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https://www.readbyqxmd.com/read/29439730/resolvin-d2-protects-against-cerebral-ischemia-reperfusion-injury-in-rats
#1
Gang Zuo, Dongping Zhang, Rutao Mu, Haitao Shen, Xiang Li, Zhong Wang, Haiying Li, Gang Chen
Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. ω-3 fatty acid supplements taken as part of a daily diet have been shown to improve the prognosis of patients with ischemic stroke. In this study, we aimed to investigate the potential effects of resolvin D2 (RvD2), a derivative of ω-3 fatty acids, and its possible advantage on cerebral I/R injury in rats. Cerebral I/R caused by middle cerebral artery occlusion and reperfusion (MCAO/R) was established in Sprague-Dawley rats...
February 13, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29434800/protective-effects-of-scopolamine-and-penehyclidine-hydrochloride-on-acute-cerebral-ischemia-reperfusion-injury-after-cardiopulmonary-resuscitation-and-effects-on-cytokines
#2
Dengqin Wang, Qi Jiang, Xiuling Du
The objective of this study was to investigate the protective effects of scopolamine and penehyclidine hydrochloride on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation, and the effect on cytokine levels. Eighty patients with cardiac arrest admitted to our hospital from June 2011 to December 2015 were recruited and randomly divided into two groups (n=40 each). Following cardiopulmonary resuscitation, scopolamine was administered in the control group, whereas penehyclidine hydrochloride was administered in the observation group...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432779/the-protective-effect-of-alpha-lipoic-acid-against-brain-ischemia-and-reperfusion-injury-via-mtor-signaling-pathway-in-rats
#3
Xinjie Gao, Wei Chen, Jinquan Li, Chao Shen, Ping Zhou, Xiaoming Che, Xiaomu Li, Rong Xie
Alpha-lipoic Acid(ALA), an endogenous short-chain fatty acid, has been found inducing a protective effect against ischemia and reperfusion(I/R) injury. Recently, mTOR signaling pathway has been proved to involve in the mechanism of I/R injury. In our previous study, we determined that ALA could protect cerebral endothelial cells against I/R injury via mTOR signaling pathway. However, whether ALA can protect against brain I/R injury in vivo and its mechanisms is uncertain. In this study, we try to explore if the ALA treatment can protect against brain I/R injury and confirm the relationship between ALA and mTOR signaling pathway...
February 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29432410/angiopoietin-like-4-attenuates-brain-edema-and-neurological-deficits-in-a-mouse-model-of-experimental-intracerebral-hemorrhage
#4
Zhandong Qiu, Jia Yang, Gang Deng, Yu Fang, Dayong Li, Suming Zhang
BACKGROUND Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to evaluate the preventive effects of ANGPTL4 on the formation of brain edema and to determine whether it promotes the recovery of neurological function following intracerebral hemorrhage (ICH). MATERIAL AND METHODS Recombinant human ANGPTL4 (rhANGPTL4; 40 µg/kg) or a vehicle was administered intraperitoneally 5 min prior to bacterial collagenase-induced ICH in male C57/B6J mice...
February 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29431886/impact-of-anemia-on-in-hospital-complications-after-ischemic-stroke
#5
Chen-Chen Wei, Shu-Ting Zhang, Ge Tan, Shi-Hong Zhang, Ming Liu
BACKGROUND: In-hospital complications after stroke represent barriers of optimal recovery and are even potentially life-threatening. Anemia is common in stroke patients and is related to poor outcome after stroke. Less is known, however, of the association of anemia with complications. We aimed to investigate the impact of anemia on a series of in-hospital complications after ischemic stroke. METHODS: Consecutive patients with ischemic stroke within 7 days were included...
February 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29427459/acute-amnestic-syndrome-in-isolated-bilateral-fornix-stroke
#6
Alessandro Salvalaggio, Annachiara Cagnin, Lucia Nardetto, Renzo Manara, Chiara Briani
BACKGROUND: Acute onset of amnestic syndrome may represent a challenging diagnostic issue. Besides non-vascular etiology, thalamic strokes or infarction involving several temporal lobe structures has been reported. PATIENTS: We describe three patients in whom an isolated bilateral anterior fornix infarction presented with an acute amnestic syndrome. Clinical presentation, differential diagnosis and MR images are discussed for each patient and vascular anatomy of the involved brain regions is also considered...
February 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29427321/effects-of-sevoflurane-preconditioning-on-microglia-macrophage-dynamics-and-phagocytosis-profile-against-cerebral-ischemia-in-rats
#7
Dan-Dan Dang, Hexige Saiyin, Qiong Yu, Wei-Min Liang
AIM: The effects of sevoflurane on microglia/macrophages, promoting or suppressing their activation, remains controversy. We aimed to determine whether sevoflurane preconditioning can protect brain via changing microglia/macrophage dynamics and phagocytosis profile after ischemia. METHODS: The impact of sevoflurane preconditioning was evaluated on microglia/macrophage migration, phagocytosis and proliferation altogether from day 1 to day 7 after transient middle cerebral arterial occlusion (tMCAO) in rats...
February 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29425910/neuroprotective-effects-of-tongxinluo-on-focal-cerebral-ischemia-and-reperfusion-injury-in-rats-associated-with-the-activation-of-the-mek1-2-erk1-2-p90rsk-signaling-pathway
#8
Zhonghai Yu, Min Cai, Xianting Li, Jingsi Zhang, Ting Wu, Feng Yang, Wen Zhu, Yijin Xiang, Wen Zhang, Jun Xiang, Dingfang Cai
Ischemic stroke brings a huge family and social burden. Although the reperfusion of ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia-reperfusion (I/R) injury further results in brain damage and even lead to death. Recent studies demonstrated that Tongxinluo (TXL) helps to protect the brain against focal cerebral I/R injury in rats by reducing neuronal apoptosis, and the MEK1/2/ERK1/2/90 ribosomal S6 kinase (p90RSK) pathway may be involved in this protective effect. Therefore, our present research was designed to identify the potential mechanisms involved...
February 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29425407/the-importance-of-understanding-the-underlying-physiology-of-exercise-when-designing-exercise-interventions-for-brain-health
#9
Ashleigh E Smith, Ashlee M Hendy, Gavin D Tempest
The societal and economic costs of conditions associated with brain pathology (for example depression, dementia and stroke) are ever increasing. This article is protected by copyright. All rights reserved.
February 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29420916/rutin-attenuates-cerebral-ischemia-reperfusion-injury-in-ovariectomized-rats-via-estrogen-receptor-mediated-bdnf-trkb-and-ngf-trka-signaling
#10
Hong Liu, Lili Zhong, Yuwei Zhang, Xuewei Liu, Ji Li
Rutin, a flavonoid glycoside, has been reported to exert neuroprotective effects. Loss of the endogenous estrogen and dysregulation of the estrogen receptor (ER) signaling pathway are associated with the increased risk of stroke in women after menopause. This study was performed to investigate whether rutin could protect against cerebral ischemia by modulating ER pathway. Ovariectomized (OVX) rats were given intraperitoneal injection of vehicle (DMSO), rutin (100 mg/kg) or 17β-estradiol (100 μg/kg) for 5 continuous days...
February 8, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29417473/impact-of-coffee-and-cacao-purine-metabolites-on-neuroplasticity-and-neurodegenerative-disease
#11
Simonetta Camandola, Natalie Plick, Mark P Mattson
Increasing evidence suggests that regular consumption of coffee, tea and dark chocolate (cacao) can promote brain health and may reduce the risk of age-related neurodegenerative disorders. However, the complex array of phytochemicals in coffee and cacao beans and tea leaves has hindered a clear understanding of the component(s) that affect neuronal plasticity and resilience. One class of phytochemicals present in relatively high amounts in coffee, tea and cacao are methylxanthines. Among such methylxanthines, caffeine has been the most widely studied and has clear effects on neuronal network activity, promotes sustained cognitive performance and can protect neurons against dysfunction and death in animal models of stroke, Alzheimer's disease and Parkinson's disease...
February 8, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29415332/ccl23-a-new-cc-chemokine-involved-in-human-brain-damage
#12
Alba Simats, Teresa García-Berrocoso, Anna Penalba, Dolors Giralt, Gemma Llovera, Yinghua Jiang, Laura Ramiro, Alejandro Bustamante, Elena Martinez-Saez, Francesc Canals, Xiaoying Wang, Arthur Liesz, Anna Rosell, Joan Montaner
BACKGROUND: CCL23 role in the inflammatory response after acute brain injuries remains elusive. Here, we evaluated whether CCL23 blood levels associate with acquired cerebral lesions and determined CCL23 predictive capacity for assessing stroke prognosis. We used pre-clinical models to study the CCL23 homologous chemokines in rodents, CCL9 and CCL6. METHODS: Baseline CCL23 blood levels were determined on 245 individuals, including ischemic strokes (IS), stroke-mimics and controls...
February 7, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29411931/neuroprotective-mechanisms-of-glucagon-like-peptide-1-based-therapies-in-ischaemic-stroke-a-systematic-review-based-on-pre-clinical-studies
#13
Ida R Marlet, Joakim N E Ölmestig, Tina Vilsbøll, Jørgen Rungby, Christina Kruuse
Glucagon-like peptide-1 (GLP-1)-based therapies, GLP-1 receptor agonists (GLP-1RAs), and dipeptidyl peptidase-4 inhibitors (DPP-4Is) are widely used for the treatment of type 2 diabetes. Increasing evidence suggests that they may provide neuroprotection. The aim of this MiniReview was to systematically evaluate the proposed mechanism of action for GLP-1-based therapies in ischaemic brain damage in animals. We performed a literature search using Medline, Embase and The Cochrane Library. GLP-1-based therapies administered before, during or after experimental stroke in diabetic and non-diabetic animals were evaluated...
February 7, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29411248/neuroprotective-effect-and-mechanism-of-action-of-tetramethylpyrazine-nitrone-for-ischemic-stroke-therapy
#14
Gaoxiao Zhang, Tao Zhang, Liangmiao Wu, Xinhua Zhou, Jianbo Gu, Cuimei Li, Wei Liu, Cheng Long, Xifei Yang, Luchen Shan, Lipeng Xu, Yuqiang Wang, Yewei Sun, Zaijun Zhang
Our previous studies demonstrated that the multifunctional agent TBN, a derivative of tetramethylpyrazine armed with a nitrone moiety, displayed high therapeutic efficacy in experimental ischemic stroke models. However, its molecular mechanisms of action underlying the neuroprotective effect need further exploration. In the present study, we found that TBN had significant activities scavenging free radicals such as ·OH, O 2·- and ONOO-, inhibiting Ca2+ overload, maintaining mitochondrial function and preventing neuronal damage in primary cortical cultures...
February 6, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29399739/icam-1null-c57bl-6-mice-are-not-protected-from-experimental-ischemic-stroke
#15
Gaby U Enzmann, Sofia Pavlidou, Markus Vaas, Jan Klohs, Britta Engelhardt
Accumulation of neutrophils in the brain is a hallmark of cerebral ischemia and considered central in exacerbating tissue injury. Intercellular adhesion molecule (ICAM)-1 is upregulated on brain endothelial cells after ischemic stroke and considered pivotal in neutrophil recruitment as ICAM-1-deficient mouse lines were found protected from experimental stroke. Translation of therapeutic inhibition of ICAM-1 into the clinic however failed. This prompted us to investigate stroke pathogenesis in Icam1tm1Alb C57BL/6 mutants, a true ICAM-1null mouse line...
February 4, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29399074/protective-effects-of-d-limonene-against-transient-cerebral-ischemia-in-stroke-prone-spontaneously-hypertensive-rats
#16
Xifeng Wang, Gang Li, Wei Shen
Stroke is a leading cause of disability and death world-wide and there is currently a lack of effective treatments for acute stroke. D-Limonene is a common natural monocyclic monoterpene possessing various activities. The present study aimed to evaluate the therapeutic efficacy of D-limonene against ischemia-associated cerebral injury in hypertensive SHRsp rats. Although systolic blood pressure was not altered by ischemia, D-Limonene decreased the systolic blood pressure of SHRsp rats following stroke. Induction of stroke resulted in increased escape latency time, decreased time spent in the target quadrant in the probe trial, decreased capacity to distinguish between familiar objects and novel objects, and increased sensory neglect in the SHRsp rat, however these symptoms were significantly inhibited by D-limonene...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398750/effects-of-the-oral-ingestion-of-probiotics-on-brain-damage-in-a-transient-model-of-focal-cerebral-ischemia-in-mice
#17
Kobra Akhoundzadeh, Abedin Vakili, Mahdi Shadnoush, Jafar Sadeghzadeh
Background: Probiotics are microorganisms that may influence brain function via altering brain neurochemistry. New research evidence suggests that probiotic bacteria might protect tissue damage through diminishing the production of free radicals and/or inflammatory cytokines. Therefore, this study was designed to evaluate the effects of probiotic bacteria on the prevention or reduction of brain damage in an experimental model of stroke in mice. Methods: In this study, 30 male BLC57 mice were randomly divided into 6 equal groups...
January 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29398538/2-2-benzofuranyl-2-imidazoline-mediates-neuroprotection-by-regulating-the-neurovascular-unit-integrity-in-a-rat-model-of-focal-cerebral-ischemia
#18
Zheng Zhang, Linlei Zhang, Jiaou Chen, Yungang Cao, Man Qu, Xinda Lin, Zhao Han, Xunming Ji
BACKGROUND: We showed previously that 2-(2-benzofuranyl)-2-imidazoline (2-BFI), a ligand to type 2 imidazoline receptor (I2R) exerts neuroprotective effects in ischemia stroke via an unknown mechanism. The present study was to investigate whether 2-BFI can protect the neurovascular unit (NVU) using a rat model of 90 min focal cerebral ischemia. METHODS: Rats were randomly divided into three groups: thesham-operated group; the vehicle control group and the 2-BFI group which received 2-BFI (3 mg/kg) immediately after the start of middle cerebralartery occlusion (MCAO)...
February 2, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29387392/effect-of-recombinant-human-prourokinase-on-thrombolysis-in-a-rabbit-model-of-thromboembolic-stroke
#19
Chunhua Hao, Wenxia Ding, Xiangwei Xu, Qian Sun, Xinxin Li, Weiting Wang, Zhuanyou Zhao, Lida Tang
The aim of the present study was to investigate the efficacy of recombinant human prourokinase (rhPro-UK) on thromboembolic stroke in rabbits. A total of 210 rabbits were used in experiments. The 180 thromboembolic stroke rabbits were divided into three therapeutic time windows with six groups in each time window (n=10). The model group was administered saline, the reagent groups were administered rhPro-UK (2.5×, 5× and 10×104 U/kg), and the positive control groups were administered 5×104 urokinase (UK) U/kg and 4...
January 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29384222/rna-interference-mediated-silencing-of-s100b-improves-nerve-function-recovery-and-inhibits-hippocampal-cell-apoptosis-in-rat-models-of-ischemic-stroke
#20
Jin-Hua Zhang, Jiang-Kun Li, Li-Li Ma, Ji-Yu Lou
OBJECTIVE: Ischemic stroke is the leading cause of worldwide mortality and long-term disability in adults. This study aims to explore the effects of RNA interference (RNAi)-mediated silencing of the S100B gene on nerve function recovery and morphological changes of hippocampus cells in rat models with ischemic stroke. METHODS: Sixty Wistar rats were assigned into different group. S100B and Caspase 3 mRNA and protein expressions were evaluated by RT-qPCR and Western blotting...
January 31, 2018: Journal of Cellular Biochemistry
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