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Emily A McCourt, Gui-Shuang Ying, Anne M Lynch, Alan G Palestine, Brandie D Wagner, Erica Wymore, Lauren A Tomlinson, Gil Binenbaum
Importance: The Colorado Retinopathy of Prematurity (CO-ROP) model uses birth weight, gestational age, and weight gain at the first month of life (WG-28) to predict risk of severe retinopathy of prematurity (ROP). In previous validation studies, the model performed very well, predicting virtually all cases of severe ROP and potentially reducing the number of infants who need ROP examinations, warranting validation in a larger, more diverse population. Objective: To validate the performance of the CO-ROP model in a large multicenter cohort...
March 15, 2018: JAMA Ophthalmology
A V Tereshchenko, Yu A Belyy, Yu A Sidorova, I G Trifanenkova, M S Tereshchenkova, Yu A Yudina
AIM: to develop the methodology of early primary vitrectomy for aggressive posterior retinopathy of prematurity. MATERIAL AND METHODS: The study included 10 preterm infants (20 eyes; gestational term - 26-30 weeks, post-conceptual age - 34-39 weeks) with severe forms of aggressive posterior retinopathy of prematurity (AP-ROP). All patients underwent a complex ophthalmic examination. Their results were compared with retrospective data of earlier treated AP-ROP patients (10 preterm infants, 20 eyes), in whom laser photocoagulation (LC) was done first (gestational period at the time of LC ranged from 26 to 30 weeks, post-conceptual age - from 34 to 39 weeks)...
2018: Vestnik Oftalmologii
O A Konikova, V V Brzhesky
Visual impairment in children with regressive retinopathy of prematurity (ROP) are diverse and widespread. PURPOSE: to describe the electrophysiological characteristics of the retina in children with I-V stages of regressive ROP. MATERIAL AND METHODS: The study included children with stages I-V aged 5 to 17 (in the disease stages of IV and V - with reattachment of the retina after surgical treatment of its detachment). Patients with concomitant diseases of the eye were excluded from the study...
2018: Vestnik Oftalmologii
Seyhan Dikci, Osman Melih Ceylan, Soner Demirel, Turgut Yılmaz
PURPOSE: To compare 0.5 mg and 0.625 mg of bevacizumab for treating aggressive posterior retinopathy of prematurity (AP-ROP). METHODS: The medical records of patients with AP-ROP who were administered intravitreal bevacizumab (IVB) as a primary treatment at a university clinic were evaluated retrospectively. Five eyes of three patients (Group 1) who received 0.625 mg/0.025 ml IVB and 10 eyes of another five patients (Group 2) who received 0.5 mg/0.02 ml IVB were evaluated...
January 2018: Arquivos Brasileiros de Oftalmologia
Ma Rong, Sun Hui, Yan Ge, Wei Qing-Kuan
At present, there are no ideal drugs and measures in the treatment and prevention of toxoplasmosis. The development of safe, convenient, and strong protective nucleic acid vaccine is an important strategy for prevention and control of toxoplasmosis. The rhoptry protein (ROP) is a large class of proteins secreted by Toxoplasma gondii . ROPs play an important role in the invasion of host cells, the formation of parsitophorous vacuole (PV) and the regulation of proliferation by T. gondii . Thus, ROPs become the most promising candidates of vaccine...
February 12, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Diego Ossandón, Mario Zanolli, Ricardo Stevenson, Ricardo Agurto, Paula Ortiz, Gad Dotan
PURPOSE: To report the results of retinopathy of prematurity (ROP) screening by a telemedicine system in Chile and evaluate its usefulness for referring patients who require treatment. METHODS: Premature infants at risk of developing ROP from 11 neonatal intensive care units were included. Screening was performed on all infants born at a gestational age of <32 weeks and/or birth weight of <1500 g. A trained nonphysician operator used an imaging system to capture retinal images, which were reviewed by two independent ROP experts...
March 10, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Achim Fieß, Ruth Kölb-Keerl, Alexander K Schuster, Markus Knuf, Bernd Kirchhof, Philipp S Muether, Jacqueline Bauer
PURPOSE: The objective of this study was to investigate the relationship between visual acuity, peripapillary retinal nerve fibre layer (pRNFL), retinal thickness at the fovea and other factors with the neurologic status of former preterm children. METHODS: In this cross-sectional hospital based study in a maximum care tertiary centre, detailed anthropometric and ophthalmological data of former preterm children ranging from 4 to 10 years of age with a gestational age (GA) ≤32 weeks were assessed...
March 9, 2018: Acta Ophthalmologica
Ahmet Yagmur Bas, Nihal Demirel, Esin Koc, Dilek Ulubas Isik, İbrahim Murat Hirfanoglu, Turan Tunc
BACKGROUND: To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. METHODS: A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)≤1500 g or gestational age (GA)≤32 weeks and those with a BW>1500 g or GA>32 weeks with an unstable clinical course were included in the study...
March 8, 2018: British Journal of Ophthalmology
Mohammad Haekal, Hidetaka Arimura, Taka-Aki Hirose, Yusuke Shibayama, Saiji Ohga, Junichi Fukunaga, Yoshiyuki Umezu, Hiroshi Honda, Tomonari Sasaki
PURPOSE: To analyze the uncertainties of the rectum due to anisotropic shape variations by using a statistical point distribution model (PDM). MATERIALS AND METHODS: The PDM was applied to the rectum contours that were delineated on planning computed tomography (CT) and cone-beam CT (CBCT) at 80 fractions of 11 patients. The standard deviations (SDs) of systematic and random errors of the shape variations of the whole rectum and the region in which the rectum overlapped with the PTV (ROP regions) were derived from the PDMs at all fractions of each patient...
February 2018: Physica Medica: PM
P P Larsen, M-C Bründer, M Petrak, V Jehle, W A Lagrèze, F G Holz, A Stahl, T U Krohne
BACKGROUND: The number of preterm births in Germany has been increasing continuously over the past decades. Retinopathy of prematurity (ROP) is a major complication of preterm birth and one of the leading causes of blindness in children. OBJECTIVES: This study analyzes the development of the incidence of ROP over the past 5 years at two German university hospitals, utilizing data from ROP screening examinations. MATERIAL AND METHODS: We assessed all children born in the years 2012-2016 who were included in the ROP screening program at two German university hospitals according to the criteria of the German ROP screening guidelines...
March 2, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Siree Kaempfen, Roland P Neumann, Kerstin Jost, Sven M Schulzke
BACKGROUND: Retinopathy of prematurity (ROP) is a vision-threatening disease of preterm neonates. The use of beta-adrenergic blocking agents (beta-blockers), which modulate the vasoproliferative retinal process, may reduce the progression of ROP or even reverse established ROP. OBJECTIVES: To determine the effect of beta-blockers on short-term structural outcomes, long-term functional outcomes, and the need for additional treatment, when used either as prophylaxis in preterm infants without ROP, stage 1 ROP (zone I), or stage 2 ROP (zone II) without plus disease or as treatment in preterm infants with at least prethreshold ROP...
March 2, 2018: Cochrane Database of Systematic Reviews
Changjuan Chen, Jinxing Jiang, Xiaoyang Mao, Yong Cong, Yaqin Cui, Xiaobo Pan, Jincai Wu
Three potassium crown ether complexes supported with bulky amidinate ligands were synthesized for the ring-opening polymerization (ROP) of rac-lactide. The side polymerization reaction initiated directly by ligand anion was suppressed well in the presence of alcohol as our design, and the synthesis of linear polylactide with a molecular weight as high as 117.7 kg/mol was successful together with an isoselectivity value of Pm = 0.88 at -70 °C. In this system, lactide can be deprotonated by amidinate anion to give lactide enolate, which can initiate the ROP of lactide as a side reaction in the absence of alcohol; however, this side reaction can also be suppressed well in the presence of alcohol by a decrease in temperature...
March 1, 2018: Inorganic Chemistry
Lynn Calvin Shaw, Sergio Li Calzi, Nan Li, Leni Moldovan, Nilanjana Sengupta-Caballero, Judith Lindsey Quigley, Mircea Ivan, Bokkyoo Jun, Nicolas G Bazan, Michael Edwin Boulton, Julia Busik, Josef Neu, Maria B Grant
Purpose: Low levels of the long chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA) have been implicated in retinopathy of prematurity (ROP). However, oral DHA suffers from poor palatability and is associated with increased bleeding in premature infants. We asked whether oral administration of the neutraceutical arginine-glutamine (Arg-Glu) could increase retinal DHA and improve outcomes in a mouse model of oxygen-induced retinopathy (OIR). Methods: Postnatal day 7 (P7) pups were maintained at 75% oxygen for 5 days and then returned to room air on P12...
February 1, 2018: Investigative Ophthalmology & Visual Science
İkbal Seza Petriçli, Caner Kara, Nihal Demirel, Dilek Ulubaş Işık, Ahmet Yağmur Baş
Background/aim: This study aimed to compare the incidence of any stage of retinopathy of prematurity (ROP) and type 1 ROP between extremely preterm multiple- and single-birth infants. Materials and methods: In this retrospective study, we included extremely preterm infants who were ≤27 weeks of gestational age at birth. The screened infants were divided into two groups: single and multiple births. The incidence of any stage of ROP and type 1 ROP was compared between the groups. Results: This study included 301 infants; 225 were in the single-birth group and 76 were in multiple-birth group...
February 23, 2018: Turkish Journal of Medical Sciences
Ebtihal Ali, Nasser Al-Shafouri, Abrar Hussain, R John Baier
Objective: Developing less invasive methods for early detection of retinopathy of prematurity (ROP) is vital to minimizing blindness in premature infants. Lofqvist and colleagues developed a computer-based ROP risk algorithm (WINROP) (, which detects downtrends in postnatal weight gain that correlate with the development of sight-threatening ROP. The aim of this study is to investigate the sensitivity and specificity of the WINROP algorithm to detect vision-threatening ROP...
July 2017: Paediatrics & Child Health
Josie M Rudolphi, Shelly Campo, Fred Gerr, Diane S Rohlman
PURPOSE: Tractor-related incidents are the leading cause of agricultural-related fatalities in the United States. Injuries from rollovers can be prevented by equipping tractors with rollover protective structures (ROPS, an engineering approach) and by using seatbelts (a behavior-based approach). While adult farmers report low seatbelt use and frequent use of tractors without ROPS, it is unknown whether the young adult population has adopted similar tractor driving practices. This study was designed to identify tractor operating practices among young adult agricultural workers and the influence of supervisors, peers, and parents on their safety behaviors...
February 22, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Nahideh Asadi, Nasim Annabi, Ebrahim Mostafavi, Maryam Anzabi, Rovshan Khalilov, Siamak Saghfi, Masoud Mehrizadeh, Abolfazl Akbarzadeh
Magnetic nanoparticles have properties that cause to apply them in cancer therapy and vehicles for the delivery of drugs such as 5FU, especially when they are modified with biocompatible copolymers. The aim of this study is to modify superparamagnetic iron oxide nanoparticles (SPIONPs) with PCL-PEG-PCL copolymers and then utilization of these nanoparticles for encapsulation of anticancer drug 5FU. The ring-opening polymerization (ROP) was used for the synthesis of PCL-PEG-PCL copolymer by ε-caprolactone (PCL) and polyethylene glycol (PEG2000)...
February 22, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Peng Wang, Jianbin Chao, Xia Chen
A series of β-quinolyl-enamino aluminium complexes [AlLMe2 ] 1-7 {L = [(2-C9 H6 N)-CH[double bond, length as m-dash]C(4-MeC6 H4 )-N(Ar)-], Ar = C6 H5 (1), 4-FC6 H4 (2), 3,4,5-F3 C6 H2 (3), C6 F5 (4), 5-t BuC6 H4 (5), 2,6-Me2 C6 H3 (6), and 2,6-i Pr2 C6 H3 (7)} were synthesized by the reaction of AlMe3 with the corresponding β-quinolyl-enamine ligands. All the complexes were characterized by1 H and13 C NMR spectroscopy and elemental analysis. The molecular structures of complexes 1-3 and 7 were confirmed by single-crystal X-ray diffraction, which revealed that all the Al atoms adopt a distorted tetrahedral geometry...
February 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Zora Lasabova, Andrea Stanclova, Marian Grendar, Silvia Mikolajcikova, Andrea Calkovska, Nina Lenhartova, Peter Ziak, Katarina Matasova, Martin Caprnda, Peter Kruzliak, Mirko Zibolen
BACKGROUND: Retinopathy of prematurity (ROP) is a multifactorial disease occurring in preterm neonates, caused by incorrect development of retinal blood vessels. It has been suggested that, in addition to gestational age, weight, and oxygen supplementation, genetic factors can play a role in the pathogenesis of ROP. METHODS: In the present prospective study, 97 neonates were enrolled based on the gestational age and weight, and genomic DNA from patients diagnosed with ROP and premature newborns without ROP was collected...
February 21, 2018: Ophthalmic Genetics
Hee Young Kim, Seung-Hoon Baek, Seong Wan Baik, Sun Sik Bae, Jung Min Ha, Minkyoung Kim, Gyeong-Jo Byeon, Hye Jin Kim, Hyun-Su Ri, So Hyun Kim
BACKGROUND: Sevoflurane is commonly used in general anesthesia for premature neonates. The main mechanism of retinopathy of prematurity (ROP) is increased levels of vascular endothelial growth factor (VEGF). For the investigation of sevoflurane's effect on angiogenesis, the angiogenesis and VEGF expression in the retina were measured after administering sevoflurane in an oxygen-induced retinopathy mice model. MATERIALS AND METHODS: The mice were divided into the normoxic group (Nc and Ns group; n = 6) and the ROP group (C, Rc, and Rs group; n = 6)...
February 20, 2018: Journal of Anesthesia
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