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https://www.readbyqxmd.com/read/28928468/ranibizumab-after-laser-photocoagulation-failure-in-retinopathy-of-prematurity-rop-treatment
#1
Anna Gotz-Więckowska, Anna Chmielarz-Czarnocińska, Marta Pawlak, Janusz Gadzinowski, Jan Mazela
The purpose of this study was to investigate the anatomical and functional outcomes of the two-stage treatment of severe retinopathy of prematurity (ROP) using laser photocoagulation and intravitreal ranibizumab injection. The medical records of 53 eyes of 28 infants treated by conventional laser photocoagulation with deferred intravitreal 0.25 mg/0.025 mL ranibizumab injection were analysed. All patients had at least 11 months of follow-up. In the analysed group, the mean gestational age at birth was 25 weeks and mean birthweight was 790 g...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926210/clinical-relevance-of-retinal-structure-in-children-with-laser-treated-retinopathy-of-prematurity-versus-controls-using-optical-coherence-tomography
#2
Florina Stoica, Adela Chirita-Emandi, Nicoleta Andreescu, Alina Stanciu, Cristian G Zimbru, Maria Puiu
PURPOSE: We aimed to assess the macular anatomy using spectral domain optical coherence tomography (SD-OCT), in children born preterm who had laser-treated retinopathy of prematurity (ROP), and to investigate the relationship between structural changes in macula and visual function. METHODS: Thirty-seven 3-8 years old children were included in the study in two groups: 20 children born preterm [(<34 weeks of gestation, birthweight (BW) <2000 g)] who had laser-treated ROP in the Neonatology Department, Municipal Clinical Emergency Hospital of Timisoara, Romania; and 17 controls (children born at term, without eye disease, matched for age and gender)...
September 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28924435/aggressive-posterior-retinopathy-of-prematurity-in-a-premature-male-infant
#3
Jun Zhou, Zheng Liu, Hai-Yan Ying, Tao Liu
A premature male infant was born at 30 weeks' gestation with a birth weight of 1,700 g in a rural hospital. He was diagnosed with respiratory distress syndrome and received continuous positive airway pressure treatment for 26 days. At 26 days after birth, the patient was transferred to our hospital for further evaluation and management. A comprehensive eye examination revealed a stage 3 retinopathy of prematurity (ROP) involving zone 2 in both eyes. The patient was recommended to a provincial-level eye hospital for emergency laser therapy...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28920626/mononuclear-salen-gallium-complexes-for-iso-selective-ring-opening-polymerization-rop-of-rac-lactide
#4
David Specklin, Christophe Fliedel, Frédéric Hild, Samir Mameri, Lydia Karmazin, Corinne Bailly, Samuel Dagorne
A series of mononuclear salen-supported gallium amido/alkoxide derivatives were prepared and structurally characterized and subsequently used as initiators in rac-lactide ring-opening polymerisation (ROP). The reaction of variously substituted salen ligands (1a-1f) with 0.5 equiv. of Ga2(NMe2)6 allowed the isolation of the corresponding (salen)Ga-NMe2 chelates (2b-2d, 2f) via an amine elimination route, as poorly soluble compounds in common solvents. The (salen)Ga-OBn derivatives (3a-3e) may be readily accessed by an amine-elimination/alcoholysis sequence and the molecular structures of 3a, 3d and 3e were confirmed through X-ray crystallography diffraction analysis...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28920494/early-postnatal-weight-gain-as-a-predictor-for-the-development-of-retinopathy-of-prematurity
#5
Manoj Biniwale, Angela Weiner, Smeeta Sardesai, Rowena Cayabyab, Lorayne Barton, Rangasamy Ramanathan
OBJECTIVE: To validate the reliability of early postnatal weight gain as an accurate predictor of type 1 retinopathy of prematurity (ROP) requiring treatment in a large predominantly Hispanic US cohort with the use of an online tool called WINROP (weight, neonatal retinopathy of prematurity (IGF-1), neonatal retinopathy of prematurity). STUDY DESIGN: Retrospective cohort study consisted of preterm infants < 32 weeks gestation and birth weight < 1500 grams...
September 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28916563/incidence-of-retinopathy-of-prematurity-rop-and-rop-treatment-in-switzerland-2006-2015-a-population-based-analysis
#6
Roland Gerull, Viviane Brauer, Dirk Bassler, Bernard Laubscher, Riccardo E Pfister, Mathias Nelle, Béatrice Müller, Christina Gerth-Kahlert, Mark Adams
BACKGROUND: Retinopathy of prematurity (ROP) is a severe complication of preterm birth and can lead to severe visual impairment or even blindness if untreated. The incidence of ROP requiring treatment is increasing in some developed countries in conjunction with higher survival rates at the lower end of gestational age (GA). MATERIAL AND METHODS: The incidence of ROP and severe ROP (sROP) requiring treatment in Switzerland was analysed using the SwissNeoNet registry...
September 15, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28905829/variation-in-the-vitreoretinal-configuration-of-stage-4-retinopathy-of-prematurity-in-photocoagulated-and-treatment-naive-eyes-undergoing-vitrectomy
#7
Salil Sharad Gadkari, Madan Deshpande
PURPOSE: We sought to document the difference in the vitreoretinal configuration of Stage 4 retinopathy of prematurity (ROP) in photocoagulated and treatment naive eyes undergoing vitrectomy and to correlate it with surgical complexity. METHODS: Consecutive eyes posted for vitrectomy with Stage 4 ROP were documented preoperatively using a RetCam for the presence of peripheral traction (PT), presence of central traction just outside the arcades, and presence of traction extending to the lens...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905828/influence-of-laser-versus-lens-sparing-vitrectomy-on-myopia-in-children-with-retinopathy-of-prematurity
#8
Sumita Agarkar, Roshani Desai, Sumeer Singh, Durgasri Jaisankar, Pramod Bhende, Rajiv Raman
PURPOSE: The purpose of this study is to compare the refractive error outcomes in the eyes of premature babies with retinopathy of prematurity (ROP) who underwent laser plus lens-sparing vitrectomy (LSV) in one eye and laser alone in the fellow eye. METHODS: This is a retrospective study. Fourteen babies with Stage 4A of ROP or worse who underwent laser plus LSV in one eye (Group 1) and laser alone in the fellow eye (Group 2) were followed at 2 months, 6 months, 1 year, one and a half year, and 2 years...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905827/refractive-and-ocular-biometric-profile-of-children-with-a-history-of-laser-treatment-for-retinopathy-of-prematurity
#9
Savleen Kaur, Jaspreet Sukhija, Deeksha Katoch, Mansi Sharma, Ramanuj Samanta, Mangat R Dogra
PURPOSE: Indian children belong to a diverse socioeconomic strata with retinopathy of prematurity (ROP) developing in mature, higher birth weight babies as well. The purpose of our study is to analyze the long-term status of refractive errors and its relationship with ocular biometry in children with ROP who were laser treated at a tertiary center in North India. METHODS: Cross sectional study. Children (<16 years) enrolled from January 2014 to December 2014 with a history of laser treatment for ROP and examined for refractive and biometric status...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28894027/activation-status-coupled-transient-s-acylation-determines-membrane-partitioning-of-a-plant-rho-related-gtpase
#10
Nadav Sorek, Limor Poraty, Hasana Sternberg, Ella Buriakovsky, Einat Bar, Efraim Lewinsohn, Shaul Yalovsky
ROPs or RACs are plant Rho-related GTPases implicated in regulation of multitude of signaling pathways that function at the plasma membrane via posttranslational lipid modifications. The relations between ROP activation status and their membrane localization has not been established. Here, we show that endogenous ROPs, as well as a transgenic His6:GFP:AtROP6 fusion protein, were partitioned between Triton X-100 soluble and insoluble membranes. In contrast, the His6:GFP:Atrop6(CA) activated mutant accumulated exclusively in detergent resistant membranes...
September 11, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28877434/reduction-responsive-polypeptide-micelles-for-intracellular-delivery-of-antineoplastic-agent
#11
Weiguo Xu, Jianxun Ding, Xuesi Chen
Reduction-responsive methoxy poly(ethylene glycol)-block-poly(S-tert-butylmercapto-L-cysteine) copolymers (i.e., mPEG113-b-PBMLC4 and mPEG113-b-PBMLC9) were facilely synthesized through primary amino-initiated ring-opening polymerization (ROP) of disulfide-containing N-carboxyanhydride monomer. The reduction-responsive block copolymers were then investigated for intracellular delivery of antitumor drug after forming smart micelles in vitro and in vivo. The micelles were denoted as P4M and P9M, respectively...
September 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28872709/implementing-higher-oxygen-saturation-targets-reduced-the-impact-of-poor-weight-gain-as-a-predictor-for-retinopathy-of-prematurity
#12
Pia Lundgren, Anna-Lena Hård, Åsa Wilde, Chatarina Löfqvist, Lois E H Smith, Ann Hellström
AIM: This study evaluated poor weight gain as a risk factor for infants who required treatment for retinopathy of prematurity (ROP), by comparing those born before and after the implementation of higher oxygen saturation (SpO2 ) targets at the Queen Silvia Children's Hospital, Gothenburg, Sweden. METHODS: We compared infants born at less than 31 weeks, who were screened and, or, treated for ROP: 127 in 2011-2012 when SpO2 targets were 88-92% and 142 in 2015-2016 when they were 91-95%...
September 5, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28870155/pessary-or-progesterone-to-prevent-preterm-delivery-in-women-with-short-cervical-length-the-quadruple-p-randomised-controlled-trial
#13
Maud D van Zijl, Bouchra Koullali, Christiana A Naaktgeboren, Ewoud Schuit, Dick J Bekedam, Etelka Moll, Martijn A Oudijk, Wilhelmina M van Baal, Marjon A de Boer, Henricus Visser, Joris van Drongelen, Flip W van de Made, Karlijn C Vollebregt, Moira A Muller, Mireille N Bekker, Jozien T J Brons, Marieke Sueters, Josje Langenveld, Maureen T Franssen, Nico W Schuitemaker, Erik van Beek, Hubertina C J Scheepers, Karin de Boer, Eveline M Tepe, Anjoke J M Huisjes, Angelo B Hooker, Evelyn C J Verheijen, Dimitri N Papatsonis, Ben Willem J Mol, Brenda M Kazemier, Eva Pajkrt
BACKGROUND: Preterm birth is in quantity and in severity the most important topic in obstetric care in the developed world. Progestogens and cervical pessaries have been studied as potential preventive treatments with conflicting results. So far, no study has compared both treatments. METHODS/DESIGN: The Quadruple P study aims to compare the efficacy of vaginal progesterone and cervical pessary in the prevention of adverse perinatal outcome associated with preterm birth in asymptomatic women with a short cervix, in singleton and multiple pregnancies separately...
September 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28869269/mono-bht-heteroleptic-magnesium-complexes-synthesis-molecular-structure-and-catalytic-behavior-in-the-ring-opening-polymerization-of-cyclic-esters
#14
I E Nifant'ev, A V Shlyakhtin, V V Bagrov, M E Minyaev, A V Churakov, S G Karchevsky, K P Birin, P V Ivchenko
Numerous heteroleptic 2,6-di-tert-butyl-4-methylphenolate (BHT) magnesium complexes have been synthesized by treatment of (BHT)MgBu(THF)2 with various alcohols. Molecular structures of the complexes have been determined by X-ray diffraction. The magnesium coordination number in [(BHT)Mg(μ-OBn)(THF)]2 (3) and [(BHT)Mg(μ-O-tert-BuC6H4)(THF)]2 (4) is equal to 4. Complexes formed from esters of glycolic and lactic acids, [(BHT)Mg(μ-OCH2COOEt)(THF)]2 (5) and [(BHT)Mg(μ-OCH(CH3)COOCH2COO(t)Bu)(THF)]2 (6) contain chelate fragments with pentacoordinated magnesium...
September 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28867518/personality-traits-in-recent-onset-of-psychosis-patients-compared-to-a-control-sample-by-gender
#15
Julia Sevilla-Llewellyn-Jones, Pablo Cano-Domínguez, Antonia de-Luis-Matilla, Alberto Espina-Eizaguirre, Berta Moreno-Küstner, Susana Ochoa
Personality traits in recent onset of psychosis (ROP) patients are an under-researched area. Our aim was to examine clinical and clinically significant personality traits in ROP patients compared with a healthy control sample by gender. Data were obtained from 94 ROP patients and a control sample matched in gender and age. The Millon Clinical Multiaxial Inventory and a sociodemographic scale were used. T for independent samples, U-Mann-Whitney and Fisher tests were applied to make comparisons. All personality traits were significantly higher in ROP than control participants in the general sample, except histrionic, narcissistic, and compulsive traits which were higher in controls...
August 31, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28867130/follow-up-to-age-4-years-of-treatment-of-type-1-retinopathy-of-prematurity-intravitreal-bevacizumab-injection-versus-laser-fluorescein-angiographic-findings
#16
Domenico Lepore, Graham E Quinn, Fernando Molle, Lorenzo Orazi, Antonio Baldascino, Marco H Ji, Maria Sammartino, Fabio Sbaraglia, Daniela Ricci, Eugenio Mercuri
PURPOSE: To compare structural outcome at age 4 years of eyes treated with intravitreal injection of bevacizumab with fellow eyes treated with conventional laser photoablation in type 1 retinopathy of prematurity (ROP). DESIGN: Single, randomized, controlled trial. PARTICIPANTS: All inborn babies with type 1 zone 1 ROP at the Neonatal Intensive Care Unit of the Catholic University, Rome, from September 1, 2009, to March 31, 2012. METHODS: In 21 infants (42 eyes), 1 eye was randomized to receive an intravitreal injection of 0...
August 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28866217/zirconium-amine-tris-phenolate-a-more-effective-initiator-for-biomedical-lactide
#17
Matthew D Jones, Xujun Wu, Julian Chaudhuri, Matthew G Davidson, Marianne J Ellis
Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization (ROP) was carried out in the melt at 130°C. The zirconium-catalyzed PLA (PLA-Zr) required 30min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn). PLA-Zr and PLA-Sn supported osteosarcoma cell (MG63) culture to the same extent (cell number, morphology, extracellular matrix production and osteogenic function) until day 14 when the PLA-Zr showed increased cell number, overall extracellular matrix production and osteogenic function...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28861355/prevalence-of-retinopathy-of-prematurity-in-iran-a-systematic-review-and-meta-analysis
#18
Saman Maroufizadeh, Amir Almasi-Hashiani, Reza Omani Samani, Mahdi Sepidarkish
AIM: To estimate overall prevalence of retinopathy of prematurity (ROP) in Iran using a systematic review and Meta-analysis. METHODS: A systematic review and Meta-analysis was performed of all published studies pertaining to prevalence of ROP using international and national electronic databases (ISI Web of Sciences, PubMed, Scopus, Google Scholar, SID, MagIran, and IranMedex) from their inception until May 2016 with standard keywords. Begg and Egger tests were used to examine the publication bias and Cochran test and I(2) statistics were used to evaluate the statistical heterogeneity...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28858003/refractive-status-in-nepalese-pre-term-and-full-term-infants-early-in-life
#19
Samir Uprety, Priya Morjaria, Jyoti B Shrestha, Gauri S Shrestha, Safal Khanal
SIGNIFICANCE: This study suggests that pre-term infants, even without retinopathy of prematurity, are at risk for abnormal refractive development and informs the need for close monitoring of refractive error in such infants, regardless of their retinopathy of prematurity status. PURPOSE: The present study aims to investigate the refractive error trend in Nepalese pre-term infants without retinopathy of prematurity (ROP) in the first 6 months of life and explore the association of refractive error with birth weight (BW) and gestational age (GA)...
August 29, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28855196/a-worldwide-survey-of-retinopathy-of-prematurity-screening
#20
Justin S Mora, Christopher Waite, Clare E Gilbert, Brenda Breidenstein, John J Sloper
BACKGROUND: To ascertain which countries in the world have retinopathy of prematurity (ROP) screening programmes and guidelines and how these were developed. METHODS: An email database was created and requests were sent to ophthalmologists in 141 nations to complete an online survey on ROP screening in their country. RESULTS: Representatives from 92/141 (65%) countries responded. 78/92 (85%) have existing ROP screening programmes, and 68/78 (88%) have defined screening criteria...
August 30, 2017: British Journal of Ophthalmology
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