keyword
MENU ▼
Read by QxMD icon Read
search

M1

keyword
https://www.readbyqxmd.com/read/28535146/role-of-spatial-inhomogenity-in-gpcr-dimerisation-predicted-by-receptor-association-diffusion-models
#1
Sneha A Deshpande, Aiswarya B Pawar, Anish Dighe, Chaitanya A Athale, Durba Sengupta
G protein-coupled receptor (GPCR) association is an emerging paradigm with far reaching implications in the regulation of signalling pathways and therapeutic interventions. Recent super resolution microscopy studies have revealed that receptor dimer steady state exhibits sub-second dynamics. In particular the GPCRs, muscarinic acetylcholine receptor M1 (M1MR) and formyl peptide receptor (FPR), have been demonstrated to exhibit a fast association/dissociation kinetics, independent of ligand binding. In this work, we have developed a spatial kinetic Monte Carlo model to investigate receptor homo-dimerisation at a single receptor resolution...
May 23, 2017: Physical Biology
https://www.readbyqxmd.com/read/28534246/microglia-housekeeper-of-the-central-nervous-system
#2
REVIEW
John Alimamy Kabba, Yazhou Xu, Handson Christian, Wenchen Ruan, Kitchen Chenai, Yun Xiang, Luyong Zhang, Juan M Saavedra, Tao Pang
Microglia, of myeloid origin, play fundamental roles in the control of immune responses and the maintenance of central nervous system homeostasis. These cells, just like peripheral macrophages, may be activated into M1 pro-inflammatory or M2 anti-inflammatory phenotypes by appropriate stimuli. Microglia do not respond in isolation, but form part of complex networks of cells influencing each other. This review addresses the complex interaction of microglia with each cell type in the brain: neurons, astrocytes, cerebrovascular endothelial cells, and oligodendrocytes...
May 22, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28533328/tendon-stem-progenitor-cells-regulate-inflammation-in-tendon-healing-via-jnk-and-stat3-signaling
#3
Solaiman Tarafder, Esther Chen, Yena Jun, Kristy Kao, Kun Hee Sim, Jungho Back, Francis Y Lee, Chang H Lee
Tendon stem/progenitor cells (TSCs) have been found in different anatomic locations and showed a promising regenerative potential. We identified a role of TSCs in the regulation of inflammation during healing of acute tendon injuries. Delivery of connective tissue growth factor (CTGF) into full-transected rat patellar tendons significantly increased the number of CD146(+) TSCs, leading to enhanced healing. In parallel, CTGF delivery significantly reduced the number of iNOS(+) M1 Mϕs and increased the expression of anti-inflammatory IL-10 at 2 d after surgery, with over 85% CD146(+) TSCs expressing IL-10...
May 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28531611/aflatoxin-m1-levels-in-milk-and-dairy-products-in-greece-relation-to-public-health
#4
Eleni Malissiova, Eymorfia Maraidoni, Dimitra Kyriazi, Michael Gonidakis, Athanasios Manouras, Olga Gortzi, Constantinos Deligiannis
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530154/determining-electrode-placement-for-transcranial-direct-current-stimulation-a-comparison-of-eeg-versus-tms-guided-methods
#5
Tonya L Rich, Jeremiah S Menk, Kyle D Rudser, Mo Chen, Gregg D Meekins, Edgar Peña, Timothy Feyma, Kay Bawroski, Christina Bush, Bernadette T Gillick
Transcranial direct current stimulation (tDCS) is increasingly researched as an adjuvant to motor rehabilitation for children with hemiparesis. The optimal method for the primary motor cortex (M1) somatotopic localization for tDCS electrode placement has not been established. The objective, therefore, was to determine the location of the M1 derived using the 10/20 electroencephalography (EEG) system and transcranial magnetic stimulation (TMS) in children with hemiparesis (CWH) and a comparison group of typically developing children (TDC)...
May 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28529490/microgravity-induced-transcriptome-adaptation-in-mouse-paraspinal-longissimus-dorsi-muscle-highlights-insulin-resistance-linked-genes
#6
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate longissimus dorsi adaptation to microgravity at both morphological and global gene expression level. C57BL/N6 male mice were flown aboard the BION-M1 biosatellite for 30 days (BF) or housed in a replicate flight habitat on ground (BG)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28529172/contribution-of-muscarinic-receptors-to-in-vitro-and-in-vivo-effects-of-ruscus-extract
#7
Isabelle Rauly-Lestienne, Peter Heusler, Didier Cussac, Frédérique Lantoine-Adam, Fatima Zely Garcia de Almeida Cyrino, Eliete Bouskela
The objectives of this study were to evaluate, in vitro and in vivo, the contribution of muscarinic receptors to the effects of Ruscus extract. Ruscus extract was tested in competition binding experiments at recombinant human muscarinic receptors, heterologous expressed in Chinese Hamster Ovary (CHO) cells and in cellular assays measuring Ca(2+) liberation and activator protein-1 (AP-1) reporter gene activation. The impact of muscarinic blockade on prolonged treatment outcome was evaluated using the hamster cheek pouch (HCP) microcirculation examining macromolecular permeability increase induced by histamine or ischemia/reperfusion (I/R), mean arteriolar and venular diameters, functional capillary density and I/R-induced leukocyte rolling and sticking...
May 18, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28528736/on-the-effectiveness-of-event-related-beta-tacs-on-episodic-memory-formation-and-motor-cortex-excitability
#8
Verena Braun, Rodika Sokoliuk, Simon Hanslmayr
BACKGROUND: Transcranial alternating current stimulation (tACS) is widely used to entrain or modulate brain oscillations in order to investigate causal relationships between oscillations and cognition. OBJECTIVE: In a series of experiments we here addressed the question of whether event-related, transient tACS in the beta frequency range can be used to entrain beta oscillations in two different domains: episodic memory formation and motor cortex excitability. METHODS: In experiments 1 and 2, 72 healthy human participants engaged in an incidental encoding task of verbal and non-verbal material while receiving tACS to the left and right inferior frontal gyrus (IFG) at 6...
April 30, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28527905/peroxisome-proliferator-activated-receptor-%C3%AE-mediated-polarization-of-macrophages-in-neospora-caninum-infection
#9
Xuexiu He, Pengtao Gong, Zhengkai Wei, Weijian Liu, Weili Wang, Jianhua Li, Zhengtao Yang, Xichen Zhang
BACKGROUND: Neospora caninum is an apicomplexan parasite closely related Toxoplasma gondii, which causes neurological disease and abortion in multiple animal species. Macrophage polarization plays an important role in host immune responses to parasites infection, such as Toxoplasma gondii, Leishmania, Trypanosoma cruzi. However, the dynamics of macrophage polarization, as well as the possible mechanism that regulate macrophage polarization, during N. caninum infection remains unclear...
May 17, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28527283/-frequency-of-helicobacter-pylori-nitroreductase-rdxa-mutations-for-metronidazole-activation-in-a-population-in-the-cauca-department-colombia
#10
Claudia Patricia Acosta, Andrés Javier Quiroga, Carlos H Sierra, Alba Alicia Trespalacios
INTRODUCTION: Resistance to metronidazole is a key factor associated with Helicobacter pylori treatment failure. Even though resistance is mostly associated with RdxA nitroreductase mutations, studies of this H. pylori protein in Popayán (Colombia) are still incipient. OBJECTIVE: To evaluate the frequency of mutations in the RdxA nitroreductase in a population of patients with H. pylori-positive gastrointestinal disease. MATERIALS AND METHODS: We amplified the DNA of 170 gastric biopsies by PCR to detect mutations in the RdxA nitroreductase...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28526805/evaluation-of-crescent-formation-as-a-predictive-marker-in-immunoglobulin-a-nephropathy-a-systematic-review-and-meta-analysis
#11
Xue Shao, Bingjue Li, Luxi Cao, Ludan Liang, Jingjuan Yang, Yucheng Wang, Shi Feng, Cuili Wang, Chunhua Weng, Xiujin Shen, Hong Jiang, Jianghua Chen
The 2009 Oxford Classification of immunoglobulin A (IgA) nephropathy (IgAN) identifies four histological features as predictors of renal prognosis: mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T). However, the clinical and prognostic significance of crescent formation still remains controversial. Therefore, we performed a meta-analysis to evaluate the association between crescents and kidney outcome in IgAN. A total of 20 studies published from January 2009 to July 2016 involving 5,285 patients were included after systematic searches of PubMed and EMBASE databases...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28526625/effects-of-resistance-training-frequency-on-cardiorespiratory-fitness-in-older-men-and-women-during-intervention-and-follow-up
#12
Elena Fernández-Lezaun, Moritz Schumann, Tuomas Mäkinen, Heikki Kyröläinen, Simon Walker
This study investigated the effects of resistance training (RT) performed with different frequencies, including a follow-up period, on cardiorespiratory fitness in healthy older individuals. Eighty-eight men and women (69±3years, 167±9cm and 78±14kg) were randomly placed into four groups: training one- (M1=11, W1=12), two- (M2=7, W2=14), or three- (M3=11, W3=13) times-per-week or a non-training control group (MCon=11, WCon=9). During months 1-3, all subjects trained two-times-per-week while during the subsequent 6months, training frequency was set according to the group...
May 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28526557/the-frog-skin-host-defense-peptide-frenatin-2-1s-enhances-recruitment-activation-and-tumoricidal-capacity-of-nk-cells
#13
Jelena M Pantic, Ivan P Jovanovic, Gordana D Radosavljevic, Nevena M Gajovic, Nebojsa N Arsenijevic, J Michael Conlon, Miodrag L Lukic
Frog skin is a source of peptides with various biological properties. Frenatin 2.1S, derived from norepinephrine-stimulated skin secretions of the Orinoco lime tree frog Sphaenorhynchus lacteus, exhibits immunostimulatory effects as demonstrated by the promotion of proinflammatory phenotypes of mononuclear cells in mouse peritoneal cavity and spleen. The aim of this study was to identify the populations of host cells sensitive to the action of frenatin 2.1S in vivo and to study its effects on their functional antitumor capacity...
May 16, 2017: Peptides
https://www.readbyqxmd.com/read/28526301/mfg-e8-reprogramming-of-macrophages-promotes-wound-healing-by-increased-bfgf-production-and-fibroblast-functions
#14
Patrick Laplante, Frédéric Brillant-Marquis, Marie-Joëlle Brissette, Benjamin Joannette-Pilon, Romain Cayrol, Victor Kokta, Jean-François Cailhier
Macrophages are essential for tissue repair. They have a crucial role in cutaneous wound healing, participating actively in the inflammation phase of the process. Unregulated macrophage activation may, however, represent a source of excessive inflammation leading to abnormal wound healing and hypertrophic scars. Our research group has demonstrated that apoptotic endothelial and epithelial cells secrete Milk Fat Globule Epidermal Growth Factor-8 (MFG-E8), which has the ability to reprogram macrophages from a M1 (pro-inflammatory) to a M2 (anti-inflammatory pro-repair) phenotype...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28524799/-y-stent-retriever-a-new-rescue-technique-for-refractory-large-vessel-occlusions
#15
Roberto Crosa, Alejandro M Spiotta, Matías Negrotto, Alejandra Jaume, Walter Casagrande
Long-awaited positive trial data have shown the efficacy of endovascular treatment in patients with ischemic stroke who arrive at the hospital within the first 6 hours with large-vessel occlusion of the anterior circulation. With the introduction of stent retrievers (SRs) for mechanical thrombectomy, efficient and safe large-artery recanalization treatment can be achieved. However, sometimes there are patients who do not attain complete flow restoration following attempts with traditional maneuvers. The authors present the case of a 57-year-old man with acute ischemic stroke due to an M1 embolus that extended into both M2 trunks...
May 19, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28524175/modulators-of-microglial-activation-and-polarization-after-intracerebral-haemorrhage
#16
REVIEW
Xi Lan, Xiaoning Han, Qian Li, Qing-Wu Yang, Jian Wang
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. Microglia are among the first non-neuronal cells on the scene during the innate immune response to ICH. Microglia respond to acute brain injury by becoming activated and developing classic M1-like (proinflammatory) or alternative M2-like (anti-inflammatory) phenotypes. This polarization implies as yet unrecognized actions of microglia in ICH pathology and recovery, perhaps involving microglial production of proinflammatory or anti-inflammatory cytokines and chemokines...
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28524127/-an-acute-subdural-hematoma-caused-by-rupture-of-a-middle-cerebral-artery-aneurysm
#17
R S Dzhindzhikhadze, O N Dreval', V A Lazarev, R L Kambiev
Acute subdural hematoma caused by cerebral aneurysm rupture is rare. We describe a clinical case of an acute subdural hematoma developed due to rupture of an aneurysm at the M1 segment bifurcation of the middle cerebral artery (MCA). The acute subdural hematoma associated with intracranial hypertension and transtentorial herniation resulted in a comatose condition. The patient underwent decompressive craniectomy, hematoma removal, and clipping of the aneurysm. A significant improvement was observed in the postoperative period...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28523425/characterization-of-electrocorticogram-high-gamma-signal-in-response-to-varying-upper-extremity-movement-velocity
#18
Po T Wang, Colin M McCrimmon, Christine E King, Susan J Shaw, David E Millett, Hui Gong, Luis A Chui, Charles Y Liu, Zoran Nenadic, An H Do
The mechanism by which the human primary motor cortex (M1) encodes upper extremity movement kinematics is not fully understood. For example, human electrocorticogram (ECoG) signals have been shown to modulate with upper extremity movements; however, this relationship has not been explicitly characterized. To address this issue, we recorded high-density ECoG signals from patients undergoing epilepsy surgery evaluation as they performed elementary upper extremity movements while systematically varying movement speed and duration...
May 18, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28523368/two-stage-prediction-on-effects-of-mixtures-containing-phenolic-compounds-and-heavy-metals-on-vibrio-qinghaiensis-sp-q67
#19
Ling-Yun Mo, Jie Liu, Li-Tang Qin, Hong-Hu Zeng, Yan-Peng Liang
Two-stage prediction (TSP) model had been developed to predict toxicities of mixtures containing complex components, but its prediction power need to be further validated. Six phenolic compounds and six heavy metals were selected as mixture components. One mixture (M1) was built with equivalent-effect concentration ratio and four mixtures (M2-M5) were designed with fixed concentration ratio. In M1-M5, the toxicities were well predicted by TSP model, while CA overestimated and IA underestimated the toxicities...
May 18, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28523230/targeting-resolution-of-neuroinflammation-after-ischemic-stroke-with-a-lipoxin-a4-analog-protective-mechanisms-and-long-term-effects-on-neurological-recovery
#20
Kimberly E Hawkins, Kelly M DeMars, Jon C Alexander, Lauren G de Leon, Sean C Pacheco, Christina Graves, Changjun Yang, Austin O McCrea, Jan C Frankowski, Timothy J Garrett, Marcelo Febo, Eduardo Candelario-Jalil
BACKGROUND: Resolution of inflammation is an emerging new strategy to reduce damage following ischemic stroke. Lipoxin A4 (LXA 4) is an anti-inflammatory, pro-resolution lipid mediator that reduces neuroinflammation in stroke. Since LXA 4 is rapidly inactivated, potent analogs have been synthesized, including BML-111. We hypothesized that post-ischemic, intravenous treatment with BML-111 for 1 week would provide neuroprotection and reduce neurobehavioral deficits at 4 weeks after ischemic stroke in rats...
May 2017: Brain and Behavior
keyword
keyword
12858
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"