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Chronic serous chorioretinopathy

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https://www.readbyqxmd.com/read/28426624/a-randomized-double-blind-placebo-control-pilot-study-of-eplerenone-for-the-treatment-of-central-serous-chorioretinopathy-ecselsior
#1
Ehsan Rahimy, John D Pitcher, Jason Hsu, Murtaza K Adam, Abtin Shahlaee, Wasim A Samara, James F Vander, Richard S Kaiser, Allen Chiang, Marc J Spirn, Mitchell S Fineman
PURPOSE: To evaluate the safety and effects of oral eplerenone in chronic central serous chorioretinopathy. METHODS: Prospective, randomized, double-blind, placebo-control study at a tertiary referral academic private practice. For a diagnosis of chronic central serous chorioretinopathy, patients must have had at least 3 months clinical follow-up demonstrating persistent symptoms, subfoveal fluid on spectral-domain optical coherence tomography, and <50% reduction in fluid thickness...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28421342/selective-retina-therapy-with-automatic-real-time-feedback-controlled-dosimetry-for-chronic-central-serous-chorioretinopathy-in-korean-patients
#2
Young Gun Park, Seungbum Kang, Minhee Kim, Nari Yoo, Young Jung Roh
PURPOSE: To evaluate the safety and efficacy of selective retina therapy (SRT) with real-time feedback-controlled dosimetry (RFD) in the treatment of chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective case series study, 50 eyes of 49 patients with chronic CSC demonstrating focal or diffuse foveal leakages on fundus fluorescein angiography (FFA) were included. Following evaluation of test spots at temporal arcades, SRT (wavelength 527 nm, pulse repetition rate 100 Hz, pulse energy ramp with maximal 15 pulses) with retinal spot diameter of 200 μm was applied to the areas of each leakage observed on fluorescein angiography...
April 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28419399/low-fluence-photodynamic-therapy-versus-graded-subthreshold-transpupillary-thermotherapy-for-chronic-central-serous-chorioretinopathy-results-from-a-prospective-study
#3
George J Manayath, Smita S Karandikar, Siddharth Narendran, Karan A Kumarswamy, V R Saravanan, Rodney J Morris, Narendran Venkatapathy
BACKGROUND AND OBJECTIVE: The authors compare low fluence photodynamic therapy (PDT) against graded subthreshold transpupillary thermotherapy (TTT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: Forty-two eyes of 42 patients with chronic CSC were included in this prospective, nonrandomized, interventional trial. All patients were offered PDT as an initial intervention. If they declined PDT, TTT was offered. RESULTS: Twenty patients underwent PDT and 22 underwent TTT...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28419395/choriocapillaris-changes-imaged-by-oct-angiography-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#4
Kyoko Fujita, Akiyuki Kawamura, Mitsuko Yuzawa
BACKGROUND AND OBJECTIVE: To evaluate the choriocapillaris using optical coherence tomographic angiography (OCTA) after half-dose verteporfin photodynamic therapy (hd-PDT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: We studied six eyes (six patients) with chronic CSC treated by hd-PDT. OCTA was performed before, 1 week after, and 1 month after hd-PDT. The area of flow abnormality at the choriocapillaris level within the PDT spot after hd-PDT was compared with that before hd-PDT...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28386700/clinical-efficacy-of-anti-vegf-medications-for-central-serous-chorioretinopathy-a-meta-analysis
#5
Shangli Ji, Yemei Wei, Jiansu Chen, Shibo Tang
Background Central serous chorioretinopathy (CSC) is a widespread retinal disorder, and 30-50% of patients eventually result in retinal pigment epithelium atrophy and irreversible vision loss. Aim of the review To evaluate the effectiveness of medications based on anti-vascular endothelial growth factor (anti-VEGF) on central serous chorioretinopathy (CSC). Method A systematic search on anti-VEGF medication treatments for CSC was performed in Pubmed, Embase, and the Cochrane Library prior to May 2016. The main outcome variables were best-corrected visual acuity (BCVA) and central macular thickness (CMT)...
April 6, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28375788/real-world-experience-with-half-time-versus-half-dose-photodynamic-therapy-in-chronic-central-serous-chorioretinopathy
#6
Shu-Yen Peng, Chi-Chun Lai, Nan-Kai Wang, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Lee-Jen Chen, Shawn Tsai, Wei-Chun Chan, Laura Liu, Ling Yeung
PURPOSE: To evaluate the real-world experience with half-time photodynamic therapy (PDT) versus half-dose PDT for chronic central serous chorioretinopathy (CSC). METHODS: This multicenter retrospective study enrolled patients who received half-time PDT (with irradiation time shortened to 42 s) or half-dose PDT (with the dosage of verteporfin reduced to 3 mg/m(2)) for chronic CSC and who were followed up for ≧12 months. The success rate, central subfield retinal thickness (CST), and best-corrected visual acuity (BCVA) were documented in each group of patients...
April 4, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28334414/association-of-a-haplotype-in-the-nr3c2-gene-encoding-the-mineralocorticoid-receptor-with-chronic-central-serous-chorioretinopathy
#7
Elon H C van Dijk, Rosa L Schellevis, Maaike G J M van Bergen, Myrte B Breukink, Lebriz Altay, Paula Scholz, Sascha Fauser, Onno C Meijer, Carel B Hoyng, Anneke I den Hollander, Camiel J F Boon, Eiko K de Jong
Importance: Chronic central serous chorioretinopathy (cCSC) is a chorioretinal disease with unknown disease etiology. The glucocorticoid receptor and the mineralocorticoid receptor, 2 glucocorticoid-binding receptors, might be involved in the pathogenesis of cCSC. Objective: To assess the association of functional variants and haplotypes in the glucocorticoid receptor (NR3C1) and mineralocorticoid receptor (NR3C2) genes with cCSC. Design, Setting, and Participants: In this case-control genetic association study, 336 patients with cCSC and 1314 unaffected controls, collected at 3 university medical centers from September 1, 2009, to May 1, 2016, underwent KASP genotyping for selected variants in NR3C1 (rs56149945, rs41423247, and rs6198) and NR3C2 (rs2070951 and rs5522)...
March 23, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28323591/treatment-and-monitoring-of-central-serous-chorioretinopathy-in-pilots
#8
Ari Shinojima, Ryusaburo Mori, Kyoko Fujita, Mitsuko Yuzawa
BACKGROUND: Central serous chorioretinopathy (CSC), which has the characteristics of a serous retinal detachment (SRD) in the macular area, affects mostly men in the 30- to 50-yr age range. Some patients have persistent SRD, which may cause retinal thinning and photoreceptor impairment. CSC symptoms are gradual vision loss and/or metamorphopsia. Some commercial airline pilots are concerned about CSC symptoms, which can disqualify them from flying for months and can also reoccur. Thus, careful monitoring and treatment of CSC are critical for pilots, especially those with chronic or recurrent CSC...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28283732/comparison-of-half-dose-photodynamic-therapy-and-689-nm-laser-treatment-in-eyes-with-chronic-central-serous-chorioretinopathy
#9
Andrea Russo, Raffaele Turano, Francesco Morescalchi, Elena Gambicorti, Anna Cancarini, Sarah Duse, Ciro Costagliola, Francesco Semeraro
PURPOSE: To compare visual and anatomical outcomes between half-dose photodynamic therapy (hd-PDT) and 689 nm laser therapy (689-LT) in chronic central serous chorioretinopathy (CSC). METHODS: Forty eyes of 40 patients with symptomatic chronic CSC were randomized in a 1:1 ratio to receive either hd-PDT or 689-LT delivering 95 J/cm(2) via an intensity application of 805 mW/cm(2) over 118 s. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography findings were compared between the two treatment groups...
March 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28277988/therapy-rationale-for-mineralocorticoid-receptor-antagonists-acetazolamide-and-a-switch-of-therapy-in-nonresponders-in-central-serous-chorioretinopathy
#10
Anne Rübsam, Claudia E Thieme, Juliane Schlomberg, Sibylle Winterhalter, Bert Müller, Antonia M Joussen, Nicole Stübiger
PURPOSE: To evaluate the efficacy of mineralocorticoid-receptor antagonists in comparison to acetazolamide and observation in the treatment of central serous chorioretinopathy. METHODS: Retrospective, interventional cohort study on 93 patients with acute or chronic central serous chorioretinopathy (37 patients: acetazolamide group, 20 patients: mineralocorticoid-receptor antagonist group, 8 patients: observation group, and 27 patients with a therapy switch between both medications)...
April 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28267114/optical-coherence-tomography-angiography-of-flat-irregular-pigment-epithelium-detachment-in-chronic-central-serous-chorioretinopathy
#11
Elodie Bousquet, Sophie Bonnin, Sarah Mrejen, Valérie Krivosic, Ramin Tadayoni, Alain Gaudric
PURPOSE: To assess the rate of choroidal neovascularization (CNV) detected by optical coherence tomography angiography (OCTA) in flat irregular pigment epithelium detachment (PED) in chronic central serous chorioretinopathy. METHODS: Data on all consecutive patients with chronic central serous chorioretinopathy who underwent OCTA over a 1-year period were reviewed. The presence of flat irregular PED, which was defined as an irregular elevation of the retinal pigment epithelium allowing the visualization of a distinct Bruch's membrane was assessed on high-resolution OCT B-scan...
March 3, 2017: Retina
https://www.readbyqxmd.com/read/28239828/the-relation-of-the-serum-aldosterone-level-and-central-serous-chorioretinopathy-a-pilot-study
#12
Q Gong, X-H Sun, S-T Yuan, Q-H Liu
OBJECTIVE: The aim of this study was to investigate the serum aldosterone level and abnormal levels of mineral corticoid in patients with the central serous chorioretinopathy (CSC). PATIENTS AND METHODS: All recruited patients with CSC received fundus fluorescein angiography (FFA), enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) and serum aldosterone assay. The patients were classified into spontaneously resolved group and unresolved group according to a 3-months follow-up of Optical Coherence Tomography (OCT) examination...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28181178/the-ocular-manifestations-of-drugs-used-to-treat-multiple-sclerosis
#13
REVIEW
Gregory Heath, Archana Airody, Richard Peter Gale
Recent times have seen an increase in the number of options to treat multiple sclerosis. Ocular manifestations of multiple sclerosis are well known to treating physicians; however, the medications used to treat multiple sclerosis can also have ocular side effects. This review article focuses on the ocular manifestations of corticosteroids and disease-modifying agents such as interferon, fingolomod, natalizumab, alemtuzumab and mitoxantron used to treat the disease. The ocular manifestations of multiple sclerosis treatments can be varied depending on the drug used, and include retinopathy, chronic central serous chorioretinopathy, macular oedema, Graves' ophthalmopathy and cortical blindness...
February 8, 2017: Drugs
https://www.readbyqxmd.com/read/28171877/a-multicenter-randomized-controlled-study-of-antioxidant-supplementation-with-lutein-for-chronic-central-serous-chorioretinopathy
#14
Ari Shinojima, Miki Sawa, Tetsuju Sekiryu, Yuji Oshima, Ryusaburo Mori, Chikako Hara, Yukinori Sugano, Aki Kato, Hitomi Asato, Mitsuko Yuzawa, Fumi Gomi, Yuichiro Ogura, Tatsuro Ishibashi, Tomoaki Nanri, Tsutomu Yasukawa
PURPOSE: To investigate functional and morphological changes in patients with chronic central serous chorioretinopathy after supplementation with antioxidants containing lutein or a placebo. PROCEDURES: One hundred eyes of 100 patients were randomly divided into 2 groups, one taking tablets with lutein plus other antioxidants and the other taking a placebo for 6 months. Best-corrected visual acuity (BCVA) and the subfoveal fluid height on optical coherence tomography were measured...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28171871/effect-of-photodynamic-therapy-on-optical-coherence-tomography-angiography-in-eyes-with-chronic-central-serous-chorioretinopathy
#15
Yishuang Xu, Yu Su, Lu Li, Hang Qi, Hongmei Zheng, Changzheng Chen
PURPOSE: To analyze the use of optical coherence tomography angiography (OCTA) in order to observe the changes in chronic central serous chorioretinopathy (CCSC) after half-dose photodynamic therapy (PDT). METHODS: This is a retrospective study evaluating an imaging technique in a cohort of patients. Fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA) (Heidelberg Spectralis, Heidelberg, Germany), OCT, and OCTA with the split-spectrum amplitude-decorrelation angiography algorithm (XR Optovue, Fremont, CA, USA) were performed prior to half-dose PDT...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28154953/half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy-evaluated-by-focal-macular-electroretinograms
#16
Kazuhiro Oiwa, Keiko Kataoka, Ruka Maruko, Shinji Ueno, Yasuki Ito, Hiroko Terasaki
PURPOSE: To evaluate the effect of half-dose verteporfin photodynamic therapy (hPDT) on the physiology of the macula determined by focal macular electroretinograms (FMERGs) in eyes with chronic central serous chorioretinopathy (CSC). METHODS: Fourteen eyes of 13 patients with chronic CSC were treated with hPDT. The best-corrected visual acuity (BCVA) was measured, and optical coherence tomography (OCT) and FMERGs were performed at the baseline, and at 4 days, 1, 3, 6, and 12 months after the hPDT...
February 2, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28058163/clinical-features-and-course-of-patients-with-peripheral-exudative-hemorrhagic-chorioretinopathy
#17
Zafer Cebeci, Yasemin Dere, Şerife Bayraktar, Samuray Tuncer, Nur Kır
OBJECTIVES: To evaluate the clinical characteristics of patients who were followed in our clinic with the diagnosis of peripheral exudative hemorrhagic chorioretinopathy (PEHC). MATERIALS AND METHODS: Medical records of 12 patients who were diagnosed with PEHC in İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology between July 2006 and June 2014 were reviewed retrospectively. RESULTS: This study included 21 eyes of 12 patients...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28053499/chronic-central-serous-chorioretinopathy-long-term-follow-up-and-vision-related-quality-of-life
#18
Myrte B Breukink, Alexander Jm Dingemans, Anneke I den Hollander, Jan Ee Keunen, Robert E MacLaren, Sascha Fauser, Giuseppe Querques, Carel B Hoyng, Susan M Downes, Camiel Jf Boon
PURPOSE: To describe the clinical findings and long-term outcome of patients with chronic central serous chorioretinopathy (cCSC). MATERIALS AND METHODS: This was a retrospective case series in 52 eyes of 36 patients with a follow-up period of at least 1 year. Extensive ophthalmic examination and a validated questionnaire concerning vision-related quality of life (National Eye Institute Visual Function Questionnaire [NEI-VFQ]-39) were analyzed. RESULTS: Mean visual acuity showed a significant decline over time of 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28009402/choroidal-characteristics-of-acute-and-chronic-central-serous-chorioretinopathy-using-enhanced-depth-imaging-optical-coherence-tomography
#19
Jorge Ruiz-Medrano, Marco Pellegrini, Matteo G Cereda, Mario Cigada, Giovanni Staurenghi
PURPOSE: Central serous chorioretinopathy (CSC) is an idiopathic disorder characterized by serous detachments of the neurosensory retina and/or the retinal pigment epithelium affecting the macular area in the majority of cases. The objective of this study was to describe choroidal findings in patients with acute and chronic CSC based on enhanced depth imaging optical coherence tomography analysis. METHODS: This is a cross-sectional, noninterventional study performed at Luigi Sacco University Hospital of Milan...
November 18, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27997459/short-term-findings-on-optical-coherence-tomography-and-microperimetry-in-chronic-central-serous-chorioretinopathy-patients-treated-with-half-dose-photodynamic-therapy
#20
Elon H C van Dijk, Greet Dijkman, Thomas Theelen, Carel B Hoyng, Camiel J F Boon
PURPOSE: To assess the short-term outcome of and possible temporary vision loss after half-dose verteporfin photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC). METHODS: In this prospective study, 14 eyes of 13 cCSC patients who underwent half-dose PDT were included. Patients received spectral-domain optical coherence tomography (OCT) imaging and microperimetry before PDT on the day of treatment and 1 week after treatment...
December 16, 2016: Retinal Cases & Brief Reports
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