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https://www.readbyqxmd.com/read/29140592/a-versatile-strategy-to-main-chain-sulfur-selenium-functionalized-polycarbonates-via-macro-ring-closure-of-diols-and-subsequent-ring-opening-polymerization
#1
Chao Wei, Yan Zhang, Bingkun Yan, Yue Xu, Zhengzhen Du, Meidong Lang
Sulfur/selenium containing cyclic carbonate monomers (MR) are designed and synthesized by enzyme catalyzed intermolecular macro-ring closure of related diols. The proposed synthetic strategy is tolerant of other functionalities such as N-substituted groups. The ring opening polymerization (ROP) of MR occurs readily as a versatile route to generate a new family of main chain sulfur/selenium substituted aliphatic polycarbonates (PR) with predictable molecular weights (MW), narrow molecular-weight distribution and controlled copolymer composition...
November 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29137074/refractive-state-and-optical-compositions-of-preterm-children-with-and-without-retinopathy-of-prematurity-in-the-first-6-years-of-life
#2
Xiaohui Zhu, Rulian Zhao, Yang Wang, Lijuan Ouyang, Jing Yang, Yong Li, Lianhong Pi
This study aimed to investigate the refractive state and optical compositions of preterm children with and without mild retinopathy of prematurity (ROP) and explore the influence of prematurity and mild ROP on the development of refractive state and optical compositions.Preterm children who received fundus screening were recruited, and divided into ROP group and non-ROP group. Term children matched in age were also recruited as controls. Several correspondence indicators were measured before and after ciliary muscle paralysis with 1% cyclopentanone...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135357/short-term-refractive-effects-of-propranolol-hydrochloride-prophylaxis-on-retinopathy-of-prematurity-in-very-preterm-newborns
#3
Levent Korkmaz, Cagatay Karaca, Mustafa Ali Akin, Osman Bastug, Mustafa Sahiner, Ahmet Ozdemir, Tamer Gunes, Mehmet Adnan Ozturk, Selim Kurtoglu
PURPOSE: Retinopathy of prematurity (ROP) is one of the major problems of surviving premature infants with several ophthalmic morbidities such as increased risk of refractive errors, strabismus, and cortical visual impairment. Use of propranolol hydrochloride (PH) for the prevention of ROP is a new promising treatment modality. However, long-term effects are still to be defined. In our study, we aimed to investigate the short-term refractive effects of PH used for ROP prophylaxis in very preterm newborns...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29131921/hot-topics-in-retinopathy-of-prematurity
#4
Irena Tsui, Alison Chu
Retinopathy of prematurity (ROP) is a condition seen in premature infants that is characterized by abnormal retinal blood vessel growth incited by relative hyperoxia and followed by hypoxia. It can have severe consequences ranging from high myopia to blindness. This article reviews recent "hot" topics related to ROP, specifically the changing incidence of ROP worldwide, the advent of predictive algorithms for screening for ROP, the emerging data behind efficacy of anti-vascular endothelial growth factor treatments for ROP, and advanced retinal imaging in children who were born premature...
November 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29118491/retinopathy-of-prematurity-like-retinopathy-in-full-term-infants
#5
Dhanashree Ratra, Lala Akhundova, Manmath Kumar Das
PURPOSE: The purpose of this study is to assess clinical characteristics, risk factors, and management outcomes of retinal changes similar to retinopathy of prematurity (ROP), seen in full-term infants. PATIENTS AND METHODS: This is a retrospective review of 46 eyes of 23 patients, born at full term or near full term and diagnosed to have active ROP-like retinopathy or sequelae of ROP-like retinopathy. RESULTS: Mean birth weight (BW) and gestational age (GA) were 2342 ± 923 g (range, 1200-4160 g) and 38...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29112152/yarrowia-lipolytica-extracellular-lipase-lip2-as-biocatalyst-for-the-ring-opening-polymerization-of-%C3%AE%C2%B5-caprolactone
#6
Karla A Barrera-Rivera, Antonio Martínez-Richa
Yarrowia lipolytica (YL) is a "non-conventional" yeast that is capable of producing important metabolites. One of the most important products that is secreted by this microorganism is lipase, a ubiquitous enzyme that has considerable industrial potential and can be used as a biocatalyst in the pharmaceutical, food, and environmental industries. In this work, Yarrowia lipolytica lipase (YLL) was immobilized on Lewatit and Amberlite beads and is used in the enzymatic ring-opening polymerization (ROP) of cyclic esters in the presence of different organic solvents...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29109051/ajo-centennial-evolving-concepts-in-the-management-of-retinopathy-of-prematurity
#7
Paul Sternberg, Alia K Durrani
PURPOSE: The introduction of anti-vascular endothelial growth factor (VEGF) agents has stimulated considerable reexamination of treatment strategies for the management of retinopathy of prematurity (ROP). Herein we will summarize and review evolving concepts and provide a personal perspective on clinical management today and future directions of treatment. DESIGN: Literature Review METHODS: To synthesize the evolving management concepts for diagnosis and treatment of retinopathy of prematurity and to provide interpretation and perspective on current emerging therapies...
November 3, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29106986/intraperitoneal-administration-of-a-novel-chimeric-immunogen-rop-elicits-ifn-%C3%AE-and-il-12p70-protective-immune-response-in-balb-c-mice-against-virulent-brucella
#8
Ganesh Tadepalli, Balakrishna Konduru, Harishchandra Sripathy Murali, Harsh Vardhan Batra
Recombinant engineering of immunologically active chimeric protein consisting of Omp19 and P39 domains of B. abortus (rOP), was purified under denaturing conditions upon expression in E. coli BL21 (DE3) and refolded to dynamic form. The immuno-protective efficacy of rOP was evaluated by challenging the BALB/c mice intraperitoneally (I.P) with the infective species of Brucella in the absence or presence of adjuvants, such as Aluminum hydroxide gel (Al), or Freund's Complete Adjuvant (FCA)/Incomplete Freund's Adjuvant (IFA)...
October 26, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29104139/retinal-vascular-changes-in-preterm-infants-heart-and-lung-diseases-and-plus-disease
#9
Andrea Elizabeth Arriola-Lopez, M Elena Martinez-Perez, Maria Ana Martinez-Castellanos
PURPOSE: To report the retinal vascular features of preterm infants with congenial heart disease (CHD), lung disease (pulmonary hypertension [PH] and bronchopulmonary dysplasia [BPD]), and ROP with plus disease to determine whether these disease entities are distinguishable on the basis of retinal morphology. METHODS: The medical records of preterm infants with CHD, lung disease, and ROP with plus disease were reviewed retrospectively. Qualitative vascular findings were validated using computer-based software to analyze 25 representative images, each corresponding to one infant's eye...
November 2, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29103792/foveal-development-in-infants-treated-with-bevacizumab-or-laser-photocoagulation-for-retinopathy-of-prematurity
#10
Ryan N Vogel, Margaret Strampe, Oladipo E Fagbemi, Alexis Visotcky, Sergey Tarima, Joseph Carroll, Deborah M Costakos
PURPOSE: To characterize and quantify early foveal development in preterm infants and to compare this development between eyes treated with intravitreal bevacizumab or laser photocoagulation (LPC) and untreated eyes. DESIGN: Observational case series. PARTICIPANTS: One hundred thirty-one preterm infants undergoing retinopathy of prematurity (ROP) screenings. METHODS: Handheld OCT imaging was performed longitudinally on all patients...
November 2, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29100330/protective-cellular-immunity-generated-by-cross-presenting-recombinant-overlapping-peptide-proteins
#11
Lili Cai, Jianbo Zhang, Renying Zhu, Weixing Shi, Xiaobing Xia, Mark Edwards, William Finch, Anthony Coombs, Ju Gao, Kangwen Chen, Sophie Owen, Shisong Jiang, Wenshu Lu
Priming of naive CD8(+) and CD4(+) T cells by dendritic cells (DCs) requires effective antigen presentation on both MHC class I and II molecules. We have developed a novel technology to use recombinant overlapping peptides (ROP) that stimulate both CD8(+) and CD4(+) T cell immune responses. The single chain protein of a ROP is made up of overlapping peptides linked by the target sequence (LRMK) for cathepsin S, a protease found in the endosomes of DCs. We designed synthetic genes encoding ROPs derived from ovalbumin (OVA), tuberculosis protein (CFP10-ESAT6), human papilloma virus (HPV) protein (E7) and survivin, a protein commonly over-expressed in tumour cells...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098279/posterior-pole-vascular-changes-before-treatment-of-retinopathy-of-prematurity
#12
S Grace Prakalapakorn, David K Wallace, Sharon F Freedman
Importance: Some proponents of telemedicine screening for retinopathy of prematurity (ROP) believe that a screening system based on the characteristics of posterior pole vessels is sufficient for identifying infants needing treatment. Objective: To evaluate the vascular characteristics present when treatment was determined to be needed and the number of days from the last examination when the vessels of both eyes were noted to be normal until a decision was made to treat...
November 2, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29095432/pregnancy-induced-hypertension-and-neonatal-outcomes-a-systematic-review-and-meta-analysis
#13
A Razak, A Florendo-Chin, L Banfield, M G Abdul Wahab, S McDonald, P S Shah, A Mukerji
OBJECTIVE: Pregnancy-induced hypertension (PIH) is associated with preterm delivery but its independent impact on neonatal outcomes remains unclear. We sought to systematically review and meta-analyze clinical outcomes of preterm infants <37 weeks' gestation born to mothers with and without PIH. STUDY DESIGN: Medline, Embase, PsychINFO and CINAHL were searched from January 2000 to October 2016. Studies with low-moderate risk of bias reporting neonatal outcomes based on PIH as primary exposure variable were included...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29095074/evaluation-of-retinopathy-of-prematurity-incidence-with-telemedicine-confirmation-in-gansu-china-a-pilot-study
#14
Xinxin Zhang, Yuping Wang, J Niklas Ulrich, Yi Yang, Leona Ding, Yi Yang, Ding Xu, Kristina Tarczy-Hornoch, Michelle T Cabrera
PURPOSE: To determine the incidence of retinopathy of prematurity (ROP) in Gansu, China by combining bedside examinations with remote RetCam (Clarity Medical Systems, Pleasanton, CA, USA) diagnosis. METHODS: ROP screening via indirect ophthalmoscopy followed by RetCam imaging was performed from 2014 to 2015. Three ROP-experienced ophthalmologists interpreted images remotely. Incidence of ROP was determined by combining bedside and telemedicine diagnoses. RESULTS: Of 139 examined infants and 137 complete records, 20 (14...
November 2, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29091782/ante-peri-and-postnatal-factors-associated-with-intraventricular-hemorrhage-in-very-premature-infants
#15
Martin Poryo, Judith Caroline Boeckh, Ludwig Gortner, Michael Zemlin, Perrine Duppré, Daniel Ebrahimi-Fakhari, Stefan Wagenpfeil, Matthias Heckmann, Eva Mildenberger, Anne Hilgendorff, Andreas W Flemmer, Georg Frey, Sascha Meyer
BACKGROUND: Intraventricular hemorrhage (IVH) is one of the most serious complications in preterm infants and is associated with neurological sequelae and mortality. Over the past few decades, the rate of IVH has decreased due to improved neonatal intensive care. However, up to 15-25% of very and extremely premature infants (<32 and <28weeks of pregnancy (WOP) respectively) still suffer from IVH. STUDY PURPOSE: The aim of this study was to perform an updated, multicenter analysis to identify ante-, peri, and postnatal factors other than gestational age/birth weight associated with IVH of any grade in a large cohort of very and extremely premature infants...
October 26, 2017: Early Human Development
https://www.readbyqxmd.com/read/29091306/effects-of-apelin-on-retinal-microglial-cells-in-a-rat-model-of-oxygen-induced-retinopathy-of-prematurity
#16
Wei Zhang, Ding-Guo Zhang, Xing Liang, Wei-Liang Zhang, Jing-Xue Ma
This study explores the effects of apelin on retinal microglial cells in rat models of oxygen-induced retinopathy of prematurity (ROP). Totally, 274 rats were selected for establishing oxygen-induced retinopathy (OIR) models, and 92 healthy rats for control group. OIR rats were assigned into OIR, 10(-5) g/L apelin, 10(-4) g/L apelin and 10(-3) g/L apelin groups. Immunohistochemistry was employed to determine morphology of microglial cells and cell number. CDllb, ionized calcium-binding adapter molecule 1 (IBA-1), TNF-α and iNOS mRNA and protein expressions were identified using RT-qPCR and western blotting, respectively...
November 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29083092/oxygen-weight-gain-igf-1-and-rop-not-a-straight-forward-equation
#17
EDITORIAL
Brian A Darlow, Gil Binenbaum
No abstract text is available yet for this article.
October 30, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29079216/macular-morphology-following-unilateral-bevacizumab-injection-for-retinopathy-of-prematurity-an-oct-study
#18
Antony Clark, Tom Wright, Maram Isaac, Carol Westall, Kamiar Mireskandari, Nasrin N Tehrani
This retrospective case series assessed the influence of unilateral intravitreal bevacizumab (IVB) for unilateral type 1 retinopathy of prematurity (ROP) on macular thickness and foveal development. Seven infants with unilateral type 1 ROP were treated with intravitreal bevacizumab 0.625 mg/0.025 ml in one eye only. To determine whether macular thickness and fovea structural development were affected by treatment, spectral domain optical coherence tomography was performed on both treated and untreated eyes...
October 24, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29075018/impact-of-healthcare-strategies-on-patterns-of-paediatric-sight-impairment-in-a-developed-population-1984-2011
#19
K Shirley, S Chamney, P Satkurunathan, S McLoone, E McLoone
PurposeThe aim of our study was to analyse paediatric sight-impairment trends in Northern Ireland (NI) over a 28-year period to better understand the impact which changes in health-care provision may be having on childhood blindness and to enable us to assess our progress towards achieving the World Health Organisation (WHO) aims.MethodsA database of Certificates of Visual Impairment completed for NI children aged <16 years was used to determine the cause of sight impairment from 1984 to 2011. Causes were classified into preventable or treatable conditions and analysed for trends...
November 2017: Eye
https://www.readbyqxmd.com/read/29072164/effects-of-a-lipid-emulsion-containing-fish-oil-on-polyunsaturated-fatty-acid-profiles-growth-and-morbidities-in-extremely-premature-infants-a-randomized-controlled-trial
#20
Svetlana Najm, Chatarina Löfqvist, Gunnel Hellgren, Eva Engström, Pia Lundgren, Anna-Lena Hård, Alexandre Lapillonne, Karin Sävman, Anders K Nilsson, Mats X Andersson, Lois E H Smith, Ann Hellström
BACKGROUND & AIMS: The purpose of the study was to compare the effects of the parenteral emulsion SMOFlipid(®), with 15% fish oil, with Clinoleic(®) on retinopathy of prematurity (ROP) and other morbidities and growth, and to compare their impact on longitudinal serum levels of fatty acids. Retinopathy of prematurity, other morbidity and growth were correlated with each parenteral lipid supplement. METHODS: Ninety infants born at gestational age <28 weeks were randomized to treatment with SMOFlipid(®) or Clinoleic(®)...
August 2017: Clinical Nutrition ESPEN
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