Daniel Komatsu, Andrea Rodrigues Esposito Cabrera, Bruna Vanessa Quevedo, Jessica Asami, Adriana Cristina Motta, Stephen Christina de Moraes, Marcia Adriana Tomaz Duarte, Moema de Alencar Hausen, Eliana Aparecida de Rezende Duek
Three-dimensional (3D) structures are actually the state-of-the-art technique to create porous scaffolds for tissue engineering. Since regeneration in cartilage tissue is limited due to intrinsic cellular properties this study aims to develop and characterize three-dimensional porous scaffolds of poly (L-co-D, L lactide-co-trimethylene carbonate), PLDLA-TMC, obtained by 3D fiber deposition technique. The PLDLA-TMC terpolymer scaffolds (70:30), were obtained and characterized by scanning electron microscopy, gel permeation chromatography, differential scanning calorimetry, thermal gravimetric analysis, compression mechanical testing and study on in vitro degradation, which showed its amorphous characteristics, cylindrical geometry, and interconnected pores...
April 22, 2024: Journal of Biomaterials Applications