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https://www.readbyqxmd.com/read/28803875/a-novel-plasma-membrane-anchored-protein-regulates-xylem-cell-wall-deposition-through-microtubule-dependent-lateral-inhibition-of-rho-gtpase-domains
#1
Yuki Sugiyama, Mayumi Wakazaki, Kiminori Toyooka, Hiroo Fukuda, Yoshihisa Oda
Spatial control of cell-wall deposition is essential for determining plant cell shape [1]. Rho-type GTPases, together with the cortical cytoskeleton, play central roles in regulating cell-wall patterning [2]. In metaxylem vessel cells, which are the major components of xylem tissues, active ROP11 Rho GTPases form oval plasma membrane domains that locally disrupt cortical microtubules, thereby directing the formation of oval pits in secondary cell walls [3-5]. However, the regulatory mechanism that determines the planar shape of active Rho of Plants (ROP) domains is still unknown...
August 7, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28800017/atypical-form-of-retinopathy-of-prematurity-with-severe-fibrovascular-proliferation-in-the-optic-disk-region
#2
Tadashi Yokoi, Satoshi Katagiri, Miina Hiraoka, Yuri Nakayama, Katsuhiro Hosono, Yoshihiro Hotta, Sachiko Nishina, Noriyuki Azuma
PURPOSE: To describe severe fibrovascular proliferation that developed in the optic disk region in an atypical form of retinopathy of prematurity (ROP). METHODS: Retrospective observational case reports. RESULTS: Four patients (8 eyes) with ROP were included. Three patients were born very prematurely (24-25 weeks of gestational age; weight, 500-1,000 grams); 1 patient was born at 33 weeks of gestational age. Among all eight eyes of four patients who received prompt ROP screening and underwent laser photocoagulation, six eyes had atypical and severe fibrovascular proliferation mainly in the optic disk region; the other two eyes, including one eye with classic ROP and one eye with aggressive posterior ROP, did not have the atypical form...
August 9, 2017: Retina
https://www.readbyqxmd.com/read/28799178/retrospective-cohort-study-shows-that-the-risks-for-retinopathy-of-prematurity-included-birth-age-and-weight-medical-conditions-and-treatment
#3
Aliaa Adel Ali, Nancy Gomaa, Ahmed Reda Awadein, Huda Hussein Al-Hayouti, Ahmed Hegazy
AIM: This study described the characteristics and risk factors of neonates who developed retinopathy of prematurity (ROP) and severe treatable ROP in two Egyptian neonatal intensive care units (NICUs). METHODS: This retrospective cohort study comprised 108 preterm neonates who were screened for ROP after being admitted to the two NICUs run by Cairo University Hospital from June 2014 to May 2015. Patients were examined using digital fundus photography and indirect ophthalmoscopy was performed if ROP was detected...
August 11, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28796856/detection-of-potentially-severe-retinopathy-of-prematurity-by-remote-image-grading
#4
Graham E Quinn, Gui-Shuang Ying, Wei Pan, Agnieshka Baumritter, Ebenezer Daniel
Importance: Telemedicine in retinopathy of prematurity (ROP) has the potential for delivering timely care to premature infants at risk for serious ROP. Objective: To describe the characteristics of eyes at risk for ROP to provide insights into what types of ROP are most easily detected early by image grading. Design, Setting, and Participants: Secondary analysis of eyes with referral-warranted (RW) ROP (stage 3 ROP, zone I ROP, plus disease) on diagnostic examination from the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) study was conducted from May 1, 2011, to October 31, 2013, in 1257 premature infants with birth weights less than 1251 g in 13 neonatal units in North America...
August 10, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28796851/association-of-maternal-preeclampsia-with-infant-risk-of-premature-birth-and-retinopathy-of-prematurity
#5
Julia P Shulman, Cindy Weng, Jacob Wilkes, Tom Greene, M Elizabeth Hartnett
Importance: Studies report conflicting associations between preeclampsia and retinopathy of prematurity (ROP). This study provides explanations for the discrepancies to clarify the relationship between preeclampsia and ROP. Objective: To evaluate the association of maternal preeclampsia and risk of ROP among infants in an unrestricted birth cohort and a restricted subcohort of preterm, very low birth weight (P-VLBW) infants. Design, Setting, and Participants: A retrospective review of 290 992 live births within the Intermountain Healthcare System in Utah from January 1, 2001, through December 31, 2010, was performed...
August 10, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28795376/arabidopsis-prk6-interacts-specifically-with-atropgef8-12-and-induces-depolarized-growth-of-pollen-tubes-when-overexpressed
#6
Yuexuan Yu, Jiali Song, Xiaohui Tian, Haiwen Zhang, Legong Li, Huifen Zhu
The pollen receptor kinases (PRK) are critical regulators of pollen tube growth. The Arabidopsis genome encodes eight PRK genes, of which six are highly expressed in pollen tubes. The potential functions of AtPRK1 through AtPRK5, but not of AtPRK6, in pollen growth were analyzed in tobacco. Herein, AtPRK6 was cloned, and its function was identified. AtPRK6 was expressed specifically in pollen tubes. A yeast two-hybrid screen of AtPRK6 against 14 Arabidopsis Rop guanine nucleotide exchange factors (RopGEFs) showed that AtPRK6 interacted with AtRopGEF8 and AtRopGEF12...
August 8, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28790417/impact-of-minocycline-on-vascularization-and-visual-function-in-an-immature-mouse-model-of-ischemic-retinopathy
#7
Wenqin Xu, Jie Yin, Lijuan Sun, Zhicha Hu, Guorui Dou, Zifeng Zhang, Haiyan Wang, Changmei Guo, Yusheng Wang
The role of microglia in the pathophysiology of ischemic retinal diseases has been extensively studied. Retinal microglial activation may be correlated with retinal neovascularization in oxygen-induced retinopathy (OIR), an animal model that has been widely used in retinopathy of prematurity (ROP) research. Minocycline is an antibiotic that decreases microglial activation following hyperoxic and hypoxic-ischemic phases in neonatal rodents. Here, we investigated the effects of minocycline on vascularization and visual function...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782073/predictors-of-treatment-warranted-retinopathy-of-prematurity-in-the-sundrop-cohort-influence-of-photographic-features
#8
Cassie A Ludwig, Margaret A Greven, Darius M Moshfeghi
PURPOSE: The Stanford University Network for the Diagnosis of Retinopathy of Prematurity (SUNDROP) initiative-an ongoing telemedicine-based initiative for in-hospital screening of high-risk infants for treatment-warranted ROP (TW-ROP)-has been shown to be a safe, reliable, and cost-effective supplement to the efforts of ROP specialists. We utilized data collected in the SUNDROP initiative to determine demographic (birth weight, sex, multiplicity), weight gain, and ocular imaging (media haze, peripapillary atrophy, fundus pigmentation) predictors of TW-ROP...
August 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28780616/the-analysis-of-posterior-segment-findings-in-term-and-premature-infants-using-retcam-images
#9
Huseyin Gursoy, Mustafa Deger Bilgec, Nazmiye Erol, Hikmet Basmak, Ertugrul Colak
OBJECTIVE: To analyze posterior segment findings in term and premature infants using the RetCam image database. METHODS: RetCam images taken of infants born between January 2012 and December 2015 were reviewed. Group 1 included infants with posterior segment findings other than retinopathy of prematurity (ROP). Group 2 included infants with mild-to-severe ROP. The baseline characteristics, anterior segment findings, and percentage of infants who received treatment were compared among the 2 groups...
August 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28776594/the-inner-retinal-structures-of-the-eyes-of-children-with-a-history-of-retinopathy-of-prematurity
#10
Y-S Lee, S H L Chang, S-C Wu, L-C See, S-H Chang, M-L Yang, W-C Wu
PurposeTo investigate the microstructural differences of the inner retina in the peripapillary and macular areas in children with or without retinopathy of prematurity (ROP).MethodsThis prospective cohort study included school-age children with a history of ROP and age-matched healthy, full-term children. The macular ganglion cell complex (mGCC), peripapillary retinal nerve fiber layer (RNFL), refractive status, and ocular biometry were measured. The metrics of the mGCC and associated anatomical changes were the primary outcomes...
August 4, 2017: Eye
https://www.readbyqxmd.com/read/28765851/ring-opening-polymerisation-of-lactide-with-uranium-iv-and-cerium-iv-phosphinoaryloxide-complexes
#11
Fern Sinclair, Johann A Hlina, Jordann A L Wells, Michael P Shaver, Polly L Arnold
The C3-symmetric uranium(iv) and cerium(iv) complexes Me3SiOM(OAr(P))3, M = U (1), Ce (2), OAr(P) = OC6H2-6-(t)Bu-4-Me-2-PPh2, have been prepared and the difference between these 4f and 5f congeners as initiators for the ring opening polymerisation (ROP) of l-lactide is compared. The poorly controlled reactivity of the homoleptic analogue U(OAr(P))4 (3) demonstrates the importance of the M-OSiMe3 initiating group. The incorporation of a nickel atom in 1 to form the U-Ni heterobimetallic complex Me3SiOU(OAr(P))3Ni (4) may be the first example of the use of the inverse trans influence to switch the reactivity of a complex...
August 2, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28765032/effect-of-nonpharmacologic-pain-control-during-examination-for-retinopathy-of-prematurity
#12
Gülümser Dolgun, Şirin Bozlak
OBJECTIVES: To examine the effects of infant swaddling with oral administration of sucrose, swaddling with oral administration of breast milk, and swaddling with oral administration of distilled water (control) on pain perception in premature infants during a screening examination for retinopathy of prematurity (ROP). DESIGN: A prospective, randomized controlled design was used. SETTING: The research was conducted in the NICU of a Level III university hospital in Istanbul...
July 29, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28761567/using-an-image-fusion-methodology-to-improve-efficiency-and-traceability-of-posterior-pole-vessel-analysis-by-roptool
#13
Sasapin G Prakalapakorn, Laura A Vickers, Rolando Estrada, Sharon F Freedman, Carlo Tomasi, Sina Farsiu, David K Wallace
BACKGROUND: The diagnosis of plus disease in retinopathy of prematurity (ROP) largely determines the need for treatment; however, this diagnosis is subjective. To make the diagnosis of plus disease more objective, semi-automated computer programs (e.g. ROPtool) have been created to quantify vascular dilation and tortuosity. ROPtool can accurately analyze blood vessels only in images with very good quality, but many still images captured by indirect ophthalmoscopy have insufficient image quality for ROPtool analysis...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28752837/an-international-comparison-of-retinopathy-of-prematurity-grading-performance-within-the-benefits-of-oxygen-saturation-targeting-ii-trials
#14
B W Fleck, C Williams, E Juszczak, K Cocker, B J Stenson, B A Darlow, S Dai, G A Gole, G E Quinn, D K Wallace, A Ells, S Carden, L Butler, D Clark, J Elder, C Wilson, S Biswas, A Shafiq, A King, P Brocklehurst, A R Fielder
PurposeTo investigate whether the observed international differences in retinopathy of prematurity (ROP) treatment rates within the Benefits of Oxygen Saturation Targeting (BOOST) II trials might have been caused by international variation in ROP disease grading.MethodsGroups of BOOST II trial ophthalmologists in UK, Australia, and New Zealand (ANZ), and an international reference group (INT) used a web based system to grade a selection of RetCam images of ROP acquired during the BOOST II UK trial. Rates of decisions to treat, plus disease grading, ROP stage grading, ROP zone grading, inter-observer variation within groups and intra-observer variation within groups were measured...
July 28, 2017: Eye
https://www.readbyqxmd.com/read/28750113/handheld-optical-coherence-tomography-angiography-and-ultra-wide-field-optical-coherence-tomography-in-retinopathy-of-prematurity
#15
J Peter Campbell, Eric Nudleman, Jianlong Yang, Ou Tan, R V Paul Chan, Michael F Chiang, David Huang, Gangjun Liu
Importance: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Optical coherence tomography (OCT) has improved the care of adults with vitreoretinal disease, and OCT angiography (OCTA) is demonstrating promise as a technique to visualize the retinal vasculature with lower risk and cost than fluorescein angiography. However, to date, there are no commercially available devices able to obtain ultra-wide-field OCT or OCTA images in neonates. Objective: To obtain ultra-wide-field OCT and OCTA images in neonates with ROP using a prototype handheld OCT and OCTA device...
July 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28746942/screening-for-retinopathy-of-prematurity-insight-into-optimizing-screening
#16
Charlotte Pallot, Agnès Soudry Faure, Camille Charvy, Ninon Ternoy, Claire Langlet Muteau, Niyazi Acar, Alain M Bron, Claude Speeg Schatz, Catherine Creuzot-Garcher
PURPOSE: To determine the factors influencing the time from preterm birth and retinopathy of prematurity (ROP) detection to optimize the timing of the initial screening. METHODS: This multicenter retrospective study enrolled preterm infants born before 32 weeks of gestational age (GA) and/or weighing less than 1,500 g between January 1, 2011, and December 31, 2015. ROP screening was performed using fundus photography with a wide-field camera. Population and follow-up characteristics were recorded...
July 27, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28738027/n-terminal-b-type-natriuretic-peptide-urinary-concentrations-and-retinopathy-of-prematurity
#17
Christoph Bührer, Ömer Erdeve, Anton van Kaam, Angelika Berger, Evelyn Lechner, Benjamin Bar-Oz, Karel Allegaert, Tom Stiris, İstemi Han Çelik, Janet Berrington
BACKGROUND AND AIMS: To validate findings of a single-center pilot study showing elevated urinary N-terminal B-type natriuretic peptide (NTproBNP) concentrations in preterm infants subsequently developing severe retinopathy of prematurity (ROP) in a multicenter setting across 8 European and Middle East countries. METHODS: Prospective observational study in 967 preterm infants<30 weeks gestational age assessing the capacity of urinary NTproBNP on day of life (DOL) 14 and 28 to predict ROP requiring treatment...
July 24, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28736379/-preparation-of-nanoparticles-for-sustained-insulin-release-using-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-poly-n-n-diethylamino-2-ethylmethaerylate
#18
Lei Wu, Wen-Ting Zhu, Jun Wang, Jie Liu, Qing-Bing Zeng
OBJECTIVE: To prepare an insulin-loaded nanoparticle assembled using pH-sensitive poly(ethylene glycol)-poly(ε-caprolactone)-poly(N,N-diethylamino-2-ethylmethaerylate) (mPEG-PCL-PDEAEMA) and investigate its performance of sustained insulin release in vitro and its hypoglycemic effects in diabetic rats. METHDOS: mPEG-PCL-PDEAEMA triblock copolymers with different hydrophobic lengths were synthesized by ring opening polymerization (ROP) combined with atom transfer radical polymerization (ATRP)...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28728176/the-epidemiology-of-retinopathy-of-prematurity-in-the-united-states
#19
Cassie A Ludwig, Tiffany A Chen, Tina Hernandez-Boussard, Andrew A Moshfeghi, Darius M Moshfeghi
BACKGROUND AND OBJECTIVE: Retinopathy of prematurity (ROP) is a leading cause of blindness in premature and low birth weight infants. Here, the authors examine the incidence of ROP in the United States and evaluate risk factors associated with ROP development. PATIENTS AND METHODS: The National Healthcare Cost and Utilization Project Kids' Inpatient Database was queried for all newborns with and without ROP. Adjusted odds ratios were constructed for predictors of ROP using multivariate logistic regression modeling...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28724325/use-and-timing-of-surfactant-administration-impact-on-neonatal-outcomes-in-extremely-low-gestational-age-infants-born-in-canadian-neonatal-intensive-care-units
#20
Amelie Stritzke, Khorshid Mohammad, Prakesh S Shah, Xiang Y Ye, Vineet Bhandari, Albert Akierman, Adele Harrison, Valerie Bertelle, Abhay Lodha
BACKGROUND: Use, timing and doses of surfactant in preterm infants are variable in practice in modern NICUs. OBJECTIVE: To explore the association between use and timing of surfactant administration and common neonatal adverse outcomes in preterm infants with gestational age (GA) < 28 weeks. MATERIAL AND METHODS: Neonates admitted to a participating Canadian Neonatal Network NICU between 2013 and 2015 were studied. Infants were divided into three groups based on surfactant administration: None, early (within 30 minutes of life), and late surfactant (> 30 minutes)...
July 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
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