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https://www.readbyqxmd.com/read/29053230/a-randomised-control-trial-of-four-different-regimes-of-biofeedback-program-in-the-treatment-of-faecal-incontinence
#1
Christopher J Young, Assad Zahid, Cherry E Koh, Jane M Young, Christopher M Byrne, Michael J Solomon, Jenny Rex, Janet Candido
AIM: Biofeedback is an established, effective and non-invasive treatment for faecal incontinence (FI). The aim was to compare the effectiveness of four different biofeedback treatment regimes. METHOD: Randomised control trial of patients with FI, stratified into two groups (metropolitan and rural) and then randomised into two subgroups (groups 1 and 2 within metropolitan, groups 3 and 4 within rural) with varying face-to-face and telephone biofeedback components...
October 20, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29050464/anti-platelet-effects-of-epigallocatechin-3-gallate-in-addition-to-the-concomitant-aspirin-clopidogrel-or-ticagrelor-treatment
#2
Hyung Joon Joo, Ji-Young Park, Soon Jun Hong, Kyoung-Ah Kim, Seung Hoon Lee, Jae-Young Cho, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Background/Aims: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in addition to current anti-platelet medications remains to be elucidated. Methods: Blood samples were obtained from 40 participants who took aspirin (ASA, n = 10), clopidogrel (CPD, n = 10), ticagrelor (TCG, n = 10) and no anti-platelet medication (Control, n = 10)...
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29048981/women-and-the-decision-to-leave-linger-or-lean-in-predictors-of-intent-to-leave-and-aspirations-to-leadership-and-advancement-in-academic-medicine
#3
Elizabeth H Ellinas, Nadya Fouad, Angela Byars-Winston
BACKGROUND: The Association of American Medical Colleges reports continued low rates of female faculty as professors and in leadership positions. While attrition and discrimination have both been proposed as explanations, recent literature has suggested that women's professional motivations, ingrained behavior, and perceptions of organizational support may also play a role. METHODS: The authors employed a series of scales informed by the turnover theory (which predicts intent to leave an organization), previously validated and used in business and engineering studies, but rarely used in academic medicine...
October 19, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29046271/client-focused-security-assessment-of-mhealth-apps-and-recommended-practices-to-prevent-or-mitigate-transport-security-issues
#4
Jannis Müthing, Thomas Jäschke, Christoph M Friedrich
BACKGROUND: Mobile health (mHealth) apps show a growing importance for patients and health care professionals. Apps in this category are diverse. Some display important information (ie, drug interactions), whereas others help patients to keep track of their health. However, insufficient transport security can lead to confidentiality issues for patients and medical professionals, as well as safety issues regarding data integrity. mHealth apps should therefore deploy intensified vigilance to protect their data and integrity...
October 18, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29045936/anti-diabetic-potential-of-the-leaves-of-anisomeles-malabarica-in-streptozotocin-induced-diabetic-rats
#5
Peddanna Kotha, Kameswara Rao Badri, Ramya Nagalapuram, Rajasekhar Allagadda, Appa Rao Chippada
BACKGROUND/AIMS: Diabetes mellitus is a pandemic metabolic disorder that is affecting a majority of populations in recent years. There is a requirement for new drugs that are safer and cheaper due to the side effects associated with the available medications. METHODS: We investigated the anti-diabetic activity of leaves of Anisomeles malabarica following bioactivity guided fractionation. The different solvent (hexane, ethyl acetate, methanol and water) extracts of A...
October 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29045609/stakeholder-perspectives-on-the-optimizing-patient-transfers-impacting-medical-quality-and-improving-symptoms-transforming-institutional-care-optimistic-project
#6
Mary Ersek, Susan E Hickman, Anne C Thomas, Brittany Bernard, Kathleen T Unroe, Suzanne Meeks
Background and Objectives: The need to reduce burdensome and costly hospitalizations of frail nursing home residents is well documented. The Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project achieved this reduction through a multicomponent collaborative care model. We conducted an implementation-focused project evaluation to describe stakeholders' perspectives on (a) the most and least effective components of the intervention; (b) barriers to implementation; and (c) program features that promoted its adoption...
October 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/29045429/preclinical-antivenom-efficacy-testing-reveals-potentially-disturbing-deficiencies-of-snakebite-treatment-capability-in-east-africa
#7
Robert A Harrison, George O Oluoch, Stuart Ainsworth, Jaffer Alsolaiss, Fiona Bolton, Ana-Silvia Arias, José-María Gutiérrez, Paul Rowley, Stephen Kalya, Hastings Ozwara, Nicholas R Casewell
BACKGROUND: Antivenom is the treatment of choice for snakebite, which annually kills an estimated 32,000 people in sub-Saharan Africa and leaves approximately 100,000 survivors with permanent physical disabilities that exert a considerable socioeconomic burden. Over the past two decades, the high costs of the most polyspecifically-effective antivenoms have sequentially reduced demand, commercial manufacturing incentives and production volumes that have combined to create a continent-wide vacuum of effective snakebite therapy...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29043693/-post-appendectomy-intra-abdominal-abscesses-six-years-experience-in-a-pediatric-surgery-department
#8
A Coelho, C Sousa, A S Marinho, J Barbosa-Sequeira, M Recaman, F Carvalho
OBJECTIVES: Post-appendectomy intra-abdominal abscesses are estimated to complicate up to 4.2% of acute non-perforated appendicitis and between 6.7% and 28% acute perforated appendicitis. This study was performed with the aim to review and characterize post-appendectomy intra-abdominal abscesses in our Pediatric Surgery department; to calculate their incidence and to evaluate the efficacy of the treatment modality. MATERIAL AND METHODS: A retrospective analysis of all patients, under 18 years and with the diagnosis of intra-abdominal abscess post-appendectomy, between January 2010 and December 2015 was performed, taking in account initial surgical approach, type of acute appendicitis, length of hospital stay and the treatment applied...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29040453/detection-of-sputum-by-interpreting-the-time-frequency-distribution-of-respiratory-sound-signal-using-image-processing-techniques
#9
Jinglong Niu, Yan Shi, Maolin Cai, Zhixin Cao, Dandan Wang, Zhaozhi Zhang, Xiaohua Douglas Zhang
Motivation: Sputum in the trachea is hard to expectorate and detect directly for the patients who are unconscious, especially those in Intensive Care Unit (ICU). Medical staff should always check the condition of sputum in the trachea. This is time-consuming and the necessary skills are difficult to acquire. Currently, there are few automatic approaches to serve as alternatives to this manual approach. Results: We develop an automatic approach to diagnose the condition of the sputum...
October 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29038069/study-protocol-and-rationale-for-a-randomized-double-blinded-crossover-trial-of-phentermine-topiramate-er-versus-placebo-to-treat-binge-eating-disorder-and-bulimia-nervosa
#10
Shebani Sethi Dalai, Sarah Adler PsyD, Thomas Najarian, Debra Lynn Safer
INTRODUCTION: Bulimia nervosa (BN) and binge eating disorder (BED) are associated with severe psychological and medical consequences. Current therapies are limited, leaving up to 50% of patients symptomatic despite treatment, underscoring the need for additional treatment options. Qsymia, an FDA-approved medication for obesity, combines phentermine and topiramate ER. Topiramate has demonstrated efficacy for both BED and BN, but limited tolerability. Phentermine is FDA-approved for weight loss...
October 13, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29037244/prediction-of-microbe-disease-association-from-the-integration-of-neighbor-and-graph-with-collaborative-recommendation-model
#11
Yu-An Huang, Zhu-Hong You, Xing Chen, Zhi-An Huang, Shanwen Zhang, Gui-Ying Yan
BACKGROUND: Accumulating clinical researches have shown that specific microbes with abnormal levels are closely associated with the development of various human diseases. Knowledge of microbe-disease associations can provide valuable insights for complex disease mechanism understanding as well as the prevention, diagnosis and treatment of various diseases. However, little effort has been made to predict microbial candidates for human complex diseases on a large scale. METHODS: In this work, we developed a new computational model for predicting microbe-disease associations by combining two single recommendation methods...
October 16, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29035667/why-doctors-consider-leaving-uk-medicine-qualitative-analysis-of-comments-from-questionnaire-surveys-three-years-after-graduation
#12
Trevor W Lambert, Fay Smith, Michael J Goldacre
Objective To report the reasons why doctors are considering leaving medicine or the UK. Design Questionnaire survey. Setting UK. Participants Questionnaires were sent three years after graduation to all UK medical graduates of 2008 and 2012. Main outcome measures Comments from doctors about their main reasons for considering leaving medicine or the UK (or both). Results The response rate was 46.2% (5291/11,461). Among the 60% of respondents who were not definitely intent on remaining in UK medicine, 50% were considering working in medicine outside the UK and 10% were considering leaving medicine...
January 1, 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29035188/finding-purpose-honing-the-practice-of-making-meaning-in-medicine
#13
Lois Leveen
Despite decades of advances in diagnosing and treating a broad range of illnesses, many changes in our health care system impede true caregiving, leaving patients and practitioners dissatisfied and creating an emotional burden for practitioners that contributes to the staggering rates of physician burnout. Given this dissatisfaction and disconnection, practitioners and patients alike can benefit from structured opportunities to explore the expectations, assumptions, and emotions that shape our understanding of health and illness, and thus our experiences within the health care system...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29033442/efficacy-of-oxycodone-for-dyspnea-in-end-stage-heart-failure-with-renal-insufficiency-a-case-report
#14
Masayuki Tanaka, Hirofumi Maeba, Takeshi Senoo, Junji Iwasaka, Aki Ohkita, Haruna Kita, Kazuki Uchitani, Yasuhiko Hirota
A 67-year-old man with dilated cardiomyopathy and renal insufficiency was admitted to our hospital with dyspnea secondary to end-stage heart failure. We introduced oxycodone for medically refractory dyspnea instead of morphine because of the patient's renal insufficiency. After the administration of oxycodone, his dyspnea was alleviated without any adverse opioid effects, such as respiratory depression. After treating his heart failure, he was able to leave the intensive care unit. Oxycodone may therefore be a reliable agent for the treatment of dyspnea in patients with end-stage heart failure and renal insufficiency...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29033138/do-you-believe-it-verbal-suggestions-influence-the-clinical-and-neural-effects-of-escitalopram-in-social-anxiety-disorder-a-randomized-trial
#15
Vanda Faria, Malin Gingnell, Johanna M Hoppe, Olof Hjorth, Iman Alaie, Andreas Frick, Sara Hultberg, Kurt Wahlstedt, Jonas Engman, Kristoffer N T Månsson, Per Carlbring, Gerhard Andersson, Margareta Reis, Elna-Marie Larsson, Mats Fredrikson, Tomas Furmark
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression and anxiety, but their efficacy relative to placebo has been questioned. We aimed to test how manipulation of verbally induced expectancies, central for placebo, influences SSRI treatment outcome and brain activity in patients with social anxiety disorder (SAD). METHODS: We did a randomized clinical trial, within an academic medical center (Uppsala, Sweden), of individuals fulfilling the DSM-IV criteria for SAD, recruited through media advertising...
September 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29033113/a-new-facilitating-technique-for-postpartum-hysterectomy-at-full-dilatation-cervical-clamp
#16
Ozan Dogan, Cigdem Pulatoglu, Murat Yassa
BACKGROUND: Postpartum hysterectomy is a life saving emergency procedure in the management of uncontrollable severe maternal hemorrhage that every obstetrician should be closely acquainted with despite developments in medical and non-surgical interventions for obstetric hemorrhage. It can be difficult to detect the real boundaries of the cervix at full effacement and dilatation in patients who undergo emergency hysterectomy after vaginal delivery. METHODS: Hereby we propose a simple and effective method to ease the operation by placing two atraumatic ring forceps to the anterior and posterior sides of the cervix during the preoperative vaginal examination and leave the two ring forceps while taking the patient into surgery...
October 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29033047/effect-of-hemodialysis-on-levels-of-high-sensitivity-cardiac-troponin-t
#17
Michael Chen, Howard Gerson, Shaun Eintracht, Sharon J Nessim, Elizabeth MacNamara
Cardiac troponin (cTn) is essential for the diagnosis of an acute coronary syndrome (ACS). However, in end-stage renal disease (ESRD) baseline cTn levels are often elevated, and it is unknown whether the hemodialysis (HD) procedure affects cTn levels. This leaves clinicians unsure of how to interpret cTn in HD patients with cardiac ischemia. We therefore sought to determine if plasma levels of high-sensitivity cardiac troponin T (hs-cTnT) vary during or after HD treatment. We prospectively enrolled 10 chronic HD patients who were admitted to our institution...
September 4, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29032350/identifying-characteristics-of-the-most-severely-impaired-chronic-pain-patients-treated-at-a-specialized-inpatient-pain-clinic
#18
Eva-Britt Hysing, Lena Smith, Mans Thulin, Rolf Karlsten, Stephen Butler, Torsten Gordh
BACKGROUND AND AIMS: Patients suffering from chronic nonmalignant pain constitute a heterogeneous population in terms of clinical presentation and treatment results. Few data are available about what distinguishes different groups in this huge population of patients with chronic persistent pain (CPP). A subgroup that is poorly studied, consists of the most severely impaired chronic pain patients. At the Uppsala University Hospital Pain Clinic, there is a specialized department accepting the most complex patients for rehabilitation...
October 12, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29031762/sleep-and-cognitive-performance-cross-sectional-associations-in%C3%A2-the%C3%A2-uk-biobank
#19
Simon D Kyle, Claire E Sexton, Bernd Feige, Annemarie I Luik, Jacqueline Lane, Richa Saxena, Simon G Anderson, David A Bechtold, William Dixon, Max A Little, David Ray, Dieter Riemann, Colin A Espie, Martin K Rutter, Kai Spiegelhalder
OBJECTIVE: The relationship between insomnia symptoms and cognitive performance is unclear, particularly at the population level. We conducted the largest examination of this association to date through analysis of the UK Biobank, a large population-based sample of adults aged 40-69 years. We also sought to determine associations between cognitive performance and self-reported chronotype, sleep medication use and sleep duration. METHODS: This cross-sectional, population-based study involved 477,529 participants, comprising 133,314 patients with frequent insomnia symptoms (age: 57...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29031219/long-term-correlation-of-subthalamic-beta-band-activity-with-motor-impairment-in-patients-with-parkinson-s-disease
#20
Wolf-Julian Neumann, Franziska Staub-Bartelt, Andreas Horn, Julia Schanda, Gerd-Helge Schneider, Peter Brown, Andrea A Kühn
OBJECTIVES: To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. METHODS: We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest...
September 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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