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https://www.readbyqxmd.com/read/28728176/the-epidemiology-of-retinopathy-of-prematurity-in-the-united-states
#1
Cassie A Ludwig, Tiffany A Chen, Tina Hernandez-Boussard, Andrew A Moshfeghi, Darius M Moshfeghi
BACKGROUND AND OBJECTIVE: Retinopathy of prematurity (ROP) is a leading cause of blindness in premature and low birth weight infants. Here, the authors examine the incidence of ROP in the United States and evaluate risk factors associated with ROP development. PATIENTS AND METHODS: The National Healthcare Cost and Utilization Project Kids' Inpatient Database was queried for all newborns with and without ROP. Adjusted odds ratios were constructed for predictors of ROP using multivariate logistic regression modeling...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28724325/use-and-timing-of-surfactant-administration-impact-on-neonatal-outcomes-in-extremely-low-gestational-age-infants-born-in-canadian-neonatal-intensive-care-units
#2
Amelie Stritzke, Khorshid Mohammad, Prakesh S Shah, Xiang Y Ye, Vineet Bhandari, Albert Akierman, Adele Harrison, Valerie Bertelle, Abhay Lodha
BACKGROUND: Use, timing and doses of surfactant in preterm infants are variable in practice in modern NICUs. OBJECTIVE: To explore the association between use and timing of surfactant administration and common neonatal adverse outcomes in preterm infants with gestational age (GA) < 28 weeks. MATERIAL AND METHODS: Neonates admitted to a participating Canadian Neonatal Network NICU between 2013 and 2015 were studied. Infants were divided into three groups based on surfactant administration: None, early (within 30 minutes of life), and late surfactant (> 30 minutes)...
July 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28722174/astrocytes-follow-ganglion-cell-axons-to-establish-an-angiogenic-template-during-retinal-development
#3
Matthew L O'Sullivan, Vanessa M Puñal, Patrick C Kerstein, Joseph A Brzezinski, Tom Glaser, Kevin M Wright, Jeremy N Kay
Immature astrocytes and blood vessels enter the developing mammalian retina at the optic nerve head and migrate peripherally to colonize the entire retinal nerve fiber layer (RNFL). Retinal vascularization is arrested in retinopathy of prematurity (ROP), a major cause of bilateral blindness in children. Despite their importance in normal development and ROP, the factors that control vascularization of the retina remain poorly understood. Because astrocytes form a reticular network that appears to provide a substrate for migrating endothelial cells, they have long been proposed to guide angiogenesis...
July 19, 2017: Glia
https://www.readbyqxmd.com/read/28716418/wheat-rop-proteins-modulate-defense-response-through-lignin-metabolism
#4
Qing-Hu Ma, Hai-Hao Zhu, Jia-Qi Han
ROP is a subfamily of small GTP-binding proteins that uniquely exist in plants. It acts as versatile molecular switches that regulate various developmental processes. Some ROP proteins are also reported to affect defense responses, although their exact mechanism is not fully understood. Herein, ROP members in wheat were mined; the functions of three wheat ROP proteins were studied. RT-PCR results showed that the expression of TaRac1 was rapidly and strongly induced after leaf rust infection. TaRac1 interacted with TaCCR in yeast-hybridization assay...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28715553/validation-of-the-children-s-hospital-of-philadelphia-retinopathy-of-prematurity-chop-rop-model
#5
Gil Binenbaum, Gui-Shuang Ying, Lauren A Tomlinson
Importance: The Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP ROP) model uses birth weight (BW), gestational age at birth (GA), and weight gain rate to predict the risk of severe retinopathy of prematurity (ROP). In a model development study, it predicted all infants requiring treatment, while greatly reducing the number of examinations compared with current screening guidelines. Objective: To validate the CHOP ROP model in a multicenter cohort that is large enough to obtain a precise estimate of the model's sensitivity for treatment-requiring ROP...
July 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28715211/alternating-sequence-controlled-copolymer-synthesis-of-%C3%AE-hydroxy-acids-via-syndioselective-ring-opening-polymerization-of-o-carboxyanhydrides-using-zirconium-hafnium-alkoxide-initiators
#6
Yangyang Sun, Zhaowei Jia, Changjuan Chen, Yong Cong, Xiaoyang Mao, Jincai Wu
The ring-opening polymerization (ROP) of O-carboxyanhydrides (OCAs) can give diverse poly(α-hydroxy acid)s (PAHAs) with different functional groups because of easy modification of the side group of OCAs, which can extend applications of PAHAs widely. The stereoselective polymerization of O-carboxyanhydrides and further sequence controlled alternating copolymerization of OCAs were still big challenges until now for lack of suitable catalysts/initiators. In this work, a highly syndioselective ROP of OCAs system as the first stereoselective example in this area is reported using zirconium/hafnium alkoxides as initiators with the highest Pr- value up to 0...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28710770/an-arabidopsis-kinase-cascade-influences-auxin-responsive-cell-expansion
#7
Tara A Enders, Elizabeth M Frick, Lucia C Strader
Mitogen-activated protein kinase (MPK) cascades are conserved mechanisms of signal transduction across eukaryotes. Despite the importance of MPK proteins in signaling events, specific roles for many Arabidopsis MPK proteins remain unknown. Multiple studies have suggested roles for MPK signaling in a variety of auxin-related processes. To identify MPK proteins with roles in auxin response, we screened mpk insertional alleles and identified mpk1-1 as a mutant that displays hypersensitivity in auxin-responsive cell expansion assays...
July 15, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28709412/study-protocol-safety-and-efficacy-of-propranolol-0-2-eye-drops-in-newborns-with-a-precocious-stage-of-retinopathy-of-prematurity-drop-rop-0-2-a-multicenter-open-label-single-arm-phase-ii-trial
#8
Luca Filippi, Giacomo Cavallaro, Elettra Berti, Letizia Padrini, Gabriella Araimo, Giulia Regiroli, Valentina Bozzetti, Chiara De Angelis, Paolo Tagliabue, Barbara Tomasini, Giuseppe Buonocore, Massimo Agosti, Angela Bossi, Gaetano Chirico, Salvatore Aversa, Roberta Pasqualetti, Pina Fortunato, Silvia Osnaghi, Barbara Cavallotti, Maurizio Vanni, Giulia Borsari, Simone Donati, Giuseppe Nascimbeni, Giancarlo la Marca, Giulia Forni, Silvano Milani, Ivan Cortinovis, Paola Bagnoli, Massimo Dal Monte, Anna Maria Calvani, Alessandra Pugi, Eduardo Villamor, Gianpaolo Donzelli, Fabio Mosca
BACKGROUND: Retinopathy of prematurity (ROP) still represents one of the leading causes of visual impairment in childhood. Systemic propranolol has proven to be effective in reducing ROP progression in preterm newborns, although safety was not sufficiently guaranteed. On the contrary, topical treatment with propranolol eye micro-drops at a concentration of 0.1% had an optimal safety profile in preterm newborns with ROP, but was not sufficiently effective in reducing the disease progression if administered at an advanced stage (during stage 2)...
July 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28701165/ethnomedicinal-and-cultural-practices-of-mammals-and-birds-in-the-vicinity-of-river-chenab-punjab-pakistan
#9
Muhammad Altaf, Arshad Javid, Muhammad Umair, Khalid Javed Iqbal, Zahid Rasheed, Arshad Mehmood Abbasi
BACKGROUND: Although, use of animal species in disease treatment and culture practices is as ancient as that of plant species; however ethnomedicinal uses and cultural values of animal species have rarely been reported. Present study is the first report on the medicinal uses of mammals and bird species in Pakistan. METHODS: Questionnaires and semi-structured interviews were applied to collect qualitative and quantitative data from local informants (N = 109). Relative frequency of mention (RFM), fidelity level (FL), relative popularity level (RPL), similarity index (SI) and rank order priority (ROP) indices were used to analyzed the data...
July 12, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28699927/short-term-outcomes-after-intravitreal-injections-of-conbercept-versus-ranibizumab-for-the-treatment-of-retinopathy-of-prematurity
#10
Enzhong Jin, Hong Yin, Xiaoxin Li, Mingwei Zhao
PURPOSE: Intravitreal injection of conbercept (IVC) is the latest applied treatment that could be used in retinopathy of prematurity (ROP) patients. The structural outcomes and recurrence of ROP among patients treated with IVC or intravitreal injection of ranibizumab (IVR) were compared. METHODS: A consecutive case series of ROP treated with IVC or IVR were retrospectively studied. The primary outcome was treatment success defined as regression of plus disease. The secondary outcomes were recurrence of plus, times of injection, and the final regression of disease...
July 7, 2017: Retina
https://www.readbyqxmd.com/read/28698357/ropgef1-plays-a-critical-role-in-polar-auxin-transport-in-early-development
#11
Yuting Liu, Qingkun Dong, Daniel Kita, Jia-Bao Huang, Guolan Liu, Xiaowei Wu, Xiaoyue Zhu, Alice Y Cheung, Hen-Ming Wu, Li-Zhen Tao
Polar auxin transport, facilitated by the combined activities of auxin influx and efflux carriers to maintain asymmetric auxin distribution, is essential for plant growth and development. Here, we show that Arabidopsis RopGEF1, a guanine nucleotide exchange factor and activator of ROPs (Rho GTPases of plants), is critically involved in polar distribution of auxin influx carrier AUX1 and differential accumulation of efflux carriers PIN7 and PIN2, and is important for embryo and early seedling development when RopGEF1 is prevalently expressed...
July 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28685784/%C3%AE-pyridylenolate-zinc-catalysts-for-the-ring-opening-homo-and-copolymerization-of-%C3%AE%C2%B5-caprolactone-and-lactides
#12
Jianliang Bai, Xia Xiao, Yue Zhang, Jianbin Chao, Xia Chen
A family of zinc β-pyridylenolates with varying α,β-substituents has been synthesized. A direct reaction of β-pyridyl ketone ligands with ZnEt2 in toluene afforded dimeric [LZnEt]2 (L = (2-C5H4N)-C(R(1))[double bond, length as m-dash]C(R(2))-O-). X-ray structural data revealed that all the [LZnEt]2 complexes exist as μ-O-bridged dimers in the solid state, although they adopt a different geometry. Each of the [LZnEt]2 complexes is a highly active catalyst for the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and racemic lactide (rac-LA), respectively...
July 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28682759/structuraland-antigenic-analysis-of-a-new-rhoptry-pseudokinase-gene-rop54-in-toxoplasma-gondii
#13
Jian Zhou, Gang Lu, Lin Wang, Aihua H Zhou, Yali L Han, Jingjing J Guo, Pengxia X Song, Huaiyu Y Zhou, Hua Cong, Ming Hou, Shenyi Y He
Toxoplasma gondii is defined as an obligate intracellular apicomplexan parasite and influences approximatelyone-third of the human all over the world. ROP54 protein is expressed in the rhoptry of Toxoplasma gondii. In the present study, we used SMART software to analyzethe secondary structure of ROP54. The 3D model of ROP54 protein was constructed and analyzed using SWISS-MODEL server and VMD software. The structure results fully showed that ROP54 proteinis an importantmember from the ROP family. Moreover, DNAMAN software and Epitope Database online service were used to analyze liner-B cell epitopes and Th-cell epitopes of the protein...
September 26, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28674824/an-update-on-retinopathy-of-prematurity-rop
#14
Mangat Ram Dogra, Deeksha Katoch, Mohit Dogra
Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease affecting the retina of premature infants. The clinical spectrum of ROP varies from spontaneous regression to bilateral retinal detachment and total blindness. Between these two extremes lies the form of ROP, which is amenable to treatment with laser photocoagulation, anti-vascular endothelial growth factor drugs or surgery. Increasing rates of preterm births coupled with better survival rates but lack of uniform quality of neonatal care and delays in diagnosis have led to increasing ROP blindness...
July 4, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28672871/pamidronate-conjugated-biodegradable-branched-copolyester-carriers-synthesis-and-characterization
#15
Ewa Oledzka, Dagmara Pachowska, Katarzyna Orłowska, Joanna Kolmas, Agata Drobniewska, Ramona Figat, Marcin Sobczak
The need for development of comprehensive therapeutic systems, (e.g., polymer-apatite composites) as a bone substitute material has previously been highlighted in many scientific reports. The aim of this study was to develop a new multifunctional composite based on hydroxyapatite porous granules doped with selenite ions (SeO₃(2-)) and a biodegradable branched copolymer-bisphosphonate conjugate as a promising bone substitute material for patients with bone tumours or bone metastasis. A series of biodegradable and branched copolymer matrices, adequate for delivery of bisphosphonate in the bone-deficient area were synthesized and physico-chemically and biologically (cyto- and genotoxicity assays) characterized...
June 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28669100/long-term-evaluation-of-refractive-changes-in-eyes-of-preterm-children-a-6-year-follow-up-study
#16
Mahmut Kaya, Ayse Tulin Berk, Aylin Yaman
PURPOSE: To investigate the longitudinal changes in refractive errors in preterm children with and without retinopathy of prematurity (ROP) in the first 6 years of life. METHODS: We included 226 preterm children with a gestational age of ≤34 weeks: 222 eyes with no ROP, 73 eyes with mild ROP and 145 eyes with severe ROP. Longitudinal cycloplegic refraction data were collected initially and yearly thereafter until 6 years of age. RESULTS: Eyes in the severe ROP group showed an increase in myopia values between the 1- and 3-year examinations (p = 0...
July 1, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28666071/highly-syndiotactic-to-isotactic-polyhydroxyalkanoates-via-ligand-controlled-yttrium-catalyzed-stereoselective-ring-opening-polymerization-of-functional-racemic-beta-lactones
#17
Romain Ligny, Mikko Hänninen, Sophie M Guillaume, Jean-Francois Carpentier
Reported herein is the first stereoselective controlled ROP of a specific family of racemic functional beta-lactones, namely 4-alkoxy-methylene-beta-propiolactones (BPLORs), using yttrium catalysts stabilized by nonchiral tetradentate amino-alkoxy-bisphenolate ligands {ONOOR'2}2-, combining both a good activity and a high degree of control over the molar masses of the resulting functional poly(3-hydroxyalkanoate)s PHBORs. The simple modification of ortho,para-R' substituents on the ligand platform allows a complete reversal from virtually pure syndioselective (Ps up to 0...
June 30, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28661514/delivery-room-resuscitation-and-adverse-outcomes-among-very-low-birth-weight-preterm-infants
#18
S Arnon, T Dolfin, B Reichman, R H Regev, L Lerner-Geva, V Boyko, I Litmanovitz
OBJECTIVE: To evaluate risk factors and impact of delivery room cardiopulmonary resuscitation (DR-CPR) on very low birth weight (VLBW) preterm infants. STUDY DESIGN: A national, population-based, observational study evaluating risk factors and short-term neonatal outcomes associated with DR-CPR among VLBW, extremely preterm infants (EPIs, 24 to 27 weeks' gestation) and very preterm infants (VPI, 28 to 31 weeks' gestation) born in 1995 to 2010. RESULTS: Among 17 564 VLBW infants, 636 (3...
June 29, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28659957/auxin-signaling-in-regulation-of-plant-translation-reinitiation
#19
REVIEW
Mikhail Schepetilnikov, Lyubov A Ryabova
The mRNA translation machinery directs protein production, and thus cell growth, according to prevailing cellular and environmental conditions. The target of rapamycin (TOR) signaling pathway-a major growth-related pathway-plays a pivotal role in optimizing protein synthesis in mammals, while its deregulation triggers uncontrolled cell proliferation and the development of severe diseases. In plants, several signaling pathways sensitive to environmental changes, hormones, and pathogens have been implicated in post-transcriptional control, and thus far phytohormones have attracted most attention as TOR upstream regulators in plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28655731/ultra-low-dose-intravitreal-bevacizumab-for-the-treatment-of-retinopathy-of-prematurity-a-case-series
#20
Roxane J Hillier, Alan J Connor, Ayad E Shafiq
BACKGROUND: Intravitreal bevacizumab (IVB) has emerged as an effective treatment modality for the management of retinopathy of prematurity (ROP) where the disease is severe and posterior. Despite evidence of systemic vascular endothelial growth factor suppression and concerns about how this might affect the developing neonate, the optimal dose is unknown to date. We report our experience of using ultra-low-dose (0.16 mg) IVB, one-quarter of the 'standard' dose that has widely been reported in the treatment of ROP...
June 27, 2017: British Journal of Ophthalmology
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