keyword
MENU ▼
Read by QxMD icon Read
search

ROP

keyword
https://www.readbyqxmd.com/read/28420777/retinopathy-of-prematurity
#1
Alice L Bashinsky
Retinopathy of prematurity (ROP) is a vasoproliferative retinal disorder unique to premature infants. As premature births increase in many areas of the world, ROP has become a leading cause of childhood blindness. A better understanding of the pathogenesis of ROP, adherence to strict screening guidelines, and evolution of treatment options have reduced the number of sight-threatening complications from ROP.
March 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28420694/caffeine-preferentially-protects-against-oxygen-induced-retinopathy
#2
Shuya Zhang, Rong Zhou, Bo Li, Haiyan Li, Yanyan Wang, Xuejiao Gu, Lingyun Tang, Cun Wang, Dingjuan Zhong, Yuanyuan Ge, Yuqing Huo, Jing Lin, Xiao-Ling Liu, Jiang-Fan Chen
Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti-VEGF therapy is concerned with delayed retinal vasculature, eye, and brain development of preterm infants. The clinical observation of reduced ROP severity in premature infants after caffeine treatment for apnea suggests that caffeine may protect against ROP. Here, we demonstrate that caffeine did not interfere with normal retinal vascularization development but selectively protected against oxygen-induced retinopathy (OIR) in mice...
April 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28418053/a-new-route-for-the-preparation-of-enriched-iso-polylactide-from-rac-lactide-via-a-lewis-acid-catalyzed-ring-opening-of-an-epoxide
#3
Mathew Anker, Choumini Balasanthiran, Vagulejan Balasanthiran, Malcolm H Chisholm, Savithra Jayaraj, Kaleb Mathieu, Parichat Piromjitpong, Siriwan Praban, Balaram Raya, William J Simonsick
Tetraphenylporphyrin aluminum(iii) salts, TPPAlX, where X = Me, OEt, OiPr, OCHMeCH2Cl, and Cl, and bis(triphenylphosphine)imminium chloride, PPN(+)Cl(-) (1 : 1) react with rac-lactide, rac-LA, in neat propylene oxide, PO, to yield chains of enriched isotactic polylactide, PLA, with end groups of PO-Cl and with time these yield cyclic polymers (PO)n(PLA) where n = 2 or 3 and even higher. There is no reaction between TPPAlOR (R = Et or (i)Pr), PPN(+)Cl(-), and rac-LA in neat THF at 25 °C even though TPPAlOR (R = Et or (i)Pr) and PPN(+)Cl(-) in neat PO yields polypropylene oxide with a terminal OR group, H(PO)nOR...
April 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28414522/a-comparison-of-breast-milk-and-sucrose-in-reducing-neonatal-pain-during-eye-exam-for-retinopathy-of-prematurity
#4
Ayşe Şener Taplak, Emine Erdem
BACKGROUND: This double-blind randomized controlled experimental study aimed to determine the effects of breast milk and sucrose in reducing pain in preterm infants during retinopathy of prematurity (ROP) examination. MATERIALS AND METHODS: This study was conducted with 60 preterm infants (breast milk group = 20, sucrose group = 20, and control/distilled water group = 20) meeting the inclusion criteria. The data were collected with the use of an Infant Evaluation Form, Procedure Monitoring Form, and Premature Infant Pain Profile (PIPP)...
April 17, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28413406/a-change-in-ocular-circulation-after-photocoagulation-for-retinopathy-of-prematurity-in-a-neonate
#5
Tadashi Matsumoto, Takashi Itokawa, Tomoaki Shiba, Kotaro Hine, Yuichi Hori
BACKGROUND: The dilation of veins and tortuosity of arteries that occur in retinopathy of prematurity (ROP) are improved by therapy, and thus posttherapy changes in ocular circulation are also conceivable. We report a case of ROP in which we were able to measure the ocular circulation before and after photocoagulation therapy, using a laser speckle flowgraphy (LSFG) system that is modified for neonates. CASE REPORT: A female infant was born at 25 weeks' gestation with a birth weight of 808 g...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28412066/ranibizumab-injection-as-primary-treatment-in-patients-with-retinopathy-of-prematurity-anatomic-outcomes-and-influencing-factors
#6
Qiujing Huang, Qi Zhang, Ping Fei, Yu Xu, Jiao Lyu, Xunda Ji, Jie Peng, Yi-An Li, Peiquan Zhao
PURPOSE: To investigate the anatomic outcomes and influencing factors of ranibizumab in the treatment of retinopathy of prematurity (ROP). DESIGN: Retrospective case series. PARTICIPANTS: A total of 283 eyes of 145 patients with type 1 ROP treated with intravitreal injection of ranibizumab (IVR) as primary treatment. METHODS: Retrospective review of infants who were diagnosed with type 1 ROP and accepted IVR (0.25 mg/0...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28404792/toxoplasma-effectors-targeting-host-signaling-and-transcription
#7
REVIEW
Mohamed-Ali Hakimi, Philipp Olias, L David Sibley
Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during invasion of host cells. These early morphological studies were followed by the exploration of the cellular contents of these secretory organelles, revealing them to be comprised of highly divergent protein families with few conserved domains or predicted functions...
July 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28404669/retinopathy-of-prematurity-screening-and-treatment-in-costa-rica
#8
Ana Catalina Tabarez-Carvajal, Milagro Montes-Cantillo, Kelly H Unkrich, Rupal H Trivedi, Mae Millicent Winfrey Peterseim
AIM: To determine the recent demographic data, risk factors and results of retinopathy of prematurity (ROP) screening and treatment in Costa Rica. METHODS: The medical records of all preterm infants meeting ROP screening criteria (≤34 weeks' gestational age (GA) or birth weight (BW) ≤1750g, and those determined at risk by neonatologists) in the national healthcare system, Costa Rica, January 2010-December 2014, were retrospectively reviewed. The numbers and percentages of infants with ROP, risk factors, percentage of patients treated and treatment outcomes were determined...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399534/retinopathy-of-prematurity-is-associated-with-increased-systolic-blood-pressure-in-adults-who-were-born-preterm
#9
Anna Kistner, Lena Jacobson, Jan Östergren, Ann Hellström
BACKGROUND: Adults born preterm are at risk of developing cardiovascular morbidities. OBJECTIVE: The aim of this study was to evaluate the relationship between retinopathy of prematurity (ROP) and blood pressure (BP) and salivary cortisol levels during adulthood. METHODS: Sixty-nine subjects (mean age 22.6 years) were included. Subjects were adults who were: (a) ex-preterm infants with severe ROP (n = 22), born at gestational age (GA) <30 weeks with a birth weight (BW) <1,000 g, (b) ex-preterm infants with no/mild ROP (n = 21), born at GA <28 weeks with a BW <1,000 g, or (c) full-term controls (n = 26)...
April 12, 2017: Neonatology
https://www.readbyqxmd.com/read/28398052/mechanistic-aspects-of-the-polymerization-of-lactide-using-a-highly-efficient-aluminum-iii-catalytic-system
#10
Carine Robert, Thibault E Schmid, Vincent Richard, Pierre Haquette, Sumesh K Raman, Marie-Noelle Rager, Régis M Gauvin, Yohann Morin, Xavier Trivelli, Vincent Guérineau, Iker Del Rosal, Laurent Maron, Christophe M Thomas
We report here a unique example of an in situ generated aluminum initiator stabilized by a C2-symmetric salen ligand which shows a hitherto unknown high activity for the ROP of rac-lactide at room temperature. Using a simple and robust catalyst system, which is prepared from a salen complex and an onium salt, this convenient route employs readily available reagents that afford polylactide in good yields with narrow polydispersity indices, without the need for time-consuming and expensive processes that are typically required for catalyst preparation and purification...
April 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28397983/high-yield-production-of-recombinant-crm197-a-non-toxic-mutant-of-diphtheria-toxin-in-the-periplasm-of-escherichia-coli
#11
Philippe Goffina, Marianne Dewerchin, Philippe De Rop, Normand Blais, Philippe Dehottay
A high cell density fed-batch process was developed for production of recombinant CRM197, a non-toxic mutant of diphtheria toxin widely used as a carrier in polysaccharide-protein conjugate vaccines. Fully soluble recombinant CRM197 was obtained in high yields and with an authentic N-terminus, by targeting the protein to the periplasm of Escherichia coli using the Signal Recognition Particle (SRP)-dependent signal sequence of FlgI. Response Surface Methodology was used to optimize the set-points of key process parameters (pH and feed rate at induction)...
April 11, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28395969/ultrasmall-polymeric-nanocarriers-for-drug-delivery-to-podocytes-in-kidney-glomerulus
#12
Riccardo Bruni, Paolo Possenti, Carlotta Bordignon, Min Li, Stefania Ordanini, Piergiorgio Messa, Maria Pia Rastaldi, Francesco Cellesi
We explored the use of new drug-loaded nanocarriers and their targeted delivery to the kidney glomerulus and in particular to podocytes, in order to overcome the failure of current therapeutic regimens in patients with proteinuric (i.e. abnormal amount of proteins in the urine) diseases. Podocytes are glomerular cells which are mainly responsible for glomerular filtration and are primarily or secondarily involved in chronic kidney diseases. Therefore, the possibility to utilise a podocyte-targeted drug delivery could represent a major breakthrough in kidney disease research, particularly in terms of dosage reduction and elimination of systemic side effects of current therapies...
April 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28395368/the-alteration-and-significance-of-erythropoietin-serum-levels-in-preterm-infants-with-retinopathy-of-prematurity
#13
Xiaofeng Yang, Bi Ze, Yi Dai, Li Zhu, Chao Chen
Objective This study aims to investigate the changes of serum erythropoietin (EPO) in premature infants with retinopathy of prematurity (ROP) after birth. Method The premature infants were divided into two groups, the first were infants with ROP, and the rest were infants without ROP. The peripheral blood of these infants after birth was collected, aiming to identify the correlation of serum EPO with ROP in the first 8 weeks after birth and before 38 weeks' postconceptual age. Results A total of 299 infants without ROP and 107 infants with ROP were recruited into our study...
April 10, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28393562/intravitreal-anti-vegf-treatment-for-retinopathy-of-prematurity-in-infants-with-active-adenoviral-keratoconjunctivitis
#14
Yusuf Koçluk, Emine Alyamaç Sukgen
PURPOSE: To evaluate the results of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) in infants with active adenoviral keratoconjunctivitis (AKC). MATERIAL AND METHODS: A retrospective analysis was performed using the medical records of all infants treated with intravitreal injections of anti-VEGF agents during an AKC outbreak previously reported in the literature at a tertiary center for treatment of ROP...
April 10, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28388642/association-of-maternal-hypertensive-disorders-with-retinopathy-of-prematurity-a-systematic-review-and-meta-analysis
#15
TingTing Zhu, Li Zhang, FengYan Zhao, Yi Qu, Dezhi Mu
BACKGROUD: The role of maternal hypertensive disorders in pregnancy (HDP) in the development of retinopathy of prematurity (ROP) is unclear. METHODS: Studies were retrieved through literature searches in PubMed, EMBASE, Web of Science and the Cochrane Library up to May 5, 2016 without language restrictions. Cohort or case-control studies that reported the association of maternal hypertensive disorders and retinopathy of prematurity were eligible. Either a fixed- or a random-effects model was used to calculate the overall combined risk estimates...
2017: PloS One
https://www.readbyqxmd.com/read/28385303/assessment-of-a-tele-education-system%C3%A2-to%C3%A2-enhance-retinopathy-of-prematurity-training-by-international-ophthalmologists-in-training-in-mexico
#16
Samir N Patel, Maria Ana Martinez-Castellanos, David Berrones-Medina, Ryan Swan, Michael C Ryan, Karyn E Jonas, Susan Ostmo, J Peter Campbell, Michael F Chiang, R V Paul Chan
PURPOSE: To evaluate a tele-education system developed to improve diagnostic competency in retinopathy of prematurity (ROP) by ophthalmologists-in-training in Mexico. DESIGN: Prospective, randomized cohort study. PARTICIPANTS: Fifty-eight ophthalmology residents and fellows from a training program in Mexico consented to participate. Twenty-nine of 58 trainees (50%) were randomized to the educational intervention (pretest, ROP tutorial, ROP educational chapters, and posttest), and 29 of 58 trainees (50%) were randomized to a control group (pretest and posttest only)...
April 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28385272/-retinopathy-of-prematurity
#17
REVIEW
V Promelle, S Milazzo
Retinopathy of prematurity is a retinal vasoproliferative disease affecting extremely preterm infants exposed to high concentrations of oxygen therapy. Infants born before 32 post-menstrual weeks or with a birth weight of less than 1500g should systematically have a dilated fundus examination. The time of screening and schedule for follow-up are guided by the various risk factors. This disease results from immaturity of the peripheral retinal vessels at the time of premature birth. The classification of ROP depends on the anteroposterior extent of involvement (from center to periphery: zone I, II and III), its extension in 30° sectors (clock hours) and its stage (stage 1 to 5)...
April 3, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28384113/the-5-minute-apgar-score-as-a-prognostic-factor-for-development-and-progression-of-retinopathy-of-prematurity
#18
Vasil G Marinov, Desislava N Koleva-Georgieva, Nelly P Sivkova, Maya B Krasteva
BACKGROUND: A low Apgar score at 5 minutes has been shown to be a risk factor for development of retinopathy of prematurity (ROP). AIM: To examine the prognostic value of Apgar score at 5 minutes for development and progression of ROP. MATERIALS AND METHODS: The study included 132 preterm infants who were screened from 4th week of life onward. Of these, 118 newborns were given Apgar score at 5 minutes. The prognostic significance of this index was studied as an absolute value and as a value ≤ 6...
March 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28383430/timing-of-surgical-ligation-and-morbidities-in-very-low-birth-weight-infants
#19
YoungAh Youn, Cheong-Jun Moon, Jae-Young Lee, Cheul Lee, In Kyung Sung
The present study examined whether early patent ductus arteriosus (PDA) surgical ligation at ≤2 weeks of life was associated with increased morbidities and mortality in very low birth weight infants (VLBWIs) who were diagnosed with hemodynamically significant (hs) PDA. Between December 2013 and December 2015, a total of 407 VLBWIs were admitted, of whom 145 (35.6%) infants were diagnosed with an hs PDA. The clinical data for these infants were retrospectively collected for analysis. Among the 145 VLBWIs with an hs PDA, 58 (40%) infants had surgical ligation for PDA; of these, 29 (50%) infants had early ligation (EL; ligation at ≤2 weeks of life) and 29 (50%) infants had late ligation (LL; ligation at ≥2 weeks of life)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28380099/the-vascularization-process-after-intravitreal-ranibizumab-injections-for-aggressive-posterior-retinopathy-of-prematurity
#20
Emine Alyamaç Sukgen, Yusuf Koçluk
Purpose: To evaluate the retinal vascularization process after intravitreal ranibizumab was administered to infants with aggressive posterior retinopathy of prematurity (AP-ROP). Methods: Twenty-six eyes of 13 infants with AP-ROP who received 0.25 mg intravitreal ranibizumab were retrospectively investigated. The patients were evaluated at weekly follow-up visits, and the findings were analyzed after retinal vascularization was complete. Results: The results showed regression in the AP-ROP of all the patients within the first 48-72 h...
January 2017: Arquivos Brasileiros de Oftalmologia
keyword
keyword
1283
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"