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https://www.readbyqxmd.com/read/28231284/correction-tracking-career-outcomes-for-postdoctoral-scholars-a-call-to-action
#1
Elizabeth A Silva, Christine Des Jarlais, Bill Lindstaedt, Erik Rotman, Elizabeth S Watkins
[This corrects the article DOI: 10.1371/journal.pbio.1002458.].
February 2017: PLoS Biology
https://www.readbyqxmd.com/read/28231138/essential-oils-in-foods-from-ancient-times-to-the-21st-century
#2
EDITORIAL
Esther Sendra
Medicinal plants and culinary herbs have been used since ancient times. Essential oils (EO) are a mixture of numerous compounds, mainly terpenes, alcohols, acids, esters, epoxides, aldehydes, ketones,aminesandsulfides,thatareprobablyproducedbyplantsasaresponsetostress[1].[...].
June 14, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230794/structural-determinant-and-its-underlying-molecular-mechanism-of-stpc2-related-to-anti-angiogenic-activity
#3
Min Hu, Ning Cui, Zhixiang Bo, Feixiang Xiang
In this study, we aimed to use different strategies to further uncover the anti-angiogenic molecular mechanism of a fucoidan-like polysaccharide STPC2, isolated from brown alga Sargassum thunbergii. A desulfated derivative, STPC2-DeS, was successfully prepared and identified. The native polysaccharide and desulfated product were subjected to evaluate their anti-angiogenic effects. In the tube formation assay, STPC2 showed dose-dependent inhibition. In addition, STPC2 could distinctly inhibit the permeation of HUVEC cells into the lower chamber...
February 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28230711/asperger-syndrome-and-early-onset-schizophrenia-associated-with-a-novel-mecp2-deleterious-missense-variant
#4
Aurore Curie, Gaëtan Lesca, Gérald Bussy, Sabine Manificat, Valérie Arnaud, Sibylle Gonzalez, Olivier Revol, Alain Calender, Daniel Gérard, Vincent des Portes
Methyl-CpG-binding protein 2 (MECP2) deleterious variants, which are responsible for Rett syndrome in girls, are involved in a wide spectrum of developmental disabilities in males. A neuropsychiatric phenotype without intellectual disability is uncommon in patients with MECP2 deleterious variants. We report on two dizygotic twins with an MECP2-related psychiatric disorder without intellectual disability. Neuropsychological and psychiatric phenotype assessments were performed, and a genetic analysis was carried out...
February 22, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28229269/in-arabidopsis-thaliana-distinct-alleles-encoding-mitochondrial-rna-processing-factor-4-support-the-generation-of-additional-5-termini-of-ccmb-transcripts
#5
Katrin Stoll, Christian Jonietz, Sarah Schleicher, Catherine Colas des Francs-Small, Ian Small, Stefan Binder
In plant mitochondria, the 5' ends of many transcripts are generated post-transcriptionally. We show that the pentatricopeptide repeat (PPR) protein RNA PROCESSING FACTOR 4 (RPF4) supports the generation of extra 5' ends of ccmB transcripts in Landsberg erecta (Ler) and a number of other Arabidopsis thaliana ecotypes. RPF4 was identified in Ler applying a forward genetic approach supported by complementation studies of ecotype Columbia (Col), which generates the Ler-type extra ccmB 5' termini only after the introduction of the RPF4 allele from Ler...
February 22, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28229219/prevalence-and-clinical-impact-of-iron-deficiency-and-anaemia-among-outpatients-with-chronic-heart-failure-the-prep-registry
#6
Stephan von Haehling, Uwe Gremmler, Michael Krumm, Frank Mibach, Norbert Schön, Jens Taggeselle, Johannes B Dahm, Christiane E Angermann
BACKGROUND: Iron deficiency (ID) and anaemia are common in heart failure (HF). The prospective, observational PReP registry (Prävalenz des Eisenmangels bei Patienten mit Herzinsuffizienz) studied prevalence and clinical impact of ID and anaemia in HF outpatients attending cardiology practices in Germany. METHODS AND RESULTS: A total of 42 practices enrolled consecutive patients with chronic HF [left ventricular ejection fraction (LVEF) ≤45%]. ID was defined as serum ferritin <100 µg/l, or serum ferritin ≥100 µg/l/<300 µg/l plus transferrin saturation <20%, and anaemia as haemoglobin <13 g/dl (12 g/dl) in men (women)...
February 22, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28227523/a-measure-of-cortico-cortical-potentials-evoked-by-10-hz-direct-electrical-stimulation-of-the-brain-and-by-means-of-a-differential-recording-mode-of-electrocorticographic-signals
#7
Marion Vincent, Olivier Rossel, Hugues Duffau, Francois Bonnetblanc, David Guiraud, Marion Vincent, Olivier Rossel, Hugues Duffau, Francois Bonnetblanc, David Guiraud, Olivier Rossel, David Guiraud, Francois Bonnetblanc, Hugues Duffau, Marion Vincent
Direct electrical stimulation (DES) at 60 Hz is used to perform real-time functional mapping of the brain during wide-awake neurosurgery. The electrophysiological effects of DES are largely unknown, locally and at a more remote distance. Here, by lowering the DES frequency to 10 Hz and by using a differential recording mode of electro-corticographic (ECoG) signals to improve the focality, we were able to record cortico-cortical evoked potentials easily with standard current amplitude of stimulation (2 mA). DES applied at 10 Hz and differential recording of ECoG could be used to map on-line the connectivity between different sub-cortical and cortical areas with a higher spatial accuracy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224228/validation-of-serological-models-for-staging-and-prognostication-of-hcc-in-patients-from-a-japanese-nationwide-survey
#8
Hienori Toyoda, Toshifumi Tada, Philip J Johnson, Namiki Izumi, Masumi Kadoya, Shuichi Kaneko, Norihiro Kokudo, Yonson Ku, Shoji Kubo, Takashi Kumada, Yutaka Matsuyama, Osamu Nakashima, Michiie Sakamoto, Tadatoshi Takayama, Masatoshi Kudo
BACKGROUND: Two serology-based scoring models for prognostication of patients with hepatocellular carcinoma (HCC), the BALAD and BALAD-2 models, were applied to a Japanese cohort of a nationwide follow-up survey of HCC. The ability of these models to predict the progression of HCC and the deterioration of liver function and to assess prognosis was evaluated. METHODS: BALAD and BALAD-2 scores were calculated in 24,029 patients from a cohort of Japanese nationwide survey based on the serum levels of five markers (bilirubin, albumin, lens culinaris agglutinin-reactive alpha-fetoprotein, alpha-fetoprotein, and des-gamma-carboxy prothrombin) measured at the time of HCC diagnosis...
February 21, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28221772/desleucyl-oritavancin-with-a-damaged-d-ala-d-ala-binding-site-inhibits-the-transpeptidation-step-of-cell-wall-biosynthesis-in-whole-cells-of-staphylococcus-aureus
#9
Sung Joon Kim, Manmilan Singh, Shasad Sharif, Jacob Schaefer
We have used solid-state NMR to characterize the exact nature of the dual mode of action of oritavancin in preventing cell-wall assembly in Staphylococcus aureu. Measurements performed on whole cells labeled selectively in vivo have established that des-N-methylleucyl-N-4-(4-fluorophenyl)benzyl-chloroeremomycin, an Edman degradation product of [19F]oritavancin, which has a damaged D-Ala-D-Ala binding aglycon, is a potent inhibitor of the transpeptidase activity of cell-wall biosynthesis. The desleucyl-drug binds to partially cross-linked peptidoglycan by a cleft formed between the drug aglycon and its biphenyl hydrophobic sidechain...
February 21, 2017: Biochemistry
https://www.readbyqxmd.com/read/28220682/the-treadmill-of-production-and-the-positional-economy-of-consumption
#10
Dean Curran
The theory of the treadmill of production highlights how the constant search for economic growth leads to advanced economies being stuck on a "treadmill," where their well-being is not improved by economic growth, yet the impacts of this pursuit of growth causes massive, unsustainable environmental damages. In interrogating the specific driving force that keeps the irrational system of the treadmill so powerfully in place, the theory of the treadmill of production focuses on how those who control the production process, corporations, are the primary agents driving the treadmill, while also highlighting how the state and workers generally continue to provide support for the treadmill's continued reproduction...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220681/canadian-university-acknowledgment-of-indigenous-lands-treaties-and-peoples
#11
Rima Wilkes, Aaron Duong, Linc Kesler, Howard Ramos
At many Canadian universities it is now common to publicly acknowledge Indigenous lands, treaties, and peoples. Yet, this practice has yet to be considered as a subject of scholarly inquiry. How does this practice vary and why? In this paper we describe the content and practice of acknowledgment, linking this content to treaty relationships (or lack thereof). We show that acknowledgment tends to be one of five general types: of land and title (British Columbia), of specific treaties and political relationships (Prairies), of multiculturalism and heterogeneity (Ontario), of no practice (most of Quebec), and of people, territory, and openness to doing more (Atlantic)...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220680/an-environmental-sociology-for-the-anthropocene
#12
Gary Bowden
Attention to the relationship between nature and society has been a defining feature of environmental sociology since its inception. Early research, incorporating insights from ecology, argued for the need to (1) theorize the causal connections between nature and society and (2) contextualize those connections in terms of biophysical limits resulting from resource scarcity. Over the past two decades, partly in response to new forms of existential threat such as climate change, the treatment of nature and society as distinct entities has given way to a focus on socio-natural assemblages...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220679/the-lac-m%C3%A3-gantic-derailment-corporate-regulation-and-neoliberal-sovereignty
#13
David Tyler Dunford
On July 6, 2013, Montreal, Maine, and Atlantic railcar 5017 hauling 72 tanker cars of Bakken crude oil derailed over the town of Lac-Mégantic, Quebec. The town erupted in a fiery inferno as 5,560,000 liters of highly flammable Bakken crude oil exploded over the town, killing 47 people and contaminating 558,000 tons of soil and local waterways. While Montreal, Maine, and Atlantic Rail Chairman Edward Burkhardt initially blamed the derailment on the lone engineer and local firefighters, this study shows how Transport Canada and the rail industry undermined regulatory and safety measures for several years before the derailment...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220677/toward-a-sociology-of-oceans
#14
John Hannigan
Despite covering around 70 percent of the earth's surface, the ocean has long been ignored by sociology or treated as merely an extension of land-based systems. Increasingly, however, oceans are assuming a higher profile, emerging both as a new resource frontier, a medium for geopolitical rivalry and conflict, and a unique and threatened ecological hot spot. In this article, I propose a new sociological specialty area, the "sociology of oceans" to be situated at the interface between environmental sociology and traditional maritime studies...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220463/can-we-improve-the-outcomes-of-multivessel-disease-using-modified-syntax-and-residual-syntax-scores
#15
REVIEW
Alfredo E Rodriguez, Carlos Fernandez-Pereira, Juan Mieres, Javier Mendoza, Florencia Sartori
PURPOSE OF REVIEW: In spite of the benefits of drug eluting (DES), these advantages were not translated to better outcome when percutaneous coronary interventions (PCI) were compared with coronary artery bypass surgery. PCI strategy allowing stent deployment in all intermediate lesions including small vessels together with DES design may be the reasons of these findings. RECENT FINDINGS: Recently randomized and observational studies demonstrated using functional flow reserve analysis, residual Syntax score risk, or residual ERACI score after PCI that a reasonably incomplete revascularization was associated with good long-term outcome and low events rate at follow-up...
March 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28220323/burden-of-fungal-infections-in-algeria
#16
M Chekiri-Talbi, D W Denning
We report for the first time in Algeria and provide burden estimates. We searched for existing data and estimated the incidence and prevalence of fungal diseases based on the population at risk and available epidemiological data. Demographic data were derived from the National Office of Statistics (Office National des Statistiques: ONS), World Health Organization (WHO), The Joint Nations Programme on HIV/AIDS (UNAIDS) and national published reports. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology...
February 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28219091/-patrouille-des-glaciers-analysis-of-course-times
#17
Benedikt Andreas Gasser
Background Backcountry skiing has become more and more popular. The development of skis and equipment has been impressive and suggests that achieving a good performance level is much easier today than it was in the past. Taking the most popular backcountry skiing race in Switzerland, the "Patrouille des Glaciers (PDG)", we addressed the question as to whether this development has led to faster course times over the past ten years and what recommendations can be made for participants. Methods The average course times for the original course Zermatt - Arolla - Verbier were calculated over the past ten years for two cohorts (top-ten and median), separated by category...
February 20, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28218838/design-and-synthesis-of-enantiomerically-pure-decahydroquinoxalines-as-potent-and-selective-%C3%AE%C2%BA-opioid-receptor-agonists-with-anti-inflammatory-activity-in-vivo
#18
Michael Soeberdt, Peter Molenveld, Roy P M Storcken, Renaud Bouzanne des Mazery, Geert Jan Sterk, Reshma Autar, Marjon G Bolster, Clemens Wagner, Sebastianus N H Aerts, Frank R van Holst, Anita Wegert, Giovanni Tangherlini, Bastian Frehland, Dirk Schepmann, Dieter Metze, Tobias Lotts, Ulrich Knie, Kun-Yuan Lin, Tai-Yu Huang, Chih-Ching Lai, Sonja Ständer, Bernhard Wünsch, Christoph Abels
In order to develop novel κ agonists restricted to the periphery, a diastereo- and enantioselective synthesis of (4aR,5S,8aS)-configured decahydroquinoxalines 5-8 was developed. Physicochemical and pharmacological properties were fine-tuned by structural modifications in the arylacetamide and amine part of the pharmacophore as well as in the amine part outside the pharmacophore. The decahydroquinoxalines 5-8 show single-digit nanomolar to subnanomolar κ-opioid receptor affinity, full κ agonistic activity in the [(35)S]GTPγS assay, and high selectivity over μ, δ, σ1, and σ2 receptors as well as the PCP binding site of the NMDA receptor...
February 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28218307/effects-of-u0126-and-mk2206-on-cell-growth-and-re-growth-of-endometriotic-stromal-cells-grown-on-substrates-of-varying-stiffness
#19
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Endometriosis is a common gynecological disorder responsible for infertility and pelvic pain. A complete cure for patients with endometriosis awaits new targets and strategies. Here we show that U0126 (a MEK inhibitor) and MK2206 (an AKT inhibitor) synergistically inhibit cell growth of deep endometriotic stromal cells (DES) grown on polyacrylamide gel substrates (PGS) of varying stiffness (2 or 30 kilopascal [kPa]) or plastic in vitro. No significant differences in cell proliferation were observed among DES, endometrial stromal cells of patients with endometriosis (EES) from the proliferative phase (P), EES-S (secretory phase) and EES-M (menstrual phase) compared to cells grown on a substrate of the same stiffness at both higher (U0126 [30 μM] and MK2206 [9 μM]) and lower (U0126 [15 μM] and MK2206 [4...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215683/effects-of-hormonal-stimulation-on-the-concentration-and-quality-of-excreted-spermatozoa-in-the-critically-endangered-panamanian-golden-frog-atelopus-zeteki
#20
Gina Della Togna, Vance L Trudeau, Brian Gratwicke, Matthew Evans, Lauren Augustine, Han Chia, Edward J Bronikowski, James B Murphy, Pierre Comizzoli
Knowledge of basic gamete biology is critical to better protect and propagate endangered amphibian species and also to develop reproductive technologies combined with germplasm cryopreservation. The objectives of the study were to test different hormonal stimulations and then characterize the quantity and quality of Panamanian golden frog (Atelopus zeteki) spermatozoa. Following intraperitoneal injection of the gonadotropin-releasing hormone agonist (des-Gly(10), D-Ala(6), Pro-NHEt(9-)-GnRH 1, 2 or 4 μg/g of body weight), human chorionic gonadotropin (hCG; 5 or 10 IU/gbw), or Amphiplex™ (0...
March 15, 2017: Theriogenology
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