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https://www.readbyqxmd.com/read/28934664/targeted-h-triggered-bubble-generating-nanosystems-for-effective-therapy-in-cancer-cells
#1
Zhili Deng, Menghuan Tang, Li Zhao, Yijuan Long, Zuhuang Wen, Yuan Cheng, Huzhi Zheng
A novel targeting drug delivery system for cancer therapy based on H(+)-triggered bubble-generating nanosystems (BGNSs) was engineered. First, hollow mesoporous silica nanoparticles (HMSNs) were used to load doxorubicin (DOX). Then, the obtained drug-loaded HMSNs were treated with NaHCO3 to prepare the BGNSs. The BGNSs were coated with polydopamine (pDA), and finally, folic acids (FA) were anchored on the nanosystems to obtain the desired nanoscale drug delivery system (BGNSs@pDA-FA). BGNSs@pDA-FA was effectively internalized by cancer cells through folate receptor-mediated endocytosis and generated CO2 bubbles under the acidic environment of the lysosomes, thus enhancing lysosomal membrane permeability (LMP) to release caspase-3 into the cytoplasm, resulting in cancer cell death via an apoptosis-like pathway...
September 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28931488/carboxylate-cross-linked-cyclodextrin-a-nanoporous-scaffold-for-enhancement-of-rosuvastatin-oral-bioavailability
#2
Mai Mahmoud Gabr, Sana Mohamed Mortada, Marwa Ahmed Sallam
Cyclodextrins play an important role in supramolecular chemistry acting as building blocks than can be cross-linked by various linker molecules forming nano-porous structures called nanosponges (NS). NS have the ability to enhance the stability, solubility and bioavailability of various actives. This work aimed at elaborating rosuvastatin (ROS) loaded NS to improve its oral bioavailability. Carboxylate-linked NS were synthesized by reacting β-CD with pyromellitic dianhydride (PDA) at different molar ratios under specific conditions...
September 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28930274/the-efficiency-of-noni-morinda-citrifolia-l-essential-oil-on-the-control-of-leaf-spot-caused-by-exserohilum-turcicum-in-maize-culture
#3
Janaina Costa E Silva, Dalmarcia de Sousa Carlos Mourão, Fabia Silva de Oliveira Lima, Renato de Almeida Sarmento, Mateus Sunti Dalcin, Raimundo Wagner de Souza Aguiar, Gil Rodrigues Dos Santos
The objective of this work was to evaluate the efficiency of noni essential oil on the control of Exserohilum turcicum, a causative agent of Exserohilum spot in maize culture. In the sanitary test 400 seeds were incubated using the blotter test method. For the transmissibility test, the fragments of damaged leaves of seedlings were removed and put into a potato, dextrose and agar (PDA) culture environment. To verify the pathogenicity, Koch´s postulates were performed. In the phytotoxicity test different concentrations of noni oil were applied in maize seedlings...
August 14, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28928609/initial-experience-with-the-3-3-fr-mongoose-%C3%A2-pigtail-catheter-for-aortic-angiography-during-patent-ductus-arteriosus-closure-in-small-patients
#4
Zachary Hena, Nicole J Sutton, Gregory J Gates, Benjamin H Taragin, Robert H Pass
BACKGROUND: Smaller femoral arterial sheaths may be associated with fewer vascular complications. The 3.3 Fr Mongoose(®) Pediavascular pigtail catheter is a catheter that allows higher flow rates, potentially resulting in improved angiographic quality. We reviewed our experience with this small catheter during patent ductus arteriosus (PDA) closure. MATERIALS AND METHODS: Review of patients ≤20 kg in whom the Mongoose(®) catheter was used during PDA closure from 12/13 to 4/15...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28925552/in-situ-bone-tissue-engineering-with-an-endogenous-stem-cell-mobilizer-and-osteoinductive-nanofibrous-polymeric-scaffolds
#5
Jong Seung Lee, Yoonhee Jin, Hyun-Ji Park, Kisuk Yang, Min Suk Lee, Hee Seok Yang, Seung-Woo Cho
Classical bone tissue engineering involves the use of culture-expanded cells and scaffolds to produce tissue constructs for transplantation. Despite promising results, clinical adoption of these constructs has been limited due to various drawbacks, including extensive cell expansion steps, low cell survival rate upon transplantation, and the possibility of immuno-rejection. To bypass the ex vivo cell culture and transplantation process, we exploited the regenerative capacity of the host by mobilizing endogenous stem cells to the site of injury...
September 19, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28923617/postdonation-anemia-in-living-kidney-donors
#6
S Shah, B Lankowsky, T Gao, Z Zaky, B R Stephany, E D Poggio
BACKGROUND: The effect of nephrectomy on development of anemia in living kidney donation has not been well studied. We hypothesized that the remaining kidney volume and function after donation are determinants of hemoglobin (Hb) concentration and postdonation anemia (PDA). METHODS: We studied 398 living kidney donors (LKDs) who donated from January 2001 to December 2013. Demographic variables, hematologic variables, renal mass, and renal function were investigated as factors associated with PDA with the use of univariate and multivariable logistical regression analysis...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28919686/high-performance-liquid-chromatography-ultraviolet-photodiode-array-detection-method-for-aflatoxin-b1-in-cattle-feed-supplements
#7
Lazuardi Mochamad, Bambang Hermanto
AIM: The objective of the current study is to determine the concentration of aflatoxin B1 using high-performance liquid chromatography (HPLC) with a photodiode array (PDA) detector. MATERIALS AND METHODS: Aflatoxin B1 certified reference grade from Trilogy Analytical Laboratory dissolved acetonitrile (ACN) at 10 µg/mL was using standard assessment. HPLC instruments such as ultraviolet-PDA detector used a Shimadzu LC-6AD pump with DGU-20A5 degasser, communication module-20A, and PDA detector SPD-M20A with FRC-10A fraction collector...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28919282/impact-of-pancreaticoduodenal-arcade-dilation-on-postoperative-outcomes-after-pancreaticoduodenectomy
#8
Yusuke Nakayama, Motokazu Sugimoto, Tatsushi Kobayashi, Naoto Gotohda, Shinichiro Takahashi, Masahiko Kusumoto, Masaru Konishi
BACKGROUND: The aim of this study was to investigate the impact of pancreaticoduodenal arcade (PDA) dilation on postoperative outcomes after pancreaticoduodenectomy. METHODS: Consecutive patients submitted to pancreaticoduodenectomy between 2008 and 2016 underwent preoperative multi-detector computed tomography, the images of which were re-reviewed. The patients were categorized according to the grade of PDA dilation into 3 groups (remarkably-dilated, slightly-dilated, and non-dilated)...
September 14, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28918408/effectiveness-cost-utility-and-implementation-of-a-decision-aid-for-patients-with-localised-prostate-cancer-and-their-partners-study-protocol-of-a-stepped-wedge-cluster-randomised-controlled-trial
#9
Hoda H M Al-Itejawi, Cornelia F van Uden-Kraan, Peter M van de Ven, Veerle M H Coupé, André N Vis, Jakko A Nieuwenhuijzen, Jeroen A van Moorselaar, Irma M Verdonck-de Leeuw
INTRODUCTION: Patient decision aids (PDAs) have been developed to help patients make an informed choice for a treatment option. Despite proven benefits, structural implementation falls short of expectations. The present study aims to assess the effectiveness and cost-utility of the PDA among newly diagnosed patients with localised prostate cancer and their partners, alongside implementation of the PDA in routine care. METHODS/ANALYSIS: A stepped-wedge cluster randomised trial will be conducted...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918291/distinguished-cr-vi-capture-with-rapid-and-superior-capability-using-polydopamine-microsphere-behavior-and-mechanism
#10
Qingrui Zhang, Yixuan Li, Qinggang Yang, He Chen, Xinqing Chen, Tifeng Jiao, Qiuming Peng
Toxic heavy metal containing Cr(VI) species is a serious threat for ecological environment and human beings. In this work, a new mussel-inspired polydopamine microsphere (PDA-sphere) is prepared through in situ oxidative polymerization at air condition with controllable sizes. The adsorption of Cr(VI) ions onto PDA-sphere is highly pH dependent with the optimal pH ranging from 2.5 to 3.8. A rapid Cr(VI) removal can approach in 8min for equilibrium. More importantly, the prepared materials exhibit a remarkable sorption selectivity, coexisting SO4(2-), NO3(-) and Cl(-) ions at high levels; The applicability model further proves its effective performances with treated capacity of 42,000kg/kg sorbent, and the effluent can be reduced from 2000ppb to below 50ppb, which meets the drinking water criterions recommended by WHO...
August 26, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28916394/a-useful-strategy-based-on-chromatographic-data-combined-with-quality-by-design-approach-for-food-analysis-applications-the-case-study-of-furanic-derivatives-in-sugarcane-honey
#11
Pedro Silva, Catarina L Silva, Rosa Perestrelo, Fernando M Nunes, José S Câmara
Sugarcane honey (SCH) is one of the Madeira Island products par excellence and it is now popular worldwide. Its sui generis and peculiar sensory properties, explained by a variety of volatile compounds including furanic derivatives (FDs), arise mainly from manufacturing and storage conditions. A simple high-throughput approach based on semi-automatic microextraction by packed sorbent (MEPS) combined with ultra-high performance liquid chromatography (UHPLC) was developed and validated for identification and quantification of target FDs in sugarcane honey...
September 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28916191/%C3%AE-the-hydro-alcoholic-extracts-of-sardinian-wild-thistles-onopordum-spp-inhibit-tnf%C3%AE-induced-il-8-secretion-and-nf-%C3%AE%C2%BAb-pathway-in-human-gastric-epithelial-ags-cells
#12
Arianna Marengo, Marco Fumagalli, Cinzia Sanna, Andrea Maxia, Stefano Piazza, Cecilia Cagliero, Patrizia Rubiolo, Enrico Sangiovanni, Mario Dell'Agli
ETHNOPHARMACOLOGICAL RELEVANCE: Thistles species (Family: Compositae) are traditionally used in the Mediterranean area, particularly in Sardinia. They are usually gathered from the wild and used for both food and therapeutic purposes, including gastrointestinal disorders. AIM OF THE STUDY: This work aims to evaluate the anti-inflammatory activity of eight wild thistles from Sardinia, in an in vitro model of gastric inflammation, and to identify the major active compounds in the extracts...
September 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28915497/pegylated-polydopamine-coated-magnetic-nanoparticles-for-combined-targeted-chemotherapy-and-photothermal-ablation-of-tumour-cells
#13
Peng Xue, Lihong Sun, Qian Li, Lei Zhang, Jinhong Guo, Zhigang Xu, Yuejun Kang
The integration of multifunctional therapeutic capabilities into a single nanosystem has attracted much attention for use as an efficient cancer therapy. However, developing biocompatible therapeutic nano-agents with desirable safety, efficiency, targeting, and synergistic effects remains challenging. Herein, we designed a class of multifunctional PEGylated magnetic nanoparticles (NPs) with a core-shell structure and polydopamine (PDA) coating, which were loaded with the anticancer drug doxorubicin (DOX) for simultaneous targeted chemotherapy and photothermal ablation of tumour cells...
September 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28914050/boric-acid-as-an-efficient-agent-for-the-control-of-polydopamine-self-assembly-and-surface-properties
#14
Anne Schneider, Joseph Hemmerlé, Manon Allais, Jeoffrey Didierjean, Marc Michel, Marco d'Ischia, Vincent Ball
The deposition of polydopamine (PDA) films on surfaces, a versatile deposition method with respect to the nature of the used substrate, is unfortunately accompanied by deposition of insoluble precipitates in solution after a prolonged oxidation time of dopamine solutions. Therefore, there is evident interest to find methods able to stop the deposition of PDA on surfaces and to simultaneously control the self-assembly of PDA in solution to get stable colloidal aggregates. In addition to proposed methods relying on the use of polymers like poly(vinyl alcohol) and proteins like human serum albumin, we show herein that boric acid is an efficient adjuvant that is simultaneously able to stop the self-assembly of PDA in solution as well as on surfaces and to change the adhesive properties of the resulting PDA coatings...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28913006/uhplc-pda-assay-for-simultaneous-determination-of-vitamin-d3-and-menaquinone-7-in-pharmaceutical-solid-dosage-formulation
#15
Muhammad Jehangir, Mahmood Ahmed, Muhammad Imtiaz Shafiq, Abdul Samad, Iftikhar-Ul-Haq
A newly developed method based on ultrahigh performance liquid chromatography (UHPLC) was optimized for the simultaneous determination of vitamin D3 and menaquinone-7 (MK-7) in tablet formulation in the present study. UHPLC separation of vitamin D3 and MK-7 was performed with ACE Excel 2 C18-PFP column (2 μm, 2.1 × 100 mm) at 0.6 mL min(-1) flow rate, whereas the mobile phase consisted of methanol/water (19 : 1, v/v, phase A) and isopropyl alcohol (99.9%, phase B) containing 0.5% triethylamine. Isocratic separation of both the analytes was performed at 40°C by pumping the mobile phases A and B in the ratio of 50 : 50 (v/v, pH, 6...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28911743/effects-of-a-ntg-based-chemical-mutagenesis-on-the-propamocarb-tolerance-of-the-nematophagous-fungus-lecanicillium-attenuatum
#16
Ming Xie, Qian Li, Xin-Ping Hu, Yan-Jun Zhang, De-Liang Peng, Xiao-Lin Zhang
Lecanicillium attenuatum is an important nematophagous fungus with potential as a biopesticide for control of plant-pathogenic nematodes. However, relatively low fungicide-tolerance limits its application in the field. To improve the propamocarb-tolerance of L. attenuatum, a NTG-based mutagenesis system was established. Among different combinations of NTG concentration and treatment time in the first-round NTG treatment, the treatment of 1.0mg/ml NTG for 60min gave a proper conidial lethality rate of 84.6% and the highest positive mutation rate of 7...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28906496/urinary-nt-probnp-levels-and-echocardiographic-parameters-for-patent-ductus-arteriosus
#17
S S Khan, T Sithisarn, H S Bada, M Vranicar, P M Westgate, M Hanna
OBJECTIVE: Patent ductus arteriosus (PDA) is common in preterm infants and is associated with significant morbidities. B type natriuretic peptide (BNP) is synthesized in the ventricles secondary to volume overload and excreted as urinary N-terminal pro-brain natriuretic peptide (NT-proBNP). STUDY DESIGN: We report an observational prospective study of 64 preterm infants with birth weight ⩽1000 g. Echocardiographic parameters were obtained from clinical echocardiograms performed in the first week of life...
September 14, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28901742/surface-modification-of-polydimethylsiloxane-with-polydopamine-and-hyaluronic-acid-to-enhance-hemocompatibility-for-potential-applications-in-medical-implants-or-devices
#18
Peng Xue, Qian Li, Yuan Li, Lihong Sun, Lei Zhang, Zhigang Xu, Yuejun Kang
Polydimethylsiloxane (PDMS) has been widely utilized in microelectromechanical systems (MEMS) and implantable devices. To improve the hemocompatibility of PDMS-based implant, a facile technique was developed by modifying PDMS with a hyaluronic acid (HA) and polydopamine (PDA) composite (HA/PDA). Under appropriate ratio of HA to PDA, platelet adhesion and activation was considerably reduced on modified PDMS substrates, indicating an enhanced hemocompatibility compared to native PDMS or those coated with HA or PDA solely...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28901229/intraoperative-high-frequency-jet-ventilation-is-equivalent-to-conventional-ventilation-during-patent-ductus-arteriosus-ligation
#19
Mackenzie Noonan, Joseph W Turek, John M Dagle, Steven J McElroy
BACKGROUND: Patent ductus arteriosus (PDA) treatment is typically pharmacologic, but if unsuccessful, surgical ligation is commonly performed. High-frequency jet ventilation (HFJV) is used at the University of Iowa Stead Family Children's Hospital for extremely low birth weight infants. Historically, neonates requiring PDA ligation were temporarily transferred to conventional ventilation (CV) prior to surgery. OBJECTIVE: The objective of this study was to determine whether conversion was necessary...
September 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28900097/electrical-properties-and-thermal-stability-in-stack-structure-of-hfo2-al2o3-insb-by-atomic-layer-deposition
#20
Min Baik, Hang-Kyu Kang, Yu-Seon Kang, Kwang-Sik Jeong, Youngseo An, Seongheum Choi, Hyoungsub Kim, Jin-Dong Song, Mann-Ho Cho
Changes in the electrical properties and thermal stability of HfO2 grown on Al2O3-passivated InSb by atomic layer deposition (ALD) were investigated. The deposited HfO2 on InSb at a temperature of 200 °C was in an amorphous phase with low interfacial defect states. During post-deposition annealing (PDA) at 400 °C, In-Sb bonding was dissociated and diffusion through HfO2 occurred. The diffusion of indium atoms from the InSb substrate into the HfO2 increased during PDA at 400 °C. Most of the diffused atoms reacted with oxygen in the overall HfO2 layer, which degraded the capacitance equivalent thickness (CET)...
September 12, 2017: Scientific Reports
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