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Dominic E Job, David Alexander Dickie, David Rodriguez, Andrew Robson, Sammy Danso, Cyril Pernet, Mark E Bastin, James P Boardman, Alison D Murray, Trevor Ahearn, Gordon D Waiter, Roger T Staff, Ian J Deary, Susan D Shenkin, Joanna M Wardlaw
The Brain Images of Normal Subjects (BRAINS) Imagebank ( is an integrated repository project hosted by the University of Edinburgh and sponsored by the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) collaborators. BRAINS provide sharing and archiving of detailed normal human brain imaging and relevant phenotypic data already collected in studies of healthy volunteers across the life-course. It particularly focusses on the extremes of age (currently older age, and in future perinatal) where variability is largest, and which are under-represented in existing databanks...
January 2017: NeuroImage
(no author information available yet)
BACKGROUND: Brain scans are essential to exclude haemorrhage in patients with suspected acute ischaemic stroke before treatment with alteplase. However, patients with early ischaemic signs could be at increased risk of haemorrhage after alteplase treatment, and little information is available about whether pre-existing structural signs, which are common in older patients, affect response to alteplase. We aimed to investigate the association between imaging signs on brain CT and outcomes after alteplase...
May 2015: Lancet Neurology
Caroline Nicholson, Claire Jackson, John Marley
BACKGROUND: Internationally, key health care reform elements rely on improved integration of care between the primary and secondary sectors. The objective of this systematic review is to synthesise the existing published literature on elements of current integrated primary/secondary health care. These elements and how they have supported integrated healthcare governance are presented. METHODS: A systematic review of peer-reviewed literature from PubMed, MEDLINE, CINAHL, the Cochrane Library, Informit Health Collection, the Primary Health Care Research and Information Service, the Canadian Health Services Research Foundation, European Foundation for Primary Care, European Forum for Primary Care, and Europa Sinapse was undertaken for the years 2006-2012...
December 20, 2013: BMC Health Services Research
Joanna M Wardlaw, Will Brindle, Ana M Casado, Kirsten Shuler, Moira Henderson, Brenda Thomas, Jennifer Macfarlane, Susana Muñoz Maniega, Katherine Lymer, Zoe Morris, Cyril Pernet, William Nailon, Trevor Ahearn, Abdul Nashirudeen Mumuni, Carlos Mugruza, John McLean, Goultchira Chakirova, Yuehui Terry Tao, Johanna Simpson, Andrew C Stanfield, Harriet Johnston, Jehill Parikh, Natalie A Royle, Janet De Wilde, Mark E Bastin, Nick Weir, Andrew Farrall, Maria C Valdes Hernandez
OBJECTIVE: MRI at 3 T is said to be more accurate than 1.5 T MR, but costs and other practical differences mean that it is unclear which to use. METHODS: We systematically reviewed studies comparing diagnostic accuracy at 3 T with 1.5 T. We searched MEDLINE, EMBASE and other sources from 1 January 2000 to 22 October 2010 for studies comparing diagnostic accuracy at 1.5 and 3 T in human neuroimaging. We extracted data on methodology, quality criteria, technical factors, subjects, signal-to-noise, diagnostic accuracy and errors according to QUADAS and STARD criteria...
November 2012: European Radiology
J Tamayo, Ca Zarate, E Vieta, M Tohen
From the neurobiochemical point of view, several alterations have been proposed to explain the symptomatology of bipolar disorders, from the classic concept of adrenergic-cholinergic imbalance to other more recent ones, such as the intraneuronal decrease of sodium, the elevation of free intracellular Ca++ and elevations of the levels of intraneuronal proteins such as inositol triphosphate, type C protein kinases and others.<p>All mood euthymics and/or stabilizers require several days or week to show a therapeutic response...
January 2004: Actas Españolas de Psiquiatría
A A Varaksin, I I Deridovich, N I Shvaleva
In marine Lamellibranchia--Patinopecten yessoensis (Jay) and Crenomytilus grayanus (Dunker)--neural cells, small ganglia and neural fibres have been revealed in the gonad wall. The sensitive and effector parts are presented by rather variable morphological formations. By means of histochemical and ultrastructural investigations, functional affiliation of axons is revealed and their relations to tissue elements of the gonad are demonstrated. The effector neural apparatus is formed by peptidergic, cholinergic and monoaminergic axons...
January 1983: Arkhiv Anatomii, Gistologii i émbriologii
Z Poljaković, D Jadro-Santel, N Besenski, M Popović, L Pazanin, L Negovetić
In this paper three cases with peculiar disease of the cerebellar cortex are presented. The disease is well known as L'hermitte-Duclos disease (LDD), but nowadays it is also called "dysplastic granulo-molecular hypertrophy of the cerebellar cortex" according to the modern theories of its etiology. Curious changes of the cerebellum in LDD are probably the result of a combination of delayed migration of Purkinje cells which occurs during the intrauterine period of cerebellar development, and of reactive hypertrophy of granular cells...
1990: Neurologija
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