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https://www.readbyqxmd.com/read/28550777/disolved-organic-matter-dom-removal-from-bio-treated-coking-wastewate-using-a-new-polymeric-adsorbent-modified-with-dimethylamino-groups
#1
Wenlan Yang, Chengda He, Xiaozhi Wang, Ya Zhang, Zhipeng Cheng, Benlin Dai, Lili Zhang
In the current study a new recyclable aminated hyper-cross-linked polymeric adsorbent (A-HPA) was prepared for effective removal of DOM from BTCW. Possibly benefited from its unique structure of polystyrene matrix, sufficient aminated groups and high specific surface area, A-HPA could remove DOM from BTCW through the synergetic effect of π-π interactions, acid-base interactions and micropore filling, and exhibited the highest removal efficiency than the other adsorbents. Moreover, the exhausted A-HPA was amenable to effective regeneration by using acid and alkaline solution, allowing for repeated use with a constant removal efficiency...
May 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28550718/attachment-to-place-in-advanced-age-a-study-of-the-lilacs-nz-cohort
#2
Janine L Wiles, Anna Rolleston, Avinesh Pillai, Joanna Broad, Ruth Teh, Merryn Gott, Ngaire Kerse
An extensive body of research theorises that attachment to place is positively associated with health, particularly for older people. Building on this, we measure how indicators of attachment to place are associated with health for in people of advanced age in New Zealand. We use data from a cohort study (LiLACS NZ), which includes an indigenous Māori cohort aged 80-90 years and a non-Māori cohort aged 85 years from a mixed urban/rural region in New Zealand. Each cohort undertook a comprehensive interview and health assessment (n = 267 Māori and n = 404 non-Māori)...
May 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28550517/early-prediction-of-autoimmune-type-1-diabetes
#3
REVIEW
Simon E Regnell, Åke Lernmark
Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children with the DR4-DQ8 haplotype, exogenous factors, yet to be identified, are thought to trigger an autoimmune reaction against insulin, signalled by insulin autoantibodies as the first autoantibody to appear. In children with the DR3-DQ2 haplotype, the triggering reaction is primarily against GAD signalled by GAD autoantibodies (GADA) as the first-appearing autoantibody...
May 26, 2017: Diabetologia
https://www.readbyqxmd.com/read/28550287/up-regulation-of-long-non-coding-rna-xloc_010235-regulates-epithelial-to-mesenchymal-transition-to-promote-metastasis-by-associating-with-snail1-in-gastric-cancer
#4
Yu-Yi Liu, Ze-Hong Chen, Jian-Jun Peng, Jia-Lin Wu, Yu-Jie Yuan, Er-Tao Zhai, Shi-Rong Cai, Yu-Long He, Wu Song
We previously performed long non-coding RNA (lncRNA) expression microarray analyses to identify novel indicators for gastric cancer (GC) metastasis and prognosis in which we identified lncRNA XLOC_010235 (XLOC) as a candidate RNA. However, XLOC_010235 molecular mechanism of action remains unclear. Gain and loss of function approaches were used to investigate the biological role of XLOC in vitro. The effects of XLOC on cell viability were assessed by CCK-8 proliferation assays. Real-time PCR, western-blot and immunofluorescence were used to evaluate the mRNA and protein expression of Snail and multiple EMT related molecules...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550032/a-predictive-score-for-thrombosis-associated-with-breast-colorectal-lung-or-ovarian-cancer-the-prospective-compass-cancer-associated-thrombosis-study
#5
Grigoris T Gerotziafas, Ali Taher, Hikmat Abdel-Razeq, Essam AboElnazar, Alex C Spyropoulos, Salem El Shemmari, Annette K Larsen, Ismail Elalamy
BACKGROUND: The stratification of outpatients on chemotherapy for breast, colorectal, lung, and ovarian cancers at risk of venous thromboembolism (VTE) remains an unmet clinical need. The derivation of a risk assessment model (RAM) for VTE in these patients was the aim of the study "Prospective Comparison of Methods for thromboembolic risk assessment with clinical Perceptions and AwareneSS in real life patients-Cancer Associated Thrombosis" (COMPASS-CAT). PATIENTS AND METHODS: The derivation cohort consisted of 1,023 outpatients...
May 26, 2017: Oncologist
https://www.readbyqxmd.com/read/28549876/prediction-and-analysis-of-promiscuous-t-cell-epitopes-derived-from-the-vaccine-candidate-antigens-of-leishmania-donovani-binding-to-mhc-class-ii-alleles-using-in-silico-approach
#6
Manju Kashyap, Varun Jaiswal, Umar Farooq
Visceral leishmaniasis is a dreadful infectious disease and caused by the intracellular protozoan parasites, Leishmania donovani and Leishmania infantum. Despite extensive efforts for developing effective prophylactic vaccine, still no vaccine is available against leishmaniasis. However, advancement in immunoinformatics methods generated new dimension in peptide based vaccine development. The present study was aimed to identify T-cell epitopes from the vaccine candidate antigens like Lipophosphogylcan-3(LPG-3) and Nucleoside hydrolase (NH) from the L...
May 23, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28549841/prevalence-of-and-risk-factors-associated-with-cesarean-section-in-lebanon-a-retrospective-study-based-on-a-sample-of-29-270-women
#7
Sandy M Zgheib, Mohammad Kacim, Karel Kostev
BACKGROUND: During the last decades, there has been an alarming and dramatic increase in the number of cesarean births in both developed and undeveloped countries. This increase has not been clinically justified but, nevertheless, has raised an important number of issues. AIM: The aim of this study was to determine the risk factors associated with the high cesarean section rates in Lebanon. METHODS: This study is based on a sample of 29,270 Lebanese women who were pregnant between 2000 and 2015...
May 23, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28549814/microbial-phytase-impact-of-advances-in-genetic-engineering-in-revolutionizing-its-properties-and-applications
#8
REVIEW
Mrudula Vasudevan Ushasree, Krishna Shyam, Jalaja Vidya, Ashok Pandey
Phytases are enzymes that increase the availability of phosphorous in monogastric diet and reduces the anti-nutrition effect of phytate. This review highlights contributions of recombinant technology to phytase research during the last decade with specific emphasis on new generation phytases. Application of modern molecular tools and genetic engineering have aided the discovery of novel phytase genes, facilitated its commercial production and expanded its applications. In future, by adopting most recent gene improvement techniques, more efficient next generation phytases can be developed for specific applications...
May 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28549735/optimization-of-the-process-of-inverted-peptides-pipe-plus-to-screen-pdz-domain-ligands
#9
Quentin Seisel, Marisa Rädisch, Nicholas P Gill, Dean R Madden, Prisca Boisguerin
PDZ domains play crucial roles in cell signaling processes and are therefore attractive targets for the development of therapeutic inhibitors. In many cases, C-terminal peptides are the physiological binding partners of PDZ domains. To identify both native ligands and potential inhibitors we have screened arrays synthesized by the process of inverted peptides (PIPE), a variant of SPOT synthesis that generates peptides with free C-termini. Here, we present the development of a new functionalized cellulose membrane as solid support along with the optimized PIPE(PLUS) technology...
May 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28549597/prolactin-receptor-targeting-in-breast-and-prostate-cancers-new-insights-into-an-old-challenge
#10
REVIEW
Vincent Goffin
In the era of precision medicine, the identification of new targets is a constant challenge to improve cancer therapy. Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Although a clear causative link with mutations of the genes encoding prolactin or its receptor is lacking, increased PRLR signaling in these cancers can be assessed by the overexpression of cognate proteins and is often confirmed by over-activation of downstream signaling effectors...
May 23, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28549531/targeting-the-akt-gsk-3-bcl-2-axis-in-acute-myeloid-leukemia
#11
REVIEW
Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Monica Piedimonte, Agostino Tafuri
Over the last few decades, there has been significant progress in the understanding of the pathogenetic mechanisms of the Acute Myeloid Leukemia (AML). However, despite important advances in elucidating molecular mechanisms, the treatment of AML has not improved significantly, remaining anchored at the standard chemotherapy regimen "3 + 7", with the prognosis of patients remaining severe, especially for the elderly and for those not eligible for transplant procedures. The biological and clinical heterogeneity of AML represents the major obstacle that hinders the improvement of prognosis and the identification of new effective therapeutic approaches...
May 19, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28549518/ganglion-cell-inner-plexiform-layer-change-detected-by-optical-coherence-tomography-indicates-progression-in-advanced-glaucoma
#12
Joong Won Shin, Kyung Rim Sung, Gary C Lee, Mary K Durbin, Daniel Cheng
PURPOSE: To examine the performance of Guided Progression Analysis (GPA; Carl Zeiss Meditec, Dublin, CA) in spectral-domain optical coherence tomography (OCT) in detecting progressive thinning of ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) in glaucoma. DESIGN: Longitudinal, observational study. PARTICIPANTS: A total of 196 eyes of 123 primary open-angle glaucoma patients (mean follow-up, 5.0 years). METHODS: Macular GCIPL and peripapillary RNFL thicknesses were measured by Cirrus HD-OCT (Zeiss, Dublin, CA), and progressive GCIPL and RNFL thinning were assessed by GPA...
May 23, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28549320/light-emission-miracle-in-the-sea-and-preeminent-applications-of-bioluminescence-in-recent-new-biotechnology
#13
Sana Sharifian, Ahmad Homaei, Roohullah Hemmati, Khosro Khajeh
Bioluminescence is referred to the light emission by a living organism due to a specific biochemical reaction. This interesting feature of the organisms could highly influences behavioral and ecosystem dynamics. Luminescence, mostly observed in marine species, is generally higher in deep-living genera than in benthic or shallow organisms. However, among creatures living in land, fireflies, beetles, springtails and fungi have shown some bioluminescent activities. Classically, the emission of light is catalyzed by luciferase from a substrate...
May 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28548921/repeatability-testing-of-a-new-hybrid-iii-6-year-old-atd-lower-extremity
#14
Laura C Boucher, Yeonsu Ryu, Yun-Seok Kang, John H Bolte
OBJECTIVE: Vehicle safety is improving, thus decreasing the number of life-threatening injuries and increasing the need for research in other areas of the body. The current child anthropomorphic test device (ATD) does not have the capabilities or instrumentation to measure many of the potential interactions between the lower extremity and the vehicle interior. A prototype Hybrid III 6-year-old ATD lower extremity (ATD-LE) was developed and contains a tibia load cell and a more biofidelic ankle...
May 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28548893/dynamic-decision-making-learning-processes-and-new-research-directions
#15
Cleotilde Gonzalez, Pegah Fakhari, Jerome Busemeyer
OBJECTIVE: The aim of this manuscript is to provide a review of contemporary research and applications on dynamic decision making (DDM). BACKGROUND: Since early DDM studies, there has been little systematic progress in understanding decision making in complex, dynamic systems. Our review contributes to better understanding of decision making processes in dynamic tasks. METHOD: We discuss new research directions in DDM to highlight the value of simplification in the study of complex decision processes, divided into experimental and theoretical/computational approaches, and focus on problems involving control tasks and search-and-choice tasks...
May 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28548861/emergent-optical-phononic-modes-upon-nanoscale-mesogenic-phase-transitions
#16
Dima Bolmatov, Mikhail Zhernenkov, Lewis Sharpnack, Dena M Agra-Kooijman, Satyendra Kumar, Alexey Suvorov, Ronald Pindak, Yong Q Cai, Alessandro Cunsolo
The investigation of phononic collective excitations in soft matter systems at the molecular scale has always been challenging due to limitations of experimental techniques in resolving low-energy modes. Recent advances in Inelastic X-ray Scattering (IXS) enabled the study of such systems with unprecedented spectral contrast at meV excitation energies. In particular, it has become possible to shed light on the low-energy collective motions in materials whose morphology and phase behavior can easily be manipulated, such as mesogenic systems...
May 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28548659/metatranscriptomic-analysis-of-prokaryotic-communities-active-in-sulfur-and-arsenic-cycling-in-mono-lake-california-usa
#17
Christian F Edwardson, James T Hollibaugh
This study evaluates the transcriptionally active, dissimilatory sulfur- and arsenic-cycling components of the microbial community in alkaline, hypersaline Mono Lake, CA, USA. We sampled five depths spanning the redox gradient (10, 15, 18, 25 and 31 m) during maximum thermal stratification. We used custom databases to identify transcripts of genes encoding complex iron-sulfur molybdoenzyme (CISM) proteins, with a focus on arsenic (arrA, aioA and arxA) and sulfur cycling (dsrA, aprA and soxB), and assigned them to taxonomic bins...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548491/deposition-of-a-sorbent-into-a-recession-on-a-solid-support-provides-a-new-mechanically-robust-solid-phase-micro-extraction-device
#18
Justen J Poole, Jonathan J Grandy, Miao Yu, Ezel Boyaci, German A Gomez Rios, Nathaly Reyes-Garcés, Barbara Bojko, Harmen Vander Heide, Janusz Pawliszyn
To date, solid-phase microextraction (SPME) fibers used for in-vivo bio-analysis can be too fragile and flexible, which limits suitability for direct tissue sampling. As a result, these devices often require a sheathing needle to pre-puncture robust sample matrices and protect the extraction phase from mechanical damage. To address this limitation, a new SPME device is herein presented which incorporates an extraction phase recessed into the body of a solid needle. This device requires no additional support or shielding during puncture events through protective tissue...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28548464/control-of-cell-death-and-mitochondrial-fission-by-erk1-2-map-kinase-signalling
#19
REVIEW
Simon J Cook, Kate Stuart, Rebecca Gilley, Matthew J Sale
The ERK1/2 signalling pathway is best known for its role in connecting activated growth factor receptors to changes in gene expression due to activated ERK1/2 entering the nucleus and phosphorylating transcription factors. However, active ERK1/2 also translocate to a variety of other organelles including the endoplasmic reticulum, endosomes, golgi and mitochondria to access specific substrates and influence cell physiology. In this article we review two aspects of ERK1/2 signalling at the mitochondria that are involved in regulating cell fate decisions...
May 26, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28548103/an-aavp-based-solid-phase-transducing-matrix-for-transgene-delivery-potential-for-translational-applications
#20
T L Smith, G R Souza, R L Sidman, W Arap, R Pasqualini
A hybrid vector of adeno-associated virus and phage (termed AAVP) has been introduced as a platform for systemic ligand-directed delivery of transgenes to tumors over the past decade. A series of studies have evaluated the AAVP platform for potential theranostic or purely therapeutic applications in several tumor models. Sufficient ligand-directed tumor targeting consistently resulted in specific molecular-genetic imaging and/or anti-tumor responses to 'suicide' transgene delivery. However, efforts to optimize transduction efficiency are still ongoing...
May 26, 2017: Cancer Gene Therapy
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