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https://www.readbyqxmd.com/read/28808872/analysis-of-blood-markers-for-early-breast-cancer-diagnosis
#1
J Bayo, M A Castaño, F Rivera, F Navarro
PURPOSE: Breast cancer is the most common neoplasm in women and has the highest associated mortality rate. Rapid detection programmes can provide early diagnosis and increase the chances of survival. There are no specific tumor biomarkers for the early phase of the disease. The primary aim of this study was to search a blood biomarker with levels that exceeded the normal range established in the general population that could be used to screen breast cancer. METHODS/PATIENTS: Case-control study...
August 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28805558/oxytocin-modulates-expression-of-neuron-and-glial-markers-in-the-rat-hippocampus
#2
T Havránek, Z Lešťanová, B Mravec, V Štrbák, J Bakoš, Z Bačová
Neuropeptides including oxytocin belong to the group of factors that may play a role in the control of neuronal cell survival, proliferation and differentiation. The aim of the present study was to investigate potential contribution of oxytocin to neuronal differentiation by measuring gene and protein expression of specific neuron and glial markers in the brain. Neonatal and adult oxytocin administration was used to reveal developmental and/or acute effects of oxytocin in Wistar rats. Gene and protein expression of neuron-specific enolase (NSE) in the hippocampus was increased in 21-day and 2-month old rats in response to neonatal oxytocin administration...
2017: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/28804908/influence-of-abiraterone-acetate-on-neuroendocrine-differentiation-in-chemotherapy-naive-metastatic-castration-resistant-prostate-cancer
#3
Baijun Dong, Liancheng Fan, Yanqing Wang, Chenfei Chi, Xiaowei Ma, Rui Wang, Wen Cai, Xiaoguang Shao, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Shaowei Xie, Xiaonan Kang, Lixin Zhou, Wei Xue
BACKGROUND: To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). METHODS: We conducted an analysis in 115 chemotherapy-naïve mCRPC patients who would be treated with chemotherapy. The serum levels of chromogranin A (CgA), neurone-specific enolase (NSE) were measured in 67 mCRPC patients without AA treatment and 48 patients after the failure of AA treatment, in which these markers were also measured in 34 patients before and after 6 months of AA treatment...
August 14, 2017: Prostate
https://www.readbyqxmd.com/read/28795017/malignant-renal-schwannoma-in-a-cat
#4
Monier Sharif, Adel Mohamed, Manfred Reinacher
A nine-year-old male European shorthair cat with rapidly enlarging mass at the left kidney doubted to be malignant was presented. The purpose of this study is to present the clinical, radiological and pathological findings of a primary renal tumor in the cat. Grossly, the mass mostly encapsulated the kidney. Histologically, excisional biopsy showed worrying histological features. A sarcoma-like tumor composed mainly of neoplastic spindle-shaped cells. Neoplastic nodules of aggregations of fusiform cells arranged in multidirectional bundles...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28791395/%C3%AE-7-nicotinic-acetylcholine-receptor-agonist-inhibits-the-damage-of-rat-hippocampal-neurons-by-tlr4-myd88-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-during-cardiopulmonary-bypass
#5
Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhang
The present study aimed to investigate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) agonist on the damage of hippocampal neurons and the expression of toll like receptor 4 (TLR4)/myeloid differentiation primary response 88 (Myd88)/nuclear factor (NF)‑κB signal pathway‑associated factors in cardiopulmonary bypass (CPB). Sprague Dawley rats were randomly divided into five groups: Sham operation (Sham); CPB; CPB + α7nAChR agonist PHA568487 (PHA); CPB + α7nAChR inhibitor MLA (MLA); and CPB + PHA568487 + TLR4 antagonist (CPT)...
August 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28764935/fractional-anisotropy-is-a-marker-in-early-stage-spinal-cord-injury
#6
Xiao-Hui Li, Feng Wu, Feng Zhao, Sheng-Li Huang
This study was designed to investigate whether fractional anisotropy (FA) contributes to study pathologic changes in SCI. Here rats were divided into a control group and three injury groups. Those in the injury groups were administered a mild, moderate, and severe contusion injury at the T10 vertebral level, respectively. Three rats were randomly selected from each group at 6, 24 and 72 h after SCI for imaging examination. Magnetic resonance diffusion tensor imaging was FA and tractography. Once magnetic resonance was completed, blood was collected and serum levels of neuron specific enolase (NSE) and soluble protein-100β (S-100β) were determined...
July 29, 2017: Brain Research
https://www.readbyqxmd.com/read/28758111/the-neuroprotective-effects-of-muscle-derived-stem-cells-via-brain-derived-neurotrophic-factor-in-spinal-cord-injury-model
#7
Donghe Han, Shurui Chen, Shiqiang Fang, Shiqiong Liu, Meihua Jin, Zhanpeng Guo, Yajiang Yuan, Yansong Wang, Chang Liu, Xifan Mei
Muscle-derived stem cells (MDSCs) possess multipotent differentiation and self-renewal capacities; however, the effects and mechanism in neuron injury remain unclear. The aim of this study was to investigate the effects of MDSCs on neuron secondary injury, oxidative stress-induced apoptosis. An in vivo study showed the Basso, Beattie, and Bresnahan (BBB) score and number of neurons significantly increased after MDSCs' transplantation in spinal cord injury (SCI) rats. An in vitro study demonstrated that MDSCs attenuated neuron apoptosis, and the expression of antioxidants was upregulated as well as the ratio of Bcl-2 and Bax in the MNT (MDSCs cocultured with injured neurons) group compared with the NT (injured neurons) group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28751064/structure-interfacial-film-properties-and-thermal-fluctuations-of-microemulsions-as-seen-by-scattering-experiments
#8
REVIEW
Julian Oberdisse, Thomas Hellweg
The physics of microemulsions and in particular Dominique Langevin's contributions to the understanding of microemulsion structure and bending properties using scattering techniques are reviewed. Among the many methods used by her and her co-workers, we particularly emphasize optical techniques and small angle neutron scattering (SANS), but also neutron spin echo spectroscopy (NSE). The review is then extended to more recent studies of properties of microemulsions close to surfaces, using reflectometry and grazing-incidence small angle neutron scattering (GISANS)...
July 16, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28744310/elevated-squamous-cell-carcinoma-antigen-cytokeratin-19-fragment-and-carcinoembryonic-antigen-levels-in-diabetic-nephropathy
#9
Jianzhong Chen, Feng Tao, Bin Zhang, Qingguang Chen, Yan Qiu, Qian Luo, Yanna Gen, Jiali Meng, Jue Zhang, Hao Lu
OBJECTIVE: We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) are elevated in diabetic nephropathy (DN) and the association between urinary albumin-to-creatinine ratio (UACR) and tumor markers in diabetic patients. METHODS: Nondialysis patients with diabetes (n = 261) and 90 healthy controls were enrolled. DN was defined as an UACR ≥ 30 mg/g in the absence of a urinary tract infection or other renal abnormalities...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28739749/analysis-of-clinicopathological-features-and-prognostic-factors-in-39-cases-of-bladder-neuroendocrine-carcinoma
#10
Hui-Hui Zhou, Li-Yan Liu, Guo-Hua Yu, Gui-Mei Qu, Pei-You Gong, Xiao Yu, Ping Yang
AIM: Through analysis and summarization of clinicopathological features, immunohistochemical expression, pathological diagnostic criteria, prognostic and other factors in patients suffering from bladder neuroendocrine carcinoma (BNEC), a better understanding of BNEC could be achieved to provide solid evidence for clinicopathology and prognosis. MATERIALS AND METHODS: The clinicopathological data of 39 cases of BNEC with up to 5-year follow-up data (median follow-up=650 days) were analyzed retrospectively based on immunohistochemical staining...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739747/application-of-serum-elavl4-hud-antigen-assay-for-small-cell-lung-cancer-diagnosis
#11
Feifei Wang, Jianyi Lu, Shentao Li, Xueyun Huo, Xin Liu, Xiaoyan DU, Changlong Li, Jinghui Wang, Zhenwen Chen
BACKGROUND/AIM: The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells. The aim of this study was to investigate the serum HuD concentration in SCLC patients and the possibility of its utilization as a biomarker of small cell lung cancer. MATERIALS AND METHODS: Our study included 47 SCLC cases and 29 normal controls. Indirect competitive inhibition ELISA method was established to detect HuD antigen of serum samples...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739499/primary-signet-ring-stromal-tumor-of-the-testis-a-study-of-13-cases-indicating-their-phenotypic-and-genotypic-analogy-to-pancreatic-solid-pseudopapillary-neoplasm
#12
Kvetoslava Michalova, Michael Michal, Dmitry V Kazakov, Monika Sedivcova, Ondrej Hes, Ladislav Hadravsky, Abbas Agaimy, Maria Tretiakova, Carlos Bacchi, Arndt Hartmann, Naoto Kuroda, Stela Bulimbasic, Marijana Coric, Tatjana Antic, Michal Michal
Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT in order to better characterize this entity. We studied 13 cases of PSRSTTs using histological, immunohistochemical (IHC) and molecular genetic methods and compared the results with pancreatic SPN...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28738850/brain-biomarkers-and-pre-injury-cognition-are-associated-with-long-term-cognitive-outcome-in-children-with-traumatic-brain-injury
#13
Amy A Wilkinson, Maureen Dennis, Nevena Simic, Margot J Taylor, Benjamin R Morgan, Helena Frndova, Karen Choong, Craig Campbell, Douglas Fraser, Vicki Anderson, Anne-Marie Guerguerian, Russell Schachar, Jamie Hutchison
BACKGROUND: Children with traumatic brain injury (TBI) are frequently at risk of long-term impairments of attention and executive functioning but these problems are difficult to predict. Although deficits have been reported to vary with injury severity, age at injury and sex, prognostication of outcome remains imperfect at a patient-specific level. The objective of this proof of principle study was to evaluate a variety of patient variables, along with six brain-specific and inflammatory serum protein biomarkers, as predictors of long-term cognitive outcome following paediatric TBI...
July 24, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28736361/-effect-of-nucleolin-silencing-on-differentiation-of-rat-neural-stem-cells-in-vitro-and-the-molecular-mechanism
#14
Chong-Feng Chen, Huai-Cai Yang, Guo-Sheng Liu
OBJECTIVE: To investigate the effect of nucleolin silencing on the differentiation of rat neural stem cells (NSCs) and the role of Wnt signaling pathway in mediating such effect. METHODS: Adenovirus vectors expressing small interfering RNA (siRNA) against nucleolin were constructed, verified, and packaged in HEK293A cells. The adenovirus was then transfected into NSCs isolated from neonatal SD rats and the differentiation of the NSCs was examined by detecting the expressions of neuron specific encloase (NSE) and glial fibrillary acidic protein (GFAP) using immunocytochemistry...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28735044/sensing-platform-for-neuron-specific-enolase-based-on-molecularly-imprinted-polymerized-ionic-liquids-in-between-gold-nanoarrays
#15
Xing Wang, Yanying Wang, Xiaoxue Ye, Tsunghsueh Wu, Hongping Deng, Peng Wu, Chunya Li
A molecularly imprinted electrochemical sensor for neuron specific enolase (NSE) was developed by electrochemical polymerizing ionic liquid, which was functionalized with pyrrole moiety, in between gold nanoarrays. A well-defined 3D structured gold nanoarray was fabricated on a glassy carbon electrode (GCE) surface by using template-assisted electrochemical deposition technique. 1-(3-mercaptopropyl)-3-vinyl-imidazolium tetrafluoroborate was self-assembled onto the surface of gold nanoarrays to produce active sites for anchoring the molecularly imprinted film...
July 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28734290/effect-of-interlamellar-interactions-on-shear-induced-multilamellar-vesicle-formation
#16
Y Kawabata, R Bradbury, S Kugizaki, K Weigandt, Y B Melnichenko, K Sadakane, N L Yamada, H Endo, M Nagao, H Seto
Shear-induced multilamellar vesicle (MLV) formation has been studied by coupling the small-angle neutron scattering (SANS) technique with neutron spin echo (NSE) spectroscopy. A 10% mass fraction of the nonionic surfactant pentaethylene glycol dodecyl ether (C12E5) in water was selected as a model system for studying weak inter-lamellar interactions. These interactions are controlled either by adding an anionic surfactant, sodium dodecyl sulfate, or an antagonistic salt, rubidium tetraphenylborate. Increasing the charge density in the bilayer induces an enhanced ordering of the lamellar structure...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28733549/pretreatment-serum-lactate-level-as-a-prognostic-biomarker-in-patients-undergoing-supratentorial-primary-brain-tumor-resection
#17
Chung-Chih Shih, Tzong-Shiun Lee, Fon-Yih Tsuang, Pei-Lin Lin, Ya-Jung Cheng, Hsiao-Liang Cheng, Chun-Yu Wu
INTRODUCTION: Malignant primary brain tumors are one of the most aggressive cancers. Pretreatment serum nonneuronal biomarkers closely associated with postoperative outcomes are of high clinical relevance. The present study aimed to identify potential pretreatment serum biomarkers that may influence oncological outcomes in patients with primary brain tumors. METHODS: A total of 74 patients undergoing supratentorial primary brain tumor resection were enrolled. Before tumor resection, serum neuronal biomarkers, namely neuron-specific enolase (NSE), S100β, and glial fibrillary acidic protein (GFAP), and serum nonneuronal biomarkers, namely neutrophil gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), and lactate, were measured and associated postoperative oncological outcomes, including brain tumor grading, progression-free survival (PFS), and overall survival (OS), were compared...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28724200/effect-of-memantine-on-serum-levels-of-neuron-specific-enolase-and-on-the-glasgow-coma-scale-in-patients-with-moderate-traumatic-brain-injury
#18
Majid Mokhtari, Hossein Nayeb-Aghaei, Mehran Kouchek, Mir Mohammad Miri, Reza Goharani, Arash Amoozandeh, Sina Akhavan Salamat, Mohammad Sistanizad
Traumatic brain injury (TBI) is a major cause of disability and death globally. Despite significant progress in neuromonitoring and neuroprotection, pharmacological interventions have failed to generate favorable results. We examined the effect of memantine on serum levels of neuron-specific enolase (NSE), a marker of neuronal damage, and the Glasgow Coma Scale (GCS) in patients with moderate TBI. Patients were randomly assigned to the control group (who received standard TBI management) and the treatment group (who, alongside their standard management, received enteral memantine 30 mg twice daily for 7 days)...
July 19, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28722674/evaluation-of-factors-associated-with-platinum-sensitivity-status-and-survival-in-limited-stage-small-cell-lung-cancer-patients-treated-with-chemoradiotherapy
#19
Qiang Wen, Xue Meng, Peng Xie, Shijiang Wang, Xindong Sun, Jinming Yu
In this retrospective study, we analyzed the association of clinicopathological factors and therapeutic plans with platinum-sensitivity status and survival of limited-stage small cell lung cancer (LS-SCLC) patients. We enrolled 452 LS-SCLC patients with 279 platinum sensitive and 173 platinum refractory patients. The low serum neuro-specific enolase levels (NSE; p = 0.011), neutrophil-to-lymphocyte ratios (NLR; p = 0.013) and higher objective response rates (p = 0.003) were associated with sensitive group but not the refractory group...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721067/phase-i-dose-escalation-study-of-long-acting-pasireotide-in-patients-with-neuroendocrine-tumors
#20
James C Yao, Jennifer A Chan, Alain C Mita, Madan G Kundu, Karina Hermosillo Reséndiz, Ke Hu, Shoba Ravichandran, Jonathan R Strosberg, Edward M Wolin
This phase I study aimed at determining the maximum tolerated dose (MTD) and characterizing the safety, tolerability, pharmacokinetics (PKs), and efficacy of pasireotide in patients with advanced neuroendocrine tumors (NETs). Patients were enrolled in two phases: dose-escalation phase (to determine the MTD) at a starting dose of 80 mg pasireotide long-acting release (LAR) i.m. followed by a dose-expansion phase (to evaluate safety and prelimi-nary efficacy). Associations between PK/pharmacodynamic parameters and clinical outcomes were evaluated using linear regression analysis...
2017: OncoTargets and Therapy
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