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Bishow Tulachan, Buddha Nath Borgohain
Background: Glomangiomyoma is a rare histological variant of glomus tumour. Clinically, it mimicks as a haemangioma and is challenging to diagnose. Its occurrence in the neck of a child has not been previously described. Case presentation: A 3 year old girl presented with the complaints of painless progressive neck swelling in the right side for one and half year. Sonography, computed tomography (CT), magnetic resonance imaging (MRI), CT neck angiography and fine needle aspiration cytology (FNAC) were suggestive of vacular malformation i...
2017: BMC Ear, Nose, and Throat Disorders
W Q Che, X J Jiang, H Dong, M Peng, Y B Zou, L Song, H M Zhang, H L Xiong, H Y Wu
Objective: To evaluate the effect of stenting for proximal atherosclerotic extracranial vertebral artery stenosis. Methods: A total of 204 proximal atherosclerotic extracranial vertebral artery stenosis patients underwent stent implantation at Fuwai Hospital were enrolled consecutively between August 2007 and June 2014 prospectively. Medical records were collected and the clinical results were obtained through outpatient and telephone follow up. Results: (1) The patients were (64.1±7.9) years old, and 179 were male (87...
January 25, 2017: Zhonghua Xin Xue Guan Bing za Zhi
Jie Cao, Min Wang, Huiqi Xie, Renqian Wei
OBJECTIVE: To prepare the small intestinal submucosa (SIS)-silk composite scaffold for anterior cruciate ligament (ACL) reconstruction, and to evaluate its properties of biomechanics, biocompatibility, and the influence on synovial fluid leaking into tibia tunnel so as to provide a better choice in the clinical application of ACL reconstruction. METHODS: The silk was used to remove sericin and then weaved as silk scaffold, which was surrounded cylindrically by SIS to prepare a composite scaffold...
December 2015: Chinese Journal of Reparative and Reconstructive Surgery
Nora Mellouk, Allon Weiner, Nathalie Aulner, Christine Schmitt, Michael Elbaum, Spencer L Shorte, Anne Danckaert, Jost Enninga
Shigella enters epithlial cells via internalization into a vacuole. Subsequent vacuolar membrane rupture allows bacterial escape into the cytosol for replication and cell-to-cell spread. Bacterial effectors such as IpgD, a PI(4,5)P2 phosphatase that generates PI(5)P and alters host actin, facilitate this internalization. Here, we identify host proteins involved in Shigella uptake and vacuolar membrane rupture by high-content siRNA screening and subsequently focus on Rab11, a constituent of the recycling compartment...
October 8, 2014: Cell Host & Microbe
B B Lee, P L Antignani, V Baraldini, I Baumgartner, P Berlien, F Blei, G P Carrafiello, R Grantzow, A Ianniello, J Laredo, D Loose, J C Lopez Gutierrez, J Markovic, R Mattassi, K Parsi, E Rabe, K Roztocil, C Shortell, M Vaghi
No abstract text is available yet for this article.
August 2015: International Angiology: a Journal of the International Union of Angiology
K Tjaden, C Adam, E Pardali, J Waltenberger
PURPOSE: Monocytes contribute to both vacular repair as well as atherogenesis. This contribution is dependent on monocyte function. Hypercholesterolemia (HC) is a cardiovascular risk factor affecting monocyte function and resulting in reduced chemotactic response towards chemokines such as VEGFA ("VEGF resistance") or MCP-1. The aim of the current project is to investigate the molecular mechanisms underlying HC-related monocyte dysfunction resulting in VEGF resistance. METHODS: We have established an in vitro model of HC by exposing primary human monocytes or mononuclear THP-1 cells to various lipid fractions to simulate the in vivo situation...
July 15, 2014: Cardiovascular Research
M T Cerqueira, R P Pirraco, A R Martins, T C Santos, R L Reis, A P Marques
Skin regeneration remains a challenge, requiring a well-orchestrated interplay of cell-cell and cell-matrix signalling. Cell sheet (CS) engineering, which has the major advantage of allowing the retrieval of the intact cell layers along with their naturally organized extracellular matrix (ECM), has been poorly explored for the purpose of creating skin substitutes and skin regeneration. This work proposes the use of CS technology to engineer cellular constructs based on human keratinocytes (hKC), key players in wound re-epithelialization, dermal fibroblasts (hDFb), responsible for ECM remodelling, and dermal microvascular endothelial cells (hDMEC), part of the dermal vascular network and modulators of angiogenesis...
July 2014: Acta Biomaterialia
Mette J Riis-Vestergaard, Mikkel W Misfeldt, Toke Bek
PURPOSE: Previous studies have shown that adenosine induces relaxation of isolated retinal arterioles mediated by the A2A receptor, but the contributions to tone regulation of adenosine receptors located both in and around the vascular wall have not been studied in detail. METHODS: Porcine retinal arterioles with preserved perivascular retinal tissue were mounted in a wire myograph, and the tone was recorded after addition of antagonists to the adenosine A1, A2A, A2B, and A3 receptors, followed by removal of the perivascular retinal tissue and repetition of the experiments...
March 2014: Investigative Ophthalmology & Visual Science
Scott A Asher, Hilliary N White, Elisa A Illing, William R Carroll, J Scott Magnuson, Eben L Rosenthal
IMPORTANCE: Pharyngocutaneous fistula formation after pharyngeal reconstruction is one of the most common and challenging problems to manage. Despite many advances in management, the published success rates indicate a role for any adjuvant therapy that could potentially decrease this complication. OBJECTIVE: To describe the use of intraluminal negative pressure dressings (NPDs) in pharyngeal reconstruction. DESIGN, SETTING, AND PARTICIPANTS: Retrospective case series at a tertiary care academic hospital...
February 2014: JAMA Otolaryngology—Head & Neck Surgery
Li Wang, HaiYing Li, JinFeng Zhang, Wei Lu, Jing Zhao, Le Su, BaoXiang Zhao, Yun Zhang, ShangLi Zhang, JunYing Miao
We previously found that phosphatidylcholine-specific phospholipase C (PC-PLC) was a key inducing element of atherosclerosis, and might negatively regulate human umbilical vein endothelial cell (HUVEC) autophagy. To further investigate the mechanism of PC-PLC action, we initially identified phosphatidylethanolamine binding protein 1 (PEBP1) as a binding partner of PC-PLC by using mass spectrometry (MS, MALDI-TOF/TOF). We found that PEBP1 positively regulated PC-PLC activity in HUVECs, and inhibition of PC-PLC by its inhibitor D609 suppressed PEBP1 expression dramatically...
October 15, 2013: Journal of Physiology
Jun Liu, Jia Huang, Wei-Yan Yao, Qi-Wen Ben, Da-Fan Chen, Xiang-Yi He, Lei Li, Yao-Zong Yuan
Vascularization is crucial for tumor growth and metastasis. Angiogenesis and vasculogenesis are widely accepted processes of tumor vascularization, particularly for endothelium-dependent vessels. In both these processes, the tumor vascular endothelial cells are derived from the host cells, including cells in normal tissues around the tumor or endothelial progenitor cells. In addition, the mosaic vessels occur as a transitional pattern between endothelium-dependent vessels and vasculogenic mimicry (VM), wherein both host endothelium and tumor cells participate in tumor vascularization...
2012: Frontiers in Bioscience (Landmark Edition)
Rania Hammami, Leila Abid, Souad Mallek, Ilyes Kharrat, Mariem Ellouz, Mourad Hentati, Imed Frikha, Samir Kammoun
Background. The discovery of a large left atrial mass through echocardiography obliges the clinician to perform a differential diagnosis to distinguish tumor from thrombus. The neovascularization of the mass could be helpful to predict the type of the malformation and whether it is in favour of a vacular tumour rather than a thrombus . Observation. A 43-years-old man who had no cardiac antecedent reported that he have had dyspnea and palpitation since 10 months. The cardiac auscultation, revealed an irregular rhythm with diastolic murmur at the apex...
2012: Case Reports in Medicine
Yin Shen Wee, Kirstin M Roundy, Janis J Weis, John H Weis
The innate response interferon-inducible transmembrane (Ifitm) proteins have been characterized as influencing proliferation, signaling complexes and restricting virus infections. Treatment of cells lacking these proteins (IfitmDel) with IFN-β resulted in the loss of clathrin from membrane compartments and the inhibition of clathrin-mediated phagocytosis, suggesting a molecular interaction between clathrin and Ifitm proteins. The pH of endosomes of IfitmDel cells, with or without IFN activation, was neutralized, suggesting the function of the vacular ATPase proton pumps in such cells was compromised...
December 2012: Innate Immunity
Engin Deveci, Yasemin Nasir, Senay Deveci
Tamoxifen is a triphenylethylene derivative commonly used in the treatment of breast cancer The Wistar rats (9 weeks old, 180-200 g body weight) used in these trials were divided into two groups of 20 animals each (control and experimental group). Animals of the experimental group were given drinking water containing 200 μg/kg tamoxifen citrate for a period of 30 day. At the end of exposure, body and uterus weights were measured. There was no statistical difference in the uterus weights between the control and treated groups (p < 0,05)...
September 2009: Tokai Journal of Experimental and Clinical Medicine
Qifeng Jiang, Renjian Huang, Shaoxi Cai, Chih-Lueh A Wang
BACKGROUND: Migration of vascular smooth muscle cells (SMCs) from the media to intima constitutes a critical step in the development of proliferative vascular diseases. To elucidate the regulatory mechanism of vacular SMC motility, the roles of caldesmon (CaD) and its phosphorylation were investigated. METHODS: We have performed Transwell migration assays, immunofluorescence microscopy, traction microscopy and cell rounding assays using A7r5 cells transfected with EGFP (control), EGFP-wtCaD or phosphomimetic CaD mutants, including EGFP-A1A2 (the two PAK sites Ser452 and Ser482 converted to Ala), EGFP-A3A4 (the two Erk sites Ser497 and Ser527 converted to Ala), EGFP-A1234 (both PAK- and Erk-sites converted to Ala) and EGFP-D1234 (both PAK- and Erk-sites converted to Asp)...
February 3, 2010: Journal of Biomedical Science
Maria Florian, Livia Florianova, Sabah Hussain, Sheldon Magder
The role of estrogen replacement therapy in postmenopausal women remains controversial. The authors hypothesized that contradictory results with estrogen therapy may be explained by estrogen's potent proangiogenic property, which could be protective in women without atherosclerotic disease but in the presence of chronic inflammation, could lead to destabilization of atherosclerotic plaques. The authors thus examined the interaction between 17beta-estradiol (E2) and the inflammatory cytokine tumor necrosis factor alpha (TNFalpha) in an early stage of angiogenesis...
September 2008: Endothelium: Journal of Endothelial Cell Research
Ching-Ti Liu, Shinsheng Yuan, Ker-Chau Li
Many successful functional studies by gene expression profiling in the literature have led to the perception that profile similarity is likely to imply functional association. But how true is the converse of the above statement? Do functionally associated genes tend to be co-regulated at the transcription level? In this paper, we focus on a set of well-validated yeast protein complexes provided by Munich Information Center for Protein Sequences (MIPS). Using four well-known large-scale microarray expression data sets, we computed the correlations between genes from the same complex...
February 2009: Nucleic Acids Research
A Aguilera Bazán, F Betancourt, S Murillo, J Benito de la Víbora, J Cisneros Ledo, J de la Peña Barthel
INTRODUCTION: Laparoscopic surgery requires a long training period of time in which the complexity of the training is increased. GOALS: The technique presented in this paper has been developed in order to find an experimental model that allows us to improve the learning of the vascular suture. Our main goal was to evaluate this technique as an experimental model for the vacular anastomosis, not to obtain a functional autotransplant. In this regard, here we summarize our experience during the first two cases performed...
January 2008: Actas Urologicas Españolas
Cédric F V Hobel, Sonja V Albers, Arnold J M Driessen, Andrei N Lupas
Sso0909 is a protein of the thermo-acidophilic crenarchaeon Sulfolobus solfataricus, annotated as a p60 katanin-like ATPase. We present here results supporting the hypothesis that Sso0909 is an orthologue of the eukaryotic ESCRT (endosomal sorting complex required for transport) ATPase Vps4 (vacular protein sorting 4). The spectrum of Sso0909 homologues is limited to several orders of Crenarchaea and to three euryarchaeal Thermoplasmata species, where they were presumably acquired by lateral gene transfer. Almost invariably, Sso0909 homologues occur in the genomic vicinity of homologues of eukaryotic ESCRT-III components, which are the targets of disassembly by Vps4, as well as with a creanarchaeal-specific coiled-coil protein...
February 2008: Biochemical Society Transactions
Ozgul Muneyyirci-Delale, Nathaniel Winer, Vita Oklander, Ibrahim Joulak, Nezar Dalloul, Vijaya Nacharaju, Shefali Dham, Hans von Gizycki
Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders in women of reproductive age, has been associated with the cardiometabolic syndrome and increased risk for cardiovascular diseases. Large (C1) and small (C2) vessel compliance and fasting lipids were measured in 45 healthy women and 36 women with PCOS. There were no differences in vacular compliance (C1, C2) between the 2 groups. Systolic blood pressure (116.8 vs 124.3 mm Hg; P=.01), mean arterial pressure (82.5 vs 87 mm Hg; P=.03), and low-density lipoprotein cholesterol (98...
2007: Journal of the Cardiometabolic Syndrome
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