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https://www.readbyqxmd.com/read/29245065/diclofenac-induced-renal-toxicity-in-female-wistar-albino-rats-is-protected-by-the-pre-treatment-of-aqueous-leaves-extract-of-madhuca-longifolia-through-suppression-of-inflammation-oxidative-stress-and-cytokine-formation
#1
Jerine Peter S, Sabina Evan Prince
CONTEXT: Kidney has a vital role in renal clearance, maintenance of blood pressure, elimination of toxic products and formation of prostaglandins. Certain medications are known to cause renal injury on its frequent usage and high dosage. Diclofenac is a non-steroidal anti-inflammatory drug which is used in the treatment of pain and arthritis. Madhuca longifolia is a deciduous tree which is known to the have anti-microbial, anti-ulcer, hepatoprotective, anti-diabetic, anti-inflammatory and analgesic activity...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29243898/invasive-treatment-of-superficial-veins-of-the-lower-extremities
#2
Jukka Saarinen
Modern invasive treatment of superficial venous insufficiency of the lower extremities is largely based on the use of intravenous procedures under ultrasound guidance. The first-line treatment is thermoablation, in which the insufficient superficial vein, typically vena saphena magna or parva, is constricted by using laser or radio frequency energy under ultrasound guidance. The procedure is nearly always successful under local anesthesia and can be performed as an outpatient operation. When necessary, visible collateral varices can be treated with foam sclerotherapy or by surgical excision...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29242062/rationale-and-design-of-the-sail-trial-for-intramuscular-injection-of-allogeneic-mesenchymal-stromal-cells-in-no-option-critical-limb-ischemia
#3
Joep G J Wijnand, Martin Teraa, Hendrik Gremmels, Femke C C van Rhijn-Brouwer, Gert J de Borst, Marianne C Verhaar
BACKGROUND: Critical limb ischemia (CLI) represents the most severe form of peripheral artery disease and has an immense impact on quality of life, morbidity, and mortality. A considerable proportion of CLI patients are ineligible for revascularization, leaving amputation as the only option. Mesenchymal stromal cells (MSCs), because of their vasculoregenerative and immunomodulatory characteristics, have emerged as a potential new treatment. METHODS: The primary objective of this trial is to investigate whether intramuscular administration of allogeneic bone marrow (BM)-derived MSCs is safe and potentially effective...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29241233/hyperbaric-oxygen-in-the-treatment-of-acute-retinal-artery-occlusion
#4
Mark J Elder, John A Rawstron, Michael Davis
INTRODUCTION: Acute retinal artery occlusion (ARAO) is a major cause of sudden, painless visual loss, often leaving no useful vision in the affected eye. Its incidence is cited at 0.85 per 100,000 persons per year but may be higher because of under-reporting. The natural history is difficult to study, but a spontaneous resolution rate of < 1-8% for acute, non-arteritic ARAO has been cited. Occurrence in an only eye is devastating for the patient. There is currently no consensus regarding management of ARAO and little evidence to support any treatment modality...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29236942/anaesthetics-stop-diverse-plant-organ-movements-affect-endocytic-vesicle-recycling-and-ros-homeostasis-and-block-action-potentials-in-venus-flytraps
#5
K Yokawa, T Kagenishi, A Pavlovic, S Gall, M Weiland, S Mancuso, F Baluška
Background and Aims: Anaesthesia for medical purposes was introduced in the 19th century. However, the physiological mode of anaesthetic drug actions on the nervous system remains unclear. One of the remaining questions is how these different compounds, with no structural similarities and even chemically inert elements such as the noble gas xenon, act as anaesthetic agents inducing loss of consciousness. The main goal here was to determine if anaesthetics affect the same or similar processes in plants as in animals and humans...
December 11, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29229419/capillary-electrophoresis-as-a-fast-and-efficient-alternative-for-the-analysis-of-urceola-rosea-leaf-extracts
#6
Vera Gufler, Hieu Nguyen Ngoc, Hermann Stuppner, Markus Ganzera
Urceola rosea, a plant whose leaves are used as food and for medical purposes, is a climbing liana found in many south-east Asian countries. Main polar compounds are flavonoids (kaempferol and quercetin glycosides) and phenolic acids. As an alternative to the established HPLC method their analysis by capillary electrophoresis is described for the first time. It was possible in <8min with a 25mM sodium tetraborate decahydrate solution with pH8.5, at a capillary temperature of 40°C and an applied voltage of 25kV...
December 8, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29228959/micro-structural-bone-changes-in-early-rheumatoid-arthritis-persist-over-1-year%C3%A2-despite-use-of-disease-modifying-anti-rheumatic-drug-therapy
#7
Lynne M Feehan, Linda L Li, Heather A McKay
BACKGROUND: We used High Resolution - peripheral Quantitative CT (HR-pQCT) imaging to examine peri-articular bone quality in early rheumatoid arthritis (RA) and explore whether bone quality improved over 12-months in individuals receiving care consistent with practice guidelines. METHODS: A 1-year longitudinal cohort study (Baseline and 12-months) evaluating individuals with early RA compared to age/sex-matched peers. Personal demographic and health and lifestyle information were collected for all...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29228876/crossing-professional-cultures-a-qualitative-study-of-nurses-working-in-a-medical-school
#8
Eileen McKinlay, Peter Gallagher, Bernadette Jones, Lindsay Macdonald, Christine Barthow
BACKGROUND: Leaving the nursing workforce is often seen as a loss to the profession. However some nurses maintain a current nursing registration and work outside their disciplinary field within university schools of medicine. Little is known about the nature of their work and why they choose to work in this setting. AIM: To explore and describe the experiences of nurses who work in a medical school. DESIGN: Qualitative descriptive informed by autoethnography...
December 11, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/29227643/structure-activity-relationship-studies-on-a-series-of-3%C3%AE-bis-4-fluorophenyl-methoxy-tropanes-and-3%C3%AE-bis-4-fluorophenyl-methylamino-tropanes-as-novel-atypical-dopamine-transporter-dat-inhibitors-for-the-treatment-of-cocaine-use-disorders
#9
Mu-Fa Zou, Jianjing Cao, Ara M Abramyan, Theresa Kopajtic, Claudio Zanettini, Daryl A Guthrie, Rana Rais, Barbara S Slusher, Lei Shi, Claus J Loland, Amy Hauck Newman
The development of medications to treat cocaine use disorders has thus far defied success, leaving this patient population without pharmacotherapeutic options. As the dopamine transporter (DAT) plays a prominent role in the reinforcing effects of cocaine that can lead to addiction, atypical DAT inhibitors have been developed that prevent cocaine from binding to DAT, but they themselves are not cocaine-like. Herein, a series of novel DAT inhibitors were synthesized, and based on its pharmacological profile, the lead compound 10a was evaluated in phase I metabolic stability studies in mouse liver microsomes and compared to cocaine in locomotor activity and drug discrimination paradigms in mice...
December 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29226458/communicating-risk-in-dementia-care-survey-of-health-and-social-care-professionals
#10
Brian J Taylor, Mabel Stevenson, Michelle McDowell
Supporting people to live at home in line with community care policies requires increasing attention to assessing, communicating and managing risks. There is a challenge in supporting client choices that include risk-taking while demonstrating professional accountability. Risk communication becomes increasingly important with the need to engage clients and families in meaningful shared decision-making. This presents particular challenges in dementia services. This survey of risk communication in dementia care was administered to all health and social care professionals in community dementia services in Northern Ireland: June-September 2016...
December 11, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29223696/key-players-in-key-roles-the-baystate-patient-progress-initiative-to-improve-emergency-department-efficiency-and-productivity
#11
Niels K Rathlev, Jacqualyn Anderson, Joseph Schmidt, Joeli Hettler, Lynn Garreffi, Molly Gray, Douglas Neal, Paul Visintainer
BACKGROUND: The percentage of patients who leave the emergency department without being seen by a provider is a measure of efficiency and presents risk-management concerns. The number of patients actually "seen" by a provider is a measure of productivity. The opening of our new emergency department in December 2012, resulted in increases in both demand and the percentage of patients who left without being seen. Operational nursing leadership managed ED patient flow, but the structure was loosely organized on an ad hoc basis...
December 6, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29222365/implementation-of-an-integrated-pharmacy-supply-management-strategy
#12
Lindsey B Amerine, Daniel R Calvert, Ashley L Pappas, Sarah M Lee, John M Valgus, Scott W Savage
PURPOSE: Implementation of an integrated pharmacy supply management strategy is described. SUMMARY: In 2011, the formulary approval process and supply management for oncology medications were independent of each other at an oncology infusion center. Numerous nonformulary medications were kept on hand and reordered based on inventory levels that were established with inadequate usage information, while some formulary agents did not have on-hand inventory levels and had to be reordered on a patient-specific basis, which required paperwork and then a review by drug information staff per institutional policy...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29221454/must-we-remain-blind-to-undergraduate-medical-ethics-education-in-africa-a-cross-sectional-study-of-nigerian-medical-students
#13
Onochie Okoye, Daniel Nwachukwu, Ferdinand C Maduka-Okafor
BACKGROUND: As the practice of medicine inevitably raises both ethical and legal issues, it had been recommended since 1999 that medical ethics and human rights be taught at every medical school. Most Nigerian medical schools still lack a formal undergraduate medical ethics curriculum. Medical education remains largely focused on traditional medical science components, leaving the medical students to develop medical ethical decision-making skills and moral attitudes passively within institutions noted for relatively strong paternalistic traditions...
December 8, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/29219136/assessment-of-village-health-sanitation-and-nutrition-committees-of-chandigarh-india
#14
Reetu Passi, Sonu Goel, Sangeeta Ajay
BACKGROUND: Village Health, Sanitation and Nutrition Committees (VHSNCs), one of the key interventions introduced by National Rural Health Mission, are an important mechanism to ensure community participation and ownership for decentralized health planning. OBJECTIVES: To assess the implementation status of VHSNCs and analyze the issues regarding their implementation in the villages of Chandigarh. METHODS: A cross-sectional mix method study was conducted in the year 2015 in all 22 VHSNCs of Chandigarh...
October 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29217338/-occupational-risks-during-pregnancy-feedback-from-occupational-medical-services
#15
J-B Henrotin, M Vaissière, M Etaix, M Dziurla, S Malard, D Lafon
OBJECTIVES: To describe the follow-up of pregnancies at work and exposures to pregnancy occupational hazards. METHODS: A cross-sectional study was performed between January and December 2014 in occupational health services of Languedoc-Roussillon region. Eligible workers were interviewed by occupational health physicians (OHPs) after delivery and at the time of returning to work (exposure, anticipation, prevention, communication, sick leave). Occupational skill levels were classified according to the French standard classification of occupations (version 2003) from the French National Institute of Statistics...
December 4, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29216609/what-kinds-of-factors-affect-the-academic-outcomes-of-university-students-with-mental-disorders-a-retrospective-study-based-on-medical-records
#16
Terumi Ishii, Hirokazu Tachikawa, Yuki Shiratori, Takafumi Hori, Miyuki Aiba, Keisuke Kuga, Tetsuaki Arai
AIMS: University students that suffer from mental disorders seem to have difficulty graduating. Therefore, we investigated risk and protective factors of dropping out with the aim of improving such students' academic outcomes. METHODS: First, we statistically compared the academic outcomes of 203 undergraduate students who received treatment in the Department of Psychiatry of the Tsukuba University Health Center to those of matched controls. Second, clinical factors of 370 mentally ill students were statistically compared between the dropout and graduate groups...
December 2, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29216602/nursing-students-learning-the-pharmacology-of-diabetes-mellitus-with-complexity-based-computerized-models-a-quasi-experimental-study
#17
Ilana Dubovi, Efrat Dagan, Ola Sader Mazbar, Laila Nassar, Sharona T Levy
BACKGROUND: Pharmacology is a crucial component of medications administration in nursing, yet nursing students generally find it difficult and self-rate their pharmacology skills as low. OBJECTIVES: To evaluate nursing students learning pharmacology with the Pharmacology Inter-Leaved Learning-Cells environment, a novel approach to modeling biochemical interactions using a multiscale, computer-based model with a complexity perspective based on a small set of entities and simple rules...
November 23, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29215370/opioid-use-after-discharge-in-postoperative-patients-a-systematic-review
#18
Adina E Feinberg, Tyler R Chesney, Sanjho Srikandarajah, Sergio A Acuna, Robin S McLeod
BACKGROUND: Over the past 2 decades, there has been an increase in opioid use and subsequently, opioid deaths. The amount of opioid prescribed to surgical patients has also increased. The aim of this systematic review was to determine postdischarge opioid consumption in surgical patients compared with the amount of opioid prescribed. Secondary outcomes included adequacy of pain control and disposal methods for unused opioids. OBJECTIVE: The objective of this study is to characterize postdischarge opioid consumption and prescription patterns in surgical patients...
December 5, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29212489/health-care-utilization-of-patients-with-chronic-back-pain-before-and-after-rehabilitation
#19
Magdalena Görge, Jeanette Ziehm, Erik Farin
BACKGROUND: Patients with chronic back pain show an increased use of health-care services leading to high direct costs. Multidisciplinary rehabilitation reduces pain intensity, depression, disability and work inability. The study aims to investigate whether health-care utilization in patients with chronic back pain is lower after rehabilitation than before rehabilitation and if, in addition to sociodemographic, medical and psychological characteristics, changes in these characteristics immediately after rehabilitation can predict health-care utilization...
December 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29211657/open-to-air-is-a-viable-option-for-initial-wound-care-in-necrotizing-soft-tissue-infection-that-allows-early-detection-of-recurrence-without-need-for-painful-dressing-changes-or-return-to-operating-room
#20
Derek Yang, April Davies, Bailey Burge, Phillip Watkins, Sharmila Dissanaike
BACKGROUND: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. We evaluated the feasibility of this approach from a pain control standpoint...
December 6, 2017: Surgical Infections
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