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JOURNAL ARTICLE
Yunjia Zhang, Hong Jiang, Mengdie Dong, Jiao Min, Xian He, Yongkang Tan, Fuhao Liu, Minghong Chen, Xiang Chen, Quanwen Yin, Longbin Zheng, Yongfeng Shao, Xuesong Li, Hongshan Chen
Macrophage activation is a hallmark of atherosclerosis, accompanied by a switch in core metabolism from oxidative phosphorylation to glycolysis. The crosstalk between metabolic rewiring and histone modifications in macrophages is worthy of further investigation. Here, we find that lactate efflux-associated monocarboxylate transporter 4 (MCT4)-mediated histone lactylation is closely related to atherosclerosis. Histone H3 lysine 18 lactylation dependent on MCT4 deficiency activated the transcription of anti-inflammatory genes and tricarboxylic acid cycle genes, resulting in the initiation of local repair and homeostasis...
May 9, 2024: Cell Reports
#22
JOURNAL ARTICLE
Merling Phaswana, Zandile June-Rose Mchiza, Sunday Olawale Onagbiye, Philippe Jean-Luc Gradidge
BACKGROUND: The burden of obesity-related, non-communicable diseases in South Africa is persistent, with poor and black South African women particularly vulnerable. The purpose of the present study was to determine relationships between obesity, physical activity, sleep patterns and beverage consumption among black South African women in a rural village in the Limpopo province. METHODS: A cross-sectional study was conducted among 200 rural-dwelling African women...
May 11, 2024: International Health
#23
REVIEW
Kannan Sridharan, Gowri Sivaramakrishnan
INTRODUCTION: Sodium glucose cotransporter-2 inhibitors (SGLT2is) are an emerging class of drugs with wide indications. Controversial evidence exists regarding the risk of urinary tract infection (UTI) and genital infections (GI) with SGLT2is paving way for undertaking this network meta-analysis and meta-regression study. METHODS: Data from randomized trials evaluating SGLT2is reporting the number of patients with UTI and GI were included. Odds ratios (OR) with 95% confidence intervals (95% CI) were the effect estimates...
May 11, 2024: Expert Review of Clinical Pharmacology
#24
REVIEW
Xinyi Ma, Mehdi Neek-Amal, Chengzhen Sun
Salinity gradient energy, often referred to as the Gibbs free energy difference between saltwater and freshwater, is recognized as "blue energy" due to its inherent cleanliness, renewability, and continuous availability. Reverse electrodialysis (RED), relying on ion-selective membranes, stands as one of the most prevalent and promising methods for harnessing salinity gradient energy to generate electricity. Nevertheless, conventional RED membranes face challenges such as insufficient ion selectivity and transport rates and the difficulty of achieving the minimum commercial energy density threshold of 5 W/m2 ...
May 11, 2024: ACS Nano
#25
JOURNAL ARTICLE
Scott D Solomon, John W Ostrominski, Muthiah Vaduganathan, Brian Claggett, Pardeep S Jhund, Akshay S Desai, Carolyn S P Lam, Bertram Pitt, Michele Senni, Sanjiv J Shah, Adriaan A Voors, Faiez Zannad, Imran Zainal Abidin, Marco Antonio Alcocer-Gamba, John J Atherton, Johann Bauersachs, Chang-Sheng Ma, Chern-En Chiang, Ovidiu Chioncel, Vijay Chopra, Josep Comin-Colet, Gerasimos Filippatos, Cândida Fonseca, Grzegorz Gajos, Sorel Goland, Eva Goncalvesová, Seok-Min Kang, Tzvetana Katova, Mikhail N Kosiborod, Gustavs Latkovskis, Alex Pui-Wai Lee, Gerard C M Linssen, Guillermo Llamas-Esperón, Vyacheslav Mareev, Felipe A Martinez, Vojtěch Melenovský, Béla Merkely, Savina Nodari, Mark C Petrie, Clara Inés Saldarriaga, Jose Francisco Kerr Saraiva, Naoki Sato, Morten Schou, Kavita Sharma, Richard Troughton, Jacob A Udell, Heikki Ukkonen, Orly Vardeny, Subodh Verma, Dirk von Lewinski, Leonid G Voronkov, Mehmet Birhan Yilmaz, Shelley Zieroth, James Lay-Flurrie, Ilse van Gameren, Flaviana Amarante, Prabhakar Viswanathan, John J V McMurray
AIMS: To describe the baseline characteristics of participants in the FINEARTS-HF trial, contextualized with prior trials including patients with heart failure (HF) with mildly reduced and preserved ejection fraction (HFmrEF/HFpEF). The FINEARTS-HF trial is comparing the effects of the non-steroidal mineralocorticoid receptor antagonist finerenone with placebo in reducing cardiovascular death and total worsening HF events in patients with HFmrEF/HFpEF. METHODS AND RESULTS: Patients with symptomatic HF, left ventricular ejection fraction (LVEF) ≥40%, estimated glomerular filtration rate ≥ 25 ml/min/1...
May 11, 2024: European Journal of Heart Failure
#26
JOURNAL ARTICLE
Saghi Zafaranieh, Monika Siwetz, Barbara Leopold-Posch, Daniel Kummer, Berthold Huppertz, Gernot Desoye, Mireille van Poppel
STUDY QUESTION: Are maternal levels of moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) in obese pregnant women associated with placental structural adaptations for facilitating oxygen delivery to the fetus? SUMMARY ANSWER: Higher maternal MVPA and ST are associated with a higher density of villi, a proxy measure of placental surface area for oxygen delivery to the fetus, without further added placental vessels. WHAT IS KNOWN ALREADY: Physical activity during pregnancy intermittently reduces uterine blood flow, potentially limiting placental and fetal oxygen supply...
May 10, 2024: Human Reproduction
#27
JOURNAL ARTICLE
Anna Kuzminova, Mariia Dmitrenko, Roman Dubovenko, Margarita Puzikova, Anna Mikulan, Alexandra Korovina, Aleksandra Koroleva, Artem Selyutin, Konstantin Semenov, Rongxin Su, Anastasia Penkova
Recently, increasing attention of researchers in the field of membrane technology has been paid to the development of membranes based on biopolymers. One of the well-proven polymers for the development of porous membranes is cellulose acetate (CA). This paper is devoted to the study of the influence of different parameters on ultrafiltration CA membrane formation and their transport properties, such as the variation in coagulation bath temperature, membrane shrinkage (post-treatment at 80 °C), introduction to casting CA solution of polymers (polyethylene glycol (PEG), polysulfone (PS), and Pluronic F127 (PL)) and carbon nanoparticles (SWCNTs, MWCNTs, GO, and C60 )...
April 28, 2024: Polymers
#28
JOURNAL ARTICLE
Sebastian Jurczyk, Jacek Andrzejewski, Adam Piasecki, Marta Musioł, Joanna Rydz, Marek Kowalczuk
The use of biodegradable polymers as matrices in composites gives a wide range of applications, especially in niche areas. The assessment of the effect of the filler content on the change of mechanical properties makes it possible to optimize the composition for specific needs. Biochar was used as a filler in the studied composites with two different biodegradable blends as a matrix. Poly(1,4-butylene adipate- co -1,4-butylene terephthalate)/polylactide/biochar (PBAT/PLA/BC) and polylactide/poly[( R )-3-hydroxybutyrate- co -4-hydroxybutyrate]/biochar (PLA/P(3HB- co -4HB)/BC) composites with 0, 10, 15, 20 and 30 wt% of biochar underwent mechanical tests...
April 28, 2024: Polymers
#29
JOURNAL ARTICLE
Yongle Li, Yao Lu, Chun Tian, Zhen Wang, Jingling Yan
This work aims to expand the structure-property relationships of bromo-containing polyimides and the influence of bromine atoms on the gas separation properties of such materials. A series of intrinsically microporous polyimides were synthesized from 2,2'-dibromo-4,4',5,5'-bipohenyltetracarboxylic dianhydride (Br-BPDA) and five bulky diamines, (7,7'-(mesitylmethylene)bis(8-methyldibenzo[b,e][1,4]dioxin-2-amine) (MMBMA), 7,7'-(Mesitylmethylene)bis(1,8-dimethyldibenzo[b,e][1,4] dioxin-2-amine) (MMBDA), 4,10-dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-diamine (TBDA1), 4,10-dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-3,9-diamine (TBDA2), and (9R,10R)-9,10-dihydro-9,10-[1,2]benzenoanthracene-2,6-diamine (DAT)...
April 25, 2024: Polymers
#30
JOURNAL ARTICLE
Zhenfeng Liang, Hui Liang
A nano-structured conjugated polymer with multiple micro-/meso-pores was synthesized by post-crosslinking of an end-functionalized hyperbranched conjugated prepolymer. Firstly, an AB2 monomer 3-((3,5-dibromo-4-(octyloxy)phenyl)ethynyl)-6-ethynyl-9-octyl-9H-carbazole (PECz) was synthesized and polymerized by Sonogashira reaction to give the -Br end-functionalized hyperbranched conjugated prepolymer hb -PPECz. The photophysical and electrochemical properties of hb -PPECz were investigated. The λmax of absorption and emission of hb -PPECz in tetrahydrofuran (THF) solution was 313 and 483 nm, respectively...
April 24, 2024: Polymers
#31
JOURNAL ARTICLE
Hadar Raphael, Eyal Klang, Eli Konen, Yael Inbar, Avshalom Leibowitz, Yael Frenkel-Nir, Sara Apter, Ehud Grossman
BACKGROUND: Obesity is associated with metabolic syndrome and fat accumulation in various organs such as the liver and the kidneys. Our goal was to assess, using magnetic resonance imaging (MRI) Dual-Echo phase sequencing, the association between liver and kidney fat deposition and their relation to obesity. METHODS: We analyzed MRI scans of individuals who were referred to the Chaim Sheba Medical Center between December 2017 and May 2020 to perform a study for any indication...
May 3, 2024: Nutrients
#32
JOURNAL ARTICLE
Francesco Trevisani, Fabiana Laurenti, Francesco Fiorio, Matteo Paccagnella, Matteo Floris, Umberto Capitanio, Michele Ghidini, Ornella Garrone, Andrea Abbona, Andrea Salonia, Francesco Montorsi, Arianna Bettiga
Nutritional therapy (NT) based on a controlled protein intake represents a cornerstone in managing chronic kidney disease (CKD). However, if a CKD patient is at the same time affected by cancer, oncologists and nutritionists tend to suggest a dietary regimen based on high protein intake to avoid catabolism and malnutrition. International guidelines are not clear when we consider onco-nephrological patients and, as a consequence, no clinical shared strategy is currently applied in clinical practice. In particular, no precise nutritional management is established in nephrectomized patients for renal cell carcinoma (RCC), a specific oncological cohort of patients whose sudden kidney removal forces the remnant one to start a compensatory mechanism of adaptive hyperfiltration...
May 3, 2024: Nutrients
#33
RANDOMIZED CONTROLLED TRIAL
Mariangela Rondanelli, Clara Gasparri, Alessandro Cavioni, Claudia Sivieri, Gaetan Claude Barrile, Francesca Mansueto, Simone Perna
Adequate diet, physical activity, and dietary supplementation with muscle-targeted food for special medical purposes (FSMP) or dietary supplement (DS) are currently considered fundamental pillars in sarcopenia treatment. The aim of this study is to evaluate the effectiveness of a DS (containing hydroxy-methyl-butyrate, carnosine, and magnesium, for its action on muscle function and protein synthesis and butyrate and lactoferrin for their contribution to the regulation of gut permeability and antioxidant/anti-inflammation activity) on muscle mass (assessed by dual X-ray absorptiometry (DXA)), muscle function (by handgrip test, chair test, short physical performance battery (SPPB) test, and walking speed test), inflammation (tumor necrosis factor-alpha (TNF-a), C-reactive protein (CRP), and visceral adipose tissue (VAT)) and gut axis (by zonulin)...
April 30, 2024: Nutrients
#34
RANDOMIZED CONTROLLED TRIAL
Kürşat Acar, Ahmet Mor, Hakkı Mor, Zehra Kargın, Dan Iulian Alexe, Mekki Abdioğlu, Raci Karayiğit, Cristina Ioana Alexe, Adin Marian Cojocaru, George Danuț Mocanu
Caffeine (CAF) has been shown to be an effective ergogenic aid in enhancing sports performance, including vertical jump (VJ), sprint, balance, agility, and freestyle swimming performance (FSP). However, whether acute CAF supplementation improves FSP in moderately trained female swimmers has not been well documented. Therefore, this study aimed to investigate the effects of CAF intake on vertical jump, balance, auditory reaction time (ART), and swimming performance in female swimmers. In a double-blind, cross-over design, eight moderately trained female swimmers (age: 21...
April 23, 2024: Nutrients
#35
JOURNAL ARTICLE
Ahmed Ali Al-Aizari, Yaser Hassan Dewir, Abdel-Halim Ghazy, Abdullah Al-Doss, Rashid Sultan Al-Obeed
Ficus palmata is an important fig species that produces edible and nutritious fruit and possesses several therapeutic uses. This study reports an effective method for the micropropagation of F. palmata using nodal explants. In vitro shoots were cultured for 7 weeks onto MS medium fortified with different concentrations of cytokinins, light intensities, sucrose concentrations, and light/dark incubation treatments. Optimal axillary shoot proliferation (10.9 shoots per explant) was obtained on a medium containing 30 g/L sucrose and supplemented with 2 mg/L 6-benzylaminopurine (BAP) under 35 μmol/m2 /s light intensity...
May 6, 2024: Plants (Basel, Switzerland)
#36
JOURNAL ARTICLE
Jinshan Wang, Ying Zhou, Cuiying Ji, Longfei Xie, Qiang Liu, Zhidong Zhang
Leaf mass per area (LMA) is a key structural parameter that reflects the functional traits of leaves and plays a vital role in simulating the material and energy cycles of plant ecosystems. In this study, vertical whorl-by-whorl sampling of LMA was conducted in a young Larix principis-rupprechtii plantation during the growing season at the Saihanba Forest Farm. The vertical and seasonal variations in LMA were analysed. Subsequently, a predictive model of LMA was constructed. The results revealed that the LMA varied significantly between different crown whorls and growing periods...
April 28, 2024: Plants (Basel, Switzerland)
#37
JOURNAL ARTICLE
Alexandra E Butler, Walaa Lubbad, Shahzad Akbar, Eric S Kilpatrick, Thozhukat Sathyapalan, Stephen L Atkin
Glomerular hyperfiltration (GH) has been reported to be higher in women with polycystic ovary syndrome (PCOS) and is an independent risk factor for renal function deterioration, metabolic, and cardiovascular disease. The aim of this study was to determine GH in type A PCOS subjects and to identify whether inflammatory markers, markers of CKD, renal tubule injury markers, and complement system proteins were associated. In addition, a secondary cohort study was performed to determine if the eGFR had altered over time...
April 30, 2024: International Journal of Molecular Sciences
#38
JOURNAL ARTICLE
Kihyeon Ahn, Kitae Park, Kambiz Sadeghi, Jongchul Seo
Despite the excellent oxygen barrier and biodegradability of polyvinyl alcohol (PVA), its poor physical properties owing to its inherent hydrophilicity limit its application. In this paper, we report a novel surface modification technique for PVA films, involving the control of the predrying conditions (i.e., amount of residual solvent) of the coated PVA film and adjusting the electrospinning process of hydrophobic polycaprolactone (PCL) nanofibers onto the PVA films. The residual solvent of the coated PVA film was varied by changing the predrying time...
April 30, 2024: Foods (Basel, Switzerland)
#39
JOURNAL ARTICLE
Hanyu Li, Mengzhuo Liu, Xinyi Ju, Huajiang Zhang, Ning Xia, Jing Wang, Zhongjiang Wang, Ahmed M Rayan
The low solubility and stability of fat-soluble curcumin in water limit its application in active packaging. This study explored the use of a pH-driven method to investigate the preparation and enhancement of the performance of films loaded with curcumin in a matrix of sodium alginate (Alg) and egg white protein (EWP). In this study, the EWP, Alg, and curcumin primarily bind through hydrogen bonding, electrostatic interactions, and hydrophobic interactions. Compared to EWP films, the films loaded with curcumin through the pH-driven method exhibited enhanced extensibility and water resistance, with an elongation at break (EB) of 103...
April 26, 2024: Foods (Basel, Switzerland)
#40
JOURNAL ARTICLE
Pavel S Gribanov, Anna N Philippova, Maxim A Topchiy, Dmitry A Lypenko, Artem V Dmitriev, Sergey D Tokarev, Alexander F Smol'yakov, Alexey N Rodionov, Andrey F Asachenko, Sergey N Osipov
An efficient access to the novel 5-(aryl)amino-1,2,3-triazole-containing 2,1,3-benzothiadiazole derivatives has been developed. The method is based on 1,3-dipolar azide-nitrile cycloaddition followed by Buchwald-Hartwig cross-coupling to afford the corresponding N -aryl and N , N -diaryl substituted 5-amino-1,2,3-triazolyl 2,1,3-benzothiadiazoles under NHC-Pd catalysis. The one-pot diarylative Pd-catalyzed heterocyclization opens the straightforward route to triazole-linked carbazole-benzothiadiazole D-A systems...
May 6, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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