Girlaine Pereira da Silva, Daniele Corrêa Fernandes, Wanderson Silva Pereira, Shirley Vânia Moura Santos, Paulo Roberto Marques, Carlos Roberto Machado Gayer, Bruna de Paiva Martins, Elisabeth Avvad Portari, Frederico Freire Bastos, Israel Felzenszwalb, Carlos Fernando Araújo Lima, Graça Justo, Kátia Costa de Carvalho Sabino, Marsen Garcia Pinto Coelho
ETHNOPHARMACOLOGICAL RELEVANCE: Echinodorus macrophyllus (Kunth.) Micheli (Alismataceae), known as chapéu-de-couro in Brazil, is popularly used to treat inflammatory diseases. We have previously demonstrated a significant reduction in the acute inflammation for the aqueous extract of E. macrophyllus (AEEm) and its ethanolic fraction (Fr20) and described that hydroxycinnamoyl derivatives present in SF1 (Fr20 subfraction) showed higher anti-inflammatory properties by mechanisms that include a reduction of TNF-α, IL-1β, CKCL1/KC, LTB4, and PGE2 levels in exudate...
November 24, 2023: Journal of Ethnopharmacology