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https://www.readbyqxmd.com/read/28636007/analysis-of-association-of-gene-variants-with-obesity-traits-in-new-zealand-european-children-at-6-years-of-age
#1
Mohanraj Krishnan, John M D Thompson, Edwin A Mitchell, Rinki Murphy, Lesley M E McCowan, Andrew N Shelling, G On Behalf Of The Children Of Scope Study Group
Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have provided novel insights into biological factors that contribute to the development of obesity. As obesity tracks through childhood into adulthood, identification of the genetic factors for obesity in early life is important. The objective of this study was to identify putative associations between genetic variants and obesity traits in children at 6 years of age...
June 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28635909/-chronic-obstructive-pulmonary-disease-concurrent-with-metabolic-syndrome-pathophysiological-and-clinical-features
#2
A V Budnevsky, E S Ovsyannikov, N B Labzhania
Chronic obstructive pulmonary disease (COPD) still remains a serious public health problem, which is a common cause of disability and death in the able-bodied population. Furthermore, the number of patients with metabolic syndrome (MS) is steadily increasing worldwide. Recently, there is also an increase in the number of patients with COPD concurrent with MS, which is a mutually confounding risk factor for concomitant cardiovascular disease and adversely affects prognosis in these patients. Systemic subclinical inflammation is a common link between COPD and the components of MS...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28635684/-spatial-analysis-of-syphilis-and-gonorrhea-infections-in-a-public-health-service-in-madrid
#3
Irene G M Wijers, Amaya Sánchez Gómez, Jose Antonio Taveira Jiménez
OBJECTIVE: Sexually transmitted diseases are a significant public health problem. Within the Madrid Autonomous Region, the districts with the highest syphilis and gonorrhea incidences are part of the same Public Health Service (Servicio de Salud Pública del Área 7, SSPA 7). The objective of this study was to identify, by spatial analysis, clusters of syphilis and gonorrhea infections in this SSPA in Madrid. METHODS: All confirmed syphilis and gonorrhea cases registered in SSPA 7 in Madrid were selected...
June 21, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28635638/antibiotic-concentrations-decrease-during-wastewater-treatment-but-persist-at-low-levels-in-reclaimed-water
#4
Prachi Kulkarni, Nathan D Olson, Greg A Raspanti, Rachel E Rosenberg Goldstein, Shawn G Gibbs, Amir Sapkota, Amy R Sapkota
Reclaimed water has emerged as a potential irrigation solution to freshwater shortages. However, limited data exist on the persistence of antibiotics in reclaimed water used for irrigation. Therefore, we examined the fate of nine commonly-used antibiotics (ampicillin, azithromycin, ciprofloxacin, linezolid, oxacillin, oxolinic acid, penicillin G, pipemidic acid, and tetracycline) in differentially treated wastewater and reclaimed water from two U.S. regions. We collected 72 samples from two Mid-Atlantic and two Midwest treatment plants, as well as one Mid-Atlantic spray irrigation site...
June 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28635501/promoting-global-action-on-hearing-loss-world-hearing-day
#5
Shelly Chadha, Alarcos Cieza
The growing need for hearing care and a general lack of policies to address it poses a significant public health challenge. The World Health Organization aims to address this through evidence-based advocacy along with technical support to countries in provision of hearing care. As part of its activities, WHO is promoting the World Hearing Day which is observed on 3rd March every year. The day is marked by an annual theme and release of information products and key messages. Through this, we aim to raise awareness and promote actions for ear and hearing care across the world...
February 23, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28635434/mental-health-professionals-and-media-professionals-a-survey-of-attitudes-towards-one-another
#6
Beth Chapman, Rohit Shankar, Joanne Palmer, Richard Laugharne
BACKGROUND: The general public regard mass media as their main source of information about mental illness. Psychiatrists are reluctant to engage with the media. There is little understanding of why this is the case. AIMS: The paper looks to explore attitudes of mental health clinicians and the media towards one another. METHOD: Media and mental health clinicians in the southwest of England completed self-report surveys. RESULTS: Of 119 questionnaires returned 85 were mental health clinicians and 34 media professionals...
February 28, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28635427/the-divergence-of-minimum-unit-pricing-policy-across-the-uk-opportunities-for-public-health-policy-development
#7
Ailsa J McKay, Anthony A Laverty, Azeem Majeed
No abstract text is available yet for this article.
January 1, 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/28635353/a-systematic-review-of-supported-accommodation-programs-for-people-released-from-custody
#8
Bethany Growns, Stuart A Kinner, Elizabeth Conroy, Eileen Baldry, Sarah Larney
One of the challenges that people recently released from custody face is securing housing. Many individuals rely on supported accommodation programs for housing in the immediate post-release period. However, the value of supported accommodation programs in producing positive criminal justice and health outcomes for people released from custody has not been widely examined. This article reviews the current literature on supported accommodation programs and the elements of these services that contribute to positive outcomes for individuals released from custody...
June 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28635349/the-association-between-alcohol-use-trajectories-from-adolescence-to-adulthood-and-cannabis-use-disorder-in-adulthood-a-22-year-longitudinal-study
#9
Jung Yeon Lee, Judith S Brook, Mario De La Rosa, Youngjin Kim, David W Brook
BACKGROUND: Due to the increasing prevalence of cannabis use disorder (CUD), the impact of cannabis use on public health may be significant. OBJECTIVE: The present study seeks the possible precursors (e.g., alcohol use) of CUD in order to minimize the potential negative consequences of CUD such as impaired coordination and performance. METHOD: The Harlem Longitudinal Development Study included 674 participants (53% African Americans, 47% Puerto Ricans), with 60% females (n=405) from a six wave survey...
March 1, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28635347/ketamine-and-international-regulations
#10
Yanhui Liao, Yi-Lang Tang, Wei Hao
BACKGROUND: Ketamine is an anesthetic commonly used in low-income countries and has recently been shown to be effective for treatment-resistant depression. However, the illicit manufacturing, trafficking, and nonmedical use of ketamine are increasing globally, and its illicit use poses major public health challenges in many countries. OBJECTIVES: To review the nonmedical use of ketamine in selected countries and its regulatory control. METHODS: We conducted a review of literature identified from searches of the China National Knowledge Infrastructure (CNKI) (1979-2016) and PubMed databases, supplemented by additional references identified by the authors...
February 13, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28635345/avatar-assisted-therapy-a-proof-of-concept-pilot-study-of-a-novel-technology-based-intervention-to-treat-substance-use-disorders
#11
Michael S Gordon, Steven B Carswell, Mary Schadegg, Kayla Mangen, Kelly Merkel, Susan Tangires, Frank J Vocci
BACKGROUND: Avatar-assisted therapy (AAT) is a novel and emerging technology that uses the Internet to enable clinicians and clients in substance abuse treatment to participate in group counseling sessions from separate and remote locations in real time through the use of avatars and virtual environments. OBJECTIVES: The current study is a pilot proof-of-concept feasibility study involving individuals in outpatient substance abuse treatment. This report addresses two questions: (1) are individuals who present for substance abuse treatment interested in receiving AAT and (2) what factors are associated with better treatment success...
February 17, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28634805/comparative-prevalence-of-escherichia-coli-carrying-virulence-genes-and-class-1-and-2-integrons-in-sub-tropical-and-cool-temperate-freshwater
#12
Jatinder P S Sidhu, Paul Jagals, Amy Smith, Simon Toze
Aquatic environments are now recognized secondary habitat of potentially pathogenic Escherichia coli. In this study, PCR-based analyses were used to determine the phylogenetic composition and frequency of occurrence of eight clinically significant virulence genes (VGs) in E. coli isolates from sub-tropical Brisbane and cool temperate Tasmania freshwater in Australia. In Brisbane, non-commensal E. coli isolates belonging to the B2 and D phylogenetic group were dominant (72%). A significantly higher number (P < 0...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634579/precision-in-setting-cancer-prevention-priorities-synthesis-of-data-literature-and-expert-opinion
#13
Jennifer Girschik, Laura Jean Miller, Tony Addiscott, Mike Daube, Paul Katris, David Ransom, Terry Slevin, Tim Threlfall, Tarun Stephen Weeramanthri
Cancer will continue to be a leading cause of ill health and death unless we can capitalize on the potential for 30-40% of these cancers to be prevented. In this light, cancer prevention represents an enormous opportunity for public health, potentially saving much of the pain, anguish, and cost associated with treating cancer. However, there is a challenge for governments, and the wider community, in prioritizing cancer prevention activities, especially given increasing financial constraints. This paper describes a method for identifying cancer prevention priorities...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28634517/introduction-of-a-quality-improvement-curriculum-in-the-department-of-internal-medicine-lincoln-medical-center
#14
Usha Venugopal, Moiz Kasubhai, Vikram Paruchuri
Community hospitals with limited resources struggle to engage physicians in Quality improvement initiatives. We introduced Quality Improvement (QI) curriculum for residents in response to ACGME requirements and surveyed the residents understanding of QI and their involvement in QI projects before and after the introduction of the curriculum. The current article describes our experiences with the process, the challenges and possible solutions to have a successful resident led QI initiative in a community hospital...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28634496/household-response-to-inadequate-sewerage-and-garbage-collection-services-in-abuja-nigeria
#15
Ismaila Rimi Abubakar
Provision of sanitation and garbage collection services is an important and yet challenging issue in the rapidly growing cities of developing countries, with significant human health and environmental sustainability implications. Although a growing number of studies have investigated the consequences of inadequate delivery of basic urban services in developing countries, few studies have examined how households cope with the problems. Using the Exit, Voice, Loyalty, and Neglect (EVLN) model, this article explores how households respond to inadequate sewerage and garbage collection services in Abuja, Nigeria...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28634286/conjugate-vaccine-immunotherapy-for-substance-use-disorder
#16
REVIEW
Paul T Bremer, Kim D Janda
Substance use disorder, especially in relation to opioids such as heroin and fentanyl, is a significant public health issue and has intensified in recent years. As a result, substantial interest exists in developing therapeutics to counteract the effects of abused drugs. A promising universal strategy for antagonizing the pharmacology of virtually any drug involves the development of a conjugate vaccine, wherein a hapten structurally similar to the target drug is conjugated to an immunogenic carrier protein...
July 2017: Pharmacological Reviews
https://www.readbyqxmd.com/read/28634248/suburban-families-experience-with-food-insecurity-screening-in-primary-care-practices
#17
Deepak Palakshappa, Stephanie Doupnik, Aditi Vasan, Saba Khan, Leah Seifu, Chris Feudtner, Alexander G Fiks
BACKGROUND: Food insecurity (FI) remains a major public health problem. With the rise in suburban poverty, a greater understanding of parents' experiences of FI in suburban settings is needed to effectively screen and address FI in suburban practices. METHODS: We conducted 23 semistructured interviews with parents of children <4 years of age who presented for well-child care in 6 suburban pediatric practices and screened positive for FI. In the interviews, we elicited parents' perceptions of screening for FI, how FI impacted the family, and recommendations for how practices could more effectively address FI...
June 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28634156/classifying-chinese-questions-related-to-health-care-posted-by-consumers-via-the-internet
#18
Haihong Guo, Xu Na, Li Hou, Jiao Li
BACKGROUND: In question answering (QA) system development, question classification is crucial for identifying information needs and improving the accuracy of returned answers. Although the questions are domain-specific, they are asked by non-professionals, making the question classification task more challenging. OBJECTIVE: This study aimed to classify health care-related questions posted by the general public (Chinese speakers) on the Internet. METHODS: A topic-based classification schema for health-related questions was built by manually annotating randomly selected questions...
June 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28633989/efficacy-and-cytotoxicity-in-cell-culture-of-novel-%C3%AE-hydroxytropolone-inhibitors-of-hepatitis-b-virus-ribonuclease-h
#19
Elena Lomonosova, Jil Daw, Aswin K Garimallaprabhakaran, Nana B Agyemang, Yashkumar Ashani, Ryan P Murelli, John E Tavis
Chronic Hepatitis B virus (HBV) infection is a major worldwide public health problem. Current direct-acting anti-HBV drugs target the HBV DNA polymerase activity, but the equally essential viral ribonuclease H (RNaseH) activity is unexploited as a drug target. Previously, we reported that α-hydroxytropolone compounds can inhibit the HBV RNaseH and block viral replication. Subsequently, we found that our biochemical RNaseH assay underreports efficacy of the α-hydroxytropolones against HBV replication. Therefore, we conducted a structure-activity analysis of 59 troponoids against HBV replication in cell culture...
June 17, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28633988/a-cross-clade-h5n1-influenza-a-virus-neutralizing-monoclonal-antibody-binds-to-a-novel-epitope-within-the-vestigial-esterase-domain-of-hemagglutinin
#20
Subha Sankar Paul, Chee-Keng Mok, Tze-Minn Mak, Oi-Wing Ng, James Odame Aboagye, Teddy John Wohlbold, Florian Krammer, Yee-Joo Tan
The sporadic outbreaks of highly pathogenic H5N1 avian influenza virus have raised public health concerns. Monoclonal antibodies (MAbs) against hemagglutinin (HA) have been increasingly used successfully for therapeutic purposes. Previously, MAb 9F4, generated against clade 1 H5N1 HA, was observed to have cross-clade neutralizing efficacy and inhibited viral entry by preventing the pH-mediated conformational change of HA. Furthermore, mouse-human chimeric MAb 9F4 was found to retain high degrees of neutralizing activity...
June 17, 2017: Antiviral Research
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