keyword
https://read.qxmd.com/read/38465347/association-between-metabolic-dysfunction-associated-fatty-liver-disease-and-macces-in-patients-with-diabetic-foot-ulcers-an-ambispective-longitudinal-cohort-study
#1
JOURNAL ARTICLE
Xiuxian Huang, Zhengming Li, Zhenwei Zhai, Qiu Wang, Rongyan Wei, Jiacheng Mo, Jianhao Huang, Wensheng Lu
AIM: Metabolic dysfunction-related fatty liver disease (MAFLD) is closely related to metabolic disorders. However, the relationship between MAFLD and the prognosis in diabetic foot ulcers (DFUs) remains unclear. This study aimed to explore the association between MAFLD and the risk of major adverse cardiac and cerebral events (MACCEs) in patients with DFUs. METHODS: 889 inpatients with DFUs (PEDIS/TEXAS mild and above) were included in this study from 2013 to 2023...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38340262/alactic-base-excess-abe-a-novel-internal-milieu-parameter-its-concept-and-clinical-importance
#2
REVIEW
Md Hoque, Jason Nagourney, Thomas Pawlowski, Joaquin Cantos, Gustavo Aroca-Martinez, Ivan Huespe, Carlos G Musso
Inspired by the Stewart-Figge acid-base approach, Gattinoni et al. recently introduced a new internal milieu parameter known as alactic base excess (ABE). The authors defined ABE as the sum of lactate and standard base excess. In the context of sepsis, ABE has been proposed as a valuable marker to discern between metabolic acidosis resulting from the accumulation of lactate and the retention of fixed acids, which can occur in cases of renal failure. Multiple studies have demonstrated that a negative ABE value (<-3 mmol/L) represents an early marker of renal dysfunction, and significantly correlates with higher mortality rates in septic patients...
February 10, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38183071/repeated-implants-failure-in-young-patient-with-idiopathic-nephrotic-syndrome-a-case-report-with-brief-review-of-the-literature
#3
JOURNAL ARTICLE
Lamees R Alssum
BACKGROUND: Nephrotic syndrome is a chronic disorder characterized by heavy proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Idiopathic minimal-change disease is the most common form encountered in children. Corticosteroids are the cornerstone for the treatment of idiopathic nephrotic syndrome (INS), with different regimens depending on the response to therapy and frequency of relapses. This case report presents complications after implant treatment in patient with INS. CASE PRESENTATION: 20 years old female patient presented for implant consultation...
January 5, 2024: BMC Oral Health
https://read.qxmd.com/read/38142456/action-mechanism-of-the-potential-biocontrol-agent-brevibacillus-laterosporus-sn19-1-against-xanthomonas-oryzae-pv-oryzae-causing-rice-bacterial-leaf-blight
#4
JOURNAL ARTICLE
Xin-Xin Su, Tian-Tian Wan, Yong-Dong Gao, Song-Han Zhang, Xiu Chen, Lan-Qi Huang, Wei Wang
The causal agent of rice bacterial leaf blight (BLB) is Xanthomonas oryzae pv. oryzae (Xoo), which causes serious damage to rice, leading to yield reduction or even crop failure. Brevibacillus laterosporus SN19-1 is a biocontrol strain obtained by long-term screening in our laboratory, which has a good antagonistic effect on a variety of plant pathogenic bacteria. In this study, we investigated the efficacy and bacterial inhibition of B. laterosporus SN19-1 against BLB to lay the theoretical foundation and research technology for the development of SN19-1 as a biopesticide of BLB...
December 24, 2023: Archives of Microbiology
https://read.qxmd.com/read/38008274/echinodorus-macrophyllus-acute-toxicological-evaluation-of-hydroxycinnamoyl-derivatives-from-sf1-subfractions
#5
JOURNAL ARTICLE
Girlaine Pereira da Silva, Daniele Corrêa Fernandes, Wanderson Silva Pereira, Shirley Vânia Moura Santos, Paulo Roberto Marques, Carlos Roberto Machado Gayer, Bruna de Paiva Martins, Elisabeth Avvad Portari, Frederico Freire Bastos, Israel Felzenszwalb, Carlos Fernando Araújo Lima, Graça Justo, Kátia Costa de Carvalho Sabino, Marsen Garcia Pinto Coelho
ETHNOPHARMACOLOGICAL RELEVANCE: Echinodorus macrophyllus (Kunth.) Micheli (Alismataceae), known as chapéu-de-couro in Brazil, is popularly used to treat inflammatory diseases. We have previously demonstrated a significant reduction in the acute inflammation for the aqueous extract of E. macrophyllus (AEEm) and its ethanolic fraction (Fr20) and described that hydroxycinnamoyl derivatives present in SF1 (Fr20 subfraction) showed higher anti-inflammatory properties by mechanisms that include a reduction of TNF-α, IL-1β, CKCL1/KC, LTB4, and PGE2 levels in exudate...
November 24, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37986146/diabetes-mellitus-affects-the-treatment-outcomes-of-drug-resistant-tuberculosis-a-systematic-review-and-meta-analysis
#6
JOURNAL ARTICLE
Guisheng Xu, Xiaojiang Hu, Yanshu Lian, Xiuting Li
BACKGROUND: Both tuberculosis (TB) and diabetes mellitus (DM) are major public health problems threatening global health. TB patients with DM have a higher bacterial burden and affect the absorption and metabolism for anti-TB drugs. Drug-resistant TB (DR-TB) with DM make control TB more difficult. METHODS: This study was completed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline. We searched PubMed, Excerpta Medica Database (EMBASE), Web of Science, ScienceDirect and Cochrance Library for literature published in English until July 2022...
November 20, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37892763/the-impact-of-transfer-related-ischemia-on-free-flap-metabolism-and-electrolyte-homeostasis-a-new-in-vivo-experimental-approach-in-pigs
#7
JOURNAL ARTICLE
Daniel Stephan, Sebastian Blatt, Julian Riedel, Katja Mohnke, Robert Ruemmler, Alexander Ziebart, Bilal Al-Nawas, Peer W Kämmerer, Daniel G E Thiem
Free flap tissue transfer represents the gold standard for extensive defect reconstruction, although malperfusion due to thrombosis remains the leading risk factor for flap failure. Recent studies indicate an increased immune response and platelet activation in connection with pathologic coagulation. The underlying cellular and molecular mechanisms remain poorly understood, however. The presented study, therefore, aims to investigate if transfer-related ischemia alters intra-flap metabolism and electrolyte concentrations compared to central venous blood after free flap transfer in pigs to establish a novel experimental model...
October 19, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37788949/effect-of-genetically-determined-bcaa-levels-on-cardiovascular-diseases-and-their-risk-factors-a-mendelian-randomization-study
#8
JOURNAL ARTICLE
Zheng Zuo, Yi Tong, Minghua Li, Zhenggui Wang, Xishu Wang, Xiaoxue Guo, Ying Sun, Zhiguo Zhang
BACKGROUND AND AIMS: Observational studies have demonstrated that serum branched-chain amino acids (BCAAs) are associated with the risk of various cardiovascular diseases (CVDs) and their risk factors. However, the causal effect is unclear. The aim of this study was to investigate the effect of genetically determined BCAA levels on CVDs and their risk factors using Mendelian randomization (MR). METHODS AND RESULTS: We performed univariable and multivariable MR analyses using summary-level data from multiple GWASs and the FinnGen consortium to investigate the association between BCAA levels and the risk of CVDs (myocardial infarction, ischemic stroke, and intracerebral hemorrhage) and their risk factors (atrial fibrillation, hypertension, heart failure, and valvular heart disease)...
August 14, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/37602070/massive-chronic-hypernatremia-associated-with-failure-to-thrive-in-a-pediatric-patient
#9
Jack A Tellerday, Vincent Calleo
Hypernatremia is a severe, potentially life-threatening condition that can manifest with altered mental status, coma, seizure, and even death. Values above 190 mmol/L are seldom reported in young pediatric patients and often have poor outcomes. We present a case of severe chronic hypernatremia secondary to failure to thrive (FTT) in a toddler, which led to significant pathology including bilateral metabolic strokes. A 21-month-old female was found unresponsive and brought to the hospital. The patient's childhood was complicated by prematurity, poor weight gain, and persistent postprandial emesis...
July 2023: Curēus
https://read.qxmd.com/read/37334359/exploring-the-genetic-association-of-allergic-diseases-with-cardiovascular-diseases-a-bidirectional-mendelian-randomization-study
#10
JOURNAL ARTICLE
Shilin Wang, Hao Liu, Peiwen Yang, Zhiwen Wang, Poyi Hu, Ping Ye, Jiahong Xia, Shu Chen
BACKGROUND: In observational and experimental studies, allergic diseases (AD) have been reported to be associated with some types of cardiovascular diseases (CVD), as both share common pathophysiological processes involving inflammation and metabolic disorders. However, the direction of the causal association between them remains unclear. This Mendelian randomization (MR) study aims to examine the bidirectional causality between AD and CVD. METHODS: We utilized publicly available genome-wide association study (GWAS) summary statistics data from European participants in the UK Biobank and the IEU Open GWAS database...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37193126/hemostatic-defects-in-congenital-disorders-of-glycosylation
#11
JOURNAL ARTICLE
Tiffany Pascreau, Claire Auditeau, Delphine Borgel
A "state of the Art" lecture titled "Hemostatic Defects in Congenital Disorders of Glycosylation" was presented at the ISTH 2022 congress. Congenital disorders of glycosylation (CDGs) are rare, inherited, metabolic diseases. The diagnosis of CDG is often challenging due to the broad variety of disorders, the variable level of severity, and phenotypic heterogeneity. Most CDGs are multisystem disorders, and neurologic involvement is frequent. Patients with CDG often present coagulation abnormalities characterized by low levels of procoagulant or anticoagulant factors...
March 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/37111562/estimation-of-pediatric-dosage-of-antimalarial-drugs-using-pharmacokinetic-and-physiological-approach
#12
JOURNAL ARTICLE
Ellen K G Mhango, Bergthora S Snorradottir, Baxter H K Kachingwe, Kondwani G H Katundu, Sveinbjorn Gizurarson
Most of the individuals who die of malaria in sub-Saharan Africa are children. It is, therefore, important for this age group to have access to the right treatment and correct dose. Artemether-lumefantrine is one of the fixed dose combination therapies that was approved by the World Health Organization to treat malaria. However, the current recommended dose has been reported to cause underexposure or overexposure in some children. The aim of this article was, therefore, to estimate the doses that can mimic adult exposure...
March 27, 2023: Pharmaceutics
https://read.qxmd.com/read/37073631/iron-metabolism-related-indicators-as-predictors-of-the-incidence-of-acute-kidney-injury-after-cardiac-surgery-a-meta-analysis
#13
JOURNAL ARTICLE
Limei Zhao, Xiaoyu Yang, Shengchao Zhang, Xiaoshuang Zhou
BACKGROUND: Some studies have found that ferroptosis plays an important role in the incidence of acute kidney injury (AKI) after cardiac surgery. However, whether iron metabolism-related indicators can be used as predictors of the incidence of AKI after cardiac surgery remains unclear. OBJECTIVES: We aimed to systematically evaluate whether iron metabolism-related indicators can be used as predictors of the incidence of AKI after cardiac surgery via meta-analysis...
December 2023: Renal Failure
https://read.qxmd.com/read/37051292/effectiveness-and-safety-of-a-fixed-dose-combination-of-valsartan-and-rosuvastatin-rovatitan-%C3%A2-tablet-in-patients-with-concomitant-hypertension-and-hyperlipidemia-an-observational-study
#14
JOURNAL ARTICLE
Kwang Je Lee, Jae-Kean Ryu, Yun-Hyeong Cho, Won Yong Shin, Jeong Su Kim, Young Won Yoon, Ji Yong Jang, Won Ho Kim, Jong Wook Beom, Seok-Min Kang
PURPOSE: This study aimed to assess the effectiveness and safety of a fixed-dose combination of rosuvastatin and valsartan (Rovatitan® ) in Korean patients with concomitant hypertension and hyperlipidemia. PATIENTS AND METHODS: A total of 1008 eligible patients with concomitant hypertension and hyperlipidemia were enrolled and treated for 12 weeks. Both upward and downward drug dose titrations were allowed based on the investigator's discretion. This study evaluated the effectiveness of the study drug, defined by the percentage of patients achieving the blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) treatment targets...
2023: Drug Design, Development and Therapy
https://read.qxmd.com/read/37009281/premature-birth-associated-with-a-favorable-course-in-gestational-alloimmune-liver-disease-gald-a-case-report
#15
Linda-Marie Mulzer, Heiko Reutter, Jörg Jüngert, A S Knisely, Margit Schmid, André Hoerning, Patrick Morhart
Gestational alloimmune liver disease (GALD) is a rare neonatal disorder with high mortality and morbidity. The patients come to caregivers' attention aged a few hours or days. The disease manifests as acute liver failure with or without siderosis. The differential diagnosis of neonatal acute liver failure (NALF) is broad, including mainly immunologic, infectious, metabolic and toxic disorders. The most common cause, however, is GALD followed by herpes simplex virus (HSV) infection. The best suited pathophysiological paradigm of GALD is that of a maternofetal alloimmune disorder...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37004118/validation-of-a-novel-testing-machine-for-the-investigation-of-the-biomechanical-properties-of-lumbar-vertebrae-in-an-osteoporotic-rat-model
#16
JOURNAL ARTICLE
G A Mackert, M Harder, H Harhaus, M Schulte, U Trinler, S Jaeger, U Kneser, L Harhaus, C Wölfl
BACKGROUND: For the investigation of the biomechanical properties of bone, various testing devices have been described. However, only a limited number have been developed to test the vertebral body of small animals. The aim of this study was to develop and validate a new bone testing device, which investigates the different biomechanical properties in small-animal vertebrae as a whole, three-dimensional unit, respecting its anatomical structure. METHODS: Thirty-five twelve-week-old female Sprague Dawley rats were utilized...
March 31, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/36995369/untargeted-metabolomic-characterization-of-glioblastoma-intra-tumor-heterogeneity-using-orbisims
#17
JOURNAL ARTICLE
Wenshi He, Max K Edney, Simon M L Paine, Rian L Griffiths, David J Scurr, Ruman Rahman, Dong-Hyun Kim
Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two years from diagnosis. The standard treatment of GBM is multimodality therapy comprising surgical resection, radiation, and chemotherapy. However, prognosis remains poor, and there is an urgent need for effective anticancer drugs. Since different regions of a single GBM contain multiple cancer subpopulations ("intra-tumor heterogeneity"), this likely accounts for therapy failure as certain cancer cells can escape from immune surveillance and therapeutic threats...
March 30, 2023: Analytical Chemistry
https://read.qxmd.com/read/36655606/spontaneous-vasomotion-propagates-along-pial-arterioles-in-the-awake-mouse-brain-like-stimulus-evoked-vascular-reactivity
#18
JOURNAL ARTICLE
Leon P Munting, Orla Bonnar, Mariel G Kozberg, Corinne A Auger, Lydiane Hirschler, Steven S Hou, Steven M Greenberg, Brian J Bacskai, Susanne J van Veluw
Sensory stimulation evokes a local, vasodilation-mediated blood flow increase to the activated brain region, which is referred to as functional hyperemia. Spontaneous vasomotion is a change in arteriolar diameter that occurs without sensory stimulation, at low frequency (∼0.1 Hz). These vessel diameter changes are a driving force for perivascular soluble waste clearance, the failure of which has been implicated in neurodegenerative disease. Stimulus-evoked vascular reactivity is known to propagate along penetrating arterioles to pial arterioles, but it is unclear whether spontaneous vasomotion propagates similarly...
January 19, 2023: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/36580090/-cardiac-rehabilitation-in-lvad-patients-aspects-regarding-exercise-and-rhythm
#19
REVIEW
Thomas Schmidt, Nils Reiss
After implantation of a left ventricular assist device (LVAD), it is strongly recommended that patients participate in an inpatient cardiac rehabilitation program (CR). Relevant topics during CR include sports and exercise therapy as well as aspects of cardiac rhythm control. Over time, LVAD patients usually regain a good quality of life and an adequate functional capacity can be observed. However, maximum performance values remain markedly reduced, in part due to the fixed LVAD pump speed and the limited total cardiac output...
December 29, 2022: Herzschrittmachertherapie & Elektrophysiologie
https://read.qxmd.com/read/36571583/microscopy-based-assessment-of-fatty-acid-uptake-and-lipid-accumulation-in-cultured-cells
#20
JOURNAL ARTICLE
Danish Khan, Tarannum Ara, Aastha Munjal, Sneha Mishra, Nagalingam Ravi Sundaresan
The heart relies predominantly on the use of fatty acids to derive energy. Metabolic disorders such as obesity, insulin resistance, and diabetes pose a major risk factor for the development of heart failure. Dysregulation of lipid metabolism observed in these diseases manifests as cardiac lipotoxicity, and is associated with cardiac dysfunction. The alarming rise in the incidence of these metabolic disorders warrants the need for tools to investigate the underlying molecular mechanisms. In this article, we describe a confocal microscopy-based approach to monitor fatty acid uptake and lipid accumulation in vitro, in neonatal murine cardiomyocytes and H9c2 cells...
December 2022: Current protocols
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