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https://www.readbyqxmd.com/read/29157007/prognostic-value-of-neuron-specific-enolase-nse-for-prediction-of-post-concussion-symptoms-following-a-mild-traumatic-brain-injury-a-systematic-review
#1
Eric Mercier, Pier-Alexandre Tardif, Peter A Cameron, Marcel Émond, Lynne Moore, Biswadev Mitra, Marie-Christine Ouellet, Jérôme Frenette, Elaine de Guise, Natalie Le Sage
BACKGROUND: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI). METHODS: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29156441/modeling-spray-drift-and-runoff-related-inputs-of-pesticides-to-receiving-water
#2
Xuyang Zhang, Yuzhou Luo, Kean S Goh
Pesticides move to surface water via various pathways including surface runoff, spray drift and subsurface flow. Little is known about the relative contributions of surface runoff and spray drift in agricultural watersheds. This study develops a modeling framework to address the contribution of spray drift to the total loadings of pesticides in receiving water bodies. The modeling framework consists of a GIS module for identifying drift potential, the AgDRIFT model for simulating spray drift, and the Soil and Water Assessment Tool (SWAT) for simulating various hydrological and landscape processes including surface runoff and transport of pesticides...
November 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29155421/characterization-of-neural-stem-cells-modified-with-hypoxia-neuron-specific-vegf-expression-system-for-spinal-cord-injury
#3
Y Yun, J Oh, Y Kim, G Kim, M Lee, Y Ha
Spinal cord injury (SCI) is an incurable disease causing an ischemic environment and functional defect, thus a new therapeutic approach is needed for SCI treatment. Vascular endothelial growth factor (VEGF) is a potent therapeutic gene to treat SCI via angiogenesis and neuroprotection, and both tissue-specific gene expression and high gene delivery efficiency are important for successful gene therapy. Here we design the hypoxia/neuron dual-specific gene expression system (pEpo-NSE) and efficient gene delivery platform can be achieved by the combination ex vivo gene therapy with erythropoietin (Epo) enhancer, neuron-specific enolase (NSE) promoter and neural stem cells (NSCs)...
November 20, 2017: Gene Therapy
https://www.readbyqxmd.com/read/29153586/non-specific-effects-of-childhood-vaccinations-a-case-control-study-nested-into-a-health-and-demographic-surveillance-system-in-rural-burkina-faso
#4
G Pfeiffer, A B Fisker, E Nebié, J Hengelbrock, A Sié, H Becher, O Müller
INTRODUCTION: Previous studies in African countries have been suggestive of non-specific effects (NSE) of vaccination on child survival. Live vaccines (e.g. measles, MV) have been found to reduce child mortality while inactivated vaccines (e.g. diphtheria-tetanus-pertussis, DTP) have been associated with increased mortality; NSE were often found to be sex-specific. METHODS: A case-control study nested into the Health and Demographic Surveillance System (HDSS) cohort of the Centre de Recherche en Santé de Nouna (CRSN) was conducted in northwestern Burkina Faso...
November 15, 2017: Vaccine
https://www.readbyqxmd.com/read/29152494/d-dimer-level-is-related-to-the-prognosis-of-patients-with-small-cell-lung-cancer
#5
Xuqin Jiang, Xiaodong Mei, Huimei Wu, Xiaojuan Chen
Background: Although the significance of D-dimer in cancer patients has been extensively studied and plasma D-dimer levels have been reported to be abnormally high in certain types of lung cancer patients, its prognostic value for small cell lung cancer (SCLC) remains largely unknown. Methods: One hundred and seven newly diagnosed SCLC patients were enrolled in this study. Variables including the clinical features, pre-treatment levels of D-dimer, serum neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) were extracted...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29145241/the-prognostic-value-of-the-serum-neuron-specific-enolase-and-lactate-dehydrogenase-in-small-cell-lung-cancer-patients-receiving-first-line-platinum-based-chemotherapy
#6
Xiaofan Liu, Weiming Zhang, Wen Yin, Yang Xiao, Changzhi Zhou, Yi Hu, Shuang Geng
The aim of this study was to investigate the associations of serum levels of neuron-specific enolase (NSE), pro-gastrin releasing peptide (ProGRP), and lactate dehydrogenase (LDH) with clinical response and survival in small cell lung cancer (SCLC) patients receiving first-line platinum-based chemotherapy.One hundred thirty-six patients with SCLC were recruited in this study. All the patients received first-line platinum-based chemotherapy. Clinical efficacy was assessed according to Response Evaluation Criteria in Solid Tumors v1...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29139614/human-dental-stem-cell-derived-transgene-free-ipscs-generate-functional-neurons-via-embryoid-body-mediated-and-direct-induction-methods
#7
Ikbale El Ayachi, Jun Zhang, Xiao-Ying Zou, Zongdong Yu, Wei Wei, Kristen M S O'Connell, George T-J Huang
Induced pluripotent stem cells (iPSCs) give rise to neural stem/progenitor cells (NSCs), serving as a good source for neural regeneration. Here, we established transgene-free (TF) iPSCs from dental stem cells (DSCs) and determined their capacity to differentiate into functional neurons in vitro. Generated TF iPSCs from stem cells of apical papilla (SCAP) and dental pulp stem cells (DPSCs) underwent two methods -- embryoid body (EB)-mediated and direct induction, to guide TF-DSC iPSCs along with H9 or H9 Syn-GFP (human embryonic stem cells) into functional neurons in vitro...
November 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29139124/histochemical-distribution-of-four-types-of-enzymes-and-mucous-cells-in-the-gastrointestinal-tract-of-reared-half-smooth-tongue-sole-cynoglossus-semilaevis
#8
Y Z Wang, J F Sun, A J Lv, S L Zhang, Y Y Sung, H Y Shi, X C Hu, S J Chen, K Z Xing
The histochemical distribution of acid phosphatase (ACP), alkaline phosphatase (ALP), non-specific esterase (NSE), peroxidase (POD) and mucous-cell types was evaluated in the gastrointestinal tract of the half-smooth tongue sole Cynoglossus semilaevis. The enzymes were detected in the entire stretch of the gastrointestinal tract. ACP activity was found in the supranuclear region of enterocytes and the lamina propria of the intestine, as well as the cytoplasm of epithelial cells of the stomach. The staining intensity of ACP in the anterior and posterior intestines was stronger than in the stomach...
November 15, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/29131327/cgrp-and-ptx3-as-predictors-of-efficacy-of-onabotulinumtoxin-type-a-in-chronic-migraine-an-observational-study
#9
Clara Domínguez, Alba Vieites-Prado, María Pérez-Mato, Tomás Sobrino, Xiana Rodríguez-Osorio, Ana López, Francisco Campos, Francisco Martínez, José Castillo, Rogelio Leira
OBJECTIVE: The aim of this study is to find a relation between several biomarkers in peripheral blood and outcome after treatment with onabotulinumtoxin A (OnabotA). BACKGROUND: OnabotA is an effective treatment in chronic migraine (CM). Different studies have tried to find predictors of response to treatment, either with clinical characteristics, neuroimaging features, or molecular biomarkers; however, it is still not possible to predict the individual outcome...
November 13, 2017: Headache
https://www.readbyqxmd.com/read/29128928/serum-neuron-specific-enolase-may-be-a-marker-to-predict-the-severity-and-outcome-of-cerebral-venous-thrombosis
#10
Yanyu Hu, Ran Meng, Xuxiang Zhang, Linlin Guo, Sijie Li, Yan Wu, Jiangang Duan, Yuchuan Ding, Xunming Ji
The objective is to explore the effective of baseline serum neuron specific enolase (NSE) on predicting the severity and outcome in patients with cerebral venous thrombosis (CVT). A total of 156 patients confirmed as CVT in Xuanwu Hospital were enrolled in this retrospective study from March 2011 through September 2016. The severity was evaluated with the National Institutes of Health Stroke Score (NIHSS), intracranial pressure (ICP), and CVT-related complications; the outcome was evaluated by modified Rankin Scale (mRS); the relationship between baseline serum NSE and mRS was analyzed with receiver operating characteristic curve (ROC), logistic regression analysis, and Kaplan-Meier curves...
November 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29122553/fisetin-as-a-caloric-restriction-mimetic-protects-rat-brain-against-aging-induced-oxidative-stress-apoptosis-and-neurodegeneration
#11
Sandeep Singh, Abhishek Kumar Singh, Geetika Garg, Syed Ibrahim Rizvi
AIM: In the present study, attempts have been made to evaluate the potential role of fisetin, a caloric restriction mimetic (CRM), for neuroprotection in D-galactose (D-gal) induced accelerated and natural aging models of rat. MAIN METHODS: Fisetin was supplemented (15mg/kg b.w., orally) to young, D-gal induced aged (D-gal 500mg/kg b.w subcutaneously) and naturally aged rats for 6weeks. Standard protocols were employed to measure pro-oxidants, antioxidants and mitochondrial membrane potential in brain tissues...
November 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/29120480/coupled-surface-and-groundwater-hydrological-modeling-in-a-changing-climate
#12
Venkataramana Sridhar, Mirza M Billah, John W Hildreth
Many current watershed modeling efforts now incorporate surface water and groundwater for managing water resources since the exchanges between groundwater and surface water need a special focus considering the changing climate. The influence of groundwater dynamics on water and energy balance components is investigated in the Snake River Basin (SRB) by coupling the Variable Infiltration Capacity (VIC) and MODFLOW models (VIC-MF) for the period of 1986 through 2042. A 4.4% increase in base flows and a 10.3% decrease in peak flows are estimated by VIC-MF compared to the VIC model in SRB...
November 9, 2017: Ground Water
https://www.readbyqxmd.com/read/29117867/epicardial-left-ventricular-leads-via-minimally-invasive-technique-a-role-of-steroid-eluting-leads
#13
Etem Caliskan, Florian Fischer, Felix Schoenrath, Maximilian Y Emmert, Francesco Maisano, Volkmar Falk, Christoph T Starck, Tomas Holubec
BACKGROUND: We retrospectively assessed two types of sutureless screw-in left ventricular (LV) leads (steroid eluting vs. non-steroid eluting) in cardiac resynchronization therapy (CRT) implantation with regards to their electrical performance. METHODS: Between March 2008 and May 2014 an epicardial LV lead was implanted in 32 patients after failed transvenous LV lead placement using a left-sided lateral minithoracotomy or video-assisted thoracoscopy (mean age 64 ± 9 years)...
November 8, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29117648/serum-neuron-specific-enolase-as-a-marker-of-brain-ischemia-reperfusion-injury-in-patients-undergoing-carotid-endarterectomy
#14
Marek Iłżecki, Joanna Iłżecka, Stanisław Przywara, Piotr Terlecki, Aneta Grabarska, Andrzej Stepulak, Tomasz Zubilewicz
In patients with atherosclerotic stenosis of the extracranial segment of internal carotid artery, surgical intervention is an effective method to prevent cerebral ischemic stroke. However, this surgical procedure may cause vascular brain damage. The aim of the study was to investigate consequential brain ischemia-reperfusion injury by measuring the cerebral specific marker, neuron-specific (NSE), in serum of patients having undergone internal carotid endarterectomy (CEA). The study involved 25 patients that underwent CEA due to internal carotid artery stenosis...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29113785/label-free-electrochemical-immunoassay-for-neuron-specific-enolase-based-on-3d-macroporous-reduced-graphene-oxide-polyaniline-film
#15
Qi Zhang, Xiaoyan Li, Chunhua Qian, Li Dou, Feng Cui, Xiaojun Chen
The content of neuron specific enolase (NSE) in serum is considered to be an essential indicator of small cell lung cancer (SCLC). Here, a novel label-free electrochemical immunoassay for the detection of NSE based on the three dimensionally macroporous reduced graphene oxide/polyaniline (3DM rGO/PANI) film has been proposed. The 3DM rGO/PANI film was constructed by electrochemical co-deposition of GO and aniline into the interspaces of a sacrificial silica opal template modified Au slice. During the co-deposition, GO was successfully reduced by aniline and PANI could be deposited on the surfaces of rGO sheets...
November 4, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29113400/evaluation-of-factors-associated-with-platinum-sensitivity-status-and-survival-in-limited-stage-small-cell-lung-cancer-patients-treated-with-chemoradiotherapy
#16
Qiang Wen, Xue Meng, Peng Xie, Shijiang Wang, Xindong Sun, Jinming Yu
In this retrospective study, we analyzed the association of clinicopathological factors and therapeutic plans with platinum-sensitivity status and survival of limited-stage small cell lung cancer (LS-SCLC) patients. We enrolled 452 LS-SCLC patients with 279 platinum sensitive and 173 platinum refractory patients. The low serum neuro-specific enolase levels (NSE; p = 0.011), neutrophil-to-lymphocyte ratios (NLR; p = 0.013) and higher objective response rates (p = 0.003) were associated with sensitive group but not the refractory group...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107882/improved-screen-printed-carbon-electrode-for-multiplexed-label-free-amperometric-immuniosensor-addressing-its-conductivity-and-reproducibility-challenges
#17
Lihua Zhao, Hongliang Han, Zhanfang Ma
A new screen-printed carbon electrode (SPCE) with multiple working electrodes and one signal output channel without counter and reference electrodes was designed. The multiple working electrodes can be individually modified for each target of interest. The SPCE contained one signal output channel, making the immuniosensor be realized by common single-channel electrochemical workstation. The counter and reference electrodes were independent of disposable SPCE, reducing costs and eliminating precious metal pollution...
October 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29098092/coronary-artery-hematoma-treated-with-fenestration-using-a-novel-nse-alpha%C3%A2-scoring-balloon
#18
Naohiro Funayama, Takao Konishi, Tadashi Yamamoto, Daisuke Hotta
The optimal management of coronary intramural hematoma has not been defined. We described a case in which coronary occlusion developed due to an intramural hematoma after percutaneous coronary intervention for mid left circumflex artery (LCX). Intravascular ultrasound (IVUS) demonstrated the progression of the intramural hematoma and a totally compressed true lumen. Our approach was based on fenestration with a scoring balloon (NSE Alpha, Goodman, Japan), which allowed the deployment of an additional stent to be avoided...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29095291/relevance-of-urinary-s100b-protein-levels-as-a-short-term-prognostic-biomarker-in-asphyxiated-infants-treated-with-hypothermia
#19
Ayham Alshweki, Alejandro Pérez-Muñuzuri, Olalla López-Suárez, Ana Baña, Maria L Couce
The initial diagnosis of neonatal hypoxic-ischemic encephalopathy is based on nervous system clinical manifestations. The use of biomarkers to monitor brain injury and evaluate neuroprotective effects allows early intervention and treatment. This study was designed to determine the short-term prognostic significance of urinary S100B calcium-binding protein (S100B) in asphyxiated newborns treated with hypothermia.An observational prospective study was conducted over a period of 5 years in 31 newborns with hypoxic-ischemic encephalopathy who received therapeutic hypothermia...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29081578/neural-semantic-encoders
#20
Tsendsuren Munkhdalai, Hong Yu
We present a memory augmented neural network for natural language understanding: Neural Semantic Encoders. NSE is equipped with a novel memory update rule and has a variable sized encoding memory that evolves over time and maintains the understanding of input sequences through read, compose and write operations. NSE can also access multiple and shared memories. In this paper, we demonstrated the effectiveness and the flexibility of NSE on five different natural language tasks: natural language inference, question answering, sentence classification, document sentiment analysis and machine translation where NSE achieved state-of-the-art performance when evaluated on publically available benchmarks...
April 2017: Proceedings of the Conference on Computational Linguistics
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