keyword
MENU ▼
Read by QxMD icon Read
search

Brain protection stroke

keyword
https://www.readbyqxmd.com/read/29225139/astrocytes-and-ischemic-tolerance
#1
REVIEW
Yuri Hirayama, Schuichi Koizumi
A mild non-lethal ischemic episode can induce resistance to a subsequent severe ischemic injury in the brain. This phenomenon is termed ischemic tolerance or ischemic preconditioning, and is an endogenous mechanism that can provide robust neuroprotection. Because of its neuroprotective effects against cerebral ischemia or stroke, ischemic tolerance has been widely studied. However, almost all studies have been performed from the viewpoint of neurons. Accumulating evidence suggests that glial cells have various roles in regulation of brain function, including modulation of synaptic transmission, neuronal excitation, and neuronal structure...
December 7, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29220869/non-obese-fatty-liver-disease-is-associated-with-lacunar-infarct
#2
Min-Sun Kwak, Kyung Won Kim, Hyobin Seo, Goh-Eun Chung, Jeong Yoon Yim, Donghee Kim
BACKGROUND/AIMS: Lacunar infarct, a small subcortical ischemic lesion, is a known risk factor for future cognitive impairment, dementia, and stroke. We evaluated the relationship between fatty liver disease(FLD) and lacunar infarct in a healthy general population. METHODS: Subjects who underwent brain magnetic resonance imaging(MRI) and abdominal ultrasonography(US) during health check-ups from 2007-2009 were included. FLD was diagnosed by US. Subjects with a history of cerebrovascular disease, radiological findings consistent with cerebrovascular stenosis, or cerebral small vessel disease were excluded...
December 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29220411/hexahydrocurcumin-protects-against-cerebral-ischemia-reperfusion-injury-attenuates-inflammation-and-improves-antioxidant-defenses-in-a-rat-stroke-model
#3
Piyawadee Wicha, Jiraporn Tocharus, Adchara Janyou, Jinatta Jittiwat, Chatchawan Changtam, Apichart Suksamrarn, Chainarong Tocharus
The purpose of the present experiment was to investigate whether hexahydrocurcumin (HHC) attenuates brain damage and improves functional outcome via the activation of antioxidative activities, anti-inflammation, and anti-apoptosis following cerebral ischemia/reperfusion (I/R). In this study, rats with cerebral I/R injury were induced by a transient middle cerebral artery occlusion (MCAO) for 2 h, followed by reperfusion. The male Wistar rats were randomly divided into five groups, including the sham-operated, vehicle-treated, 10 mg/kg HHC-treated, 20 mg/kg HHC-treated, and 40 mg/kg HHC-treated I/R groups...
2017: PloS One
https://www.readbyqxmd.com/read/29218547/expression-of-class-i%C3%A2-histone-deacetylases-in-ipsilateral-and-contralateral-hemispheres-after-the-focal-photothrombotic-infarction-in-the-mouse-brain
#4
Svetlana Demyanenko, Maria Neginskaya, Elena Berezhnaya
Histone acetylation and deacetylation are among the most important epigenetic processes that regulate gene expression. Nonselective inhibitors of histone deacetylases (HDAC) can protect brain cells during ischemia and stroke. However, which HDAC isoform is involved in this effect is unknown. Some isoforms of histone deacetylases (HDACs) protect brain cells after ischemia, whereas others can promote their death. Most studies consider early periods (1-24 h) after stroke, whereas little is known on the involvement of HDACs during recovery after stroke...
December 7, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29212737/astrocytic-lrp4-low-density-lipoprotein-receptor-related-protein-4-contributes-to-ischemia-induced-brain-injury-by-regulating-atp-release-and-adenosine-a2ar-adenosine-a2a-receptor-signaling
#5
Xin-Chun Ye, Jin-Xia Hu, Lei Li, Qiang Li, Fu-Lei Tang, Sen Lin, Dong Sun, Xiang-Dong Sun, Gui-Yun Cui, Lin Mei, Wen-Cheng Xiong
BACKGROUND AND PURPOSE: Lrp4 (low-density lipoprotein receptor-related protein 4) is predominantly expressed in astrocytes, where it regulates glutamatergic neurotransmission by suppressing ATP release. Here, we investigated Lrp4's function in ischemia/stroke-induced brain injury response, which includes glutamate-induced neuronal death and reactive astrogliosis. METHODS: The brain-specific Lrp4 conditional knockout mice (Lrp4GFAP-Cre), astrocytic-specific Lrp4 conditional knockout mice (Lrp4GFAP-creER), and their control mice (Lrp4f/f) were subjected to photothrombotic ischemia and the transient middle cerebral artery occlusion...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29210074/white-matter-degeneration-in-vascular-and-other-ageing-related-dementias
#6
REVIEW
Yoshika Hase, Karen Horsburgh, Masafumi Ihara, Raj N Kalaria
Advances in neuroimaging have enabled greater understanding of the progression of cerebral degenerative processes associated with ageing-related dementias. Leukoaraiosis or rarefied white matter (WM) originally described on computed tomography is one of the most prominent changes which occurs in older age. White matter hyperintensities (WMH) evident on magnetic resonance imaging have become commonplace to describe WM changes in relation to cognitive dysfunction, types of stroke injury, cerebral small vessel disease and neurodegenerative disorders including Alzheimer's disease...
December 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29206299/microrna-137-promotes-endothelial-progenitor-cell-proliferation-and-angiogenesis-in-cerebral-ischemic-stroke-mice-by-targeting-nr4a2-through-the-notch-pathway
#7
Xing-Li Liu, Gang Wang, Wei Song, Wei-Xin Yang, Jian Hua, Liang Lyu
Cerebral ischemic stroke (CIS) is one of the common causes of death and disability worldwide. This study aims to investigate effect of miR-137 on endothelial progenitor cells and angiogenesis in CIS by targeting NR4A2 via the Notch pathway. Brain tissues were extracted from CIS and normal mice. Immunohistochemistry was used to determine positive rate of NR4A2 expression. Serum VEGF, Ang, HGF and IκBα levels were determined by ELISA. RT-qPCR and western blotting were used to determine expression of related factors...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29205357/hexokinase-2-dependent-hyperglycolysis-driving-microglial-activation-contributes-to-ischemic-brain-injury
#8
Yuan Li, Bingzheng Lu, Longxiang Sheng, Zhu Zhu, Hongjiaqi Sun, Yuwei Zhou, Yang Yang, Dongdong Xue, Wenli Chen, Xuyan Tian, Yun Du, Min Yan, Wenbo Zhu, Fan Xing, Kai Li, Suizhen Lin, Pengxin Qiu, Xingwen Su, Yijun Huang, Guangmei Yan, Wei Yin
Hyperglycolysis, observed within the penumbra zone during brain ischemia, was shown to be detrimental for tissue survival due to lactate accumulation and reactive oxygen species (ROS) overproduction in clinical and experimental settings. Recently, mounting evidence suggests that glycolytic reprogramming and induced metabolic enzymes can fuel the activation of peripheral immune cells. However, the possible roles and details regarding hyperglycolysis in neuroinflammation during ischemia are relatively poorly understood...
December 5, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29204249/dietary-polyphenols-in-the-prevention-of-stroke
#9
REVIEW
A Tressera-Rimbau, S Arranz, M Eder, A Vallverdú-Queralt
Polyphenols have an important protective role against a number of diseases, such as atherosclerosis, brain dysfunction, stroke, cardiovascular diseases, and cancer. Cardiovascular diseases are the number one cause of death worldwide: more people die annually from cardiovascular diseases than from any other cause. The most important behavioural risk factors of heart disease and stroke are unhealthy diet, physical inactivity, tobacco use, and excess alcohol intake. The dietary consumption of polyphenols has shown to be inversely associated with morbidity and mortality by cardio- and cerebrovascular diseases...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29203579/heads-and-tails-of-natriuretic-peptides-neuroprotective-role-of-brain-natriuretic-peptide
#10
Héctor Fernández-Susavila, Manuel Rodríguez-Yáñez, Antonio Dopico-López, Susana Arias, María Santamaría, Paulo Ávila-Gómez, Juan M Doval-García, Tomás Sobrino, Ramón Iglesias-Rey, José Castillo, Francisco Campos
BACKGROUND: Besides the relevant role of brain-type natriuretic peptide (BNP) as biomarker of cardioembolic strokes, new experimental evidences suggest that this peptide may mediate neuroprotective effects. In this study, we have evaluated for the first time the clinical association between BNP (by means of proBNP) and good outcome in ischemic stroke patients, and analyzed the effect of blood BNP increase in an ischemic animal model. METHODS AND RESULTS: A retrospective study with 2 different cohorts (262 patients in cohort I and 610 in cohort II) from the same prospective stroke registry was performed...
December 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29203245/klf4-protects-brain-microvascular-endothelial-cells-from-ischemic-stroke-induced-apoptosis-by-transcriptionally-activating-malat1
#11
Haojie Yang, Xixiang Xi, Bin Zhao, Zhenxi Su, Zhenyi Wang
In this study, we investigated the expression profile and functional role of Kruppel-like family of transcription factor 4 (KLF4) in mouse cerebral microvascular endothelial cells (MECs) after focal cerebral ischemia and in cultured b.End3 cells after oxygen-glucose deprivation (OGD). Its downstream regulation was also studied. Our data showed that KLF4 was significantly upregulated in the cerebral MECs after transient ischemic insult and in cultured b.End3 cells after 24 h OGD exposure. In in vitro b.End3 cell model, KLF4 shRNA significantly increased OGD-induced activation of caspase-3 and also increased OGD-induced b...
December 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29201197/calcitonin-gene-related-peptide-has-protective-effect-on-brain-injury-induced-by-heat-stroke-in-rats
#12
Cheng-Xiang Lu, Ting Qiu, Zhi-Feng Liu, Lei Su, Biao Cheng
Heat stroke often leads to multiple organ dysfunction syndrome (MODS) with a neurological morbidity of 30%. Current studies suggested that pathophysiological responses to heat stroke may be due to a systemic inflammatory response syndrome and a series of peptidergic nerve reactions. The mechanisms underlying the high neurological morbidity in heat stroke have remained largely elusive. In recent years, calcitonin gene-related peptide (CGRP) has been considered to have a positive role in central nervous system injury...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29198900/time-course-of-flow-mediated-dilation-and-vascular-endothelial-growth-factor-following-acute-stroke
#13
Sandra A Billinger, Jason-Flor V Sisante, Alicen A Whitaker, Michael G Abraham
OBJECTIVES: People after stroke demonstrate alterations in vascular endothelial function measured by flow-mediated dilation. Limited information is available in the literature on possible protective factors following stroke. The aims of the secondary analysis were (1) to characterize the time course of vascular endothelial function using flow-mediated dilation at 72 hours after stroke and 1 week later during inpatient stroke rehabilitation and (2) to determine whether flow-mediated dilation was related to vascular endothelial growth factor, brain-derived neurotrophic factor, or estimated prestroke peak oxygen uptake...
November 30, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29196212/axl-activation-attenuates-neuroinflammation-by-inhibiting-the-tlr-traf-nf-%C3%AE%C2%BAb-pathway-after-mcao-in-rats
#14
Guangyong Wu, Devin W McBride, John H Zhang
BACKGROUND AND PURPOSE: Ischemic stroke activates Toll-like receptors (TLRs), triggering rapid inflammatory cytokine production. Axl signaling has multiple roles, including regulating cytokine secretion, clearing apoptotic cells, and maintaining cell survival, however, its role in inflammation after ischemic stroke has not been examined. We hypothesized that activation of Axl by recombinant Growth-arrest-specific protein 6 (rGas6) attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after middle cerebral artery occlusion (MCAO) in rats...
November 28, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29195783/platelet-glycoprotein-receptor-ib-blockade-ameliorates-experimental-cerebral-ischemia-reperfusion-injury-by-strengthening-the-blood-brain-barrier-function-and-anti-thrombo-inflammatory-property
#15
Chunyan Chen, Tingting Li, Yuchen Zhao, Yinfeng Qian, Xiaoyi Li, Xiangrong Dai, Dake Huang, Tanzhong Pan, Lanlan Zhou
Blood-brain barrier (BBB) disruption, thrombus formation and immune-mediated inflammation are important steps in the pathophysiology of cerebral ischemia-reperfusion injury but are still inaccessible to therapeutic interventions. Recent studies have provided increasing evidence that blocking of platelet glycoprotein (GP) receptor Ib might represent a novel target in treating acute ischemic stroke. This research was conducted to explore the therapeutic efficacy and potential mechanisms of GPIba inhibitor (anfibatide) in a model of brain ischemia-reperfusion injury in mice...
November 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29194929/procarboxypeptidase-u-procpu-tafi-procpb2-in-cerebrospinal-fluid-during-ischemic-stroke-is-associated-with-stroke-progression-outcome-and-blood-brain-barrier-dysfunction
#16
Joachim C Mertens, Dorien Leenaerts, Raf Brouns, Sebastiaan Engelborghs, Margareta Ieven, Peter P De Deyn, Anne-Marie Lambeir, Dirk Hendriks
BACKGROUND: Procarboxypeptidase U (proCPU, TAFI, proCPB2), the zymogen of CPU which is a potent antifibrinolytic enzyme and a modulator of inflammation has previously been investigated in plasma of stroke patients, but so far, no information on the proCPU levels in cerebrospinal fluid (CSF) during acute ischemic stroke (AIS) is available. OBJECTIVES: This case-control observational study investigates proCPU in CSF of AIS patients compared with controls with an intact blood-brain barrier (BBB) and evaluates the relationship of CSF/plasma proCPU ratios with stroke parameters...
December 1, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29193143/anti-inflammatory-and-anti-apoptotic-effects-of-the-combination-of-ligusticum-chuanxiong-and-radix-paeoniae-against-focal-cerebral-ischaemia-via-tlr4-myd88-mapk-nf-%C3%AE%C2%BAb-signalling-pathway-in-mcao-rats
#17
Junfei Gu, Shulan Su, Jianming Guo, Yue Zhu, Ming Zhao, Jin-Ao Duan
OBJECTIVE: This study was performed to assess the anti-inflammatory and anti-apoptotic effects of the combination of Ligusticum chuanxiong and Radix Paeoniae (XS) on focal cerebral ischaemic stroke. METHODS: MCAO rats were used to evaluate the effect of XS on stroke. Cerebral water content was measured, and the levels of IFN-γ, IL-1β, IL-6 and IL-12 in serum and brain were assessed by ELISA kits. Protein expressions including p-p38, p-38, TLR-4, p-ERK, ERK, TLR-5, NF-κBp65, Myd88, Caspase-3 and Caspase-12 were examined by WB and IHC...
November 28, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29193080/neuroprotection-mediated-post-ischemically-by-a-non-peptidic-%C3%AE-opioid-receptor-agonist-tan-67-in-ischemic-stroke-mice-is-associated-with-altered-amyloid-precursor-protein-expression-maturation-and-processing
#18
Jia-Wei Min, Yanying Liu, David Wang, Fangfang Qiao, Hongmin Wang
Tan-67 is a selective non-peptidic δ-opioid receptor (DOR) agonist that confers neuroprotection against cerebral ischemia/reperfusion (I/R)-caused neuronal injury in pre-treated animals. In this study, we examined whether post-ischemic administration of Tan-67 in stroke mice is also neuroprotective and whether the treatment affects expression, maturation and processing of the amyloid precursor protein (APP). A focal cerebral I/R model in mice was induced by middle cerebral artery occlusion for 1 hour (h) and Tan-67 (1...
November 29, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29187583/mir-375-attenuates-injury-of-cerebral-ischemia-reperfusion-via-targeting-ctgf
#19
Jianying Ou, Li Kou, Lingyan Liang, Chaogang Tang
Ischemic stroke is the leading cause of disability and death worldwide. MicroRNAs have been shown to play an important role in development and pathogenesis of the nervous system. However, the precise function and mechanism of miRNAs are not fully understood in the brain injury induced by ischemia/reperfusion (I/R). Herein, our study showed that miR-375 expression was significantly down-regulated in the rat I/R brain. With the in vivo and in vitro I/R stroke models we found that miR-375 mimic provides significant protection from injury of cerebral I/R, which is reflected by reduced infarct volumes and cell apoptosis, increased proliferation and migration of PC12 cells...
November 29, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29186705/mesenchymal-stem-cell-treatment-prevents-post-stroke-dysregulation-of-matrix-metalloproteinases-and-tissue-inhibitors-of-metalloproteinases
#20
Bharath Chelluboina, Koteswara Rao Nalamolu, Gustavo G Mendez, Jeffrey D Klopfenstein, David M Pinson, David Z Wang, Krishna Kumar Veeravalli
BACKGROUND/AIMS: Stem cell treatment is one of the potential treatment options for ischemic stroke. We recently demonstrated a protective effect of human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) in a rat model of ischemic stroke. The treatment attenuated apoptosis and prevented DNA damage. A collection of published studies, including several from our laboratory, indicated the induction and detrimental role for several matrix metalloproteinases (MMPs) in post-stroke brain injury...
November 30, 2017: Cellular Physiology and Biochemistry
keyword
keyword
12887
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"