Yuan-Chin Tsai, Shu-Pin Huang, Wei-Chung Cheng, Yu-Ching Fan, Ya-Ching Lin, Shin-Yu Tsai, Chao-Yuan Huang, Chia-Cheng Yu, Victor C Lin, Jiun-Hung Geng, Chia-Yang Li, Te-Ling Lu, Bo-Ying Bao
One-carbon metabolism plays a crucial role in tumorigenesis as it supplies the one-carbon units necessary for nucleotide synthesis, epigenetic regulation, and redox metabolism, ensuring the rapid proliferation of cancer cells. However, their roles in prostate cancer progression remain poorly understood. In this study, we investigated the association between genetic variants in the one-carbon metabolism pathway and clinical outcomes in patients receiving androgen deprivation therapy for prostate cancer. The associations of 130 single-nucleotide polymorphisms located within 14 genes involved in the one-carbon metabolism pathway with cancer-specific survival (CSS), overall survival, and progression-free survival were assessed using Cox regression in 630 patients with prostate cancer...
2024: American Journal of Cancer Research