazia Tundo, Sara Soldi, Serena Galletti, Daniela Stoppoloni, Roberta Bernardini, Anamaria Bianca Modolea, Laura Luberto, Emanuele Marra, Fabrizio Giorgi, Stefano Marini
Crohn's and ulcerative colitis are common conditions associated with inflammatory bowel disease as well as intestinal flora and epithelial barrier dysfunction. A novel fermented Lactobacillus brevis (AL0035) herein assayed in a trinitro benzene sulfonic acid (TNBS)-induced colitis mice model after oral administration significantly counteracted the body weight loss and improves the disease activity index and histological injury scores. AL0035 significantly decreased the mRNA and protein expression of different pro-inflammatory cytokines (TNFalpha, IL-1beta, IL-6, IL-12, IFN-gamma) and enhanced the expression of IL-10...
March 24, 2024: Nutrients
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