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https://www.readbyqxmd.com/read/27913306/effect-of-bradykinin-receptor-antagonism-on-ace-inhibitor-associated-angioedema
#1
Brittany T Straka, Claudia E Ramirez, James B Byrd, Elizabeth Stone, Alencia Woodard-Grice, Hui Nian, Chang Yu, Aleena Banerji, Nancy J Brown
BACKGROUND: The B2 receptor antagonist icatibant is approved for treatment of attacks of hereditary angioedema. Icatibant has been reported to decrease time-to-resolution of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema in one study of European patients. METHODS: Patients with ACE inhibitor-associated angioedema (defined as swelling of lips, tongue, pharynx or face during ACE inhibitor use and no swelling in the absence of ACE inhibitor use) were enrolled at Vanderbilt University Medical Center from October 2007 through September 2015 and at Massachusetts General Hospital in 2012...
November 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27913021/climate-and-land-use-changes-effects-on-soil-organic-carbon-stocks-in-a-mediterranean-semi-natural-area
#2
Beatriz Lozano-García, Miriam Muñoz-Rojas, Luis Parras-Alcántara
A thorough knowledge of the effects of climate and land use changes on the soil carbon pool is critical to planning effective strategies for adaptation and mitigation in future scenarios of global climate and land use change. In this study, we used CarboSOIL model to predict changes in soil organic carbon stocks in a semi-natural area of Southern Spain in three different time horizons (2040, 2070, 2100), considering two general circulation models (BCM2 and ECHAM5) and three IPCC scenarios (A1b, A2, B2). The effects of potential land use changes from natural vegetation (Mediterranean evergreen oak woodland) to agricultural land (olive grove and cereal) on soil organic carbon stocks were also evaluated...
November 29, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27907814/platelet-function-one-and-three-months-after-coronary-bypass-surgery-in-relation-to-once-or-twice-daily-dosing-of-acetylsalicylic-acid
#3
Torbjörn Ivert, Magnus Dalén, Charlotte Ander, Ragnhild Stålesen, Per Näsman, Marie Lordkipanidzé, Paul Hjemdahl
INTRODUCTION: Current guidelines recommend acetylsalicylic acid (ASA) treatment after coronary artery bypass grafting (CABG) to reduce thrombotic vein graft occlusion. The optimal dosage of ASA is not known. MATERIALS AND METHODS: Forty-two patients undergoing elective CABG were randomized to receive either ASA 75mg or 160mg once daily (OD) or 75mg twice daily (BID) after the operation. Platelet function testing was performed before, and one and three months after the operation...
November 21, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27904507/impact-of-variants-in-cetp-and-apo-ai-genes-on-serum-hdl-cholesterol-levels-in-men-and-women-from-the-polish-population
#4
Marta Włodarczyk, Małgorzata Wrzosek, Grażyna Nowicka, Beata Jabłonowska-Lietz
INTRODUCTION: Polymorphisms in the cholesterol ester transfer protein (CETP) gene and apolipoprotein AI (apo AI) gene are identified as the most common genetic factors influencing high-density lipoprotein cholesterol (HDL cholesterol) levels. Low HDL cholesterol is an important risk factor for cardiovascular disease. We investigated the effect of the TaqIB polymorphism of the CETP gene and the 75G/A polymorphism of the apo AI gene on the HDL cholesterol concentration in a sample of Polish adults...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27901143/a-butterfly-motion-of-formic-acid-and-cyclobutanone-in-the-1%C3%A2-%C3%A2-1-hydrogen-bonded-molecular-cluster
#5
Luca Evangelisti, Lorenzo Spada, Weixing Li, Susana Blanco, Juan Carlos López, Alberto Lesarri, Jens-Uwe Grabow, Walther Caminati
Upon supersonic expansion, formic acid and cyclobutanone (CBU) form a molecular cluster in which the two constituent molecules, linked by OHO and CHO hydrogen bonds, undergo a rapid interconversion between two equivalent forms. The tunneling motion takes place through the rupture and reformation of the C-HO hydrogen bond between the carbonyl oxygen of HCOOH and one of the two hydrogen atoms of the methylenic group adjacent to the cyclobutanone keto group. From the microwave spectra, tunneling energy splittings (ΔE01) have been determined for the parent (1122...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27900488/additive-antiatherogenic-effects-of-cetp-rs708272-on-serum-ldl-subfraction-levels-in-patients-with-chd-under-statin-therapy
#6
Deniz Kanca, Uzay Gormus, Bengu Tokat, Allison P Eronat, Zehra Bugra, Oğuz Ozturk, Hulya Yilmaz-Aydogan
Recently, subfraction analysis of serum low density lipoprotein (LDL) is considered to be a better predictor of the risk of coronary heart disease (CHD) compared to the other lipid parameters. The aim of this study was to examine the effects of the HDL-associated Taq1B (rs708272) SNP of cholesterol ester transfer protein (CETP) gene on serum LDL subfractions in patients with CHD. Serum lipid levels were measured enzymatically and LDL subfraction analysis was carried out by the Lipoprint System (Quantimetrix, CA, USA)...
November 30, 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27899921/high-prevalence-of-%C3%AE-lactamase-and-plasmid-mediated-quinolone-resistance-genes-in-extended-spectrum-cephalosporin-resistant-escherichia-coli-from-dogs-in-shaanxi-china
#7
Xiaoqiang Liu, Haixia Liu, Yinqian Li, Caiju Hao
Objective: The aim of this study was to investigate the occurrence and molecular characterization of extended-spectrum β-lactamases (ESBL), plasmid-mediated AmpC β-lactamase (pAmpC) and carbapenemases as well as plasmid-mediated quinolone-resistant (PMQR) among extended-spectrum cephalosporin-resistant (ESC-R) Escherichia coli from dogs in Shaanxi province in China. Methods: A total of 40 ESC-R Escherichia coli selected from 165 Extraintestinal pathogenic E. coli (ExPEC) isolated from dogs were screened and characterized for the genes encoding for the ESBLs, pAmpC, carbapenemases and PMQR genes by PCR and sequencing...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27899151/lung-ultrasound-can-be-used-to-predict-the-potential-of-prone-positioning-and-assess-prognosis-in-patients-with-acute-respiratory-distress-syndrome
#8
Xiao-Ting Wang, Xin Ding, Hong-Min Zhang, Huan Chen, Long-Xiang Su, Da-Wei Liu
BACKGROUND: It is very important to assess the effectiveness of prone positioning (PP) in patients with severe acute respiratory distress syndrome (ARDS). However, it is difficult to identify patients who may benefit from PP. The purpose of this study was to investigate whether prone positioning potential (PPP) can be predicted by lung ultrasound in patients with ARDS. METHODS: In this prospective study, 45 patients with ARDS were included for the assessment of PPP...
November 30, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27898922/influence-of-pork-and-pork-by-products-on-macronutrient-and-energy-digestibility-and-palatability-in-large-exotic-felids
#9
C J Iske, C L Morris, K L Kappen
Two experiments were conducted to evaluate digestibility and palatability of a new commercial pork-based raw diet for zoo-managed felids. Currently 2 protein sources (beef or horse) comprise the majority of commercial raw meat diet formulations for exotic carnivores in zoological institutions. Pork-based diets have traditionally not been widely utilized and thus nutrient digestibility of pork has not been adequately evaluated in exotic carnivores. The objectives of this study were 1) to determine if a pork-based diet had similar apparent total tract macronutrient digestibility and fecal scores as standard zoo carnivore diets formulated with either horse or beef, in large exotic felids and 2) evaluate palatability of pork for use in zoos...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897255/high-entropy-metal-diborides-a-new-class-of-high-entropy-materials-and-a-new-type-of-ultrahigh-temperature-ceramics
#10
Joshua Gild, Yuanyao Zhang, Tyler Harrington, Sicong Jiang, Tao Hu, Matthew C Quinn, William M Mellor, Naixie Zhou, Kenneth Vecchio, Jian Luo
Seven equimolar, five-component, metal diborides were fabricated via high-energy ball milling and spark plasma sintering. Six of them, including (Hf0.2Zr0.2Ta0.2Nb0.2Ti0.2)B2, (Hf0.2Zr0.2Ta0.2Mo0.2Ti0.2)B2, (Hf0.2Zr0.2Mo0.2Nb0.2Ti0.2)B2, (Hf0.2Mo0.2Ta0.2Nb0.2Ti0.2)B2, (Mo0.2Zr0.2Ta0.2Nb0.2Ti0.2)B2, and (Hf0.2Zr0.2Ta0.2Cr0.2Ti0.2)B2, possess virtually one solid-solution boride phase of the hexagonal AlB2 structure. Revised Hume-Rothery size-difference factors are used to rationalize the formation of high-entropy solid solutions in these metal diborides...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27897081/the-time-between-venepuncture-and-blood-incubation-is-critical-for-serum-thromboxane-b2-synthesis
#11
María Teresa Santos, Antonio Moscardó, Ana Latorre, Belén Cortina, Juana Vallés
No abstract text is available yet for this article.
November 29, 2016: Platelets
https://www.readbyqxmd.com/read/27895858/distribution-of-pathogenicity-island-pai-markers-and-phylogenetic-groups-in-diarrheagenic-and-commensal-escherichia-coli-from-young-children
#12
Ghazal Naderi, Fakhri Haghi, Habib Zeighami, Fatemeh Hemati, Neda Masoumian
AIM: This case-control study investigated the various PAI markers, phylogenetic groups and antimicrobial susceptibility among DEC and commensal E. coli isolates. BACKGROUND: Diarrheagenic Escherichia coli (DEC) is an emerging agent among pathogens that cause diarrheal diseases and represents a major public health problem in developing countries. The major difference in virulence among DEC pathotype and commensals may be related to the presence of specific genomic segments, termed pathogenicity islands (PAIs)...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27894813/salicylic-acid-retention-impairs-aspirin-reactivity-in-type-2-diabetes
#13
Haowen Zhang, Hao Xie, Xiao Zheng, Yingying Chai, Zhiyuan Tang, Hanyu Chen, Feiyan Li, Heier Christoph, Jiandong Chen, Weixin Sun, Hui Ye, Shiguang Wang, Haiping Hao, Xiaohu Chen
High on-aspirin platelet reactivity (HAPR) has been associated with compromised aspirin efficacy in patients with diabetes suffering from acute cardiovascular events, but the key mechanisms remain elusive. The objective of this study was to uncover the potential link between pathogenic accumulation of salicylic acid (SA), the major metabolite of aspirin, and HAPR in diabetic state. Aspirin failed to inhibit platelet CD62P expression and thromboxane (TX) B2/ 6-keto-prostaglandin(PG)F1α ratio in a type 2 diabetes mellitus (T2DM) mice model, particularly in the female, which were unanimously accompanied by significantly higher plasma SA concentrations...
November 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27893696/molecular-epidemiological-study-of-enteroviruses-associated-with-encephalitis-in-children-from-hangzhou-china
#14
Wei Li, Zhang Qiong, Shen Xiao-Ting, Liu Yu-Jie, Mao Jian-Hua, Shu Qiang, Shang Shi-Qiang
Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27892850/determination-of-16-mycotoxins-in-vegetable-oils-using-a-quechers-method-combined-with-high-performance-liquid-chromatography-tandem-mass-spectrometry
#15
Hongxia Zhao, Xiuying Chen, Chen Shen, Baocheng Qu
A simple and efficient method for determining multiple mycotoxins was developed using a QuEChERS (quick, easy, cheap, effective, rugged and safe) based extraction procedure in vegetable oils. High performance liquid chromatography tandem mass spectrometry (HPLC-MSMS) was used for the quantification and confirmation of 16 chemically diversified mycotoxins. Different extraction procedures were studied and optimized by spiking 16 analytes into blank matrix, and the extraction with 85% MeCN solution and C18 as cleaning sorbent allowed an efficient recovery of 72...
November 28, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27889885/investigating-factors-involved-in-post-laparoscopic-sleeve-gastrectomy-lsg-neuropathy
#16
Almaha Alsabah, Salman Al Sabah, Suleiman Al-Sabah, Ahmad Al-Serri, Eliana Al Haddad, Waleed M Renno
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity as the leading bariatric procedure for the treatment of morbid obesity. Due to the rising numbers of bariatric surgeries, neurologic complications have become increasingly recognized. Our aim was to examine biochemical and hormonal factors that are associated with neuropathy post-LSG. METHODS: Thirty-two patients were included: 16 patients with neuropathy in the neuropathic group (NG) and 16 patients without neuropathy in the control group (CG)...
November 26, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27889763/inhibition-of-the-jak2-stat3-sosc1-signaling-pathway-improves-secretion-function-of-vascular-endothelial-cells-in-a-rat-model-of-pregnancy-induced-hypertension
#17
Jian-Ying Luo, Dan Fu, Ya-Qin Wu, Ying Gao
BACKGROUND/AIMS: The present study aimed to investigate the effects of the JAK2/STAT3/SOSC1 signaling pathway on the secretion function of vascular endothelial cells (VECs) in a rat model of pregnancy-induced hypertension (PIH). METHODS: A PIH rat model was established. Forty-eight pregnant Sprague-Dawley female rats were selected and assigned into four groups: the normal group (normal non-pregnant rats), the non-PIH group (pregnant rats without PIH), the PIH group (pregnant rats with PIH) and the AG490 group (pregnant rats with PIH treated with AG490)...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27889108/positive-regulation-of-lyn-kinase-by-cd148-is-required-for-b-cell-receptor-signaling-in-b1-but-not-b2-b-cells
#18
Katarzyna M Skrzypczynska, Jing W Zhu, Arthur Weiss
B1 and B2 B cells differ in their ability to respond to T-cell-independent (TI) antigens. Here we report that the Src-family kinase (SFK) regulator CD148 has a unique and critical role in the initiation of B1 but not B2 cell antigen receptor signaling. CD148 loss-of-function mice were found to have defective B1 B-cell-mediated antibody responses against the T-cell-independent antigens NP-ficoll and Pneumovax 23 and had impaired selection of the B1 B cell receptor (BCR) repertoire. These deficiencies were associated with a decreased ability of B1 B cells to induce BCR signaling downstream of the SFK Lyn...
November 15, 2016: Immunity
https://www.readbyqxmd.com/read/27888487/mycotoxins-as-human-carcinogens-the-iarc-monographs-classification
#19
Vladimir Ostry, Frantisek Malir, Jakub Toman, Yann Grosse
Humans are constantly exposed to mycotoxins (e.g. aflatoxins, ochratoxins), mainly via food intake of plant and animal origin. The health risks stemming from mycotoxins may result from their toxicity, in particular their carcinogenicity. In order to prevent these risks, the International Agency for Research on Cancer (IARC) in Lyon (France)-through its IARC Monographs programme-has performed the carcinogenic hazard assessment of some mycotoxins in humans, on the basis of epidemiological data, studies of cancer in experimental animals and mechanistic studies...
November 25, 2016: Mycotoxin Research
https://www.readbyqxmd.com/read/27888406/rotovibrational-states-of-the-water-molecule-on-the-sun
#20
Bruno S Leite, Cristiano C Bastos, Antonio C Pavão
The infrared spectrum of water observed in sunspots is complex and dense, with bands separated by approximately 0.01 cm(-1). For top asymmetrical molecules, there is no theoretical approach that allows for the calculation of rotovibrational energy with such precision. Experimentally derived rotovibracional energy levels of water at high temperatures combined with variational calculations have been used for the band assignments. These energy levels are employed to refine the analysis of a small portion of the infrared absorption spectrum...
December 2016: Journal of Molecular Modeling
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