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https://www.readbyqxmd.com/read/29673410/association-of-an-active-surveillance-and-decolonization-program-on-incidence-of-clinical-cultures-growing-staphylococcus-aureus-in-the-neonatal-intensive-care-unit
#1
Annie Voskertchian, Ibukunoluwa C Akinboyo, Elizabeth Colantuoni, Julia Johnson, Aaron M Milstone
No abstract text is available yet for this article.
April 20, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29671723/evaluation-of-staphylococcus-aureus-eradication-therapy-in-orthopaedic-surgery
#2
S T J Tsang, M P McHugh, D Guerendiain, P Gwynne, J Boyd, I F Laurenson, K E Templeton, S Lewis, A H R W Simpson, T S Walsh
PURPOSE: Despite WHO recommendations, there is currently no national screening and eradication policy for the detection of methicillin-sensitive Staphylococcus aureus (MSSA) in the UK prior to elective orthopaedic surgery. This study aimed to evaluate the effectiveness of current standard methicillin-resistant S. aureus (MRSA) eradication therapies in the context of S. aureus (both MRSA and MSSA) decolonization in an elective orthopaedic population. METHODOLOGY: A total of 100 patients awaiting joint replacement surgery who were positive for S...
April 19, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29669512/a-systematic-review-of-transmission-dynamic-studies-of-methicillin-resistant-staphylococcus-aureus-in-non-hospital-residential-facilities
#3
Kin On Kwok, Jonathan M Read, Arthur Tang, Hong Chen, Steven Riley, Kai Man Kam
BACKGROUND: Non-hospital residential facilities are important reservoirs for MRSA transmission. However, conclusions and public health implications drawn from the many mathematical models depicting nosocomial MRSA transmission may not be applicable to these settings. Therefore, we reviewed the MRSA transmission dynamics studies in defined non-hospital residential facilities to: (1) provide an overview of basic epidemiology which has been addressed; (2) identify future research direction; and (3) improve future model implementation...
April 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29649257/an-experimental-staphylococcus-aureus-carriage-and-decolonization-model-in-rhesus-macaques-macaca-mulatta
#4
Bibi C G C Slingerland, Merei Keehnen, Boudewijn Ouwerling, Mehri Tavakol, Susan V Snijders, Henri A Verbrugh, Margreet C Vos, Edmond J Remarque, Jan A M Langermans, Willem J B van Wamel
Our human model of nasal colonization and eradication of S. aureus is limited by safety issues. As rhesus macaques are closely related to humans and natural hosts for S. aureus, we developed an experimental decolonization and inoculation protocol in these animals. Animals were screened for nasal carriage of S. aureus and 20 carriers were selected. Decolonization was attempted using nasal mupirocin (10 animals) or mupirocin plus trimethoprim/sulfadiazine intramuscularly (10 animals) both once daily for 5 days, and checked by follow-up cultures for 10 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29619291/mrsa-prevalence-among-patient-transport-staff-in-hamburg
#5
Anja Schablon, Olaf Kleinmüller, Albert Nienhaus, Claudia Peters
Introduction: Patient transport employees frequently come into contact with multidrug-resistant organisms (MDROs) and therefore are at a greater risk of infection than the general population. These pathogens pose a significant challenge for employees of patient transport services since they can spread over long distances through patient transfers. To date, little is known about the occupational risk of MRSA infection in patient transport settings. Methods: A cross-sectional study was conducted to investigate the prevalence of MRSA in patient transport personnel, including taxi drivers, as well as the potential risk factors for MRSA colonization...
2018: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/29570150/cost-effectiveness-research-in-anesthesiology
#6
Bijan J Teja, Tori N Sutherland, Sheila R Barnett, Daniel S Talmor
Perioperative interventions aimed at decreasing costs and improving outcomes have become increasingly popular in recent years. Anesthesiologists are often faced with a choice among different treatment strategies with little data available on the comparative cost-effectiveness. We performed a systematic review of the English language literature between 1980 and 2014 to identify cost-effectiveness analyses of anesthesiology and perioperative medicine interventions. We excluded interventions related to critical care or pediatric anesthesiology, and articles on interventions not normally ordered or performed by anesthesiologists...
March 21, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29566738/fecal-microbiota-transplantation-against-intestinal-colonization-by-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-a-proof-of-principle-study
#7
Ramandeep Singh, Pieter F de Groot, Suzanne E Geerlings, Caspar J Hodiamont, Clara Belzer, Ineke J M Ten Berge, Willem M de Vos, Frederike J Bemelman, Max Nieuwdorp
OBJECTIVE: Infections with multidrug-resistant microorganisms are associated with increased hospitalization, medication costs and mortality. Based on our fecal microbiota transplantation (FMT) experience for Clostridium difficile infection, we treated 15 patients carrying ESBL-producing Enterobacteriaceae (ESBL-EB) with FMT. Seven patients underwent a second FMT after 4 weeks when ESBL-EB remained, amounting to a total number of 22 transplants. The objective was decolonization of ESBL-EB...
March 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29555678/evaluation-of-the-pig-tailed-macaque-macaca-nemestrina-as-a-model-of-human-staphylococcus-aureus-nasal-carriage
#8
Amy L Cole, Yvonne Cosgrove Sweeney, Amanda G Lasseter, Justin M Gray, Ashley C Beavis, Christine F Chong, Safarali V Hajheidari, Alex Beyene, Dorothy L Patton, Alexander M Cole
Staphylococcus aureus ( SA ) nasal carriage is a common condition effecting both healthy and immunocompromised populations, and provides a reservoir for dissemination of potentially infectious strains by casual contact. Factors regulating the onset and duration of nasal SA colonization are mostly unknown, and a human-relevant animal model is needed. Here, we screened 17 pig-tailed macaques ( Macaca nemestrina ) for SA carriage, and 14 of 17 animals tested positive in the nose at one or both screening sessions (8 weeks apart), while the other three animals were negative in the nose but positive in the pharynx at least once...
March 19, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29540160/effect-of-lactobacillus-rhamnosus-hn001-on-carriage-of-staphylococcus-aureus-results-of-the-impact-of-probiotics-for-reducing-infections-in-veterans-improve-study
#9
Shoshannah Eggers, Anna K Barker, Susan Valentine, Timothy Hess, Megan Duster, Nasia Safdar
BACKGROUND: Infection by Staphylococcus aureus (S. aureus) is a major cause of morbidity and mortality. Colonization by S. aureus increases the risk of infection. Little is known about decolonization strategies for S. aureus beyond antibiotics, however probiotics represent a promising alternative. A randomized controlled trial was conducted to determine the efficacy of Lactobacillus rhamnosus (L. rhamnosus) HN001 in reducing carriage of S. aureus at multiple body sites. METHODS: One hundred thirteen subjects, positive for S...
March 14, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29537999/reducing-infection-rates-in-implant-based-breast-reconstruction-impact-of-an-evidence-based-protocol
#10
Kasandra R Dassoulas, Jessica Wang, Jenna Thuman, Idorenyin Ndem, Christine Schaeffer, Madeline Stovall, Alexandra Tilt, Andy Lee, Kant Y Lin, Christopher A Campbell
BACKGROUND: Infection is the most significant complication in implant-based breast reconstruction, potentially leading to reconstructive failure. We hypothesized that implementation of an evidence-based protocol marked by preoperative decolonization and sterility optimization would result in a decline in postoperative infection rates. METHODS: Informed by a literature review, we developed an evidence-based, perioperative infection prevention protocol implemented in 2015...
May 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29525793/zero-surgical-site-infection-in-primary-knee-arthroplasty-with-multidisciplinary-intervention-is-it-possible
#11
Zehra Çağla Karakoç, Uğur Haklar
Surgical site infections (SSI) are among the most important complications in knee arthroplasty. In this article we aim to retrospectively evaluate effects of preoperative multidisciplinary assessment and treatment of focal infections in primary knee arthroplasty patients operated by a single surgeon in a single center. A total of 93 patients undergoing 120 primary knee arthroplasty operations were included in the study. In the preoperative assessment all patients were consulted by infectious diseases, otorhinolaryngology (ENT) and dentistry departments, and female patients additionally by gynecology departments to evaluate and treat possible focal infections...
March 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29510950/the-cost-effectiveness-of-preoperative-staphylococcus-aureus-screening-and-decolonization-in-total-joint-arthroplasty
#12
Yehuda E Kerbel, Anisha R Sunkerneni, Gregory J Kirchner, John P Prodromo, Vincent M Moretti
BACKGROUND: This article presents a break-even analysis for preoperative Staphylococcus aureus colonization screening and decolonization protocols in total hip arthroplasty (THA) and total knee arthroplasty (TKA). METHODS: Protocol costs, baseline infection rates after arthroplasty, and average revision costs were obtained from institutional records and the literature. The break-even analysis determined the absolute risk reduction (ARR) in infection rate required for cost-effectiveness...
January 31, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29506927/cost-efficacy-of-methicillin-resistant-staphylococcus-aureus-decolonization-with-intranasal-povidone-iodine
#13
G Ryan Rieser, Joseph T Moskal
BACKGROUND: With increasing rates of virulent drug resistant organisms, MRSA (methicillin-resistant Staphylococcus aureus) decolonization has been demonstrated to decrease infection rates. Recent research has shown the antiseptic povidone-iodine to be equally effective and potentially cost saving compared to intranasal mupirocin. This study's purpose is to evaluate the incidence of MRSA colonization in a more rural community-based population, rates of infection on a mupirocin decolonization protocol, and develop a cost analysis model to compare costs of utilizing povidone-iodine...
January 31, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29490536/efficacy-of-infection-control-interventions-other-than-decolonization-in-reducing-the-incidence-of-new-mrsa-acquisition-in-a-neurosurgical-intensive-care-unit
#14
Eunsung You, Sung-Shin Kim, Juyeon Lee, Tae Yang Yu, Jihyun Cho, Jae Hoon Lee
No abstract text is available yet for this article.
February 28, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29477634/clearance-of-carbapenem-resistant-enterobacteriaceae-versus-vancomycin-resistant-enterococci-carriage-after-fecal-microbiota-transplant-a-prospective-comparative-study
#15
Aurélien Dinh, Hafedh Fessi, Clara Duran, Rui Batista, Hugues Michelon, Frédérique Bouchand, Raphaël Lepeule, Daniel Vittecoq, Lelia Escaut, Iradj Sobhani, Christine Lawrence, François Chast, Pierre Ronco, Benjamin Davido
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) and Vancomycin-resistant enterococci (VRE) carriage is increasing worldwide. Fecal microbiota transplantation (FMT) appears to be an attractive option for decolonization. We aimed to evaluate CRE versus VRE clearance by FMT among carriers. METHODS: We performed a multicentre trial on patients with CRE or VRE digestive tract colonization who received FMT between January 2015 and April 2017. Adult patients with CRE or VRE colonization were included; confirmed by three consecutive rectal swabs at weekly intervals, including one in the week prior to FMT...
February 22, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29468091/surgical-technical-evidence-review-for-elective-total-joint-replacement-conducted-for-the-ahrq-safety-program-for-improving-surgical-care-and-recovery
#16
REVIEW
Christopher P Childers, Anaar E Siletz, Emily S Singer, Claire Faltermeier, Q Lina Hu, Clifford Y Ko, Gregory J Golladay, Stephen L Kates, Elizabeth C Wick, Melinda Maggard-Gibbons
Background: Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns Hopkins Medicine Armstrong Institute for Patent Safety and Quality have developed the Safety Program for Improving Surgical Care and Recovery-a national effort to catalyze implementation of practices to improve perioperative care and enhance recovery of surgical patients...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29463447/novel-inhibitors-of-staphylococcus-aureus-rnpa-that-synergize-with-mupirocin
#17
Nicole Lounsbury, Tess Eidem, Jennifer Colquhoun, George Mateo, Magid Abou-Gharbia, Paul M Dunman, Wayne E Childers
We recently discovered RnpA as a promising new drug discovery target for methicillin-resistant S. aureus (MRSA). RnpA is an essential protein that is thought to perform two required cellular processes. As part of the RNA degrasome Rnpa mediates RNA degradation. In combination with rnpB it forms RNase P haloenzymes which are required for tRNA maturation. A high throughput screen identified RNPA2000 as an inhibitor of both RnpA-associated activities that displayed antibacterial activity against clinically relevant strains of S...
April 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29432868/repurposing-niclosamide-for-intestinal-decolonization-of-vancomycin-resistant-enterococci
#18
Haroon Mohammad, Ahmed AbdelKhalek, Nader S Abutaleb, Mohamed N Seleem
Enterococci are commensal microorganisms present in the gastrointestinal (GI) tract of humans. Though normally innocuous to the host, strains of Enterococcus exhibiting resistance to vancomycin (VRE) have been associated with high rates of infection and mortality in immunocompromised patients. Decolonization of VRE represents a key strategy to curb infection in highly-susceptible patients. However, there is a dearth of decolonizing agents available clinically that are effective against VRE. The present study confirms that niclosamide, an anthelmintic drug, has potent antibacterial activity against clinical isolates of vancomycin-resistant E...
February 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29422820/decolonization-of-staphylococcus-aureus-in-patients-with-atopic-dermatitis-a-reason-for-increasing-resistance-to-antibiotics
#19
Izabela Błażewicz, Maciej Jaśkiewicz, Marta Bauer, Lidia Piechowicz, Roman J Nowicki, Wojciech Kamysz, Wioletta Barańska-Rybak
Introduction: Exacerbation of atopic dermatitis can be associated with bacterial infection. The skin of patients is colonized with Staphylococcus aureus in 90% of cases. An attempt has been made to demonstrate that eradication significantly reduces the severity of the disease. Studies indicate the efficacy of topical antibiotics, topical corticosteroids and calcineurin inhibitors. Due to increasing resistance to drugs and the defective antimicrobial peptide profile, decolonization is virtually impossible...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29420501/how-decolonization-could-reshape-south-african-science
#20
Linda Nordling
No abstract text is available yet for this article.
February 8, 2018: Nature
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