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https://www.readbyqxmd.com/read/29432868/repurposing-niclosamide-for-intestinal-decolonization-of-vancomycin-resistant-enterococci
#1
Haroon Mohammad, Ahmed AbdelKhalek, Nader S Abutaleb, Mohamed N Seleem
Enterococci are commensal microorganisms present in the gastrointestinal (GI) tract of humans. Though normally innocuous to the host, strains of Enterococcus exhibiting resistance to vancomycin (VRE) have been associated with high rates of infection and mortality in immunocompromised patients. Decolonization of VRE represents a key strategy to curb infection in highly-susceptible patients. However, there is a dearth of decolonizing agents available clinically that are effective against VRE. The present study confirms that niclosamide, an anthelmintic drug, has potent antibacterial activity against clinical isolates of vancomycin-resistant E...
February 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29422820/decolonization-of-staphylococcus-aureus-in-patients-with-atopic-dermatitis-a-reason-for-increasing-resistance-to-antibiotics
#2
Izabela Błażewicz, Maciej Jaśkiewicz, Marta Bauer, Lidia Piechowicz, Roman J Nowicki, Wojciech Kamysz, Wioletta Barańska-Rybak
Introduction: Exacerbation of atopic dermatitis can be associated with bacterial infection. The skin of patients is colonized with Staphylococcus aureus in 90% of cases. An attempt has been made to demonstrate that eradication significantly reduces the severity of the disease. Studies indicate the efficacy of topical antibiotics, topical corticosteroids and calcineurin inhibitors. Due to increasing resistance to drugs and the defective antimicrobial peptide profile, decolonization is virtually impossible...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29420501/how-decolonization-could-reshape-south-african-science
#3
Linda Nordling
No abstract text is available yet for this article.
February 8, 2018: Nature
https://www.readbyqxmd.com/read/29395724/risk-factors-for-staphylococcus-aureus-nasal-colonization-in-joint-arthroplasty-patients
#4
Amanda L Walsh, Adam C Fields, James D Dieterich, Darwin D Chen, Michael J Bronson, Calin S Moucha
BACKGROUND: Several studies have shown that Staphylococcus aureus (S aureus) nasal colonization is associated with surgical site infection and that preoperative decolonization can reduce infection rates. Up to 30% of joint arthroplasty patients have positive S aureus nasal swabs. Patient risk factors for colonization remain largely unknown. The aim of this study was to determine whether there is a specific patient population at increased risk of S aureus nasal colonization. METHODS: This study is a retrospective review of 716 patients undergoing hip or knee arthroplasty beginning in 2011...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29361196/-thank-you-for-including-us-introducing-a-community-based-collaborative-approach-to-translating-clinic-materials
#5
J Maria Bermúdez, Bertranna Muruthi, Lisa M Zak-Hunter, Morgan A Stinson, Desiree M Seponski, Joshua L Boe, Narumi Taniguchi
When working with clients in another language, having culturally relevant and properly translated clinic materials is vital to effective clinical practice. Not having them presents a barrier for bilingual therapists and their clients. This paper reviews common translation methods and introduces a multi-level, community-based approach for translating clinic materials for non-English speaking clients. Informed by decolonizing practices, this five-tier method includes members from the target community as cultural brokers to verify the accuracy and nuances of language for their cultural group, as well as a constant comparative method to ensure methodological rigor in the process of inclusion...
January 23, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29357913/screening-of-methicillin-resistant-staphylococcus-aureus-nasal-colonization-among-elective-surgery-patients-in-referral-hospital-in-indonesia
#6
Erni J Nelwan, Robert Sinto, Decy Subekti, Randy Adiwinata, Lia Waslia, Tonny Loho, Dodi Safari, Djoko Widodo
OBJECTIVE: Methicillin-resistant Staphylococcus aureus (MRSA) colonization is associated with serious surgical site infection in high-risk patients. High prevalence of MRSA colonization was reported in many settings, nonetheless local data is required. The purpose of this study is to identify the prevalence and risk factor of MRSA nasal carriage in adult patients in National Referral Hospital in Indonesia before underwent elective surgical procedure. RESULTS: From 384 patients, 16...
January 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29343312/fecal-microbiota-transplant-for-multidrug-resistant-organism-decolonization-administered-during-septic-shock
#7
Srinivasa Nithin Gopalsamy, Amy Sherman, Michael H Woodworth, Joseph D Lutgring, Colleen S Kraft
No abstract text is available yet for this article.
January 18, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29336763/methicillin-resistant-staphylococcus-aureus-in-a-trauma-population-does-decolonization-prevent-infection
#8
Robert A Maxwell, Chasen A Croft, C Buddy Creech, Isaac Thomsen, Nicole Soper, Laura E Brown, Vicente A Mejia, Benjamin W Dart, Donald E Barker
The purpose of this study was to determine if a decolonization regimen reduces the frequency of methicillin-resistant Staphylococcus aureus (MRSA) infections and if colonization isolates are genetically related to subsequent infectious strains. Trauma patients admitted to the intensive care unit with positive MRSA nasal swabs were randomized to either daily chlorhexidine gluconate (CHG) baths and mupirocin (MUP) ointment to the nares or soap and water baths and placebo ointment for five days. Nasal swabs performed at the end of treatment and invasive MRSA infections during the remaining hospitalization were compared with the original nasal isolate via polymerase chain reaction for genetic relatedness as well as CHG and MUP resistance genes...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29336224/treatment-of-a-klebsiella-pneumoniae-kpc-cellulitis-and-gut-decolonization-with-ceftazidime-avibactam-in-a-migrant-from-libya
#9
Novella Carannante, Carlo Pallotto, Mariano Bernardo, Giovanni Di Caprio, Carlo Tascini
KPC-producing Klebsiella pneumoniae (KPC-Kp) is nowadays a global concern. Ceftazidime/avibactam is the most promising novel antibiotic combination available at the moment. We describe the case of a migrant with no risk factors for an infection due to multidrug resistant bacteria. He suffered from a KPC-Kp cellulitis and was treated with a ceftazidime/avibactam-meropenem-fosfomycin combination that not only eradicated the infection but also decontaminated his gut. Ceftazidime/avibactam-based treatment can be useful also in decontamination procedures...
January 16, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29319509/prevalence-influencing-factors-antibiotic-resistance-toxin-and-molecular-characteristics-of-staphylococcus-aureus-and-mrsa-nasal-carriage-among-diabetic-population-in-the-united-states-2001-2004
#10
Jialing Lin, Yang Peng, Chan Bai, Ting Zhang, Haoqu Zheng, Xiaojie Wang, Jiaping Ye, Xiaohua Ye, Ying Li, Zhenjiang Yao
Diabetic population were reported more likely to suffer carriage and infection with Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) than non-diabetic population. We aim to elucidate the prevalence and characteristics of S. aureus and MRSA nasal carriage among diabetic population in the United States National Health and Nutrition Examination Survey, 2001-2004. Univariate analyses were conducted using Chi-square test, Fisher's exact probability test or student t test, as appropriate...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29311241/cessation-from-smoking-improves-innate-host-defense-and-clearance-of-experimentally-inoculated-nasal-s-aureus
#11
Amy L Cole, Mary Schmidt-Owens, Ashley C Beavis, Christine F Chong, Patrick M Tarwater, James Schaus, Michael G Deichen, Alexander M Cole
Staphylococcus aureus (SA) nasal carriage is transient in most humans and usually benign, but dissemination of SA to extranasal sites causes the majority of clinical infections, and SA is a major cause of serious infections in the U.S. A better understanding of innate nasal decolonization mechanisms is urgently needed, as are relevant models for studying SA clearance. Here, we screened a population of healthy smokers for nasal SA carriage, and compared participants' abilities to clear experimentally applied nasal SA before and after completion of a smoking cessation program...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29306970/preoperative-decolonization-to-reduce-infections-in-urgent-lower-extremity-repairs
#12
Daniel S Urias, Merin Varghese, Thomas Simunich, Shawna Morrissey, Russell Dumire
PURPOSE: Medical implants and surgical site infections (SSIs) can be a burden on both patients and healthcare systems with a significant rise in morbidity, mortality and costs. Preoperatively, our practice of a chlorohexidine gluconate (CHG) washcloth bath or solution shower was supplemented with nasal painting using povidone-iodine skin and nasal antiseptic (PI-SNA). We sought to measure the effectiveness in reducing SSIs in patients undergoing repair of lower extremity fractures. METHODS: A retrospective review of trauma patients undergoing orthopedic operations conducted at Conemaugh Memorial Medical Center from 10/1/2012 through 9/30/2016...
January 6, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29290149/body-mapping-to-explore-reproductive-ethno-physiological-beliefs-and-knowledge-of-contraception-in-timor-leste
#13
Heather Julie Wallace, Susan McDonald, Suzanne Belton, Agueda Isolina Miranda, Eurico da Costa, Livio da Conceicao Matos, Helen Henderson, Angela Taft
Maternal mortality remains a significant public health challenge for Timor-Leste. Although access to quality family planning measures may greatly reduce such deaths, consideration of indigenous perceptions, and how they influence reproductive health decision-making and behavior, is crucial if health services are to provide initiatives that are accepted and helpful in improving reproductive health outcomes. We aimed to demonstrate that body mapping is an effective method to traverse language and culture to gain emic insights and indigenous worldviews...
December 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29283668/mindful-activism-embracing-the-complexities-of-international-border-crossings
#14
Kathryn L Norsworthy
I am one of many psychologists from the minority world, or Global North, who regularly travel to the Global South, or majority world, to engage in activist research and practice. Drawing on postcolonial and decolonial frameworks, this testimonio discusses tensions and complexities that arise in these transnational border crossings, particularly given the current internationalization movement in U.S. psychology. A testimonio is a first-person narrative of experiences with oppression, resilience, and empowerment, that can "re-script history ...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29281844/-decolonization-of-health-care-workers-in-a-neonatal-intensive-care-unit-carrying-a-methicillin-susceptible-staphylococcus-aureus-isolate
#15
Annika Richter, Ines Eder, Brigitte König, Bettina Lutze, Arne C Rodloff, Ulrich H Thome, Melanie Weiss, Iris F Chaberny
BACKGROUND: In 2016, an increased rate of methicillin-susceptible Staphylococcus aureus colonization was detected on a neonatal intensive care unit at the Leipzig University Hospital. Typing results showed a predominant spa-type t091. Considering nosocomial clustering, several infection prevention measures (e. g. intensified standard precautions, single-occupancy room, cohorted patients, continuing education of staff) were introduced, including staff screening followed by decolonization of colonized health care workers...
December 27, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29262416/consensus-on-wound-antisepsis-update-2018
#16
Axel Kramer, Joachim Dissemond, Simon Kim, Christian Willy, Dieter Mayer, Roald Papke, Felix Tuchmann, Ojan Assadian
Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication...
December 21, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29246843/tonsillectomy-for-persistent-mrsa-carriage-in-the-throat-description-of-three-cases
#17
Renske REMLabordus-van Helvoirt, Miranda MMLvan Rijen, Peter Pvan Wijngaarden
In several countries, including the Netherlands, a search and destroy policy is part of the standard of care. Due to this policy and restrictive use of antibiotics the prevalence of MRSA carrier state and infections in The Netherlands is among the lowest in the world. In the Netherlands health care workers with a MRSA carrier state are not allowed to carry out work involving direct patient care. This means that treatment failure can have major implications for their working career. Despite repeated treatments according to guidelines, eradication of MRSA fails in a minority of cases...
December 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29234644/prophylaxis-with-nasal-decolonization-in-patients-submitted-to-total-knee-and-hip-arthroplasty-systematic-review-and-meta-analysis
#18
REVIEW
David Sadigursky, Henrique Santos Pires, Saulo Américo Caldas Rios, Francisco Luiz Borja Rodrigues Filho, Gustavo Castro de Queiroz, Mateus Lemos Azi
Despite the evolution of the total knee and hip arthroplasty surgery, high postoperative complication rates in the short and long term still persist. Infection is one of the most challenging complications; due to its gravity and treatment difficulties, prophylaxis protocols have been created to decrease its incidence. The objective of this study was to evaluate the impact of the prophylaxis protocol for methicillin-resistant Staphylococcus aureus decolonization of the nares in patients previously identified by swab cultures, who were to be submitted to a total joint arthroplasty...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29191610/incidence-and-prevention-of-infective-endocarditis-and-bacteraemia-after-transcatheter-aortic-valve-implantation-in-a-french-university-hospital-a-retrospective-study
#19
M Gallouche, G Barone-Rochette, P Pavese, B Bertrand, G Vanzetto, H Bouvaist, I Pierre, D Schmitt, J Fauconnier, Y Caspar, C Recule, R Picot-Guéraud, J P Stahl, M R Mallaret, C Landelle
Infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is a rare but severe complication. Among 326 patients who underwent TAVI in Grenoble Alpes university hospital, 6 (1.8%) IE cases and 11 (3.4%) bacteraemia cases were identified. No EI was linked to the intervention; one was due to Staphylococcus aureus despite a screening and targeted decolonization strategy. This underscores the need for randomized studies to evaluate benefit and cost-effectiveness of this policy.
November 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29190327/control-of-healthcare-and-community-associated-mrsa-recent-progress-and-persisting-challenges
#20
Andrew Henderson, Graeme R Nimmo
Background: Healthcare adapted meticillin-resistant Staphylococcus aureus (MRSA) has spread to hospitals around the world over 50 years. More recently, other strains of MRSA have emerged with the ability to spread in the community and infect otherwise healthy individuals. Morbidity and mortality associated with MRSA remains high and its control in both the healthcare and community setting has proven challenging. Sources of data: Pubmed (Medline). Areas of agreement: The use of targeted screening and decolonization, hand hygiene and antimicrobial stewardship is supported by the most robust studies, though many studies have implemented bundles for effective healthcare-associated (HA)-MRSA control...
November 28, 2017: British Medical Bulletin
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