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https://www.readbyqxmd.com/read/29453515/micro-fragmented-adipose-tissue-injection-for-the-treatment-of-complex-anal-fistula-a-pilot-study-accessing-safety-and-feasibility
#1
G Naldini, A Sturiale, B Fabiani, I Giani, C Menconi
BACKGROUND: The aim of the present study was to evaluate the safety and efficacy of autologous, micro-fragmented and minimally manipulated adipose tissue injection associated closure of the internal opening in promoting healing of complex anal fistula. METHODS: A pilot study was conducted on patients referred to our center with anal fistula, from April 2015-December 2016. Inclusion criteria were age over 16 years old and a diagnosis of complex anal fistula according to the American Gastroenterological Association classification The patients were divided into 2 groups; the "first time group" (Group I) in which micro-fragmented adipose tissue injection with closure of the internal opening was the first sphincter-saving procedure, and the "recurrent group" (Group II) consisting of patients who had failed prior sphincter-saving procedures...
February 16, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29452968/analysis-and-description-of-disease-specific-quality-of-life-in-patients-with-anal-fistula
#2
Manuel Ferrer-Márquez, Natalia Espínola-Cortés, Ángel Reina-Duarte, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla
INTRODUCTION: In patients diagnosed with anal fistula, knowing the quality of life specifically related to the disease can help coloproctology specialists to choose the most appropriate therapeutic strategy for each case. The aim of our study is to analyzse and describe the factors related to the specific quality of life in a consecutive series of patients diagnosed with anal fistula. METHODS: Observational, cross-sectional study carried out from March 2015 to February 2017...
February 13, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29442064/pilonidal-disease-mimicking-anterior-anal-fistula-and-associated-with-posterior-anal-fistula-a-two-step-surgery-case-report
#3
Chiara Eberspacher, D Mascagni, L Fralleone, G Grimaldi, P Antypas, P Mascagni, A Maturo, F M Di Matteo, S Pontone, D Pironi
AIM: Anal fistula is a common disease originated from abscess according the cryptoglandular theory. A rare etiology is the pilonidal disease. In our case we observed a pilonidal disease mimicking an anterior perianal fistula, associated with another posterior anal fistula. CASE PRESENTATION: A 36-year old man was referred to our department with an anal fistula with an anterior opening. Despite the clinical examination and the endoanal ultrasound, only during the surgery we discovered the origin of the anterior fistula from a misdiagnosed pilonidal sinus...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29411947/silk-fibroin-based-fibrous-anal-fistula-plug-with-drug-delivery-function
#4
Xusheng Xie, Lei Liu, Zhaozhu Zheng, Zhifen Han, Min Zhi, David L Kaplan, Gang Li, Xiaoqin Wang
The aim of this work is to develop a drug-loaded silk fibroin fibrous membrane (DSFM) that can be attached to the surface of an anal fistula plug to improve the treatment of Crohn's disease (CD). Curcumin (CUR) and 5-aminosalicylic acid (5-ASA)-loaded silk fibroin (SF) membranes are coaxially electrospun onto the surface of a braided silk filament plug. The membranes show a predominant structure of random coil and silk I conformation. The concentration of CUR/5-ASA (weight ratio of 1/1) in the SF solution is optimized to 0...
February 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29397638/otsc%C3%A2-proctology-vs-fistulectomy-and-primary-sphincter-reconstruction-as-a-treatment-for-low-trans-sphincteric-anal-fistula-in-a-randomized-controlled-pilot-trial
#5
Domenico Mascagni, Daniele Pironi, Gianmarco Grimaldi, Anna M Romani, Giuseppe LA Torre, Chiara Eberspacher, Rossella Palma, Salvatore Sorrenti, Stefano Pontone
BACKGROUND: To compare OTSC® Proctology and fistulectomy with primary sphincter reconstruction results as treatment strategies for anorectal low trans-sphincteric fistula. METHODS: Between February 2012 and March 2013, patients affected by trans-sphincteric anal fistula were consecutively enrolled in the trial. Patients were randomized to receive fistulectomy with primary sphincter reconstruction or OTSC® Proctology. Demographic characteristics, comorbodities, previous anorectal treatments, and recurrent fistula data were acquired...
February 1, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29394765/-a-case-of-more-than-five-year-survival-of-carcinoma-associated-with-anal-fistula-effectively-treated-by-combined-modality-therapy
#6
Mizunori Yaegashi, Koki Otsuka, Toshimoto Kimura, Teppei Matsuo, Kei Sato, Kiyoharu Takashimizu, Tomoki Hatanaka, Toru Yoshida, Chihiro Tono, Yukihiro Minagawa, Masanori Takahashi, Hideki Ishioka, Ryo Sugimoto, Tamotsu Sugai, Akira Sasaki
The patient was a 56-year-old man who presented with perianal pain and a perianal abscess. After admission, he underwent debridement and colostomy due to poor control of the perianal abscess. Following a biopsy of the resected specimens, he was diagnosed with adenocarcinoma in the anorectal fistula. CT and MRI revealed that the tumor had invaded into the internal obturator muscle. Therefore, preoperative chemoradiotherapy and chemotherapy were given for locally advanced cancer. Subsequent to tumor shrinkage, we performed an abdominoperineal resection...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394675/-a-case-of-locally-advanced-rectal-cancer-with-abscess-and-rectovesical-fistula-curatively-resected-following-preoperative-chemotherapy
#7
Tatsuya Matsumoto, Masayoshi Nakanishi, Mahito Miyamae, Koji Takao, Tomohiko Fukunaga, Eigo Otsuji
A 63-year-old man with bloody stools, anal incompetence, and feeling of fatigue was diagnosed as having a RAS mutanttype rectal cancer with abscess and rectovesical fistula. Computed tomography revealed that the tumor had invaded the seminal vesicle, prostate, and bladder and formed an abscess. In addition, his general condition was poor. Thus, we evaluated the lesion as unresectable. His nutritional status improved, and the infection was controlled after colostomy. Then, we performed chemotherapy with 5-fluorouracil, Leucovorin, and oxaliplatin(FOLFOX)plus bevacizumab...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394660/-neoadjuvant-chemoradiotherapy-for-locally-advanced-carcinoma-associated-with-anal-fistula
#8
Teppei Miyakawa, Satoru Iida, Takahiro Igaki, Hiroyuki Shiobara, Ryo Matsumoto, Katsutaka Mitachi, Yoshiteru Ohata, Katsumasa Saito, Tomoya Miura, Takumi Irie, Shigeru Yamazaki
The patient was a 59-year-old man. He was admitted to our hospital because of increasing anal pain with induration of the perianal region. There were large secondary orifices with mucous discharge on the left side of the perineal resion and buttock. We diagnosed adenocarcinoma on analysis of a biopsy specimen from induration of the perianal region. Pelvic CT and MRI showed that the tumor spreaded within the pelvis, with invasion of the prostate and sacrum. We performed neoadjuvant chemoradiotherapy preoperatively...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29386757/anterior-sagittal-anorectoplasty-with-external-sphincter-preservation-for-the-treatment-of-recto-vestibular-fistula-a-new-approach
#9
Mohamed Ibrahim Elsawaf, Mohamed S Hashish
Context: To our knowledge, there is no description of anterior sagittal anorectoplasty (ASARP) with external anal sphincter preservation and passing neorectum in the middle of muscle complex under direct vision for the treatment of recto-vestibular fistula (VF). Aim: This study evaluates a new modification combining ASARP with under vision sphincter preservation. Subjects and Methods: This prospective study was conducted on thirty female infants with VF...
January 2018: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/29380371/novel-application-of-internal-obturator-and-semitendinosus-muscle-flaps-for-rectal-wall-repair-or-reinforcement
#10
J Riggs, J F Ladlow, L J Owen, J L Hall
Internal obturator and/or semitendinosus muscle flaps were used to reinforce primary appositional rectal wall repair in three dogs and one cat in this case series. All three dogs incurred rectal wall compromise during surgical excision of anal sac tumours. The cat sustained bite wounds to the perianal region resulting in abscessation and a rectal tear. Our results indicate that application of an internal obturator and/or semitendinosus muscle flap can reduce the risk of rectal wall dehiscence after primary repair, and consequently the risk of pararectal abscess or rectocutaneous fistula formation...
January 29, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29373345/basic-knowledge-of-tracheoesophageal-fistula-and-esophageal-atresia
#11
Sura Lee
BACKGROUND: Tracheoesophageal fistula (TEF) and esophageal atresia (EA) are rare anomalies in neonates. Up to 50% of neonates with TEF/EA will have Vertebral anomalies (V), Anal atresia (A), Cardiac anomalies (C), Tracheoesophageal fistula (T), Esophageal atresia (E), Renal anomalies (R), and Limb anomalies (L) (VACTERL) association, which has the potential to cause serious morbidity. PURPOSE: Timely management of the neonate can greatly impact the infant's overall outcome...
February 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29370278/diagnostic-performance-of-intravoxel-incoherent-motion-diffusion-weighted-imaging-and-dynamic-contrast-enhanced-mri-for-assessment-of-anal-fistula-activity
#12
Philippe Lefrançois, Mathieu Zummo-Soucy, Damien Olivié, Jean-Sébastien Billiard, Guillaume Gilbert, Juliette Garel, Emmanuel Visée, Perrine Manchec, An Tang
OBJECTIVE: To evaluate intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) sequences for quantitative characterization of anal fistula activity. METHODS: This retrospective study was approved by the institutional review board. One hundred and two patients underwent MRI for clinical suspicion of anal fistula. Forty-three patients with demonstrable anal fistulas met the inclusion criteria...
2018: PloS One
https://www.readbyqxmd.com/read/29366306/video-assisted-anal-fistula-treatment-vaaft-in-the-management-of-complex-anal-fistula-single-center-experience-of-224-consecutive-patients
#13
Alessandro Stazi, Paolo Izzo, Francesco D'Angelo, Monica Radicchi, Manuele Mazzi, Federico Tomassini, Luciano Izzo, Stefano Valabrega
BACKGROUND: Video Assisted Anal Fistula Treatment (VAAFT) is now a mature technique, supported by many short-term published case series. METHODS: We designed a monocentric, retrospective and observational study in order to evaluate early and long-term outcomes of VAAFT in the treatment of primary and recurrent complex anal fistula. Between November 2011 and March 2014, 224 consecutive patients affected by complex perianal fistula underwent Video Assisted Anal Fistula Treatment...
January 23, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29362337/-a-case-of-metastatic-carcinoma-of-anal-fistula
#14
Atsuo Imagawa, Satoshi Okumura, Sho Toyoda, Hiroshi Kawashima, Hiroshi Yasuda, Kansuke Yamamoto, Aya Ito, Naoto Mizumura, Ken Yoo, Hiromitsu Maehira, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama, Genichiro Yoneda
A 58-year-old man underwent rectal resection(D2 dissection)for rectal cancer and liver/lung metastases in August 2009. Histopathological findings were Ra, type 2, 70×80mm, tub1>tub2, int, pSI(peritoneum), INF b, ly1, v1, pN1(2/13), pPM0, pDM0, M1a(H1, PUL1), fStage IV . The lung metastasis had disappeared on chest CT after postoperative chemotherapy and we were able to perform radical resection of the liver metastasis by performing hepatectomy twice. In October 2013, anal pain appeared and a painful tumor approximately 2 cm in size was found in the 5 o'clock direction of the anus...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29340544/interesfincterial-ligation-of-fistula-tract-lift-for-patients-with-anal-fistulas-a-brazilian-bi-institutional-experience
#15
Sérgio Eduardo Alonso Araújo, Marcelli Tainah Marcante, Carlos Ramon Siveira Mendes, Alexandre Bruno Bertoncini, Victor Edmond Seid, Lucas Araujo Horcel, Rodrigo Oliva Perez, Sidney Klajner
BACKGROUND: The best treatment for anal fistula should extirpate infection and promote healing of the tract, whilst preserving the anal sphincter complex and full continence. AIM: To analyze the success rate after a modified technique for ligation of the intersphincteric fistula tract (LIFT) for patients with anal fistulas. METHODS: A prospective (observational cohort study) Brazilian bi-institutional experience with a modified (ligation of the intersphincteric fistula tract without excision) LIFT technique was undertaken...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29323430/transsphincteric-repair-of-rectourethral-fistulas-15-years-of-experience-with-the-york-mason-approach
#16
George Dafnis
OBJECTIVES: To evaluate the surgical and functional outcomes of our single institution's 15-year experience with surgically treated rectourethral fistulas using a modification of the York Mason technique. METHODS: Prospectively recorded data between 2002 and 2016 of all patients who underwent transsphincteric repair of rectourethral fistula using a modified York Mason technique at Eskilstuna County Hospital, Eskilstuna, Sweden, were assessed. A total of 20 consecutive patients, including 17 referrals (85%) and three patients (15%) from our hospital have undergone the modified York Mason procedure...
January 11, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29315090/incidence-and-risk-factors-for-anastomotic-failure-in-1594-patients-treated-by-transanal-total-mesorectal-excision-results-from-the-international-tatme-registry
#17
Marta Penna, Roel Hompes, Steve Arnold, Greg Wynn, Ralph Austin, Janindra Warusavitarne, Brendan Moran, George B Hanna, Neil J Mortensen, Paris P Tekkis
OBJECTIVE: To determine the incidence of anastomotic-related morbidity following Transanal Total Mesorectal Excision (TaTME) and identify independent risk factors for failure. BACKGROUND: Anastomotic leak and its sequelae are dreaded complications following gastrointestinal surgery. TaTME is a recent technique for rectal resection, which includes novel anastomotic techniques. METHODS: Prospective study of consecutive reconstructed TaTME cases recorded over 30 months in 107 surgical centers across 29 countries...
January 5, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29302751/primary-fecal-diversion-and-bowel-dysfunction-in-restorative-proctocolectomy-for-ulcerative-colitis-a-nationwide-cross-sectional-study
#18
Anders Mark-Christensen, Søren Brandsborg, Søren Laurberg
PURPOSE: The aim of this study was to explore the effects of primary fecal diversion on the risk of pouch dysfunction. METHODS: Patients operated with an ileal pouch-anal anastomosis in Denmark in 2000-2010 were identified and validated bowel function questionnaires retrieved from a cross-sectional study. Multivariate logistic regression analysis was performed to determine the effect of primary fecal diversion on pouch dysfunction. A diagnostic or procedural code for intraabdominal abscesses and fistulas, occurring within 1 year after pouch creation, and anastomotic leakage or extremely early-onset pouchitis within 30 days of surgery defined a pelvic complication...
January 4, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29285682/efficacy-of-autologous-fat-graft-injection-in-the-treatment-of-anovaginal-fistulas
#19
S Norderval, L Lundby, H Hougaard, S Buntzen, S Weum, L de Weerd
BACKGROUND: Injection of autologous fat is an established method within plastic surgery for soft tissue augmentation. The aim of the present study was to determine whether transperineal fat graft injection could promote healing of anovaginal fistulas. METHODS: The procedures were performed at the University Hospital of North Norway, Tromsø, Norway, and at Aarhus University Hospital, Aarhus, Denmark, between May 2009 and September 2016. After abdominal liposuction, fat was injected around the fistula tract that was finally transected percutaneously with a sharp cannula and fat injected between the cut parts...
December 28, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29280126/-association-of-serum-mirna6086-expression-with-postoperative-anal-fistula-recurrence
#20
Yong Tao, Guangen Yang, Jianming Qiu, Hongtao Wang, Dong Wang, Shuxian Shao
OBJECTIVE: To investigate the association between serum miRNA-6086 expression level and anal fistula recurrence. METHODS: Clinical data and serum samples of 60 patients with anal fistula and mix hemorrhoid identified by pathology undergoing resection in our department from August 2015 to August 2016 were collected. In addition, serum samples of 20 patients matching with fistula group in age, gender and body weight and receiving only hemorroidectomy were collected as control during the same period...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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