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Intrinsic Factor

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https://www.readbyqxmd.com/read/29778849/influence-of-aortic-dilation-on-the-regional-aortic-stiffness-of-bicuspid-aortic-valve-assessed-by-4-dimensional-flow-cardiac-magnetic-resonance-comparison-with-marfan-syndrome-and-degenerative-aortic-aneurysm
#1
Andrea Guala, Jose Rodriguez-Palomares, Lydia Dux-Santoy, Gisela Teixido-Tura, Giuliana Maldonado, Laura Galian, Marina Huguet, Filipa Valente, Laura Gutiérrez, Teresa González-Alujas, Kevin M Johnson, Oliver Wieben, Augusto Sao Avilés, David Garcia-Dorado, Arturo Evangelista
OBJECTIVES: This study sought to ascertain whether patients with a bicuspid aortic valve (BAV) have an intrinsic alteration in regional aortic stiffness compared with patients with tricuspid aortic valve (TAV) and Marfan syndrome (MFS) patients with similar aortic sizes, as well as to assess the influence of ascending aorta (AAo) dilation on regional stiffness parameters in BAV patients. BACKGROUND: Imaging biomarkers as predictors of BAV, MFS, and degenerative AAo aneurysms in TAV patients (DA-TAV) are lacking...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778527/adipose-derived-mesenchymal-stem-cells-release-microvesicles-with-procoagulant-activity
#2
Tomas Fiedler, Magdalena Rabe, Ralf G Mundkowski, Sonja Oehmcke-Hecht, Kirsten Peters
Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF...
May 17, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29777587/epidermal-growth-factor-receptor-egfr-density-may-not-be-the-only-determinant-for-the-efficacy-of-egfr-targeted-photoimmunotherapy-in-human-head-and-neck-cancer-cell-lines
#3
Wei Peng, Henriette S de Bruijn, Eric Farrell, Mouldy Sioud, Vida Mashayekhi, Sabrina Oliveira, Go M van Dam, Jan L N Roodenburg, Max J H Witjes, Dominic J Robinson
OBJECTIVE: The aim of this study was to investigate the effects of targeted photoimmunotherapy (PIT) in vitro on cell lines with various expression levels of epidermal growth factor receptor (EGFR) using an anti-EGFR targeted conjugate composed of Cetuximab and IR700DX, phthalocyanine dye. MATERIALS AND METHODS: Relative EGFR density and cell binding assay was conducted in three human head & neck cancer cell lines (scc-U2, scc-U8, and OSC19) and one reference cell line A431...
May 19, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29777585/potential-vascular-mechanisms-in-an-ex-vivo-functional-pig-bladder-model
#4
Uzoma A Anele, Paul H Ratz, Andrew F Colhoun, Sydney Roberts, Ryan Musselman, Randy A Vince, John E Speich, Adam P Klausner
AIMS: Chronic ischemia is a recognized factor in the pathophysiology of underactive bladder (UAB). Although relative ischemia (ie, low blood flow) is known to occur during filling, little is known regarding the pathophysiology that leads to UAB. Therefore, we developed an ex vivo functional porcine model to investigate the role of transient ischemia and whether autoregulation, a mechanism that maintains tissue oxygenation in certain vital organs, also exists in the bladder. METHODS: Using bladders from slaughtered pigs, we prepared an isolated perfused model where we studied the effects of bladder perfusion flow rate on perfusion pressure and tissue oxygenation during the filling phase...
May 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29777298/aortic-elasticity-deterioration-proves-intrinsic-abnormality-of-the-ascending-aorta-in-pediatric-turner-syndrome-unrelated-to-the-aortic-valve-morphology
#5
Christiane Pees, Julian A Heno, Gabriele Häusler, Diana-Alexandra Ertl, Talin Gulesserian, Ina Michel-Behnke
Turner syndrome (TS) is a common genetic disorder in females with high incidence of ascending aortic dilatation and even dissection occurring as early as in the second decade. Known risk factors (RF) are bicuspid aortic valves (BAV), coarctation of the aorta (CoA), and arterial hypertension. Since 10% of dissections occur in patients without RF, an intrinsic aortic wall abnormality has been postulated. This study aimed to investigate the elasticity of the ascending aorta as a surrogate marker of aortic wall texture...
May 18, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29776870/historical-bibliometric-analysis-of-the-top-cited-articles-on-vesicoureteral-reflux-1950-2016-and-incorporation-of-a-novel-impact-index
#6
N Fernandez, A Puerto, A Azuero, F O'Kelly, J Hannick, M Rickard, A Kirsch, A Caldamone, M Koyle
INTRODUCTION AND OBJECTIVES: Vesicoureteral reflux (VUR) has been one of the defining conditions unique to pediatric urology since its inception. The clinical implications of this disease process depend on intrinsic patient factors such as age, genetics, epigenetics, voiding habits, anatomic anomalies, and extrinsic factors such as the pathogenicity of infectious agents. Knowledge about its natural history, the implications of conservative and surgical management, and their associated outcomes have evolved dramatically over time...
April 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29776381/wnt-signaling-in-multiple-myeloma-a-central-player-in-disease-with-therapeutic-potential
#7
REVIEW
Ingrid Spaan, Reinier A Raymakers, Anja van de Stolpe, Victor Peperzak
Multiple myeloma is the second most frequent hematological malignancy in the western world and remains incurable, predominantly due to acquired drug resistance and disease relapse. The highly conserved Wnt signal transduction pathway, which plays a key role in regulating cellular processes of proliferation, differentiation, migration, and stem cell self-renewal, is associated with multiple aspects of disease. Bone homeostasis is severely disturbed by Wnt antagonists that are secreted by the malignant plasma cells in the bone marrow...
May 18, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29775828/size-season-and-origin-of-gastropods-matter-in-imposex-assessments
#8
Martina Rossato, Mércia Barcelos Costa, Ítalo Braga de Castro, Grasiela Lopes Leães Pinho
Through controlled exposure to tributyltin (TBT), the effects of season, size, and population origin were evaluated on imposex incidence in Stramonita brasiliensis. Four experiments were carried out with organisms collected from three different sites on the Brazilian coast (Torres - Rio Grande do Sul, Farol de Santa Marta - Santa Catarina, and Aracruz - Espírito Santo). S. brasiliensis were anesthetized, sexed, measured, classified by size in small (< 30 mm), medium (≥ 30 to ≤ 40 mm), or big (> 40 mm) and injected in the foot muscle with 0...
May 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29775636/epithelial-proliferation-in-inflammatory-skin-disease-is-regulated-by-ttc7-in-fibroblasts-and-lymphocytes
#9
Ursina Nüesch, Andrea A Mauracher, Lennart Opitz, Benjamin Volkmer, Katarzyna Michalak-Mićka, Jivko Kamarachev, Tom Hartwig, Ernst Reichmann, Burkhard Becher, Stefano Vavassori, Jana Pachlopnik Schmid
BACKGROUND: Mutations in tetratricopeptide repeat domain 7A (TTC7A) and its mouse orthologue Ttc7 result in a multisystemic disease, mostly affecting epithelial barriers and the immune system. Despite successful hematopoietic stem cell transplantation, ongoing progression of gastrointestinal manifestations can be life-threatening in TTC7A-deficient patients. OBJECTIVE: To identify whether TTC7A mutations dysregulate epithelial cells only, or whether a cell-intrinsic defect in lymphocytes or other cells contributes to disease manifestations...
May 15, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29773518/developmental-trajectories-of-brain-maturation-and-behavior-relevance-to-major-mental-illnesses
#10
REVIEW
Sedona Lockhart, Akira Sawa, Minae Niwa
Adverse events in childhood and adolescence, such as social neglect or drug abuse, are known to lead to behavioral changes in young adulthood. This is particularly true for the subset of people who are intrinsically more vulnerable to stressful conditions. Yet the underlying mechanisms for such developmental trajectory from early life insult to aberrant adult behavior remains elusive. Adolescence is a period of dynamic physiological, psychological, and behavioral changes, encompassing a distinct neurodevelopmental stage called the 'critical period'...
May 3, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29772990/the-effects-of-meniscal-geometry-on-susceptibility-for-meniscal-and-acl-injury-in-non-arthritic-knees-a-retrospective-case-control-study
#11
Alexander Tejani, Qais Naziri, Preston W Grieco, Robert Pivec, Damon Greene, Bhaveen V Kapadia, Dipal Chatterjee, William P Urban
Prior studies have not found significant differences in meniscal parameters between patients with meniscal and ligamentous injury and those without. The purpose of this study was to determine whether such relationships exist. Clinical records and magnetic resonance images of three subject groups were reviewed. Group 1 solely had meniscal tears (medial/lateral), Group 2 had meniscal tears with concurrent ACL tears, and Group 3 had healthy knees. The mean age of subjects included was 35.9 years (range 8.2-72...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29772958/arf6-and-rab11-as-intrinsic-regulators-of-axon-regeneration
#12
Bart Nieuwenhuis, Richard Eva
Adult central nervous system (CNS) axons do not regenerate after injury because of extrinsic inhibitory factors, and a low intrinsic capacity for axon growth. Developing CNS neurons have a better regenerative ability, but lose this with maturity. This mini-review summarises recent findings which suggest one reason for regenerative failure is the selective distribution of growth machinery away from axons as CNS neurons mature. These studies demonstrate roles for the small GTPases ARF6 and Rab11 as intrinsic regulators of polarised transport and axon regeneration...
May 17, 2018: Small GTPases
https://www.readbyqxmd.com/read/29772599/a-contextual-work-life-experiences-model-to-understand-nurse-commitment-and-turnover
#13
Dilmi Aluwihare-Samaranayake, Ian Gellatly, Greta Cummings, Linda Ogilvie
AIMS: To present a discussion and model depicting most effecting work life experience contextual factors that influence commitment and turnover intentions for nurses in Sri Lanka. BACKGROUND: Increasing demand for nurses has made the retention of experienced, qualified nursing staff a priority for health care organizations and highlights the need to capture contextual work-life experiences that influence nurses' turnover decisions. DESIGN: Discussion paper...
May 17, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29771955/crispr-cas9-mediated-high-efficiency-knockout-of-the-eye-color-gene-vermillion-in-helicoverpa-zea-boddie
#14
Omaththage P Perera, Nathan S Little, Calvin A Pierce
Among various genome editing tools available for functional genomic studies, reagents based on clustered regularly interspersed palindromic repeats (CRISPR) have gained popularity due to ease and versatility. CRISPR reagents consist of ribonucleoprotein (RNP) complexes formed by combining guide RNA (gRNA) that target specific genomics regions and a CRISPR associated nuclease (Cas). The gRNA targeting specific gene sequences may be delivered as a plasmid construct that needs to be transcribed or as a synthetic RNA...
2018: PloS One
https://www.readbyqxmd.com/read/29771908/elevated-temperature-increases-meiotic-crossover-frequency-via-the-interfering-type-i-pathway-in-arabidopsis-thaliana
#15
Jennifer L Modliszewski, Hongkuan Wang, Ashley R Albright, Scott M Lewis, Alexander R Bennett, Jiyue Huang, Hong Ma, Yingxiang Wang, Gregory P Copenhaver
For most eukaryotes, sexual reproduction is a fundamental process that requires meiosis. In turn, meiosis typically depends on a reciprocal exchange of DNA between each pair of homologous chromosomes, known as a crossover (CO), to ensure proper chromosome segregation. The frequency and distribution of COs are regulated by intrinsic and extrinsic environmental factors, but much more is known about the molecular mechanisms governing the former compared to the latter. Here we show that elevated temperature induces meiotic hyper-recombination in Arabidopsis thaliana and we use genetic analysis with mutants in different recombination pathways to demonstrate that the extra COs are derived from the major Type I interference sensitive pathway...
May 17, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29771297/measurement-of-protein-digestibility-in-humans-by-a-dual-tracer-method
#16
Sarita Devi, Aneesia Varkey, M S Sheshshayee, Thomas Preston, Anura V Kurpad
Background: Recent evaluations of the risk of dietary protein deficiency have indicated that protein digestibility may be a key limiting factor in the provision of indispensable amino acids (IAAs), particularly for vulnerable populations living in challenging environments where intestinal dysfunction may exist. Since the digestion of protein occurs only in the small intestine, and the metabolic activity of colonic bacteria confounds measurements at the fecal level, there is a need to develop noninvasive protein digestibility measurements at the ileal level...
May 15, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29770972/fractional-excretion-of-electrolytes-in-volume-responsive-and-intrinsic-acute-kidney-injury-in-dogs-diagnostic-and-prognostic-implications
#17
Roberta Troìa, Marta Gruarin, Chiara Grisetti, Federica Serafini, Luca Magna, Erika Monari, Massimo Giunti, Francesco Dondi
BACKGROUND: The value of fractional excretion (FE) of electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs. OBJECTIVES: To evaluate the diagnostic and prognostic roles of FE of electrolytes in dogs with AKI. ANIMALS: Dogs (n = 135) with AKI treated with standard care (February 2014-December 2016). METHODS: Prospective study. Clinical and laboratory variables including FE of electrolytes, were measured upon admission...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29769392/cleavage-blastomere-explant-culture-in-xenopus
#18
Sally A Moody
The individual blastomeres of Xenopus two- to 32-cell embryos have been fate mapped. This work identified the precursors of most of the embryonic cell types, tissues and organs; however, the maps do not reveal the cell interactions or signaling pathways that are required for establishing cell fates. This protocol describes an explant culture approach for culturing blastomeres in isolation to test whether a cell's fate has been determined. Cleavage blastomeres can be cultured in a simple salt medium without added factors because they contain intracellular yolk platelets, which provide an intrinsic energy source...
May 16, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29769390/cell-transplantation-as-a-method-to-investigate-spinal-cord-regeneration-in-regenerative-and-nonregenerative-xenopus-stages
#19
Emilio E Méndez-Olivos, Juan Larraín
Mammals are not capable of regenerating their central nervous system (CNS); anamniotes, however, can regenerate in response to injury. The mechanisms that explain the different regenerative capabilities include: (i) extrinsic mechanisms that consider the cellular environment and extracellular matrix composition, (ii) intrinsic factors implicating the presence or absence of genetic programs that promote axon regeneration, and (iii) the presence or absence of neural stem and progenitors cells (NSPCs) that allow neurogenesis...
May 16, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29769087/replacement-of-feline-foamy-virus-bet-by-feline-immunodeficiency-virus-vif-yields-replicative-virus-with-novel-vaccine-candidate-potential
#20
Carmen Ledesma-Feliciano, Sarah Hagen, Ryan Troyer, Xin Zheng, Esther Musselman, Dragana Slavkovic Lukic, Ann-Mareen Franke, Daniel Maeda, Jörg Zielonka, Carsten Münk, Guochao Wei, Sue VandeWoude, Martin Löchelt
BACKGROUND: Hosts are able to restrict viral replication to contain virus spread before adaptive immunity is fully initiated. Many viruses have acquired genes directly counteracting intrinsic restriction mechanisms. This phenomenon has led to a co-evolutionary signature for both the virus and host which often provides a barrier against interspecies transmission events. Through different mechanisms of action, but with similar consequences, spumaviral feline foamy virus (FFV) Bet and lentiviral feline immunodeficiency virus (FIV) Vif counteract feline APOBEC3 (feA3) restriction factors that lead to hypermutation and degradation of retroviral DNA genomes...
May 16, 2018: Retrovirology
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