keyword
https://read.qxmd.com/read/38504874/-mycoplasma-genitalium-infection-among-gay-bisexual-and-other-men-who-have-sex-with-men-in-montr%C3%A3-al-canada
#21
JOURNAL ARTICLE
Anne-Sophie Lê, Annie-Claude Labbé, Alain Fourmigue, Milada Dvorakova, Joseph Cox, Claude Fortin, Irene Martin, Daniel Grace, Trevor Hart, David Moore, Gilles Lambert
BACKGROUND: The bacteria Mycoplasma genitalium has been identified as a causative agent of urethritis in men, especially in gay, bisexual and other men who have sex with men (gbMSM). Canadian clinic-based data have identified a high prevalence of M. genitalium and resistance to antibiotic treatments. This article estimates the prevalence of M. genitalium infections among Montréal gbMSM, explores correlates for M. genitalium infection and estimates the prevalence of mutations associated with antimicrobial resistance (AMR)...
November 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38503380/antimicrobial-resistance-landscape-in-a-metropolitan-city-context-using-open-drain-wastewater-based-metagenomic-analysis
#22
JOURNAL ARTICLE
Manas Kumar Madhukar, Nirupama Singh, V Rajesh Iyer, Divya Tej Sowpati, Karthik Bharadwaj Tallapaka, Rakesh Kumar Mishra, Shivranjani Chandrashekhar Moharir
One Health concept recognizes the inextricable interactions of diverse ecosystems and their subsequent effect on human, animal and plant health. Antimicrobial resistance (AMR) is a major One Health concern and is predicted to cause catastrophes if appropriate measures are not implemented. To understand the AMR landscape in a south Indian metropolitan city, metagenomic analysis of open drains was performed. The data suggests that in January 2022, macrolide class of antibiotics contributed the highest resistance of 40...
March 17, 2024: Environmental Research
https://read.qxmd.com/read/38502239/risk-of-cardiovascular-events-after-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-in-patients-receiving-long-term-low-dose-azithromycin
#23
JOURNAL ARTICLE
Tommaso Bucci, Dennis Wat, Dilip Nazareth, Sarah Sibley, Dan Wootton, Gregory Yh Lip, Freddy Frost
No abstract text is available yet for this article.
March 19, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38501534/covid-19-in-patients-with-down-syndrome-a-systematic-review
#24
REVIEW
Praveen N K Pitchan Velammal, Suryakumar Balasubramanian, Fathima Shehnaz Ayoobkhan, Gautham V K Mohan, Pearl Aggarwal, Ali A Rabaan, Syed A Khan, Farah Yasmin, Thoyaja Koritala, Salim R Surani
INTRODUCTION: Down syndrome (DS) is associated with multiple comorbid conditions and chronic immune dysfunction. Persons with DS who contract COVID-19 are at high risk for complications and have a poor prognosis. We aimed to study the clinical symptoms, laboratory and biochemical profiles, radiologic findings, treatment, and outcomes of patients with DS and COVID-19. METHOD: We systematically searched PubMed, MEDLINE, Web of Science, Scopus, and the Cochrane Library using the keywords COVID-19 or coronavirus or SARS-CoV-2 and DS or trisomy 21...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38500629/developing-a-novel-magnetic-organic-polymer-for-selective-extraction-and-determination-of-16-macrolides-in-water-and-honey-samples
#25
JOURNAL ARTICLE
Mengnan Liang, Na Li, Hao Zhang, Ling Ma, Ke Wang
A novel magnetic organic polymer Fe3 O4 @SiO2 @Tb-PDAN was designed and synthesized, which was used as an adsorbent for magnetic solid-phase extraction (MSPE) of 16 macrolides (MALs) in water and honey. The synthesized adsorbent was characterized using techniques including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). Then several parameters of the extraction process were further optimized. Under the optimized conditions, an MSPE-LC-MS/MS method was established for extraction and determination of 16 MALs, which showed good linearity ( r ≥ 0...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38500139/bigger-problems-from-smaller-colonies-emergence-of-antibiotic-tolerant-small-colony-variants-of-mycobacterium-avium-complex-in-mac-pulmonary-disease-patients
#26
JOURNAL ARTICLE
Hyun-Eui Park, Kyu-Min Kim, Minh Phuong Trinh, Jung-Wan Yoo, Sung Jae Shin, Min-Kyoung Shin
BACKGROUND: Mycobacterium avium complex (MAC) is a group of slow-growing mycobacteria that includes Mycobacterium avium and Mycobacterium intracellulare. MAC pulmonary disease (MAC-PD) poses a threat to immunocompromised individuals and those with structural pulmonary diseases worldwide. The standard treatment regimen for MAC-PD includes a macrolide in combination with rifampicin and ethambutol. However, the treatment failure and disease recurrence rates after successful treatment remain high...
March 18, 2024: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/38497844/a-survey-study-on-antibiotic-prescription-practices-for-acute-asthma-exacerbations-an-european-academy-of-allergy-and-clinical-immunology-task-force-report
#27
JOURNAL ARTICLE
Anne-Lotte Redel, Wojciech Feleszko, Alessandra Arcolaci, Francesca Cefaloni, Marina Atanaskovic-Markovic, Gert-Jan Braunstahl, Cristina Boccabella, Matteo Bonini, Aspasia Karavelia, Eefje Louwers, Norbert Mülleneisen, Liam O'Mahony, Laura Pini, Anna Rapiejko, Esmeralda Shehu, Milena Sokolowska, Eva Untersmayr, Gerdien Tramper-Stranders
INTRODUCTION: Guidelines recommend treating asthma exacerbations (AAEs) with bronchodilators combined with inhaled and/or systemic corticosteroids. Indications for antibiotic prescriptions for AAEs are usually not incorporated although the literature shows antibiotics are frequently prescribed. AIM: To investigate the antibiotic prescription rates in AAEs and explore the possible determining factors of those practices. METHODS: A digital survey was created to determine the antibiotic prescription rates in AAEs and the influencing factors for the prescription practices...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38496201/purpuric-type-drug-eruption-caused-by-azithromycin-a-case-report-and-literature-review
#28
Natsuko Saito-Sasaki, Yu Sawada
Azithromycin, an azolide antibiotic with structural and functional similarities to macrolides, possesses distinct features such as its effects persisting for seven days, an extended half-life by administering it once daily for three days, and strong antimicrobial activity. Notably, vomiting and diarrhea are recognized as the primary adverse events related to azithromycin. In this particular case, we present a unique case describing a purpuric-type drug eruption associated with azithromycin, which represents an uncommon cutaneous manifestation...
February 2024: Curēus
https://read.qxmd.com/read/38495516/macrolide-resistance-in-mannheimia-haemolytica-isolates-associated-with-bovine-respiratory-disease-from-the-german-national-resistance-monitoring-program-ge-rm-vet-2009-to-2020
#29
JOURNAL ARTICLE
Valeria Kostova, Dennis Hanke, Heike Kaspar, Stefan Fiedler, Stefan Schwarz, Henrike Krüger-Haker
Data collected from the German national resistance monitoring program GE RM -Vet showed slowly increasing prevalence of macrolide resistance among bovine respiratory disease (BRD)-associated Pasteurellacae from cattle over the last decade. The focus of this study was to analyze the genetic basis of antimicrobial resistance (AMR) and the prevalence of multidrug-resistance (MDR)-mediating integrative and conjugative elements (ICEs) in 13 German BRD-associated Mannheimia haemolytica isolates collected between 2009 and 2020 via whole-genome sequencing...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38493570/longitudinal-antimicrobial-susceptibility-trends-of-canine-staphylococcus-pseudintermedius
#30
JOURNAL ARTICLE
Caroline Calabro, Ritwik Sadhu, Yuchen Xu, Melissa Aprea, Cassandra Guarino, Casey L Cazer
Antimicrobial resistance within Staphylococcus pseudintermedius poses a significant risk for the treatment of canine pyoderma and as a reservoir for resistance and potential zoonoses, but few studies examine long-term temporal trends of resistance. This study assesses the antimicrobial resistance prevalence and minimum inhibitory concentration (MIC) trends in S. pseudintermedius (n=1804) isolated from canine skin samples at the Cornell University Animal Health Diagnostic Center (AHDC) between 2007 and 2020...
March 12, 2024: Preventive Veterinary Medicine
https://read.qxmd.com/read/38491782/treatment-of-mycoplasma-genitalium-infection-in-pregnancy-a%C3%A2-systematic-review-of-international-guidelines
#31
REVIEW
Richard J Drew, Maeve Eogan
BACKGROUND: Mycoplasma genitalium is an emerging pathogen, which has been linked to cervicitis, urethritis and pelvic inflammatory disease (PID). With the advent of multiplex polymerase chain reaction (PCR) panels for sexually transmitted infections, it is increasingly being identified in pregnant women. OBJECTIVES: The aim was to review international guidelines, which had explicit recommendations for treatment of M. genitalium infection in pregnancy and breastfeeding...
March 15, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38491220/comparative-genomics-of-an-extensively-drug-resistant-strain-klebsiella-pneumoniae-iitr008-with-international-high-risk-clonal-lineage-st147-isolated-from-river-water
#32
JOURNAL ARTICLE
Deeksha Singh, Shilpee Pal, Srikrishna Subramanian, Natesan Manickam
Carbapenem resistant Klebsiella pneumoniae causing severe infection resulting in morbidity and mortality have become a global health concern. K. pneumoniae with sequence type ST147 is an international high-risk clonal lineage, genomic studies have been done on K. pneumoniae ST147 isolated from clinical origin but genomic data for environmental K. pneumoniae ST147 is very scarce. Herein, K. pneumoniae IITR008, an extensively drug resistant and potentially hypervirulent bacterium, was isolated from Triveni Sangam, the confluence of three rivers where religious congregations are organized...
March 15, 2024: Antonie Van Leeuwenhoek
https://read.qxmd.com/read/38491069/metagenomic-insights-into-the-wastewater-resistome-before-and-after-purification-at-large%C3%A2-scale-wastewater-treatment-plants-in-the-moscow-city
#33
JOURNAL ARTICLE
Shahjahon Begmatov, Alexey V Beletsky, Alexander G Dorofeev, Nikolai V Pimenov, Andrey V Mardanov, Nikolai V Ravin
Wastewater treatment plants (WWTPs) are considered to be hotspots for the spread of antibiotic resistance genes (ARGs). We performed a metagenomic analysis of the raw wastewater, activated sludge and treated wastewater from two large WWTPs responsible for the treatment of urban wastewater in Moscow, Russia. In untreated wastewater, several hundred ARGs that could confer resistance to most commonly used classes of antibiotics were found. WWTPs employed a nitrification/denitrification or an anaerobic/anoxic/oxic process and enabled efficient removal of organic matter, nitrogen and phosphorus, as well as fecal microbiota...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490163/characterization-and-in-vitro-plant-based-control-of-hindgut-bacteria-isolated-from-odontotermes-obesus-rambur-termitidae-and-heterotermes-indicola-wasmann-rhinotermitidae
#34
JOURNAL ARTICLE
Asma Ashraf, Saima Qadeer, Sana Ullah, Muhammad Asad, Huma Fatima, Muhammad Farhan Nasir, Nargis Shaheen, Naveeda Akhtar Qureshi
Termites cause a serious menace to wooden structures all over the world. They rely mostly on entozoic fauna residing in their hindgut for the digestion of cellulosic and hemicellulosic materials. One of the ways to control termites is through their gut symbionts. The present study was designed to characterize the hindgut bacteria isolated from Odontotermes obesus and Heterotermes indicola . Furthermore, the growth inhibitory effect of eight tropical plant extracts was investigated to find out potential control agents for these bacterial isolates...
2024: Science Progress
https://read.qxmd.com/read/38483935/association-between-social-vulnerability-and-streptococcus-pneumoniae-antimicrobial-resistance-in-us-adults
#35
JOURNAL ARTICLE
Salini Mohanty, Gang Ye, Charles Sheets, Nicole Cossrow, Kalvin C Yu, Meghan White, Kenneth P Klinker, Vikas Gupta
BACKGROUND: Growing evidence indicates antimicrobial resistance disproportionately affects individuals living in socially vulnerable areas. This study evaluated the association between Streptococcus pneumoniae (SP) antimicrobial resistance (AMR) and the CDC/ATSDR Social Vulnerability Index (SVI) in the United States. METHODS: Adult patients ≥ 18 years with 30-day nonduplicate SP isolates from ambulatory/hospital settings from January 2011-December 2022 with zip codes of residence were evaluated across 177 facilities in the BD Insights Research Database...
March 14, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38479468/diversity-and-genetic-characterization-of-chlamydia-isolated-from-siamese-crocodiles-crocodylus-siamensis
#36
JOURNAL ARTICLE
Somjit Chaiwattanarungruengpaisan, Metawee Thongdee, Nlin Arya, Weena Paungpin, Wanna Sirimanapong, Ladawan Sariya
Chlamydiosis, an infection caused by several Chlamydia species, has been reported in Nile, saltwater, and Siamese crocodiles. Despite its widespread reports in various countries, including Thailand, genetic information on Chlamydia species remains limited. This study presents a whole-genome-based characterization of Siamese crocodile-isolated Chlamydia. The results showed that Siamese crocodile Chlamydia contained a single circular chromosome with a size of 1.22-1.23 Mbp and a plasmid with a size of 7.7-8.0 kbp...
March 11, 2024: Acta Tropica
https://read.qxmd.com/read/38479352/enantioselective-total-synthesis-of-the-marine-macrolides-salarins-a-and-c
#37
JOURNAL ARTICLE
Darryl M Wilson, Robert Britton
Here we report the first total synthesis of the marine macrolide salarin C, a potent anticancer agent, and demonstrate the biomimetic oxidation-Wasserman rearrangement to access salarin A. This synthesis relies on L-proline catalysis to install a chlorohydrin function that masks the sensitive C16-C17 epoxide and potentially mimics the biosynthesis of these compounds where a related chlorohydrin may yield both THF- and epoxide-containing salarins. Additional and key features of the synthesis include (i) macrocycle formation via ring-closing metathesis, (ii) macrocyclic substrate-controlled epoxidation of the C12-C13 allylic alcohol, and (iii) a late-stage Julia-Kocienski olefination to install the side chain...
March 13, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38472522/human-campylobacter-spp-infections-in-italy
#38
JOURNAL ARTICLE
Verena Zerbato, Stefano Di Bella, Riccardo Pol, Roberto Luzzati, Gianfranco Sanson, Simone Ambretti, Stefano Andreoni, Richard Aschbacher, Mariano Bernardo, Alessandra Bielli, Gioconda Brigante, Marina Busetti, Giulio Camarlinghi, Davide Carcione, Antonella Carducci, Nicola Clementi, Edoardo Carretto, Chiara Chilleri, Giulia Codda, Alessandra Consonni, Venera Costantino, Venere Cortazzo, Manuela Di Santolo, Saveria Dodaro, Barbara Fiori, Aurora García-Fernández, Claudio Foschi, Elisa Gobbato, Francesca Greco, Roberto Marcello La Ragione, Nicasio Mancini, Alberto Enrico Maraolo, Anna Marchese, Daniela Marcuccio, Roberta Marrollo, Carola Mauri, Annarita Mazzariol, Gianluca Morroni, Adriana Mosca, Giacomo Nigrisoli, Elisabetta Pagani, Eva Maria Parisio, Simona Pollini, Mario Sarti, Annarita Sorrentino, Domenico Trotta, Laura Villa, Chiara Vismara, Luigi Principe
PURPOSE: Campylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017-2021. METHODS: Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472346/-difficult-to-treat-chronic-rhinosinusitis-when-the%C3%A2-standard-treatment-is-not-effective-and-biologics-are-not-available
#39
REVIEW
Robert Böscke
BACKGROUND: In recent years, significant improvements have been made in the treatment options for uncontrolled chronic rhinosinusitis (CRS) refractory to standard medical and surgical therapy. This is the result of a better understanding of the pathophysiology and the resulting development of biologicals for CRS with nasal polyps (CRSwNP). However, biologics are not (yet) available for all patients in Europe. OBJECTIVE: Based on the session "Difficult-to-treat CRS, when biologics are not available" at the 29th Congress of the European Rhinologic Society (ERS) 2023 in Sofia, Bulgaria, the treatment options for uncontrolled CRS with the exclusion of biologics will be discussed...
April 2024: HNO
https://read.qxmd.com/read/38472028/inhibitory-action-of-antibiotics-on-kluyveromyces-marxianus
#40
JOURNAL ARTICLE
Rafael Lisandro Althaus, Orlando Guillermo Nagel, Dafna Eluk
A bioassay containing Kluyveromyces marxianus in microtiter plates was used to determine the inhibitory action of 28 antibiotics (aminoglycosides, beta-lactams, macrolides, quinolones, tetracyclines and sulfonamides) against this yeast in whey. For this purpose, the dose-response curve for each antibiotic was constructed using 16 replicates of 12 different concentrations of the antibiotic. The plates were incubated at 40°C until the negative samples exhibited their indicator (5-7h). Subsequently, the absorbances of the yeast cells in each plate were measured by the turbidimetric method (λ=600nm) and the logistic regression model was applied...
March 11, 2024: Revista Argentina de Microbiología
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