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https://www.readbyqxmd.com/read/28324112/recurrence-of-retinopathy-of-prematurity-after-intravitreal-ranibizumab-monotherapy-timing-and-risk-factors
#1
Jiao Lyu, Qi Zhang, Chun-Li Chen, Yu Xu, Xun-Da Ji, Jia-Kai Li, Qiu-Jing Huang, Pei-Quan Zhao
Purpose: To investigate timing and risk factors of recurrent retinopathy of prematurity (ROP) after intravitreal ranibizumab (IVR) monotherapy. Methods: Fifty eyes (the more severe eye) of 50 infants treated with IVR monotherapy for type 1 ROP were studied retrospectively. The mean follow-up time was 31 weeks after IVR. Recurrent ROP (recurrence of extraretinal fibrovascular proliferation [EFP]) was determined by RetCam wide-angle fundus imaging and binocular indirect ophthalmoscopy...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28317076/an-experimental-tool-to-estimate-the-probability-of-a-nucleotide-presence-in-the-crystal-structures-of-the-nucleotide-protein-complexes
#2
Maria Nemchinova, Vitaly Balobanov, Ekaterina Nikonova, Natalia Lekontseva, Alisa Mikhaylina, Svetlana Tishchenko, Alexey Nikulin
A correlation between the ligand-protein affinity and the identification of the ligand in the experimental electron density maps obtained by X-ray crystallography has been tested for a number of RNA-binding proteins. Bacterial translation regulators ProQ, TRAP, Rop, and Hfq together with their archaeal homologues SmAP have been used. The equilibrium dissociation constants for the N-methyl-anthraniloyl-labelled adenosine and guanosine monophosphates titrated by the proteins have been determined by the fluorescent anisotropy measurements...
March 20, 2017: Protein Journal
https://www.readbyqxmd.com/read/28315736/colorado-retinopathy-of-prematurity-screening-algorithm-co-rop-a-validation-study-at-a-tertiary-care-center
#3
Jason M Huang, Xihui Lin, Yu-Guang He, Jennifer H Cao
PURPOSE: The Colorado Retinopathy of Prematurity Screening Algorithm (CO-ROP) recommends screening for infants meeting the following criteria for retinopathy of prematurity (ROP): gestational age ≤30 weeks, birth weight of ≤1500 g, and net weight gain of ≤650 g between birth and 4 weeks of age. This study was performed to evaluate the validity of CO-ROP in a tertiary referral county hospital. METHODS: CO-ROP was used to retrospectively analyze the data from consecutive newborns screened for ROP using national screening guidelines at Parkland Hospital, Dallas, Texas, between April 1, 2009, to August 30, 2013...
March 15, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28314794/the-microtubule-associated-protein-map18-affects-rop2-gtpase-activity-during-root-hair-growth
#4
Erfang Kang, Mingzhi Zheng, Yan Zhang, Ming Yuan, Shaul Yalovsky, Lei Zhu, Ying Fu
Establishment and maintenance of the polar site are important for root hair tip growth. We previously reported that Arabidopsis (Arabidopsis thaliana) MICROTUBULE-ASSOCIATED PROTEIN18 (MAP18) functions in controlling the direction of pollen tube growth and root hair elongation. Additionally, the Rop GTPase ROP2 was reported as a positive regulator of both root hair initiation and tip growth in Arabidopsis. Both loss-of-function of ROP2 or knock-down of MAP18 leads to a decrease in root hair length, whereas overexpression of either MAP18 or ROP2 causes multiple tips or a branching hair phenotype...
March 17, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28304327/retinopathy-of-prematurity-in-indonesia-incidence-and-risk-factors
#5
J Edy Siswanto, P Jj Sauer
BACKGROUND: Retinopathy of prematurity (ROP) is a vaso-proliferative disease of the eye, which mainly affects preterm newborn infants with an incompletely vascularized retina. The incidence of ROP has increased in industrialized countries due to the increased survival of extremely low birth weight (ELBW) infants. ROP is also increasing in developing countries like Indonesia, where it is most likely due to the improved survival of ELBW infants. OBJECTIVE: To ascertain the incidence of ROP and possible risk factors associated with the development of ROP in preterm infants in Indonesia...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28303934/redox-sensing-regulator-rex-regulates-aerobic-metabolism-morphological-differentiation-and-avermectin-production-in-streptomyces-avermitilis
#6
Xingchao Liu, Yaqing Cheng, Mengya Lyu, Ying Wen, Yuan Song, Zhi Chen, Jilun Li
The regulatory role of redox-sensing regulator Rex was investigated in Streptomyces avermitilis. Eleven genes/operons were demonstrated to be directly regulated by Rex; these genes/operons are involved in aerobic metabolism, morphological differentiation, and secondary metabolism. Rex represses transcription of target genes/operons by binding to Rex operator (ROP) sequences in the promoter regions. NADH reduces DNA-binding activity of Rex to target promoters, while NAD(+) competitively binds to Rex and modulates its DNA-binding activity...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303270/high-level-potential-energy-surface-and-mechanism-of-al-ch3-2och3-promoted-lactone-polymerization-initiation-and-propagation
#7
Stefan Vogt-Geisse, Ricardo A Mata, Alejandro Toro-Labbé
Despite increasing experimental interest in aliphatic polyesters as biodegradable and bioassimilable polymers a theoretical description of ring-opening polymerization (ROP) is not yet fully established. We report a detailed theoretical account of the mechanism of the ROP of three lactones (glycolide, 1,5-dioxepan-2-one and ε-caprolactone) using dimethylaluminium methoxide (Al(CH3)2OCH3) as the initiator. Both the initiation and propagation steps of the ROP are investigated using a composite method consisting of explicitly correlated Moller-Plesset (DF-MP2-F12) and explicitly correlated local coupled cluster methods (DF-LCCSD(T)-F12), for an accurate and definitive determination of the transition state and intermediate electronic energies...
March 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28298861/retinopathy-of-prematurity-revisiting-incidence-and-risk-factors-from-oman-compared-to-other-countries
#8
Zenaida Soriano Reyes, Sharef Waadallah Al-Mulaabed, Flordeliz Bataclan, Cheryl Montemayor, Anuradha Ganesh, Sanaa Al-Zuhaibi, Huda Al-Waili, Fatma Al-Wahibi
PURPOSE: The purpose of this study is to determine the incidence of retinopathy of prematurity (ROP) and the maternal/neonatal risk factors at a tertiary care hospital in Oman, compared to other countries. PATIENTS AND METHODS: A retrospective analysis of premature neonates born with gestational age (GA) 24-32 weeks at Sultan Qaboos University Hospital, Oman, from January 2007 to December 2010. Maternal and neonatal in-hospital course was retrieved. The incidence of ROP was reported...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28298858/mobile-unit-for-retinopathy-of-prematurity-screening-and-management-at-urban-neonatal-intensive-care-units-outcomes-and-impact-assessment
#9
Jai Kelkar, Supriya Agashe, Aditya Kelkar, Rajiv Khandekar
PURPOSE: To study the outcomes and impact of a mobile unit for retinopathy of prematurity (ROP) screening and management at urban Neonatal Intensive Care Units (NICUs). STUDY DESIGN: Public health intervention study. METHODS: This study was conducted in 2012. Staff of a mobile unit assessed all infants aged 32 weeks or less and/or weight 1250 g or less admitted in five NICUs between 2009 and 2011. An ophthalmologist performed bedside ROP screening through dilated pupils using indirect ophthalmoscopy...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28297342/in-house-quality-check-of-external-beam-plans-using-3d-treatment-planning-systems-a-dvh-comparison
#10
Ayyalasomayajula Anil Kumar, Roopa Rani Akula, Komanduri Ayyangar, Reddy P Krishna, Srinivas Vuppu, P V Lakshmi Narayana, A Durga Prasada Rao
This paper presents a new approach towards the quality assurance of external beam plans using in-house-developed DICOM import and export software in a clinical setup. The new approach is different from what is currently used in most clinics, viz., only MU and point dose are verified. The DICOM-RT software generates ASCII files to import/export structure sets, treatment beam data, and dose-volume histograms (DVH) from one treatment planning system (TPS) to the other. An efficient and reliable 3D planning system, ROPS, was used for verifying the accuracy of treatment plans and treatment plan parameters...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297039/reactivation-of-retinopathy-of-prematurity-three-years-after-treatment-with-bevacizumab
#11
Amir R Hajrasouliha, Jose M Garcia-Gonzales, Michael J Shapiro, Hawke Yoon, Michael P Blair
Although intravitreal injection of anti-vascular endothelial growth factor agents (IVA) can induce rapid regression of retinopathy of prematurity (ROP), late reactivation of the ROP can occur in the form of tractional retinal detachment (TRD) from contracted recurrent extraretinal fibrovascular proliferation. The authors report a case of bilateral TRD for recurrent ROP in a 3-year-old, which is the latest-reported reactivation to date. The authors propose that persistent avascular retina in eyes that have undergone IVA for ROP receive laser ablation to prevent late recurrences...
March 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28288915/investigation-of-the-effect-of-hemoglobin-f-and-a-levels-on-development-of-retinopathy-of-prematurity
#12
Hidayet Erdöl, Dilek Hacioglu, Mehmet Kola, Adem Türk, Yakup Aslan
PURPOSE: To investigate the effect of hemoglobin F (HbF) and hemoglobin A (HbA) levels on development of retinopathy of prematurity (ROP) in premature infants. METHODS: In this prospective study, blood samples were collected from the side of the heel of 49 premature infants at postnatal months 0, 1, 2, and 3. HbF and HbA levels were measured in all samples and analyzed statistically. Furthermore, correlation analysis was performed regarding development of ROP, blood transfusion, and HbF and HbA levels...
March 10, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28282150/ph-responsive-peptide-supramolecular-hydrogels-with-antibacterial-activity
#13
Yaoming Wan, Libing Liu, Shuaishuai Yuan, Jing Sun, Zhibo Li
Smart hydrogels have received increasing attention for many applications. Here, we synthesized a class of cationic peptide amphiphiles that can self-assemble into hydrogels by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of cationic lysine residues suppress the formation of fibril-like structure and further the gelation ability of the samples. Sodium alginate (SA) is used to enhance the rheology performance of the hydrogels. The hydrogels exhibit pH-dependent self-assembling and the gelation behaviour that enables them ideal smart hydrogel system for biomedical applications...
March 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28281426/the-efficacy-of-intravitreal-antivascular-endothelial-growth-factor-as-primary-treatment-of-retinopathy-of-prematurity-experience-from-a-tertiary-hospital
#14
H Kana, I Mayet, D Soma, H Dawood Alli, S Biddulph
BACKGROUND: Retinopathy of prematurity (ROP) is a vasoproliferative disease affecting premature babies and a major cause of blindness in childhood. Appropriate screening and treatment can prevent blindness. OBJECTIVE: To report on the efficacy of using antivascular endothelial growth factor (bevacizumab) as first-line therapy in ROP. METHODS: This was a retrospective analysis of patients with ROP treated at St John Eye Hospital, Johannesburg, South Africa, over a 3-year period...
February 27, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28277877/results-of-intravitreal-ranibizumab-treatment-for-retinopathy-of-prematurity-in-infants
#15
Emine Alyamaç Sukgen, Yusuf Koçluk
PURPOSE: To assess the results of intravitreal ranibizumab treatment for retinopathy of prematurity (ROP) in infants. METHODS: A single-institution, retrospective consecutive case series. RESULTS: Thirty-one patients who received ranibizumab treatment for ROP were evaluated in this study. The mean follow-up time was 14 ± 1.37 months. Vascularization of the peripheral retina had completed with delay in the majority of cases and also avascular areas were present in the peripheral retinas of five infants at one year of age...
March 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28274943/functional-analysis-and-associated-factors-of-the-peripapillary-retinal-nerve-fibre-layer-in-former-preterm-and-full-term-infants
#16
Achim Fieß, Luka Christian, Johannes Janz, Ruth Kölb-Keerl, Markus Knuf, Bernd Kirchhof, Philipp S Muether, Jacqueline Bauer
PURPOSE: The aim of the study was to investigate peripapillary retinal nerve fibre layer thickness (RNFLT) in former preterm infants and full-term neonates using spectral-domain optical coherence tomography (SD-OCT). METHODS: The prospective, controlled, cross-sectional, hospital-based study in a tertiary centre with maximum care examined 503 infants with a former gestational age (GA) of ≥37 and ≤32 weeks now aged between 4 and 10 years. In total, we analysed 432 participants with successful circular peripapillary RNFLT OCT measurements...
March 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28272877/enantioselective-ring-opening-polymerization-of-rac-lactide-dictated-by-densely-substituted-aminoacids
#17
Ana Sanchez-Sanchez, Iván Rivilla, Maddalen Agirre, Andere Basterretxea, Agustin Etxeberria, Antonio Veloso, Haritz Sardón, David Mecerreyes, Fernando P Cossio
Although organometallic catalysts have shown great ability to promote stereocontrolled polymerization reactions, their substantial toxicity and other drawbacks are accelerating the development of organic catalysts. To date, organic catalysts have demonstrated some ability to promote stereocontrolled polymerizations. However, none of them has been able to promote different stereochemical outcomes depending on the chirality of the organic catalyst. In this work we report for the first time the chirality transfer from catalyst to polymer in the ring-opening polymerization (ROP) of rac-lactide (rac-LA)...
March 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28270489/international-variations-and-trends-in-the-treatment-for-retinopathy-of-prematurity
#18
Brian A Darlow, Kei Lui, Satoshi Kusuda, Brian Reichman, Stellan Håkansson, Dirk Bassler, Neena Modi, Shoo K Lee, Liisa Lehtonen, Maximo Vento, Tetsuya Isayama, Gunnar Sjörs, Kjell K Helenius, Mark Adams, Franca Rusconi, Naho Morisaki, Prakesh S Shah
OBJECTIVE: To compare the rates of retinopathy of prematurity (ROP) and treatment of ROP by laser or intravitreal anti-vascular endothelial growth factor among preterm neonates from high-income countries participating in the International Network for Evaluating Outcomes (iNeo) of neonates. METHODS: A retrospective cohort study was conducted on extremely preterm infants weighing <1500 g at 24(0) to 27(6) weeks' gestation who were admitted to neonatal units in Australia/New Zealand, Canada, Finland, Israel, Japan, Spain, Sweden, Switzerland, Tuscany (Italy) and the UK between 2007 and 2013...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28268567/toward-a-severity-index-for-rop-an-unsupervised-approach
#19
Peng Tian, Esra Ataer-Cansizoglu, Jayashree Kalpathy-Cramer, Susan Ostmo, Karyn Jonas, R V Paul Chan, J Peter Campbell, Michael F Chiang, Deniz Erdogmus
Retinopathy of prematurity (ROP) is a disease affecting low birth-weight infants and is the major cause of childhood blindness. Although accurate diagnosis is important, there is a high variability among expert decisions mostly due to subjective thresholds. Existing work focused on automated diagnosis of ROP. In this study, we construct a continuous severity index as an alternative to discrete classification. We follow an unsupervised approach by performing nonlinear dimensionality reduction. Instead of extracting several statistics of image features, each image is represented by the probability distribution of its features...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267322/stereorigid-osso-type-group-4-metal-complexes-in-the-ring-opening-polymerization-of-rac-lactide
#20
Rosita Lapenta, Antonio Buonerba, Assunta De Nisi, Magda Monari, Alfonso Grassi, Stefano Milione, Carmine Capacchione
The synthesis and characterization of a series of group 4 metal complexes of general formula {OSSOX}M(OR)2 (X = R = (t)Bu, M = Zr (1); X = cumyl, M = Zr, R = (t)Bu (2); X = cumyl, M = Ti, R = (i)Pr (4); X = cumyl, M = Hf, R = (t)Bu (5)) and {OSSOX}2Zr (X = Cl (3)) supported by o-phenylene-bridged bis(phenolato) ligands (OSSOtBu-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-di-tert-butyphenol); OSSOCum-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-bis(2-phenylpropan-2-yl)phenol); OSSOCl-H = 6,6'-((1,2-phenylenebis(sulfanediyl))bis(methylene))bis(2,4-dichlorophenol)) are described herein...
March 7, 2017: Inorganic Chemistry
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