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Rs1360780

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https://www.readbyqxmd.com/read/29674169/intergenerational-gene-%C3%A3-environment-interaction-of-fkbp5-and-childhood-maltreatment-on-hair-steroids
#1
Alexandra M Koenig, Laura Ramo-Fernández, Christina Boeck, Maria Umlauft, Markus Pauly, Elisabeth B Binder, Clemens Kirschbaum, Harald Gündel, Alexander Karabatsiakis, Iris-Tatjana Kolassa
BACKGROUND: The inconsistency in results of cortisol alterations after childhood maltreatment (CM) might arise due to the fact that no study so far considered the effects of environmental factors such as maltreatment load and genetic factors such as the influence of FKBP5 genotype on stress hormone regulation. This study analyzed the interaction between the single nucleotide polymorphism rs1360780 within the FKBP5 gene and the severity of maternal CM experiences (maltreatment load) on hair steroid levels of mother-infant-dyads...
April 5, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29578315/genes-involved-in-stress-response-influence-lithium-efficacy-in-bipolar-patients
#2
Aleksandra Szczepankiewicz, Beata Narozna, Janusz K Rybakowski, Sebastian Kliwicki, Piotr Czerski, Monika Dmitrzak-Węglarz, Maria Skibińska, Joanna Twarowska-Hauser, Joanna Pawlak
OBJECTIVES: In mood disorders, chronic stimulation with stress results in aberrant regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Lithium was shown to influence HPA axis function. The underlying genetic background as well as environmental context may influence the stress response, and therefore lithium efficacy. The aim of the present study was to analyze if genetic variants located in genes involved in HPA axis regulation affect the response to long-term lithium treatment in bipolar patients...
March 26, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29576410/the-effects-of-early-trauma-and-the-fkbp5-gene-on-ptsd-and-the-hpa-axis-in-a-clinical-sample-of-gulf-war-veterans
#3
Dmitri A Young, Sabra S Inslicht, Thomas J Metzler, Thomas C Neylan, Jessica A Ross
Previous research indicates that interactions between FKBP5 single nucleotide polymorphisms (SNPs) and child abuse are associated with posttraumatic stress disorder (PTSD) in adulthood. We examined the relationship between the T-allele of the rs1360780 FKBP5 SNP and child abuse on PTSD and the HPA axis in a clinical sample of Gulf War veterans. Genotyping was completed on 266 veterans and 174 veterans additionally participated in a low dose dexamethasone suppression test (DST). The CAPS was used to determine PTSD status and the THQ was used to determine child abuse operationalized as either childhood physical or sexual abuse...
March 16, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29535036/interactive-effects-of-genetic-polymorphisms-and-childhood-adversity-on-brain-morphologic-changes-in-depression
#4
REVIEW
Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Han
The etiology of depression is characterized by the interplay of genetic and environmental factors and brain structural alteration. Childhood adversity is a major contributing factor in the development of depression. Interactions between childhood adversity and candidate genes for depression could affect brain morphology via the modulation of neurotrophic factors, serotonergic neurotransmission, or the hypothalamus-pituitary-adrenal (HPA) axis, and this pathway may explain the subsequent onset of depression...
March 10, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29466454/interaction-between-fkbp5-variability-and-recent-life-events-in-the-anxiety-spectrum-evidence-for-the-differential-susceptibility-model
#5
Beatriz Pérez-Pérez, Paula Cristóbal-Narváez, Tamara Sheinbaum, Thomas R Kwapil, Sergi Ballespí, Elionora Peña, Marta de Castro-Catala, Maria Dolors Riba, Araceli Rosa, Neus Barrantes-Vidal
BACKGROUND: Gene-environment interaction (GxE) research has highlighted the importance of investigating the FK506 binding protein 51 (FKBP5) gene as a sensitivity gene. However, previous GxE studies with FKBP5 have not measured the full environmental spectrum or applied statistical tests to discern whether the GxE interaction fits better with the differential-susceptibility or diathesis-stress hypotheses. This study examined whether single nucleotide polymorphisms (SNPs) on FKBP5 gene moderate the association of positive and negative recent life events (LEs) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits...
2018: PloS One
https://www.readbyqxmd.com/read/29182159/epigenetic-changes-of-fkbp5-as-a-link-connecting-genetic-and-environmental-risk-factors-with-structural-and-functional-brain-changes-in-major-depression
#6
Leonardo Tozzi, Chloe Farrell, Linda Booij, Kelly Doolin, Zsofia Nemoda, Moshe Szyf, Florence B Pomares, Julian Chiarella, Veronica O'Keane, Thomas Frodl
The gene for the glucocorticoid receptor regulator FK506 binding protein 5 (FKBP5) plays a role for risk, response to treatment, and changes in brain areas in major depressive disorder (MDD). Chronic stress is associated with lower methylation of FKBP5. Our aim was to investigate whether methylation of FKBP5 reflected exposure to childhood adversity in MDD and controls and whether it was associated with structure and function of emotional processing regions. FKBP5 intron 7 GR response element region methylation and rs1360780 allelic status were assessed from whole blood in 56 MDD adults and 50 controls...
November 28, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29162173/change-in-fk506-binding-protein-5-fkbp5-methylation-over-time-among-preschoolers-with-adversity
#7
Stephanie H Parade, Justin Parent, Kantoniony Rabemananjara, Ronald Seifer, Carmen J Marsit, Bao-Zhu Yang, Huiping Zhang, Audrey R Tyrka
FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29074884/evidence-for-stress-like-alterations-in-the-hpa-axis-in-women-taking-oral-contraceptives
#8
Johannes Hertel, Johanna König, Georg Homuth, Sandra Van der Auwera, Katharina Wittfeld, Maik Pietzner, Tim Kacprowski, Liliane Pfeiffer, Anja Kretschmer, Melanie Waldenberger, Gabi Kastenmüller, Anna Artati, Karsten Suhre, Jerzy Adamski, Sönke Langner, Uwe Völker, Henry Völzke, Matthias Nauck, Nele Friedrich, Hans Joergen Grabe
Using oral contraceptives has been implicated in the aetiology of stress-related disorders like depression. Here, we followed the hypothesis that oral contraceptives deregulate the HPA-axis by elevating circulating cortisol levels. We report for a sample of 233 pre-menopausal women increased circulating cortisol levels in those using oral contraceptives. For women taking oral contraceptives, we observed alterations in circulating phospholipid levels and elevated triglycerides and found evidence for increased glucocorticoid signalling as the transcript levels of the glucocorticoid-regulated genes DDIT4 and FKBP5 were increased in whole blood...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891785/attachment-style-moderates-effects-of-fkbp5-polymorphisms-and-childhood-abuse-on-posttraumatic-stress-symptoms-results-from-the-national-health-and-resilience-in-veterans-study
#9
Amanda J F Tamman, Lauren M Sippel, Shizhong Han, Yuval Neria, John H Krystal, Steven M Southwick, Joel Gelernter, Robert H Pietrzak
OBJECTIVES: To determine the main and interactive effects of four FKBP5 polymorphisms (rs9296158, rs3800373, rs1360780, and rs9470080), childhood abuse, and attachment style in predicting severity of PTSD symptoms in two independent, nationally representative samples of U.S. military veterans. METHODS: Data were analyzed from two independent samples of European American (EA) U.S. military veterans who participated in the National Health and Resilience in Veterans Study (N = 1,585 and 577 respectively)...
September 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28889074/interaction-between-fkbp5-gene-and-childhood-trauma-on-psychosis-depression-and-anxiety-symptoms-in-a-non-clinical-sample
#10
Marta de Castro-Catala, Elionora Peña, Thomas R Kwapil, Sergi Papiol, Tamara Sheinbaum, Paula Cristóbal-Narváez, Sergi Ballespí, Neus Barrantes-Vidal, Araceli Rosa
BACKGROUND: Childhood trauma has been associated with a heightened risk for presenting clinical and non-clinical psychopathology in adulthood. Genes related with the stress response, such as the FK506 binding protein 51 (FKBP5), are plausible candidates moderating the effects of childhood trauma on the emergence of such symptoms later on. The present study aimed to explore the moderating role of FKBP5 genetic variability on the association of different types of childhood trauma with subclinical psychosis, depression and anxiety in a non-clinical sample...
August 26, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28654774/fkbp5-moderation-of-the-relationship-between-childhood-trauma-and-maladaptive-emotion-regulation-strategies-in-adolescents
#11
Thorhildur Halldorsdottir, Ana Paula Soares de Matos, Yvonne Awaloff, Eiríkur Örn Arnarson, W Edward Craighead, Elisabeth B Binder
Maladaptive emotion regulation strategies, such as rumination and catastrophizing, are transdiagnostic risk factors for psychopathology. FK506-binding protein 51 (FKBP5) has been found to moderate the relationship between stressful life events and various psychiatric disorders. Given the cross-disorder moderation effect of FKBP5 at the diagnostic level, the aim of the current study was to examine whether the relationship between exposure to childhood trauma and transdiagnostic maladaptive emotion regulation processes would also be moderated by genetic FKBP5 variation in a community sample of adolescents...
June 17, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28364727/hypothalamic-pituitary-adrenal-axis-genetic-variation-and-early-stress-moderates-amygdala-function
#12
Christina R Di Iorio, Caitlin E Carey, Lindsay J Michalski, Nadia S Corral-Frias, Emily Drabant Conley, Ahmad R Hariri, Ryan Bogdan
Early life stress may precipitate psychopathology, at least in part, by influencing amygdala function. Converging evidence across species suggests that links between childhood stress and amygdala function may be dependent upon hypothalamic-pituitary-adrenal (HPA) axis function. Using data from college-attending non-Hispanic European-Americans (n=308) who completed the Duke Neurogenetics Study, we examined whether early life stress (ELS) and HPA axis genetic variation interact to predict threat-related amygdala function as well as psychopathology symptoms...
June 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28198448/influence-of-fkbp5-polymorphism-and-dna-methylation-on-structural-changes-of-the-brain-in-major-depressive-disorder
#13
Kyu-Man Han, Eunsoo Won, Youngbo Sim, June Kang, Changsu Han, Yong-Ku Kim, Seung-Hyun Kim, Sook-Haeng Joe, Min-Soo Lee, Woo-Suk Tae, Byung-Joo Ham
A single nucleotide polymorphism of rs1360780 in the FKBP5 gene is associated with a predisposition to developing major depressive disorder (MDD). We investigated the interactive effects of FKBP5 rs1360780 allelic variants, DNA methylation, and the diagnosis of MDD on structural changes of the entire brain. One hundred and fourteen patients with MDD and eighty-eight healthy controls underwent T1-weighted structural magnetic resonance imaging and FKBP5 rs1360780 genotyping, including DNA methylation of intron 7...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28025095/a-cross-species-study-of-heterogeneity-in-fear-extinction-learning-in-relation-to-fkbp5-variation-and-expression-implications-for-the-acute-treatment-of-posttraumatic-stress-disorder
#14
Isaac R Galatzer-Levy, Raül Andero, Takehito Sawamura, Tanja Jovanovic, Santiago Papini, Kerry J Ressler, Seth Davin Norrholm
Deficits in fear extinction learning are hypothesized to underlie the development of posttraumatic stress disorder (PTSD). Such deficits may, in part, be due to genetic and epigenetic variation in the stress related gene FKBP5. Conversely, altering FKBP5 epigenetic responses during memory consolidation may rescue extinction deficits making it a target for acute intervention to prevent the development of PTSD. Study 1 (Humans) examines if FKBP5 single nucleotide polymorphisms (SNPs) and PTSD symptom domains (re-experiencing, avoidance/numbing, hyperarousal) are associated with abnormal fear extinction phenotypes identified using latent growth mixture modeling (LGMM)...
December 23, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/28007534/fkbp5-polymorphism-is-associated-with-insulin-resistance-in-children-and-adolescents-with-obesity
#15
Marta Fichna, Izabela Krzyśko-Pieczka, Magdalena Żurawek, Bogda Skowrońska, Danuta Januszkiewicz-Lewandowska, Piotr Fichna
OBJECTIVE: Since metabolic syndrome shares several clinical features with hypercortisolism, it was hypothesised that genes altering individual glucocorticoid (GC) sensitivity might be implicated in pathogenesis of obesity and its adverse outcomes. FKBP5 gene encodes a chaperon protein in the GC receptor (GR) complex, which modulates steroid action upon target genes. Its functional variant, rs1360780, may enhance FKBP5 gene transcription, affect GR signalling and thereby influence the hypothalamo-pituitary-adrenal axis...
December 19, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28002634/fkbp5-polymorphisms-influence-pre-learning-stress-induced-alterations-of-learning-and-memory
#16
Phillip R Zoladz, Alison M Dailey, Hannah E Nagle, Miranda K Fiely, Brianne E Mosley, Callie M Brown, Tessa J Duffy, Amanda R Scharf, McKenna B Earley, Boyd R Rorabaugh
FK506 binding protein 51 (FKBP5) is a co-chaperone of heat shock protein 90 and significantly influences glucocorticoid receptor sensitivity. Single nucleotide polymorphisms (SNPs) in the FKBP5 gene are associated with altered hypothalamus-pituitary-adrenal (HPA) axis function, changes in the structure and function of several cognitive brain areas, and increased susceptibility to post-traumatic stress disorder, major depression, bipolar disorder and suicidal events. The mechanisms underlying these associations are largely unknown, but it has been speculated that the influence of these SNPs on emotional memory systems may play a role...
March 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27941579/early-life-stress-fkbp5-polymorphisms-and-quantitative-glycemic-traits
#17
Anna Suarez, Jari Lahti, Eero Kajantie, Johan G Eriksson, Katri Räikkönen
OBJECTIVE: Early life stress (ELS) has been shown to influence health later in life. Functioning of the hypothalamic-pituitary-adrenal axis, regulated partly by FKBP5 gene, may moderate these effects. We examined whether FKBP5 single-nucleotide polymorphisms (SNPs) interact with ELS on Type 2 diabetes, cardiovascular disease, and quantitative glycemic traits. METHODS: A total of 1728 Helsinki Birth Cohort Study participants born from 1934 to 1944 were genotyped for FKBP5 SNPs (rs1360780, rs9394309, rs9470080) and were administered a 2-hour (75 g) oral glucose tolerance test and a questionnaire on physician-diagnosed and medication use for chronic diseases at a mean age of 61...
June 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27915167/examining-fkbp5-mrna-expression-in-human-ipsc-derived-neural-cells
#18
Richard Lieberman, Henry R Kranzler, Eric S Levine, Jonathan Covault
In peripheral blood leukocytes, FKBP5 mRNA expression is upregulated following glucocorticoid receptor activation. The single nucleotide polymorphism rs1360780 in FKBP5 is associated with psychiatric illness and has functional molecular effects. However, examination of FKBP5 regulation has largely been limited to peripheral cells, which may not reflect regulation in neural cells. We used 27 human induced pluripotent stem cell lines (iPSCs) derived from 20 subjects to examine FKBP5 mRNA expression following GR activation...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27760575/the-interactive-effects-of-child-maltreatment-and-the-fk506-binding-protein-5-gene-fkbp5-on-dissociative-symptoms-in-adolescence
#19
Fatima Tuba Yaylaci, Dante Cicchetti, Fred A Rogosch, Okan Bulut, Susan R Hetzel
The FK506 binding protein 5 gene (FKBP5) has been associated with susceptibility to pathogenic effects of childhood trauma including dissociative symptoms. This study examines the impact of maltreatment on dissociative tendencies in adolescence as moderated by the FKBP5 gene. Dissociative symptoms and variation within FKBP5 were assessed in a high-risk, low socioeconomic status community sample of 279 maltreated and 171 nonmaltreated adolescents. Following the assignment of haplotypes across four single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080), individuals with one or more copies of the CATT haplotype (N = 230) were grouped together and compared to individuals with zero copies of this haplotype (N = 185)...
October 20, 2016: Development and Psychopathology
https://www.readbyqxmd.com/read/27754486/association-of-fkbp5-polymorphisms-and-resting-state-activity-in-a-frontotemporal-parietal-network
#20
R A Bryant, K L Felmingham, B Liddell, P Das, G S Malhi
The FKBP5 polymorphism is a key regulator of the glucocorticoid system underpinning stress responsivity, and risk alleles can increase vulnerability for developing posttraumatic stress disorder. To delineate the specific role of FKBP5 risk alleles unencumbered by the confounds of psychopathology, this study investigated whether high-risk alleles of the FKBP5 polymorphism are characterized by distinctive neural activity during resting state. Thirty-seven healthy participants were selected on the basis of four SNPs in the FKBP5 gene region (rs3800373, rs9296158, rs1360780 and rs9470080) to determine participants who were carriers of the FKBP5 high- and low-risk alleles...
October 18, 2016: Translational Psychiatry
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