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Chronic serous chorioretinopathy

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https://www.readbyqxmd.com/read/29200818/photodynamic-therapy-combined-with-antivascular-endothelial-growth-factor-treatment-for-recalcitrant-chronic-central-serous-chorioretinopathy
#1
Masumi G Asahi, Andrew T Chon, Esmeralda Gallemore, Ron P Gallemore
Purpose: To determine whether combination photodynamic therapy (PDT) and antivascular endothelial growth factor (VEGF) therapy is effective in the management of chronic central serous chorioretinopathy (CSC) recalcitrant to conventional therapy. Methods: This was a retrospective analysis of eight patients with chronic CSC unresponsive to topical nonsteroidal anti-inflammatory drugs, focal photocoagulation, anti-VEGF alone, or PDT alone. All patients were evaluated with a full ophthalmic examination, spectral-domain optical coherence tomography (OCT), fluorescein angiography (FA), and most with indocyanine green angiography (ICGA) followed by treatment with half-fluence PDT and intravitreal anti-VEGF injection (seven bevacizumab, one aflibercept)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29176603/the-association-between-visual-function-and-retinal-structure-in-chronic-central-serous-chorioretinopathy
#2
Aya Sugiura, Ryosuke Fujino, Nobuko Takemiya, Kimiko Shimizu, Masato Matsuura, Hiroshi Murata, Tatsuya Inoue, Ryo Obata, Ryo Asaoka
The purpose of the current study was to investigate the association between visual function and retinal structure in central serous chorioretinopathy (CSC). In 22 eyes of 22 chronic CSC patients with serous retinal detachment at the macula, retinal sensitivity was measured using MP3 microperimetry (NIDEK, Japan) and mean sensitivity within two degrees (MS2), four degrees (MS4) and six degrees (MS6), as well as foveal sensitivity (MS0), were calculated. Retinal structure was measured using optical coherence tomography (OCT, Spectralis, Heidelberg)...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29156649/short-term-choriocapillaris-changes-in-patients-with-central-serous-chorioretinopathy-after-half-dose-photodynamic-therapy
#3
Marco Nassisi, Carlo Lavia, Camilla Alovisi, Luca Musso, Chiara M Eandi
BACKGROUND: Although photodynamic therapy (PDT) has become the standard treatment for central serous chorioretinopathy (CSC), its mechanism of action remains unclear. It is assumed that PDT induces short-term choriocapillaris (CC) occlusion and long-term choroidal vascular remodeling. In this paper, we describe the short-term CC changes induced by Half-Dose PDT (HD-PDT) in chronic CSC using optical coherence tomography-angiography (OCTA). METHODS: This is a prospective interventional case series...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29109866/correlation-between-choroidal-neovascularization-shown-by-oct-angiography-and-choroidal-thickness-in-patients-with-chronic-central-serous-chorioretinopathy
#4
Joanna Gołębiewska, Joanna Brydak-Godowska, Joanna Moneta-Wielgoś, Monika Turczyńska, Dariusz Kęcik, Wojciech Hautz
Purpose: To assess the occurrence of choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR) using optical coherence tomography angiography (OCTA) and correlate these findings with choroidal thickness (CT). Materials and Methods: This retrospective study included 25 consecutive patients (43 eyes), mean age 48.12 ± 7.8 years, diagnosed with persistent CSCR. All patients underwent a complete ophthalmic examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography, and OCTA...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29098100/chronic-central-serous-chorioretinopathy-in-a-patient-with-pigment-dispersion-syndrome-a-possible-correlation
#5
Dimitrios Kourkoutas, George Tsakonas, Aristotelis Karamaounas, Nikolaos Karamaounas
Chronic central serous chorioretinopathy (CSCR) is a progressive chorioretinopathy with widespread atrophic RPE abnormalities and serous retinal detachments (SRDs) present for 6 months or longer. We report a case of CSCR in a 38-year-old patient with Pigment Dispersion Syndrome (PDS). In the presented case of CSCR, the chronic course of the disease may in part be associated with an underlying generalized degenerative dysfunction of the pigmented cells of the eye on grounds of PDS. We suggest that a chronic course of disease may be suspected in the setting of CSCR with concurrent RPE pathology, such as what is found in PDS...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29077604/twelve-month-efficacy-of-intravitreal-bevacizumab-injection-for-chronic-atypical-or-recurrent-central-serous-chorioretinopathy
#6
Yoo-Ri Chung, Jong Wan Kim, Ji Hun Song, Aram Park, Min Ho Kim
PURPOSE: To evaluate intravitreal bevacizumab (IVB) injection efficacy for the treatment of chronic, atypical, or recurrent central serous chorioretinopathy (CSC). METHODS: Clinical data from 77 eyes of 71 patients with chronic, atypical, or recurrent CSC treated with IVB were retrospectively analyzed. After initial 6-weekly IVB administration until no subretinal fluid remained at the fovea, additional as-needed IVBs were administered, based on optical coherence tomography findings...
October 26, 2017: Retina
https://www.readbyqxmd.com/read/29063192/spectrum-of-retinal-abnormalities-in-renal-transplant-patients-using-chronic-low-dose-steroids
#7
Elon H C van Dijk, Darius Soonawala, Vera Rooth, Carel B Hoyng, Onno C Meijer, Aiko P J de Vries, Camiel J F Boon
PURPOSE: To assess the ophthalmological characteristics of asymptomatic patients with a renal transplant on chronic low-dose steroids for at least the last 2 years prior to examination. METHODS: Cross-sectional study. All patients underwent an extensive ophthalmological examination. RESULTS: Of the 37 included patients [25 male, 12 female; 59 ± 11 years (range, 38-77 years)] ophthalmological phenotyping revealed abnormalities in 22 patients (59%)...
October 23, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29016451/concurrent-idiopathic-macular-telangiectasia-type-2-and-central-serous-chorioretinopathy
#8
Alexandre Matet, Suzanne Yzer, Emily Y Chew, Alejandra Daruich, Francine Behar-Cohen, Richard F Spaide
PURPOSE: To describe cases presenting with features of idiopathic macular telangiectasia (MacTel) Type 2 and central serous chorioretinopathy (CSC). METHODS: Databases from four tertiary retina centers were searched for cases copresenting CSC and MacTel Type 2. RESULTS: Five cases were identified (4 men, 1 woman; mean age: 67.2 years). Four patients were referred for chronic or nonresolving CSC, and the diagnosis of MacTel Type 2 was made based on multimodal imaging findings...
October 9, 2017: Retina
https://www.readbyqxmd.com/read/28860700/changes-of-outer-retinal-microstructures-after-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#9
Kimiko Shimizu, Yohei Hashimoto, Keiko Azuma, Yoko Nomura, Ryo Obata, Hidenori Takahashi, Yasuo Yanagi
PURPOSE: To evaluate the morphological changes in retinal microstructures following modified photodynamic therapy (PDT) for chronic central serous chorioretinopathy. SUBJECTS AND METHODS: Retrospective study of 21 consecutive eyes (age, 59±8.0 years [mean ± SD]) of 21 patients with chronic central serous chorioretinopathy. Inner foveal thickness (the distance between the internal limiting membrane and external limiting membrane), photoreceptor outer segment (PROS) length at the point without serous retinal detachment and choroidal thickness were assessed with enhanced depth imaging optical coherence tomography before treatment and at 1, 3 and 6 months after modified PDT...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28832738/multimodal-assessment-of-patients-with-chronic-central-serous-chorioretinopathy
#10
COMPARATIVE STUDY
Karlos Ítalo Souza Viana, Pedro M Souza Leão, Letícia Fernandes, Rubens Siqueira, Jefferson Ribeiro, Rodrigo Jorge
PURPOSE: To examine differences between fluorescein angiography (FA) and indocyanine green angiography (ICG) findings in patients with chronic central serous chorioretinopathy (CSC), comparing these with optical coherence tomography (OCT) findings. METHODS: Ten consecutive patients with chronic CSC (19 eyes; 7 men; mean age, 50.7 ± 8.4 years) underwent multimodal evaluation that included FA, ICG, and OCT (Spectralis HRA-OCT, Heidelberg Engineering, Heidelberg, Germany)...
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28831603/functional-and-morphological-outcome-in-patients-with-chronic-central-serous-chorioretinopathy-treated-by-subthreshold-micropulse-laser
#11
Maciej Gawęcki, Agnieszka Jaszczuk-Maciejewska, Anna Jurska-Jaśko, Andrzej Grzybowski
BACKGROUND: Chronic central serous chorioretinopathy is a serious therapeutic problem as it may lead to significant visual impairment. The aim of this retrospective study is to evaluate functional and morphological effects, as well as factors influencing visual outcome in patients treated by subthreshold micropulse laser. METHODS: Fifty-one eyes with chronic central serous chorioretinopathy lasting longer than 4 months (18 months on average) underwent up to two sessions of subtreshold micropulse laser treatment...
August 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28814876/neutrophil-lymphocyte-ratio-and-mean-platelet-volume-in-central-serous-chorioretinopathy
#12
Muhammet Kazim Erol, Ayse Balkarli, Ozgur Yucel, Yusuf Akar, Berna Dogan, Elcin Suren
PURPOSE: This study aimed to evaluate mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) values and their relationship with clinical findings in patients with central serous chorioretinopathy (CSCR). METHODS: Overall, 87 patients fulfilling inclusion criteria and 320 age- and sex-matched healthy individuals as controls were included in the study. The CSCR patients (n=87) were classified into 2 groups as acute CSCR (group 1, n=43) and chronic CSCR (group 2, n=44)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28798899/diagnosed-a-patient-with-central-serous-chorioretinopathy-now-what-management-of-central-serous-chorioretinopathy
#13
Brian E Goldhagen, Raquel Goldhardt
PURPOSE OF REVIEW WHAT IS THE GOAL OF YOUR PAPER? WHAT QUESTIONS DID YOU SEEK TO ANSWER?: The goal of this paper is to provide a comprehensive review of the management options for central serous chorioretinopathy (CSCR). RECENT FINDINGS SUMMARIZE THE LATEST RESEARCH ON YOUR TOPIC: The majority of cases of acute CSCR may be managed with observation and cessation of corticosteroids, if possible, as well as life-style modifications including stress reduction and control of hypertension...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28797227/changes-in-macular-sensitivity-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#14
Alp Atik, Yijun Hu, Honghua Yu, Chun Yang, Bin Cai, Yijing Tao, Dongli Li, Yan Chen, Li Lu, Guodong Li, Ling Yuan
BACKGROUND: To evaluate the macular sensitivity changes after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR). METHODS: Eighteen patients (26 eyes) with chronic CSCR were recruited in the same hospital between April 2011 and December 2012. All patients were treated with one session of half-dose PDT after complete ophthalmic examination. Macular sensitivity examination was performed at baseline and 1, 3 and 6 months post-treatment...
August 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28791061/visual-and-anatomical-outcomes-of-spironolactone-therapy-in-patients-with-chronic-central-serous-chorioretinopathy
#15
Khalil Ghasemi Falavarjani, Anahita Amirsardari, Abbas Habibi, Acieh Eshaghi, Shohreh Bakhti, Kaveh Abri Aghdam
PURPOSE: To evaluate the effect of spironolactone on chronic central serous chorioretinopathy (CSC). METHODS: In this prospective interventional case series, patients with chronic CSC were treated with spironolactone (25 mg daily) for at least 6 weeks. If the subretinal fluid (SRF) had not completely resolved by this time, treatment was continued, and the dosage was increased to 25 mg twice daily. Primary outcome measure was the change in maximum SRF height at the final follow-up visit, as detected by optical coherence tomography...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28774289/acute-uveal-effusion-during-phacoemulsification-with-preoperative-central-serous-chorioretinopathy-a-case-report
#16
Ruiqi Chang, Yu Du, Zhou Peng, Yi Lu, Xiangjia Zhu
BACKGROUND: We report a case of acute uveal effusion during phacoemulsification in an eye with preoperative chronic central serous chorioretinopathy (CSC). CASE PRESENTATION: A 55-year-old man with a history of chronic CSC for >18 months presented with bilateral opaque lenses. A preoperative ophthalmic examination showed suspected lenticonus and risky anatomical features, including a thick ciliary body, and anterior rotation of the ciliary process and iris root in both eyes...
August 3, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28742138/long-term-prognostic-factors-of-chronic-central-serous-chorioretinopathy-after-half-dose-photodynamic-therapy-a-3-year-follow-up-study
#17
Fuminori Haga, Ruka Maruko, Chiaki Sato, Keiko Kataoka, Yasuki Ito, Hiroko Terasaki
PURPOSE: To evaluate the long-term efficacy and factors involved in the recurrence and persistence of subretinal fluid (SRF) after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective observational case series, 79 eyes (73 patients) with chronic CSC were treated with half-dose PDT and followed up for at least 3 years. They were divided into successful (64 eyes) and unsuccessful (15 eyes) groups based on SRF absorption and disease recurrence after one PDT session...
2017: PloS One
https://www.readbyqxmd.com/read/28728183/early-focal-laser-photocoagulation-in-acute-central-serous-chorioretinopathy-a-prospective-randomized-study
#18
RANDOMIZED CONTROLLED TRIAL
Vikas Ambiya, Mitali Khodani, Abhilash Goud, Raja Narayanan, Mudit Tyagi, Padmaja Kumari Rani, Jay Chhablani
BACKGROUND AND OBJECTIVE: To evaluate the role of early focal laser photocoagulation in acute central serous chorioretinopathy (CSC). PATIENTS AND METHODS: A total of 58 eyes with acute naïve CSC (less than 2 months' duration) with focal leak on fundus fluorescein angiography (FFA) were randomized into either a laser or a sham laser group. Eyes with chronic CSC and subfoveal leak were excluded. Visual acuity assessment, microperimetry, optical coherence tomography, and FFA were done at baseline, 1 month (minus FFA), 3 months, and 6 months after treatment...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28699928/anti-vegf-therapy-versus-photodynamic-therapy-in-the-treatment-of-choroidal-neovascularization-secondary-to-central-serous-chorioretinopathy
#19
Enrico Peiretti, Giulia Caminiti, Rita Serra, Lea Querques, Riccardo Pertile, Giuseppe Querques
PURPOSE: To evaluate the efficacy of photodynamic therapy (PDT) compared with intravitreal vascular endothelial growth factor (VEGF) inhibitors alone or combined with PDT in the treatment of choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR). METHODS: Retrospective study of a consecutive series of 34 white patients (34 eyes) with angiographic evidence of choroidal neovascularization secondary to chronic central serous chorioretinopathy, divided into two groups followed for at least 12 months: 16 were treated with full fluence PDT (PDT group) and 18 with vascular endothelial growth factor inhibitors (intravitreal [IVT] group)...
July 7, 2017: Retina
https://www.readbyqxmd.com/read/28674835/photodynamic-therapy-in-chronic-central-serous-chorioretinopathy-with-subretinal-fluid-outside-the-fovea
#20
Elon H C van Dijk, Greet Dijkman, Camiel J F Boon
PURPOSE: To assess the efficacy of photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC), in whom subretinal fluid (SRF) was solely present outside the foveal area. METHODS: In this retrospective study, 16 eyes of 15 cCSC patients who received half-dose PDT because of notable subjective visual complaints due to the presence of extrafoveal SRF, were included. An ophthalmic examination was performed before treatment, including Early Treatment Diabetic Retinopathy Study best-corrected visual acuity measurement, applanation tonometry, slit-lamp examination, and indirect ophthalmoscopy, followed by multimodal imaging, including fundus photography, fundus autofluorescence, spectral-domain optical coherence tomography (OCT), enhanced-depth imaging OCT of the choroid, fluorescein angiography, and indocyanine green angiography...
October 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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