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Panic disorder

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https://www.readbyqxmd.com/read/29042589/glrb-variants-regulate-nearby-gene-expression-in-human-brain-tissues
#1
Qing-Jian Wu, Ming-Feng Yang, Pi-da Hao, Cheng-Jun Yan, Chun-Jing Du, Han-Xia Li, Ya-Jun Hou, Bao-Liang Sun, Shu-Yin Sun
A recent genome-wide association study (GWAS) identified four genetic variants rs78726293, rs191260602, rs17035816 and rs7688285 in GLRB gene to be associated with panic disorder (PD) risk. In fact, GWAS is an important first step to investigate the genetics of human complex diseases. In order to translate into opportunities for new diagnostics and therapies, we must identify the genes perturbed by these four variants, and understand how these variant functionally contributes to the underlying disease pathogenesis...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037266/is-cognitive-behavioural-therapy-more-effective-than-relaxation-therapy-in-the-treatment-of-anxiety-disorders-a-meta-analysis
#2
Jesus Montero-Marin, Javier Garcia-Campayo, Alba López-Montoyo, Edurne Zabaleta-Del-Olmo, Pim Cuijpers
BACKGROUND: It is not clear whether relaxation therapies are more or less effective than cognitive and behavioural therapies in the treatment of anxiety. The aims of the present study were to examine the effects of relaxation techniques compared to cognitive and behavioural therapies in reducing anxiety symptoms, and whether they have comparable efficacy across disorders. METHOD: We conducted a meta-analysis of 50 studies (2801 patients) comparing relaxation training with cognitive and behavioural treatments of anxiety...
October 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29036201/impact-of-social-separation-during-pregnancy-on-the-manifestation-of-defensive-behaviors-related-to-generalized-anxiety-and-panic-throughout-offspring-development
#3
Flaviane Cristina de Brito Guzzo Soliani, Rafael Cabbia, Matheus Fitipaldi Batistela, Amarylis Garcia Almeida, Vinícius Dias Kümpel, Luiz Yamauchi Junior, Telma Gonçalves Carneiro Spera de Andrade
The multiple insecurities, anatomical, physiological and psychological changes arising from the gestational period can generate an overload of stress in the mother and cause disturbances in the offspring, affecting it throughout its development. The existing analysis linking prenatal stress and offspring's anxiety have divergent results, being limited as to gestational week, type of stressor and age of progeny's assessment. Social separation has been described as a stressor that causes increase in anxiety. Thus, the present study evaluated the effects of social separation applied in one of the three gestational weeks of rat dams on the manifestation of the defensive behaviors related to generalized anxiety disorder and panic in the Elevated T Maze of the male progeny in three stages of development (1, 3 or 6 months of life)...
2017: PloS One
https://www.readbyqxmd.com/read/29034525/reliability-and-validity-of-severity-dimensions-of-psychopathology-assessed-using-the-structured-clinical-interview-for-dsm-5-scid
#4
Stewart A Shankman, Carter J Funkhouser, Daniel N Klein, Joanne Davila, Debra Lerner, Danelle Hee
This study examined whether the Structured Clinical Interview for DSM (SCID), a widely used semistructured interview designed to assess psychopathology categorically, can be adapted to identify reliable and valid severity dimensions of psychopathology. The present study also examined whether these severity dimensions have better psychometric properties (internal consistency, test-retest reliability, and concurrent and predictive validity) than categorical diagnoses. Participants (N = 234) were recruited from the community and clinics...
October 16, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29034101/lamotrigine-induced-sexual-dysfunction-and-non-adherence-case-analysis-with-literature-review
#5
Kenneth R Kaufman, Melissa Coluccio, Kartik Sivaraaman, Miriam Campeas
BACKGROUND: Optimal anti-epileptic drug (AED) treatment maximises therapeutic response and minimises adverse effects (AEs). Key to therapeutic AED treatment is adherence. Non-adherence is often related to severity of AEs. Frequently, patients do not spontaneously report, and clinicians do not specifically query, critical AEs that lead to non-adherence, including sexual dysfunction. Sexual dysfunction prevalence in patients with epilepsy ranges from 40 to 70%, often related to AEDs, epilepsy or mood states...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/29031568/anxiety-disorders-in-old-age-psychiatric-comorbidities-quality-of-life-and-prevalence-according-to-age-gender-and-country
#6
Alessandra Canuto, Kerstin Weber, Marc Baertschi, Sylke Andreas, Jana Volkert, Maria Christina Dehoust, Susanne Sehner, Anna Suling, Karl Wegscheider, Berta Ausín, Mike J Crawford, Chiara Da Ronch, Luigi Grassi, Yael Hershkovitz, Manuel Muñoz, Alan Quirk, Ora Rotenstein, Ana Belén Santos-Olmo, Arieh Shalev, Jens Strehle, Hans-Ulrich Wittchen, Holger Schulz, Martin Härter
OBJECTIVES: Previous estimates of the prevalence of anxiety disorders in late life vary greatly due to the lack of reliable diagnostic tools. This MentDis_ICF65+ study assessed 12-month prevalence rates of anxiety disorders and age- and gender-related differences in comorbidities, as well as impact on quality of life. DESIGN: The study used a cross-sectional multicenter survey. PARTICIPANTS: The study sample comprised 3,142 men and women aged 65 to 84 years, living in five European countries and Israel...
September 5, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29019550/salivary-stress-biomarkers-and-anxiety-symptoms-in-children-with-and-without-temporomandibular-disorders
#7
Fernanda Yukie Kobayashi, Maria Beatriz Duarte Gavião, Maria Carolina Salomé Marquezin, Fernando Luiz Affonso Fonseca, Ana Bheatriz Marangoni Montes, Taís de Souza Barbosa, Paula Midori Castelo
The etiology of temporomandibular disorders (TMD), which are considered as a heterogeneous group of psychophysiological disturbances, remains a controversial issue in clinical dentistry. This study aimed to evaluate whether the salivary alpha-amylase (sAA), cortisol levels, and anxiety symptoms differ between children with and without TMD. Initially, 316 young subjects were screened in public schools (nonreferred sample); 76 subjects aged 7-14 years were selected and comprised the TMD and control groups with 38 subjects each matched by sex, age, and the presence/absence of sleep bruxism...
September 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29018160/dopamine-dysregulation-syndrome-in-parkinson-s-disease-a-systematic-review-of-published-cases
#8
Nicola Warren, Cullen O'Gorman, Alexander Lehn, Dan Siskind
OBJECTIVES: Dopamine dysregulation syndrome (DDS) is an uncommon complication of the treatment of Parkinson's disease, characterised by addictive behaviour and excessive use of dopaminergic medication. DDS may frequently go unrecognised or misdiagnosed. We aimed to clarify current understanding of presentation, risk factors, comorbidities and management of DDS. METHODS: Case reports were identified through a systematic search of databases (PubMed, Embase) with the following terms: dopaminergic dysregulation syndrome, hedonistic homeostatic dysregulation, dopamine/levodopa addiction...
October 10, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29016983/predictors-of-sleep-disordered-breathing-in-children-the-panic-study
#9
Tiina Ikävalko, Matti Närhi, Aino-Maija Eloranta, Niina Lintu, Riitta Myllykangas, Anu Vierola, Henri Tuomilehto, Timo Lakka, Riitta Pahkala
Objective: We studied longitudinally the associations of craniofacial morphology, mouth breathing, orthodontic treatment, and body fat content with the risk of having and developing sleep disordered breathing (SDB) in childhood. We hypothesized that deviant craniofacial morphology, mouth breathing, and adiposity predict SDB among children. Materials and methods: The participants were 412 children 6-8 years of age examined at baseline and 329 children aged 9-11 years re-examined at an average 2...
July 11, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28972930/insomnia-and-hypersomnia-in-major-depressive-episode-prevalence-sociodemographic-characteristics-and-psychiatric-comorbidity-in-a-population-based-study
#10
Pierre A Geoffroy, Nicolas Hoertel, Bruno Etain, Frank Bellivier, Richard Delorme, Frédéric Limosin, Hugo Peyre
OBJECTIVES: To examine (i) the frequency of different sleep complaints (early wake-up, trouble falling asleep, hypersomnia) and their co-occurrence and (ii) the sociodemographic characteristics and psychiatric comorbidity associated with each type of sleep profiles. METHODS: Data were drawn from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative survey of the US adult population (wave 1, 2001-2002; wave 2, 2004-2005)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28972592/genetically-driven-brain-serotonin-deficiency-facilitates-panic-like-escape-behavior-in-mice
#11
J Waider, S Popp, M D Lange, R Kern, J F Kolter, J Kobler, N C Donner, K R Lowe, J H Malzbender, C J Brazell, M R Arnold, B Aboagye, A Schmitt-Böhrer, C A Lowry, H C Pape, K P Lesch
Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice. Functional assessment of c-Fos after associated foot shock, electrophysiological recordings of GABAergic synaptic transmission, differential expression of the Slc6a4 gene in serotonergic neurons were combined with locomotor and anxiety-like measurements in different contextual settings...
October 3, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28971725/transcranial-sonography-in-psychiatry-as-a-potential-tool-in-diagnosis-and-research
#12
Carsten Drepper, Julia Geißler, Giuseppe Pastura, Rezzak Yilmaz, Daniela Berg, Marcel Romanos, Manfred Gerlach
Objectives During the last two decades' transcranial sonography (TCS) of the brain parenchyma evolved from a pure research tool to a clinical relevant neuroimaging method especially in Parkinson's disease and related movement disorders. The aim of this systematic review is to update and summarize the published TCS findings in psychiatric disorders and critically address the question whether TCS may be a valuable tool for the diagnosis or differential diagnosis of psychiatric disorders similarly to the field of movement disorders...
October 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28960158/age-differences-in-death-and-suicidal-ideation-in-anxious-primary-care-patients
#13
Andrew J Petkus, Julie Loebach Wetherell, Murray B Stein, Denise A Chavira, Michelle G Craske, Cathy Sherbourne, Greer Sullivan, Alexander Bystritsky, Peter Roy-Byrne
OBJECTIVES: The objective of this study was to examine age differences in the likelihood of endorsing of death and suicidal ideation in primary care patients with anxiety disorders. METHOD: Participants were drawn from the Coordinated Anxiety Learning and Management (CALM) Study, an effectiveness trial for primary care patients with panic disorder (PD), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and/or social anxiety disorder (SAD)...
July 25, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28957984/health-related-quality-of-life-in-adolescent-patients-with-hepatitis-c-genotype-1-treated-with-sofosbuvir-and-ledipasvir
#14
Zobair M Younossi, Maria Stepanova, William Balistreri, Kathleen Schwarz, Karen F Murray, Philip Rosenthal, Sanjay Bansal, Sharon Hunt
OBJECTIVE: To assess the impact of treatment with ledipasvir/sofosbuvir (LDV/SOF) on the health-related quality of life (HRQL) of pediatric patients with chronic hepatitis C virus (HCV) infection. METHODS: Adolescents (12-17 years) with HCV were treated with LDV/SOF (90 mg/400 mg daily) for 12 weeks. HRQL was assessed using the PedsQLv4.0-SF15 completed by the children and caregivers before, during, and after treatment. RESULTS: We included 100 adolescents with HCV genotype 1 infection [14...
September 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28956948/mental-disorders-among-undocumented-mexican-immigrants-in-high-risk-neighborhoods-prevalence-comorbidity-and-vulnerabilities
#15
Luz M Garcini, Juan M Peña, Thania Galvan, Christopher P Fagundes, Vanessa Malcarne, Elizabeth A Klonoff
OBJECTIVE: This study aimed to: (a) provide population-based estimates for the prevalence of mental disorders, including substance use, among undocumented Mexican immigrants; (b) assess for relevant comorbidities; and (c) identify sociodemographic, immigration and contextual vulnerabilities associated with meeting criteria for a disorder. METHOD: This cross-sectional study used Respondent Driven Sampling (RDS) to collect and analyze data from clinical interviews with 248 undocumented Mexican immigrants residing near the California-Mexico border...
October 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28954634/the-effect-of-agomelatine-and-melatonin-on-sleep-related-eating-a-case-report
#16
Angela Alexandra Zapp, Eva Caroline Fischer, Michael Deuschle
BACKGROUND: Sleep-related eating may occur in the context of mental illness, sleep disorders, or psychopharmacological treatment. Frequently, sleep-related eating leads to severe weight gain and, so far, there are no treatment options for the condition. CASE PRESENTATION: We report the case of a 54-year-old white woman with depression, panic disorder, and sleep apnea under treatment with various antidepressants who developed severe sleep-related eating. Her sleep-related eating completely vanished after addition of agomelatine, it reoccurred after cessation of agomelatine, and vanished again after her re-exposure to another melatonergic drug, extended melatonin...
September 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28953790/decision-making-in-panic-disorder-preliminary-report
#17
Katarzyna Jakuszkowiak-Wojten, Alicja Raczak, Jerzy Landowski, Mariusz Stanisław Wiglusz, Maria Gałuszko-Węgielnik, Krzysztof Krysta, Wiesław Jerzy Cubała
BACKGROUND: The impaired decision-making with high risk-aversive behavior and elevated impulsivity are reported as a trait feature in anxiety disorders including panic disorder (PD). It is hypothesised that PD patients exhibit difficulties in executive functions which can influence patients behavioural strategies e.g. problem solving, decision making, planning, impulse control. The aim of this study was to asses decision making process, risk-taking and impulsivity in PD patients as compared to healthy controls...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28950925/psychiatric-epidemiology-and-disaster-exposure-in-australia
#18
L Reifels, K Mills, M L A Dückers, M L O'Donnell
AIMS: To examine the lifetime prevalence and risk of psychiatric disorders associated with natural and man-made disaster exposure in Australia. METHODS: We utilised data from a nationally representative population survey (N = 8841) which were analysed through univariate and multivariate logistic regression in order to examine the full spectrum of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) affective, anxiety and substance use disorders associated with exposure to natural and man-made disaster...
September 27, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28950918/specific-amygdala-response-to-masked-fearful-faces-in-post-traumatic-stress-relative-to-other-anxiety-disorders
#19
P Neumeister, K Feldker, C Y Heitmann, C Buff, L Brinkmann, M Bruchmann, T Straube
BACKGROUND: Altered amygdala activation to fear-related stimuli has been proposed to be a potential neural correlate of heightened threat sensitivity in anxiety- and stress-related disorders. However, the role of stimulus awareness and disorder specificity remains widely unclear. Here we investigated amygdala responses to conscious and unconscious fearful faces in patients suffering from panic disorder (PD), generalized anxiety disorder (GAD), or post-traumatic stress disorder (PTSD) and in a large sample of healthy controls (HC)...
September 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28949287/cardiorespiratory-concerns-shape-brain-responses-during-automatic-panic-related-scene-processing-in-patients-with-panic-disorder
#20
Katharina Feldker, Carina Yvonne Heitmann, Paula Neumeister, Leonie Brinkmann, Maximillan Bruchmann, Pienie Zwitserlood, Thomas Straube
BACKGROUND: Increased automatic processing of threat-related stimuli has been proposed as a key element in panic disorder. Little is known about the neural basis of automatic processing, in particular to task-irrelevant, panic-related, ecologically valid stimuli, or about the association between brain activation and symptomatology in patients with panic disorder. METHODS: The present event-related fMRI study compared brain responses to task-irrelevant, panic-related and neutral visual stimuli in medication-free patients with panic disorder and healthy controls...
September 26, 2017: Journal of Psychiatry & Neuroscience: JPN
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